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Serum triglycerides concentration in relation to total and cardiovascular mortality in an elderly Chinese population

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Journal of Geriatric Cardiology 2022年第8期19卷 603-609页

作者： Chao-Ying MIAO xiao-fei ye Wei ZHANG Chang-Sheng SHENG Qi-Fang HUANG Ji-Guang WANG School of Public Health Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Cardi-ovascular Medicine the Shanghai Institute of HypertensionRuijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

OBJECTIVE To investigate serum triglycerides in relation to all-cause,cardiovascular,and non-cardiovascular mortality in an elderly Chinese *** The study participants(n=3565)were elderly(≥60 years)community dwellers living in a suburban town of *** was defined as a serum triglycerides concentration≥2.30 mmol/L(definite)and≥1.70 mmol/L(borderline),*** The prevalence of definite and borderline hypertriglyceridemia at baseline was 7.5%and 29.5%,*** was higher in women(n=1982,9.0%and 33.8%,respectively)than men(n=1583,6.2%and 27.9%,respectively),in obese and over-weight participants(n=1566,10.5%and 36.4%,respectively)than normal weight participants(n=1999,5.6%and 27.1%,respect-ively),and in diabetic participants(n=177,11.9%and 39.0%,respectively)than non-diabetic participants(n=3388,7.5%and 30.8%,respectively).During a median of 7.9 years follow-up,all-cause,cardiovascular and non-cardiovascular deaths occurred in 529,216 and 313 participants,*** analyses according to the quintile distributions of serum triglycerides concentration,the sex-and age-standardized mortality rate was lowest in the middle quintile for all-cause,cardiovascular and non-cardiovascu-lar mortality(18.6,7.8 and 11.9 per 1000 person-years,respectively,versus 21.5,10.5 and 12.7 per 1000 person-years,respectively,in the two lower quintiles and 21.7,9.5 and 14.0 per 1000 person-years,respectively,in the two higher quintiles).The fully adjus-ted hazard ratios(95%CI)for the middle quintile versus the combined two lower with two higher quintiles were 0.85(95%CI:0.67-1.07,P=0.17),0.81(95%CI:0.54-1.19,P=0.28)and 0.87(95%CI:0.64-1.17,P=0.35)for all-cause,cardiovascular and non-cardiovascular mortality,*** Our study showed high prevalence of hypertriglyceridemia,especially when defined as borderline and in obese and overweight participants,and mildly but non-significantly elevated risks of cardiovascular mort

关键词： cardiovascular mortality Serum

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Current and recent cigarette smoking in relation to cardiovascular and non-cardiovascular mortality in an elderly male Chinese population

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Journal of Geriatric Cardiology 2023年第8期20卷 567-576页

作者： Wen-Yuan-Yue WANG xiao-fei ye Chao-Ying MIAO Wei ZHANG Chang-Sheng SHENG Qi-Fang HUANG Ji-Guang WANG School of Public Health Shanghai Jiaotong University School of MedicineShanghaiChina Department of Cardiovascular Medicine The Shanghai Institute of HypertensionRuijin HospitalShanghai Jiaotong University School of MedicineShanghaiChina

OBJECTIVE To investigate the association between current and former smoking and the risk of mortality in elderly Chinese *** Our study participants were elderly(≥60 years)men recruited in a suburban town of *** smoking status was categorized as never smoking,remote(cessation>5 years)and recent former smoking(cessation≤5 years),and light-to-moderate(≤20 cigarettes/day)and heavy current smoking(>20 cigarettes/day).Cox proportional hazards models and restricted cubic splines were used to examine the associations of *** The 1568 participants had a mean age of 68.6±7.1 *** all participants,311 were never smokers,201 were remote former smokers,133 were recent former smokers,783 were light-to-moderate current smokers and 140 were heavy current *** a median follow-up of 7.9 years,all-cause,cardiovascular and non-cardiovascular deaths occurred in 267,106 and 161 participants,*** current smokers had the highest risk of all-cause and non-cardiovascular mortality,with an adjusted hazard ratio(HR)of 2.30(95%CI:1.34-4.07)and 3.98(95%CI:2.03-7.83)versus never smokers,*** former smokers also had a higher risk of all-cause(HR=1.62,95%CI:1.04-2.52)and non-cardiovascular mortality(HR=2.40,95%CI:1.32-4.37)than never *** regression restricted cubic spline models showed the highest risk of all-cause and non-cardiovascular mortality within 5 years of smoking cessation and decline *** subgroup analyses showed interaction between smoking status and pulse rate(≥70 beats/min vs.<70 beats/min)in relation to the risk of all-cause and non-cardiovascular mortality,with a higher risk in current versus never smokers in those participants with a pulse rate below 70 beats/*** Cigarette smoking in elderly Chinese confers significant risks of mortality,especially when recent former smoking is considered together with current smoking.

