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Chinese Journal of Astronomy and Astrophysics 2009年第2期9卷 213-219页

作者： xiao-hui zhang Department of Physics Yunnan University Kunming 650091 China

The X-ray afterglows of GRBs 060413, 060522, 060607A and 080330 are characterized by a plateau followed by a very sharp drop. The plateau could be explained within the framework of the external forward shock model but the sharp drop can not. We interpret the plateau as the afterglows of magnetized central engines, plausibly magnetars. In this model, the X-ray afterglows are powered by the internal magnetic energy dissipation and the sudden drop is caused by the collapse of the magnetar. Accordingly, the X-ray plateau photons should have a high linear polarization, which can be tested by future X-ray polarimetry.

关键词： gamma-rays bursts -- ISM jets and outflows -- radiation mechanisms non-thermal

Distributed framework for yard planning in container terminals

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第12期11卷 992-997页

作者： Kap Hwan KIM xiao-hui zhang Department of Industrial Engineering Pusan National University Department of Logistics Information Technology Pusan National University

This study discusses a yard planning system,which considers various resources such as storage space,yard cranes,and traffic areas in container *** system is based on the function for estimating resource requirements of yard *** a given yard plan,the proposed system allows planners to check the feasibility of the plan which requires a certain amount of workload of resources in related blocks during a planning *** yard planning system in this study is aimed at balancing workloads among the blocks and providing the ability to modify current yard plans by detecting blocks and periods with overloaded *** system implements its planning function in a distributed manner in which planners construct yard plans under their individual control and send and receive only limited necessary information for the negotiation.

关键词： Workload Yard planning Container terminal Distributed planning

The ROCK pathway inhibitor Y-27632 mitigates hypoxia and oxidative stress-induced injury to retinal Müller cells

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Neural Regeneration Research 2018年第3期13卷 549-555页

作者： xiao-hui zhang Zhao-hui Feng xiao-yu Wang Department of Ophthalmology Second Affiliated Hospital of Xi'an Jiaotong University Medical College Xi'an Shaanxi Province China

Rho kinase （ROCK） was the first downstream Rho effector found to mediate RhoA-induced actin cytoskeletal changes through effects on myosin light chain phosphorylation. There is abundant evidence that the ROCK pathway participates in the pathogenesis of retinal endothelial injury and proliferative epiretinal membrane traction. In this study, we investigated the effect of the ROCK pathway inhibitor Y-27632 on retinal Müller cells subjected to hypoxia or oxidative stress. Müller cells were subjected to hypoxia or oxidative stress by exposure to CoCl2 or H2O2. After a 24-hour treatment with Y-27632, the 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyl tetrazolium bromide assay was used to assess the survival of Müller cells. Hoechst 33258 was used to detect apoptosis, while 2′,7′-dichlorodihydrofluorescein diacetate was used to measure reactive oxygen species generation. A transwell chamber system was used to examine the migration ability of Müller cells. Western blot assay was used to detect the expression levels of α-smooth muscle actin, glutamine synthetase and vimentin. After treatment with Y-27632, Müller cells subjected to hypoxia or oxidative stress exhibited a morphology similar to control cells. Y-27632 reduced apoptosis, α-smooth muscle actin expression and reactive oxygen species generation under oxidative stress, and it reduced cell migration under hypoxia. Y-27632 also upregulated glutamine synthetase expression under hypoxia but did not impact vimentin expression. These findings suggest that Y-27632 protects Müller cells against cellular injury caused by oxidative stress and hypoxia by inhibiting the ROCK pathway.

关键词： nerve regeneration diabetic retinopathy Rho kinases Müller cells reactive oxygen species glutamine synthetase α-smooth muscle actin CoCl2 H2O2 hypoxia oxidative stress neural regeneration

Embracing the age of artificial intelligence:paradigm shifts,opportunities,and challenges in the treatment of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

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Science China(Life Sciences) 2024年第6期67卷 1302-1304页

作者： Zhuo-Yu An xiao-hui zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Collaborative Innovation Center of Hematology Peking UniversityBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China

Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is an important medical development in treating hematological ***,the risk of acute graft-versus-host disease(a GVHD)severely limits its use.a GVHD is a sev... 详细信息

关键词： hematopoietic graft artificial

pigment epithelium-derived factor protects the morphological structure of retinal Müller cells in diabetic rats

