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Application of extended criteria donor grafts in liver transplantation for acute-on-chronic liver failure:A retrospective cohort study

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World Journal of Gastroenterology 2023年第41期29卷 5630-5640页

作者： Jin-Long Gong Jia Yu Tie-Long Wang xiao-Shun He Yun-Hua Tang xiao-feng zhu Department of Hepatobiliary Surgery Hunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410005Hunan ProvinceChina Organ Transplant Center The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina Department of Gastroenterology Surgery The First Affiliated Hospital of University of South ChinaHengyang 421005Hunan ProvinceChina

BACKGROUND There is no consensus on the usage of extended criteria donor(ECD)grafts in liver transplantation(LT)for acute-on-chronic liver failure(ACLF)patients.AIM To summarize the experience of using ECD livers in ACLF-LT.METHODS A retrospective cohort study was conducted,enrolling patients who underwent LT at the First Affiliated Hospital of Sun Yat-Sen University from January 2015 to November 2021.The patients were divided into ECD and non-ECD groups for analysis.RESULTS A total of 145 recipients were enrolled in this study,of which ECD and non-ECD recipients accounted for 53.8%and 46.2%,respectively.Donation after cardiac death(DCD)recipients accounted for the minority compared with donation after brain death(DBD)recipients(16.6%vs 83.4%).Neither overall survival nor graft survival significantly differed between ECD and non-ECD and DCD and DBD recipients.ECD grafts were associated with a significantly higher incidence of early allograft dysfunction(EAD)than non-ECD grafts(67.9%vs 41.8%,P=0.002).Postoperative outcomes between DCD and DBD recipients were comparable(P>0.05).ECD graft(P=0.009),anhepatic phase(P=0.034)and recipient gamma glutamyltransferase(P=0.016)were independent risk factors for EAD.Recipient preoperative number of extrahepatic organ failures>2(P=0.015)and intraoperative blood loss(P=0.000)were independent predictors of poor post-LT survival.CONCLUSION Although related to a higher risk of EAD,ECD grafts can be safely used in ACLF-LT.The main factors affecting post-LT survival in ACLF patients are their own severe preoperative disease and intraoperative blood loss.

关键词： Extended criteria donor Acute-on-chronic liver failure Liver transplantation

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Electrolyte perspective on stabilizing LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)cathode for lithium-ion batteries

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稀有金属：英文版 2023年第2期42卷 387-398页

作者： xiao-feng zhu Xiu Li Tian-Quan Liang Xin-Hua Liu Jian-Min Ma School of Resources Environment and MaterialsGuangxi UniversityNanning530004China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu611731China School of Transportation Science and Engineering Beihang UniversityBeijing102206China

Nickel-rich LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)is regarded as the promising cathode for lithium-ion batteries(LIBs).However,the challenges such as safety issues and poor cycling performance have seriously hindered its commercial applications.In order to overcome these difficulties,there has been extensive research and development of electrolyte modifications for high-energy-density LIBs with Ni-rich cathodes.Herein,this review introduces the research progress based on solvent additives,salt type additives and other electrolytes for LIBs with NCM811cathode materials and discusses how they control the interface stability.In particular,some recommendations for further modification of enhancing electrolyte stability and improving NCM811 electrochemical properties are summarized and proposed,which put forward new design rules for the screening and customizing ideal electrolyte additives for high performance NCM811 cathode-based LIBs.

关键词： Nickel-rich LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811) Interface Electrolyte additives Cathode electrolyte interphase(CEI) Electrolyte

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Krüppel-like factor 7 attenuates hippocampal neuronal injury after traumatic brain injury

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Neural Regeneration Research 2022年第3期17卷 661-672页

作者： Wen-Yuan Li Xiu-Mei Fu Zhen-Dong Wang Zhi-Gang Li Duo Ma Ping Sun Gui-Bo Liu xiao-feng zhu Ying Wang Institute of Neural Tissue Engineering Mudanjiang Medical UniversityMudanjiangHeilongjiang ProvinceChina Department of Anatomy College of Basic Medical SciencesChengde Medical UniversityChengdeHebei ProvinceChina Hebei Key Laboratory of Nerve Injury and Repair Chengde Medical UniversityChengdeHebei ProvinceChina Department of Otorhinolaryngology Mudanjiang City Second People’s HospitalMudanjiangHeilongjiang ProvinceChina The First Department of General Surgery Hongqi HospitalMudanjiang Medical UniversityMudanjiangHeilongjiang ProvinceChina