关键词： relation cubic restricted

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Dietary cooking oils and cardiometabolic measurements in an elderly Chinese population

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Journal of Geriatric Cardiology 2024年第6期21卷 642-650页

作者： Xin-Yu WANG Chao-Ying MIAO xiao-fei ye Wen-Yuan-Yue WANG Jia-Bo ZHU Yi ZHOU Yan LI Ji-Guang WANG School of Public Health Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Cardiovascular Medicine Centre for Epidemiological Studies and Clinical TrialsThe Shanghai Institute of HypertensionRuijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

OBJECTIVE To investigate three features of dietary cooking oil intake,namely,the consumption,cooking style,and composition of fatty acids in relation to several cardiometabolic measurements in an elderly Chinese *** The elderly(≥65 years)participants for this study were recruited from two community health centers in the urban area of Shanghai.A questionnaire was administered to collect information on dietary oil consumption(low,medium and high)and cooking styles(fry or stir-fry ***)and the composition of fatty acids(poly-unsaturated ***-unsaturated).The cardiometabolic measurements included anthropometry,blood pressure,fasting plasma glucose and serum *** The 1186 study participants had a mean age of 70.9±5.4 *** mean dietary oil consumption was 35.0 g/d,being low(<25 g/d),medium(25-49 g/d)and high(≥50 g/d)in 485,467 and 234 participants,*** proportion of the fry or stir-fry cooking style and oils rich in mono-unsaturated fatty acids was 30.4%and 27.4%,*** before and after adjustment for sex,age,current smoking and alcohol intake,dietary oil consumption was significantly(P≤0.02)and positively associated with the prevalence of treated hypertension and fasting plasma glucose *** similar adjustments as above and additional adjustment for dietary oil consumption,the fry or stir-fry cooking style was significantly(P≤0.048)and positively associated with body mass index,but inversely with systolic and diastolic blood pressure and serum low-density lipoprotein cholesterol,and the dietary intake of oils rich in mono-unsaturated fat acids was significantly(P≤0.02)and positively associated with diastolic blood pressure,serum triglycerides,total cholesterol and low-density lipoprotein cholesterol,and the prevalence of hypertriglyceridemia and *** This study showed that both the consumption and composition of fatty acids of the dietary oils mattered with regard to sev

关键词： cooking elderly unsaturated

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著作权视角下知识付费行业的侵权行为分析

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编辑之友 2022年第5期 77-82页

作者：肖叶飞安徽师范大学新闻与传播学院安徽芜湖241000

知识付费是知识创造者把知识变成产品与服务,满足用户在知识、信息、技术等方面需求的一种经济形态。知识付费行业中侵犯著作权分为两种类型,知识付费作品被侵犯著作权的行为,知识付费行业中的用户、知识创作者与平台侵犯他人的著作权... 详细信息

知识付费是知识创造者把知识变成产品与服务,满足用户在知识、信息、技术等方面需求的一种经济形态。知识付费行业中侵犯著作权分为两种类型,知识付费作品被侵犯著作权的行为,知识付费行业中的用户、知识创作者与平台侵犯他人的著作权的行为。知识付费行业中的侵权行为需要厘清侵权主体、客体以及侵权责任,完善知识付费版权保护体系,促进行业健康发展。

