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World Journal of Gastroenterology 2024年第8期30卷 843-854页

作者： hong-xiao wu xiao-Yan Ding Ya-Wen Xu Ming-Hua Yu xiao-Mi Li Na Deng Jing-Long Chen Cancer Center Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

BACKGROUND Hepatocellular carcinoma(HCC)patients complicated with portal vein tumor thrombus(PVTT)exhibit poor prognoses and treatment *** To investigate efficacies and safety of the combination of PD-1 inhibitor,transcatheter arterial chemoembolization(TACE)and Lenvatinib in HCC subjects comorbid with *** From January 2019 to December 2020,HCC patients with PVTT types Ⅰ-Ⅳ were retrospectively enrolled at Beijing Ditan *** were distributed to either the PTL or TACE/Lenvatinib(TL)*** median progression-free survival(mPFS)was set as the primary endpoint,while parameters like median overall survival,objective response rate,disease control rate(DCR),and toxicity level served as secondary *** Forty-one eligible patients were finally recruited for this study and divided into the PTL(n=18)and TL(n=23)*** a median follow-up of 21.8 months,the DCRs were 88.9%and 60.9%in the PTL and TL groups(P=0.046),***,mPFS indicated significant improvement(HR=0.25;P<0.001)in PTL-treated patients(5.4 months)compared to TL-treated(2.7 months)*** were no treatment-related deaths or differences in adverse events in either *** A triplet regimen of PTL was safe and well-tolerated as well as exhibited favorable efficacy over the TL regimen for advanced-stage HCC patients with PVTT types Ⅰ-Ⅳ.

关键词： Hepatocellular carcinoma Transcatheter arterial chemoembolization Lenvatinib PD-1 inhibitor Portal vein tumor thrombus

NUMERICAL SIMULATION OF A HORIZONTAL MOMENTUM JET IN CROSS-FLOW

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Journal of Hydrodynamics 2006年第1期18卷 118-125页

作者： xiao Yang TANG hong-wu College of Water Conservancy and Hydropower Engineering Hohai University Nanjing 210098 China

The mixing characteristics of a Horizontal Momentum Jet in Cross flow （HMJC） were investigated using the CFD code Fluent. The realizable k-ε model was employed for turbulent closure of the Reynolds-averaged Navier-Stokes equations. The computed results, including concentration field and velocity field, agree well with the relations of dimen sional analysis, as well as the experimental results by Sherif and Pletcher, Ali and Yu et al.

关键词： horizontal momentum jet cross-flow realizable k-ε model LIF PIV

Two Structure-Preserving-Doubling Like Algorithms to Solve the Positive Definite Solution of the Equation X-A^(H)X^(-1)A=Q

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Communications on Applied Mathematics and Computation 2021年第1期3卷 123-135页

作者： xiao-Xia Guo hong-xiao wu School of Mathematical Science Ocean University of ChinaQingdao 266100Shandong ProvinceChina

In this paper,we study the nonlinear matrix equation X-A^(H)X^(-1)A=Q,where A,Q∈C^(n×n),Q is a Hermitian positive definite matrix and X∈C^(n×n)is an unknown *** prove that the equation always has a unique Hermitian positive definite *** present two structure-preserving-doubling like algorithms to find the Hermitian positive definite solution of the equation,and the convergence theories are ***,we show the effectiveness of the algorithms by numerical experiments.

关键词： Positive definite solution Structure-preserving-doubling like algorithm Convergence Numerical experiment

On the Origin and Numerical Range of Bounded Operators

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Acta Mathematica Sinica,English Series 2019年第10期35卷 1715-1722页

作者： xiao hong wu Jun Jie HUANG ALATANCANG School of Mathematical Sciences Inner Mongolia UniversityHohhot 010021P.R.China Department of Mathematics Hohhot Minzu CollegeHohhot 010051P.R.China

Numerical range has an important applications on spectrum distribution of operators. In this paper, we devoted to characterizing operators whose numerical range contains the origin. Some necessary and sufficient conditions are given by operator decomposition technique and constructive methods. Furthermore, the closeness of the numerical range of a given operator is also investigated.