Our previous study has shown that the transcription factor Krüppel-like factor 7(KLF7) promotes peripheral nerve regeneration and motor function recovery after spinal cord injury.KLF7 also participates in traumatic brain injury,but its regulatory mechanisms remain poorly understood.In the present study,an HT22 cell model of traumatic brain injury was established by stretch injury and oxygenglucose deprivation.These cells were then transfected with an adeno-associated virus carrying KLF7(AAV-KLF7).The results revealed that,after stretch injury and oxygen-glucose deprivation,KLF7 greatly reduced apoptosis,activated caspase-3 and lactate dehydrogenase,downregulated the expression of the apoptotic markers B-cell lymphoma 2(Bcl-2)-associated X protein(Bax) and cleaved caspase-3,and increased the expression of βIII-tubulin and the antiapoptotic marker Bcl-2.Furthermore,KLF7 overexpression upregulated Janus kinase 2(JAK2) and signal transducer and activator of transcription 3(STAT3) phosphorylation in HT22 cells treated by stretch injury and oxygenglucose deprivation.Immunoprecipitation assays revealed that KLF7 directly participated in the phosphorylation of STAT3.In addition,treatment with AG490,a selective inhibitor of JAK2/STAT3,weakened the protective effects of KLF7.A mouse controlled cortical impact model of traumatic brain injury was then established.At 30 minutes before modeling,AAV-KLF7 was injected into the ipsilateral lateral ventricle.The protein and m RNA levels of KLF7 in the hippocampus were increased at 1 day after injury and recovered to normal levels at 3 days after injury.KLF7 reduced ipsilateral hippocampal atrophy,decreased the injured cortex volume,downregulated Bax and cleaved caspase-3 expression,and increased the number of 5-bromo-2'-deoxyuridine-positive neurons and Bcl-2 protein expression.Moreover,KLF7 transfection greatly enhanced the phosphorylation of JAK2 and STAT3 in the ipsilateral hippocampus.These results suggest that KLF7 may protect hippocampal neurons after traumatic brain injury

关键词： apoptosis hippocampus JAK2/STAT3 Kruppel-like factor 7 neuroprotection oxygen-glucose deprivation stretch traumatic brain injury

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Parathyroid adenoma combined with a rib tumor as the primary disease: A case report

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World Journal of Clinical Cases 2020年第19期8卷 4681-4687页

作者： Lu Han xiao-feng zhu College of Medicine Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina Department of Thoracic Surgery The First Affiliated Hospital of Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina

BACKGROUND Parathyroid adenoma is a benign parathyroid tumor,with serum parathyroid hormone and calcium ion concentrations as the typical basis for diagnosis.Its clinical manifestations are complex and changeable;thus it is easily missed or misdiagnosed.Approximately 85%of patients with parathyroid adenoma develop primary hyperparathyroidism,and abnormalities in bones,kidneys and other organs can occur.Brown tumors are rare.CASE SUMMARY We report a rare case of fibrocystic osteitis associated with a parathyroid adenoma,which was discovered by chance due to a rib tumor.Abnormally elevated serum parathyroid hormone and calcium ion were found before surgery.We suspected primary hyperparathyroidism,and color Doppler ultrasound suggested the presence of a thyroid mass.With informed consent by the patient and her family,we first removed the rib tumor,and one week later,resection of the parathyroid adenoma and thyroid mass was performed on both sides,and the patient recovered well after surgery.CONCLUSION In the case of parathyroid adenoma combined with brown tumor,the bone cyst will gradually decrease in size with time without treatment.If not,surgery should be performed as soon as possible.

关键词： Parathyroid adenoma Rib Brown tumor Primary hyperparathyroidism Treatment Operation Case report

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Small nucleolar RNAs (snoRNAs) as potential non-invasive biomarkers for early cancer detection

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Chinese Journal of Cancer 2013年第2期32卷 99-101页

作者： Wen-Dan Chen xiao-feng zhu State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer Center

Small nucleolar RNAs (snoRNAs) are non-coding RNA (ncRNA) molecules,which are associated with specific proteins to form small nucleolar ribonucleoparticles.However,the function of snoRNAs in cancer still remains elusive.Recently,several independent lines of evidence have indicated that these ncRNAs might have crucial roles in controlling tumorigenesis,and snoRNAs could be potential biomarkers for cancer.