关键词：知识付费著作权付费平台付费问答

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知识付费行业:基于知识传播与共享的服务经济

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编辑之友 2023年第1期 88-92,109页

作者：肖叶飞苏州大学传媒学院江苏苏州215127

知识付费是基于互联网平台有关知识、信息、经验、技术等付费的服务经济,也是知识分享与知识变现的共享经济。知识付费包括知识社区问答、大众化知识付费、垂直化知识付费、在线教育、社群阅读、工具型知识付费平台等不同类型,构建了按... 详细信息

知识付费是基于互联网平台有关知识、信息、经验、技术等付费的服务经济,也是知识分享与知识变现的共享经济。知识付费包括知识社区问答、大众化知识付费、垂直化知识付费、在线教育、社群阅读、工具型知识付费平台等不同类型,构建了按次付费、订阅、广告、悬赏、打赏、会员制等商业模式。知识付费也面临着很多挑战,需要在内容建设、平台服务、版权保护等方面逐步完善产业价值链。

关键词：知识付费共享经济社区问答粉丝经济

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新型主流媒体的基本特征、构建路径与价值实现

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编辑之友 2020年第7期 52-57页

作者：肖叶飞安徽师范大学新闻与传播学院安徽芜湖241000

新型主流媒体是凭借内容优势、资源优势与品牌优势,通过流程优化、平台再造,新旧媒体一体化发展,各种媒介资源、生产要素有效整合,信息内容、技术应用、平台终端、管理手段共融互通,形成具有强大传播力、影响力、引导力、公信力的全媒... 详细信息

新型主流媒体是凭借内容优势、资源优势与品牌优势,通过流程优化、平台再造,新旧媒体一体化发展,各种媒介资源、生产要素有效整合,信息内容、技术应用、平台终端、管理手段共融互通,形成具有强大传播力、影响力、引导力、公信力的全媒体。新型主流媒体在媒体形态、传播内容、平台终端方面具有显著特点,形成了一次生产、多渠道传播、多元增值的融合新闻生产机制,需要在组织架构、商业模式、资本运营等方面不断创新。

关键词：新型主流媒体融合新闻生产中央厨房构建路径

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新闻出版企业并购重组的路径、效应与风险

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编辑之友 2014年第12期 18-21页

作者：肖叶飞安徽师范大学传媒学院安徽师范大学创意产业发展研究中心

在转企改制的背景下,新闻出版企业要通过兼并、收购、重组等资本运营手段,降低企业运营成本,减少交易费用,产生协同效应,完善产业链,优化产业结构,发挥规模经济与范围经济效应。与此同时,出版企业要加强管理、文化、财务和资源整合,打... 详细信息

在转企改制的背景下,新闻出版企业要通过兼并、收购、重组等资本运营手段,降低企业运营成本,减少交易费用,产生协同效应,完善产业链,优化产业结构,发挥规模经济与范围经济效应。与此同时,出版企业要加强管理、文化、财务和资源整合,打造主营业务和核心竞争力,防范并购带来的各种风险。

关键词：转企改制新闻出版企业并购重组

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Alcohol consumption in relation to the incidence of atrial fibrillation in an elderly Chinese population

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Journal of Geriatric Cardiology 2022年第1期19卷 52-60页

作者： xiao-fei ye Wei ZHANG Yi CHEN Chao-Ying MIAO Qi-Fang HUANG Chang-Sheng SHENG Shuai SHAO Dian WANG Shao-Kun XU Lei LEI Di ZHANG Yi-Lin CHEN Lei-xiao HU Jia-Hui XIA Yi-Bang CHENG Ying WANG Qian-Hui GUO Yan LI Nicole Lowres Ben Freedman Ji-Guang WANG School of Public Health Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Cardiovascular Medicine The Shanghai Institute of HypertensionRuijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Heart Research Institute Sydney Medical SchoolCharles Perkins Centerand Cardiology DepartmentConcord HospitalUniversity of SydneySydneyAustralia