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International Journal of Ophthalmology(English edition) 2014年第6期7卷 941-946页

作者： xiao-hui zhang Zhao-hui Feng Yi zhang Department of Ophthalmology the Second Affiliated Hospital of Xi'an Jiaotong University Medical College

AIM: To investigate if pigment epithelium-derived factor(PEDF) has any protective effect on the retinal Müller cells of Sprague-Dawley rats suffering from diabetes ***: Sixty Sprague-Dawley rats were randomly divided into a negative control group, a group receiving0.1 μg/μL PEDF, another group receiving 0.2 μg/μL PEDF,and a group receiving balanced salt solution(BSS). Rats in both the PEDF and BSS groups were treated intravitreally based on previously established diabetic models. After 4wk of treatment, morphological alterations of Müller cells and protein expression of glutamine synthase(GS) and glial fibrillary acidic protein(GFAP)were ***:PEDFateither0.1μg/μLor0.2μg/μLsignificantly improved the structures of both nuclei and organelles of Müller cells compared to the BSS-treated *** of GS was significantly higher in the 0.2 μg/μL PEDF group than that in the BSS group(P =0.012), but expression of GFAP was significantly lower in the 0.2 μg/μL PEDF group than that in the BSS group(P =0.000);however, there were no significant differences in expression of these proteins between the 0.1 μg/μL PEDF group and the BSS group(P =0.608, P =0.152). CONCLUSION: PEDF protects the morphological ultrastructure of Müller cells, improves the expression of glutamate synthase and prevents cell gliosis.

关键词： diabetes mellitus pigment epitheliumderived factor retinal Müller cells glutamine synthase glial fibrillary acidic protein

Instantaneous deformation characteristics of a single bubble in immiscible fluids

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Journal of Iron and Steel Research International 2022年第10期29卷 1601-1612页

作者： Jia-rui Xu xiao-hui zhang Shan Qing Hao zhang Hua Wang Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming650093YunnanChina National Local Joint Engineering Research Center of Energy Saving and Environmental Protection Technology in Metallurgy and Chemical Engineering Industry Kunming University of Science and TechnologyKunming650093YunnanChina

The passage of a rising bubble through immiscible fluids is encountered in bath *** order to investigate characteristics of bubble deformation in immiscible fluids,the bubble shape change at the interface and the relationship between the bubble aspect ratio(E)and dimensionless number of forces were obtained.A three-dimensional model was established,and the free-floating behavior of a single bubble in immiscible fluids was numerically simulated by phase-field *** simulation results are in good agreement with experimental *** results indicate that when the bubble passes through the interface,the bubble shape is divided into four types in turn:“pear”,inverted“pear”,“convex”and“droplet”*** the lower liquid,the relationship of E to Weber number(We),Tadaki number(Ta),and Reynolds number(Re)is distributed between two intersecting *** relationship of E to Eötvös number(Eo),a dimensionless group,and Galilei number(Ga)is distributed near the lines with slopes of−3.325×10^(-5),−0.0855,and−8.73×10^(-4),*** the upper liquid,the relationship of E to We,Ta,and Re is distributed between two parallel *** with gravity,the inertial force plays a leading role in the bubble shape in the lower and upper *** with the viscous force,the surface tension dominates the bubble shape in the lower liquid.

关键词： Bubble shape Immiscible fluid Dimensionless number Phase-field method

Interference of Y-27632 on the signal transduction of transforming growth factor beta type 1 in ocular Tenon capsule fibroblasts

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International Journal of Ophthalmology(English edition) 2012年第5期5卷 576-581页

作者： xiao-hui zhang, Jian-Ming Wang Department of Ophthalmology the Second Affiliated Hospital College of Medicine Xi'an Jiaotong University Xi'an 710004 Shaanxi Province China Department of Pharmacology Xijing Hospital Fourth Military Medical University Xi'an 710032 Shaanxi Province China