关键词：核仁小分子RNA 生物标志物癌症检测侵入性非编码RNA 早期蛋白质肿瘤

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Alternating Copolymerization of Epoxides and Isothiocyanates to Diverse Functional Polythioimidocarbonates and Related Block Polymers

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Chinese Journal of Chemistry 2023年第23期41卷 3311-3318页

作者： xiao-feng zhu Xin-Yu Lu Cheng-Kai Xu Yu-Bo Fang Guan-Wen Yang Wei Li Jingdai Wang Guang-Peng Wu MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhouZhejiang310027 China Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology College of Chemical and Biological EngineeringZhejiang UniversityHangzhouZhejiang310027 China

Synthesis of diverse polythioimidocarbonates via ring-opening copolymerization of epoxides and isothiocyanates catalyzed by organoboron catalyst was reported herein.Both aromatic and aliphatic isothiocyanates underwent successful copolymerization with terminal and internal epoxides,allowing for the precise tuning of the performance of the resultant copolymers over a broad range.The wide scope of available isothiocyanates and epoxides enables the direct construction of sulfur-containing functional polymers featuring both high glass transition temperature and refractive index.Additionally,it was observed that aromatic isothiocyanates polymerize much faster than aliphatic ones,and the reactivity difference facilitated the one-step synthesis of block polymers from mixed aromatic isothiocyanates,aliphatic isothiocyanates and epoxides due to the preferential incorporation of aromatic isothiocyanates over the aliphatic analogues during their alternating copolymerization with epoxides.The produced polythioimidocarbonates can be used as positive resists for electron beam lithography(sensitivity of 130μC/cm^(2) and contrast of 1.53 for poly(CHO-alt-EITC)).Coupling with their high refractive index(1.58—1.68),polythioimidocarbonates might find functional applications in optics.These results render ring-opening copolymerization of epoxides and isothiocyanates a facile route to enrich functional polymer library.

关键词： Ring-opening copolymerization Metal-free catalysis Sulfur-containing polymers Block polymers Electron beam lithography High refractive index

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Kinetics of carbonated decomposition of hydrogarnet with different silica saturation coefficients

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International Journal of Minerals,Metallurgy and Materials 2020年第4期27卷 472-482页

作者： xiao-feng zhu Ting-an Zhang Guo-zhi Lü State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of TechnologyLanzhou 730050China School of Material Science and Engineering Lanzhou University of TechnologyLanzhou 730050China Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education Northeastern UniversityShenyang 110819China Special Metallurgy and Process Engineering Institute School of MetallurgyNortheastern UniversityShenyang 110819China

Carbonated decomposition of hydrogarnet is one of the vital reactions of the calcification–carbonation method,which is designed to dispose of low-grade bauxite and Bayer red mud and is a novel eco-friendly method.In this study,the effect of the silica saturation coefficient(x)on the carbonation of hydrogarnet was investigated from the kinetic perspective.The results indicated that the carbonation of hydrogarnets with different x values(x=0.27,0.36,0.70,and 0.73)underwent two stages with significantly different rates,and the kinetic mechanisms of the two stages can be described by the kinetic functions R3 and D3.The apparent activation energies at Stages 1 and 2 were 41.96–81.64 and 14.80–34.84 kJ/mol,respectively.Moreover,the corresponding limiting steps of the two stages were interfacial chemical reaction and diffusion.

关键词： Bayer red mud hydrogarnet calcification carbonation kinetics silica saturation coefficient

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Asymptotic Approximations of Jacobi Functions and Their Zeros with Error Bounds

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Acta Mathematica Sinica,English Series 2006年第3期22卷 729-740页

作者： xiao feng zhu Xiu Chun LI Department of Basic Science Beijing Institute of Graphic Communication

The study of zeros of orthogonal functions is an important topic. In this paper, by improving the middle variable x（t）, we＇ve got a new form of asymptotic approximation, completed with error bounds, it is constructed for the Jacobi functions φu^（α,β）（t）（α 〉 -1） as μ→∞. Besides, an accurate approximation with error bounds is also constructed correspondingly for the zeros tμ,s of φu^（α,β）（t）（α≥ 0） as μ→∞, uniformly with respect to s = 1, 2,....

关键词： Asymptotic approximation Jacobi function Zero Error bounds

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Trim21 depletion alleviates bone loss in osteoporosis via activation of YAP1/β-catenin signaling

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Bone Research 2023年第4期11卷 819-833页

作者： Ri-Xu Liu Rong-He Gu Zhi-Peng Li Zhi-Quan Hao Qin-xiao Hu Zhen-Yan Li xiao-Gang Wang Wang Tang xiao-He Wang Yu-Kai Zeng Zhen-Wei Li Qiu Dong xiao-feng zhu Di Chen Ke-Wei Zhao Rong-Hua Zhang Zhen-Gang Zha Huan-Tian Zhang Department of Bone and Joint Surgery the First Affiliated Hospital of Jinan UniversityKey Laboratory of Regenerative Medicine of Ministry of EducationJinan UniversityGuangzhou 510630 GuangdongChina Department of Orthopedic and Spine Surgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120 GuangdongChina School of Basic Medical Sciences of Guangxi Medical University the Fifth Affiliated Hospital of Guangxi Medical UniversityNanning 530022 GuangxiChina Key Laboratory of Big Data-Based Precision Medicine School of Engineering MedicineBeihang University100191 BeijingChina Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization College of PharmacyJinan UniversityGuangzhou 510630 GuangdongChina Research Center for Computer-aided Drug Discovery Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences518005 ShenzhenChina Guangzhou Key Laboratory of Chinese Medicine Research on Prevention and Treatment of Osteoporosis the Third Affiliated Hospital of Guangzhou University of Chinese Medicine510375 GuangzhouChina