BACKGROUND Alcohol consumption is a known modifiable risk factor for atrial *** association,however,might differ according to *** investigated gender-specific associations between alcohol consumption and incident atrial fibrillation in an elderly Chinese *** Our study participants were elderly residents(≥65 years)recruited from five community health centers in the urban area of Shanghai(n=6,618).Alcohol intake was classified as never drinkers and current light-to-moderate(years(interquartile range:2.0−2.2)follow-up,the incidence rate of atrial fibrillation was 1.10%in all study *** was slightly but non-significantly higher in men(n=2849)than women(n=3769,1.30%vs.0.96%,P=0.19)and in current drinkers(n=793)than never drinkers(n=5825,1.64%vs.1.03%,P=0.12).In both unadjusted and adjusted analyses,there was interaction between sex and current alcohol intake in relation to the incidence of atrial fibrillation(P<0.0001).After adjustment for confounding factors,current drinkers had a significantly higher incidence rate of atrial fibrillation than never drinkers in women(12.96%[7/54]vs.0.78%[29/3715],adjusted odds ratio[OR]=10.25,95%confidence interval[CI]:3.54−29.67,P<0.0001),but not in men(0.81%[6/739]vs.1.47%[31/2110],OR=0.62,95%CI:0.25−1.51,P=0.29).CONCLUSIONS Our study showed a significant association between alcohol intake and the incidence of atrial fibrillation in elderly Chinese women,but not men.

关键词： fibrillation intake Alcohol

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Single-balloon and spiral enteroscopy may have similar diagnostic and therapeutic yields to double-balloon enteroscopy:Results from a meta-analysis of randomized controlled trials and prospective studies

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World Journal of Meta-Analysis 2020年第2期8卷 153-162页

作者： Yong Gu Xin Shi Yan Yang xiao-fei ye Qiong Wu Zhi-Ping Yang Shui-Xiang He Department of Gastroenterology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of Digestive System Diseases Shaanxi Provincial Crops Hospital of Chinese People's Armed Police ForceXi'an 710054Shaanxi ProvinceChina State Key Laboratory of Cancer Biology National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi'an 710032Shaanxi ProvinceChina Department of Health Statistics Second Military Medical UniversityShanghai 200433China

BACKGROUND Double-balloon,single-balloon,and spiral enteroscopy(DBE,SBE,and SE)have revolutionized the management of intestinal ***,evidence about efficacies of these methods is *** aimed to conduct a meta-analysis comparing the clinical outcomes among DBE,SBE,and *** We searched randomized controlled trials and prospective studies in MEDLINE,PubMed,EMBASE,Cochrane Library,and Chinese CQVIP *** referencing the comparison of at least two of these three methods were *** outcome was diagnostic *** outcomes were therapeutic yield,total enteroscopy,examination time,time to maximum insertion,and depth of maximal insertion(DMI).RESULTS Eleven studies including 727 patients were identified:DBE vs SE(n=6),DBE vs SBE(n=4),and SBE vs SE(n=1).The diagnostic and therapeutic yields did not differ significantly when comparing DBE with SE[odds ratio(OR)=1.19,95%confidence interval(CI):0.68-2.08;OR=1.17,95%CI:0.61-2.23]and DBE with SBE(OR=0.85,95%CI:0.55-1.33;OR=1.71,95%CI:0.64-4.60).Total enteroscopy,examination time,time to maximum insertion,and DMI were similar between SBE and *** was superior to SE with regard to DMI[mean difference(MD)=36.76,95%CI:5.09-68.43],with longer time to maximum insertion(MD=15.14,95%CI:12-18.27)and examination time(MD=12.98,95%CI:9.57-16.38).CONCLUSION DBE and SBE have similar clinical *** with DBE,SE seems to have similar diagnostic and therapeutic yields,but shorter procedural time in cost of less depth of *** needs further evaluation vs *** is recommended for complete enteroscopy.

关键词： Double-balloon enteroscopy Single-balloon enteroscopy Spiral enteroscopy Meta-analysis Randomized controlled trials

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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu xiao-Li Li xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu xiao-Jia Yang Qian-Ru He fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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