AIM: To investigate the interfering effect of Y-27632, a ROCK-I selective inhibitor, on the signal transduction pathway of transforming growth factor-beta 1 (TGF-beta 1) in ocular Tenon capsule fibroblasts (OTFS) in vitro. METHODS: After OTFS from passages 4 to 6 47 vitro were induced by TGF-beta 1 and then treated by Y-27632, the changes of the OTFS cell cycles were analyzed via flow cytometry, and the proteins expression of the alpha -smooth muscular actin (alpha -SMA), connective tissue growth factor (CTGF), collagen I were calculated by Western blot. After OTFS treated by the different concentrations of Y-27632, the expression levels of the alpha -SMA, CTGF and collagen I mRNA were assayed by RT-PCR. RESULTS: Y-27632 had no markedly effect on the OTFS cell cycles. After treated by TGF-beta 1, OTFS in G1 period significantly increased. The cell cycles distribution by both TGF-beta 1 and Y-27632 had no remarkable difference from that in control group. Y-27632 significantly inhibited the proteins expressions of both alpha -SMA and CTGF, while to some extent inhibited that of collagen I. TGF-beta 1 significantly promoted the proteins expressions of alpha -SMA, CTGF and collagen I. After OTFS treated by both TGF-beta 1 and Y-27632, of alpha -SMA, the protein expression was similar with that in control group (P=0.066>0.05), but the protein expression of CTGF or collagen I, respectively, was significantly different from that in control group (P=0.000<0.01). The differences of expressions of the alpha -SMA, CTGF and collagen I mRNA in 30, 150, 750 mu mol/L Y-27632 group were statistically significant, compared with those in control group, respectively (alpha -SMA, P=0.002, 0.000, 0.000; CTGF, P=0.014, 0.002, 0.001; collagen I,P=0.003, 0.002, 0.000). CONCLUSION: Blocking the Rho/ROCK signaling pathway by using of Y-27632 could inhibit the cellular proliferation and the expression of both CTGF and alpha -SMA whatever OTFS induced by TGF-beta 1 or not. Y-27632 suppressed t

关键词： Y-27632 ocular Tenon's capsule fibroblasts transforming growth factor beta type 1 α-smooth muscular actin connective tissue growth factor collagen I

Morphogenesis of Pistillate Flowers of Cercidiphyllum japonicum(Cercidiphyllaceae)

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Journal of Integrative Plant Biology 2007年第9期49卷 1400-1408页

作者： xiao-Ling Yan Yi Ren Xian-Hua Tian xiao-hui zhang College of Life Sciences Shaanxi Normal University Key Laboratory of Medicinal Plant Resource and Natural Pharmaceutical Chemistry of Ministry of Education Xi'an 710062 China

Floral morphogenesis and the development of Cercidiphyllumjaponicum Sieb. et Zucc. were observed by scanning electron microscopy （SEM）. The results showed that the pistillate inflorescences were congested spikes with the flowers arranged opposite. Great differences between the so-called ＂bract＂ and the vegetative leaf were observed both in morphogenesis and morphology. In morphogenesis, the ＂bract＂ primordium is crescent-shaped, truncated at the apex and not conduplicate, has no stipule primordium at the base but does have some inconspicuous teeth in the margin that are not glandular. The leaf primordium is triangular, cycloidal at the apex, conduplicate, has two stipule primordia at the base, has one gland-tooth at the apex occurring at first and some gland-teeth in the margin that occur later. In morphology, the ＂bract＂ is also different to the vegetative leaf in some characteristics that were also illustrated in the present paper. Based on the hypothesis that the bract is more similar to the vegetative leaf than the tepal, we considered that the so-called ＂bract＂ of *** might be the tepal of the pistillate flower in morphological nature. Therefore, each pistillate flower contains a tepal and a carpel. We did not find any trace of other floral organs in the morphogenesis of the pistillate flower. Therefore we considered that the unicarpellate status of extant Cercidiphyllum might be to highly reduce and advance characteristics that make the extant Cercidiphyllum isolated from both fossil Cercidiphyllum-like plants and its extant affinities.

关键词： Cercidiphyllumjaponicum leaf morphogenesis pistillate flower tepal.