关键词： Bounded linear operator numerical range origin

Diagnostic value of optic disc retinal nerve fiber layer thickness for diabetic peripheral neuropathy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第11期21卷 911-920页

作者： xiao-hong wu Jing-wen FANG Yin-qiong HUANG Xue-feng BAI Yong ZHUANG xiao-yu CHEN Xia-hong LIN Department of Endocrinology the Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000China Department of Endocrinology the First Hospital of QuanzhouQuanzhou 362000China

Objective:To investigate the value of optic disc retinal nerve fiber layer(RNFL)thickness in the diagnosis of diabetic peripheral neuropathy(DPN).Methods:Ninety patients with type 2 diabetes,including 60 patients without DPN(NDPN group)and 30 patients with DPN(DPN group),and 30 healthy participants(normal group)were *** coherence tomography(OCT)was used to measure the four quadrants and the overall average RNFL thickness of the optic *** receiver operator characteristic curve was drawn and the area under the curve(AUC)was calculated to evaluate the diagnostic value of RNFL thickness in the optic disc area for ***:The RNFL thickness of the DPN group was thinner than those of the normal and NDPN groups in the overall average((101.07±12.40)μm vs.(111.07±6.99)μm and(109.25±6.90)μm),superior quadrant((123.00±19.04)μm vs.(138.93±14.16)μm and(134.47±14.34)μm),and inferior quadrant((129.37±17.50)μm vs.(143.60±12.22)μm and(144.48±14.10)μm),and the differences were statistically *** diagnostic efficiencies of the overall average,superior quadrant,and inferior quadrant RNFL thicknesses,and a combined index of superior and inferior quadrant RNFL thicknesses were similar,and the AUCs were 0.739(95%confidence interval(CI)0.635–0.826),0.683(95%CI 0.576–0.778),0.755(95%CI 0.652–0.840),and 0.773(95%CI 0.672–0.854),*** diagnostic sensitivity of RNFL thickness in the superior quadrant reached 93.33%.Conclusions:The thickness of the RNFL in the optic disc can be used as a diagnostic method for DPN.

关键词： Type 2 diabetes Peripheral neuropathy Retinal nerve fiber layer thickness Optical coherence tomography Diagnosis

Cryoglobulinemia is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients

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Chinese Medical Journal 2012年第22期125卷 4014-4017页

作者： FAN xiao-hong wu Chi-hong WANG Li-fen ZHENG Ying-ying YAO Ying LU Hai-ying XU xiao-yuan WEI Lai Peking Univ Hosp 1 Dept Infect Dis Beijing 100034 Peoples R China Peking Univ Hosp 1 Dept Nephrol Beijing 100034 Peoples R China Peking Univ Peoples Hosp Inst Hepatol Beijing 100044 Peoples R China

Background Mixed cryoglobulinemia （MC） is one of the most common and severe symptoms in chronic hepatitis C patients. The aim of this study was to investigate whether mixed cryoglobulinemia is a factor associated with sustained virological response in chronic hepatitis C patients treated with combination therapy of pegylated interferon alpha-2a and ribavirin. Methods This is a single-center study including 57 chronic hepatitis C patients who received combination treatments of pegylated interferon alfa-2a and ribavirin. Serum cryoglobulin was detected by cryoprecipitation prior to treatment. Serum hepatitis C virus （HCV） RNA levels were checked before treatment, during the fourth and 12th week of treatment, and during the 24th week after cessation of treatment. The genotype of HCV was determined at baseline. Logistic regression analysis was used to assess the factors associated with sustained virological response. Results Twenty-five patients were with MC （43.9%）. Twenty-four weeks after cessation of antiviral treatment, sustained virological response achievement in MC~ patients was significantly lower than that in MC- patients （32.0% vs. 75.0%, P=-0.001）. Univariate Logistic regression analysis and multivariate Logistic regression analysis found that only MC （odds ratio： 6.375; 95% Ch 1.998-20.343, P=0.002） was negatively associated with sustained virological response achievement. Conclusion MC is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients treated with pegylated interferon alpha-2a and ribavirin.

关键词： hepatitis C cryoglobulinemia virological response

Two-person device-free localization system based on ZigBee and transformer

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High Technology Letters 2024年第1期30卷 61-67页

作者：刘天蒙 YANG Hai xiao wu hong School of Electronic Information and Optical Engineering Nankai UniversityTianjin 300350P.R.China Tianjin Key Laboratory of Optoelectronic Sensor and Sensing Network Technology Nankai UniversityTianjin 300350P.R.China Engineering Research Center of Thin Film Optoelectronics Technology Nankai UniversityTianjin 300350P.R.China

Most studies on device-free localization currently focus on single-person *** paper proposes a novel method for device-free localization that utilizes ZigBee received signal strength indication(RSSI)and a Transformer network *** method aims to address the limited research and low accuracy of two-person device-free *** paper first describes the construction of the sensor network used for collecting ZigBee *** then examines the format and features of ZigBee data *** algorithm design of this paper is then *** box plot method is used to identify abnormal data points,and a neural network is used to establish the mapping model between ZigBee RSSI matrix and localization *** neural network includes a Transformer encoder layer as the encoder and a fully connected network as the *** proposed method's classification accuracy was experimentally tested in an online test stage,resulting in an accuracy rate of 98.79%.In conclusion,the proposed two-person localization system is novel and has demonstrated high accuracy.