Despite the diverse roles of tripartite motif(Trim)-containing proteins in the regulation of autophagy,the innate immune response,and cell differentiation,their roles in skeletal diseases are largely unknown.We recently demonstrated that Trim21 plays a crucial role in regulating osteoblast(OB)differentiation in osteosarcoma.However,how Trim21 contributes to skeletal degenerative disorders,including osteoporosis,remains unknown.First,human and mouse bone specimens were evaluated,and the results showed that Trim21 expression was significantly elevated in bone tissues obtained from osteoporosis patients.Next,we found that global knockout of the Trim21 gene(KO,Trim2^(1-/-))resulted in higher bone mass compared to that of the control littermates.We further demonstrated that loss of Trim21 promoted bone formation by enhancing the osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)and elevating the activity of OBs;moreover,Trim21 depletion suppressed osteoclast(OC)formation of RAW264.7 cells.In addition,the differentiation of OCs from bone marrow-derived macrophages(BMMs)isolated from Trim21^(-/-)and Ctsk-cre;Trim21^(f/f)mice was largely compromised compared to that of the littermate control mice.Mechanistically,YAP1/β-catenin signaling was identified and demonstrated to be required for the Trim21-mediated osteogenic differentiation of BMSCs.More importantly,the loss of Trim21 prevented ovariectomy(OVX)-and lipopolysaccharide(LPS)-induced bone loss in vivo by orchestrating the coupling of OBs and OCs through YAP1 signaling.Our current study demonstrated that Trim21 is crucial for regulating OB-mediated bone formation and OC-mediated bone resorption,thereby providing a basis for exploring Trim21 as a novel dual-targeting approach for treating osteoporosis and pathological bone loss.

关键词： YAP1 osteoporosis depletion

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miR-26a regulates mouse hepatocyte proliferation via directly targeting the 3' untranslated region of CCND2 and CCNE2

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Hepatobiliary & Pancreatic Diseases International 2016年第1期15卷 65-72页

作者： Jian Zhou Wei-Qiang Ju xiao-Peng Yuan xiao-feng zhu Dong-Ping Wang xiao-Shun He Organ Transplant Center the First Affiliated HospitalSun Yat-Sen University

BACKGROUND： The deficiency of liver regeneration needs to be addressed in the fields of liver surgery, split liver transplan- tation and living donor liver transplantation. Researches of microRNAs would broaden our understandings on the mecha- nisms of various diseases. Our previous research confirmed that miR-26a regulated liver regeneration in mice; however, the relationship between miR-26a and its target, directly or in- directly, remains unclear. Therefore, the present study further investigated the mechanism of miR-26a in regulating mouse hepatocyte proliferation. METHODS： An established mouse liver cell line, Nctc-1469, was transfected with Ad5-miR-26a-EGFP, Ad5-anti-miR-26a- EGFP or AdS-EGFP vector. Cell proliferation was assessed by MTS, cell apoptosis and cell cycle by flow cytometry, and gene expression by Western blotting and quantitative real-time PCR. Dual-luciferase reporter assays were used to test targets of miR-26a. RESULTS： Compared with the Ad5-EGFP group, Ad5-anti- miR-26a-EGFP down-regulated miR-26a and increased prolif- eration of hepatocytes, with more cells entering the G1 phase of cell cycle （82.70%＋1.45% vs 75.80%＋_3.92%）, and decreased apoptosis （5.50%＋0.35% vs 6.73%_＋0.42%）. CCND2 and CCNE2 were the direct targeted genes of miR-26a, miR-26a down- regulation up-regulated CCND2 and CCNE2 expressions and down-regulated p53 expression in Nctc-1469 cells. On the con- trary, miR-26a over-expression showed the opposite results. CONCLUSIONS： miR-26a regulated mouse hepatocyte pro- liferation by directly targeting the 3＇ untranslated regions of cyclin D2/cyclin E2; miR-26a also regulated p53-mediated apoptosis. Our data suggested that miR-26a may be a promis- ing regulator in liver regeneration.

关键词： microRNA miR-26a gene expression hepatocyte proliferation regulation

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