Inhibition of RhoA/Rho-kinase pathway suppresses the expression of extracellular matrix induced by CTGF or TGF-β in ARPE-19

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International Journal of Ophthalmology(English edition) 2013年第1期6卷 8-14页

作者： Jing Zhu Duy Nguyen Hong Ouyang xiao-hui zhang xiao-Ming Chen Kang zhang Department of Ophthalmology West China Hospital Sichuan University Department of Ophthalmology and Shiley Eye Center and Institute for Genomic MedicineUniversity of California San Diego Beijing Institute of Ophthalmology Beijing Tongren Eye CenterCapital Medical University

AIM:To investigate the role of Rho-associated protein kinase (ROCK) inhibitor, Y27632, in mediating the production of extracellular matrix (ECM) components including fibronectin, matrix metallo-proteinase-2 (MMP-2) and type I collagen as induced by connective tissue growth factor(CTGF) or transforming growth factor-β (TGF-β) in a human retinal pigment epithelial cell line, ARPE-19. METHODS:The effect of Y27632 on the CTGF or TGF-β induced phenotype in ARPE-19 cells was measured with immunocytochemistry as the change in F-actin. ARPE-19 cells were treated with CTGF (1, 10, 100ng/mL)and TGF-β (10ng/mL) in serum free media, and analyzed for fibronectin, laminin, and MMP-2 and type I collagen by RT-qPCR and immunocytochemistry. Cells were also pretreated with an ROCK inhibitor, Y27632, to analyze the signaling contributing to ECM production. ·RESULTS:Treatment of ARPE-19 cells in culture with TGF-β or CTGF induced an ECM change from a cobblestone morphology to a more elongated swirl pattern indicating a mesenchymal phenotype. RT-qPCR analysis and different gene expression analysis demonstrated an upregulation in expression of genes associated with cytoskeletal structure and motility. CTGFor TGF-β significantly increased expression of fibronectin mRNA (P =0.006, P =0.003 respectively), laminin mRNA (P =0.006, P =0.005), MMP-2 mRNA (P =0.006, P =0.001), COL1A1 mRNA (P =0.001, P =0.001), COL1A2 mRNA (P = 0.001, P =0.001). Preincubation of ARPE-19 with Y27632 (10mmol/L) significantly prevented CTGF or TGF-β induced fibronectin (P=0.005, P=0.003 respectively), MMP-2 (P = 0.003, P =0.002), COL1A1 (P =0.006, P =0.003), and COL1A2 (P =0.006, P =0.004) gene expression, but not laminin (P =0.375, P =0.516). CONCLUSION:Our study demonstrated that both TGF-β and CTGF upregulate the expression of ECM components including fibronectin, laminin, MMP-2 and type I collagen by activating the RhoA/ROCK signaling pathway. During this process, ARPE-19 cells were shown to change from an epith

关键词： Rho-associated protein kinase inhibitor Connective tissue growth factor transforming growth factor-β proliferative vitreoretinopathy

Extra-pulmonary tuberculosis infection in the dialysis patients with end stage renal diseases:case reports and literature review

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第1期14卷 76-82页

作者： Wen-fang YANG Fei HAN xiao-hui zhang Ping zhang Jiang-hua CHEN Kidney Disease Center the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

The diagnosis of extra-pulmonary tuberculosis(TB) seems relatively difficult due to the absence of specific symptoms and signs in patients on peritoneal dialysis or *** report four cases of extra-pulmonary tuberculosis on dialysis,with two cases on peritoneal dialysis and two cases on *** presentations,therapy,and outcomes of TB infection in these patients were ***,the English literature published in the PubMed database associating extra-pulmonary tuberculosis on dialysis over the last three decades is reviewed.A total of 61 studies containing 70 cases were *** most common primary disease was diabetic nephropathy(22.86%,16/70).The peritoneum(31.42%,22/70),bone(21.42%,15/70),and lymph node(20%,14/70) were the most frequently *** organ infection was common(90%,63/70).Fever(58.57%,41/70),pain(35.71%,25/70),and enlarged lymph node(20%,14/70) were the most common ***(67.14%,47/70) and culture(40%,28/70) provided most reliable methods for clear diagnosis of *** combined treatment of isoniazid,rifampicin,pyrazinamide,and ethambutol(44.29%,31/70) was the most common *** majority of patients improved(82.86%,58/70);however,12 cases got worse(17.14%),with 10 of them dying(14.29%).Physicians should be aware of the non-specific symptoms and location of infection,and consider tuberculosis in their differential diagnoses in dialysis patients presenting with symptoms such as fever,pain,and weight loss.

关键词： Extra-pulmonary tuberculosis End stage renal disease Dialysis