关键词： device-free localization deep learning ZigBee

Current Status and Prospect of Stent Placement for May-Thurner Syndrome

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Current Medical Science 2021年第6期41卷 1178-1186页

作者： Qin LIU Fang LIU Ping LÜ hong-xiao wu Pin YE Yun YOU Zhong YAO Department of Vascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Nuclear Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Donnelly Centre for Cellular and Biomolecular Research University of TorontoTorontoOntario M5S 2E8Canada

Stent implantation has been proven to be safe and has become the first-line intervention for May-Thumer syndrome(MTS),with satisfactory mid-term patency rates and clinical *** research has demonstrated that catheter-directed thrombolysis is the preferred strategy when MTS is combined with deep vein thrombosis after self-expanding stent ***,the stent used for the venous system was developed based on the experience obtained in the treatment of arterial ***,relatively common corresponding complications may come along later,which include stent displacement,deformation,and *** measures such as adopting a stent with a larger diameter,improving stent flexibility,and increasing stent strength have been employed in order to prevent these *** ideal venous stent is presently being evaluated and will be introduced in detail in this review.

关键词： May-Thumer syndrome deep vein thrombosis post-thrombotic syndromes stent stent placement

Effects of Hydrogen Charging Time and Pressure on the Hydrogen Embrittlement Susceptibility of X52 Pipeline Steel Material

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 293-307页

作者： hong-Jiang Wan xiao-Qi wu hong-Liang Ming Jian-Qiu Wang En-Hou Han School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China CAS Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Materials Science and Engineering Northeastern UniversityShenyang110819China Institute of Corrosion Science and Technology Guangzhou510530China

The effects of hydrogen charging time and pressure on the hydrogen embrittlement(HE)susceptibility of X52 pipeline steel material are studied by slow strain rate tensile *** fracture morphologies of the specimens are observed by scanning electron *** HE susceptibility of the X52 pipeline steel material increases with an increase in both hydrogen charging time and hydrogen *** a charging time of 96 h,the HE susceptibility index reaches 45.86%,approximately 3.6 times that at a charging time of 0 ***,a charging pressure of 4 MPa results in a HE susceptibility index of 31.61%,approximately 2.5 times higher than that at a charging pressure of 0.3 MPa.

关键词： Hydrogen embrittlement X52 pipeline steel material Tubular specimen Hydrogen charging time Hydrogen charging pressure

Nkx2-1:a novel tumor biomarker of lung cancer

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第11期13卷 855-866页

作者： LiYANG Min LIN Wen-jing RUAN Liang-liang DONG En-guo CHEN xiao-hong wu Ke-jing YING Department of Respiratory Medicine the First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310006 China Department of Radiology the Third Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310005 China Key Laboratory of Biotherapy of Zhejiang Province Department of Respiratory Medicine Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China

Nkx2-1 (Nkx homeobox-1 gene), also known as TTF-1 (thyroid transcription factor-1), is a tissue-specific transcription factor of the thyroid, lung, and ventral forebrain. While it has been shown to play a critical role in lung development and lung cancer differentiation and morphogenesis, molecular mechanisms mediating Nkx2-1 cell- and tissue-specific expression in normal and cancerous lungs have yet to be fully elucidated. The recent identification of prognostic biomarkers in lung cancer, particularly in lung adenocarcinoma (ADC), and the different reactivity of patients to chemotherapeutic drugs have opened new avenues for evaluating patient survival and the development of novel effective therapeutic strategies. The function of Nkx2-1 as a proto-oncogene was recently characterized and the gene is implicated as a contributory factor in lung cancer development. In this review, we summarize the role of this transcription factor in the development, diagnosis, and prognosis of lung cancer in the hope of providing insights into the utility of Nkx2-1 as a novel biomarker of lung cancer.

关键词： Nkx2-1 TTF-1 Lung cancer Biomarker Diagnosis Prognosis Therapy