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BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： Qin Wang Qing-Rong Li Lei Xu Zi-chun Yuan xiao Liu mao-Ju Tang Man Luo xiao-Wu Zhong Qiang Ma xiao-Lan Guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory Medicine&Translational Medicine Research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are DNA-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an RNA-dependent DNA polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBR1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of RESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBR1532 exposure were 48.53μM and 39.59μM,*** values decreased to 37.22μM and 22.71μM,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTERT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBR1532 upregulated the expression of the DDR protein,γ-H2AX,and activated the ataxia telangiectasia and Rad3-related protein(ATR)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATM)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TRF1),TRF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBR1532 significantly suppressed tumor growth,reduced hTERT expression,and increasedγ-H2AX protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins

Effects of plant density on cotton yield components and quality

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Journal of Integrative Agriculture 2016年第7期15卷 1469-1479页

作者： ZHI xiao-yu HAN Ying-chun LI Ya-bing WANG Guo-ping DU Wen-li LI xiao-xin mao Shu-chun FENG Lu Institute of Cotton Research Chinese Academy of Agricultural Sciences/State Key Laboratory of Cotton Biology

Yield and ifber quality of cotton even varies within locules in a bol, but it is not clear how yield components and quality parameters are altered across seed positions of a locule （SPL）. A ifeld experiment was arranged in a split plot design with transgenic insect resistant Bt （Bacilus thuringiensis） cotton hybrid cultivar CRI75 and conventional cultivar SCRC28 as the main plots, and three plant densities （15000, 51000 and 87000 plants ha–1） as the subplots in 2012 and 2013 at Anyang, Henan Province, China. Cotton was hand harvested by node and fruiting position, and then seeds of the ifrst fruiting posi-tion bols from nodes 6–10 were separated by SPL. The effects of plant density on lint yield, ifber quality, especialy across SPL were determined. It was showed that plant densities of 51000 and 87000 plants ha–1 increased lint yield by 61.3 and 65.3% in 2012 and 17.8 and 15.5% in 2013 relative to low plant density （15000 plants ha–1）, however, no signiifcant differ-ence was observed between 51000 and 87000 plants ha–1. The number of bols （bol density） increased while bol weight decreased as plant density raised, and no signiifcant changes occured in lint percentage in 2013 but increased with plant density in 2012. The number of bols in upper nodes and distal fruiting positions, the number of seeds per bol, seed area （SA） and seed vigor index increased with decreasing plant density. Seed area was found to be greater from the base to the middle compared to the apex of a locule. Mote frequency （MF） increased as plant density increased, and ifber quality was the best at the middle of the locule regardless of plant density. As the number of ifbers per seed area is geneticaly determined, adjusting plant density to produce more seeds and greater seed area can be a potentialy promising alternative to improve lint yield in cotton. These ifndings might be of great importantance to cotton breeding and ifled management.

关键词： cotton plant density yield quality seed position

Abscisic acid induces differential expression of genes involved in wound-induced suberization in postharvest tomato fruit

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Journal of Integrative Agriculture 2018年第12期17卷 2670-2682页

作者： HAN Xue-yuan mao Lin-chun LU Wen-jing TAO xiao-ya WEI xiao-peng LUO Zi-sheng College of Biosystems Engineering and Food Science/Fuli Institute of Food Science/Zhejiang Key Laboratory of AgroFood Processing Zhejiang University

Fruit wounding occurred at harvest and transportation requires rapid suberization as a major part of the healing process to prevent infection and desiccation. The focus of this work was to explore the mediation of abscisic acid(ABA) on woundinduced suberization and to determine expression profiles of specific genes involved in wound-induced suberization in tomato fruit. The measurements of weight loss and fruit firmness suggested wound-induced suberization started at 2 d after wounding. The suberization process with the accumulation of suberin polyphenolics(SPP) and polyaliphatics(SPA) observed through autofluorescence microscopy and Sudan IV staining was accelerated by ABA. Expressions of SlPAL5 and Sl4 CL involved in the synthesis of SPP reached the highest at 4 and 8 d after wounding following ABA application, respectively. Associated with SPA biosynthesis, SlLACS1 and SlLACS2 showed the most abundant transcripts at 8 and 6 d in ABA group, respectively. Transcript levels including SlKCSs, SlCYP86 B1, SlFAR3, and Sl GPATs were up-regulated at 2 d after wounding by ABA. Activities of polyphenol oxidase and lipoxygenase were also enhanced during wound-induced suberization following ABA application. The results in this study proved that ABA accelerated the wound-induced suberization progress by increasing the transcript levels of relevant genes in postharvest tomato fruit.

关键词： tomato abscisic acid wound-induced suberization genes

Efect of light response on the photocatalytic activity of BiOClxBr1-x in the removal of Rhodamine B from water

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International Journal of Minerals,Metallurgy and Materials 2013年第11期20卷 1089-1096页

作者： xiao-ming mao Cai-mei Fan College of Chemistry and Chemical Engineering Taiyuan University of Technology

BiOClxBr1-x catalysts were synthesized through an alcoholysis method and characterized by X-ray diffraction （XRD）, transmission electron microscopy （TEM）, high-resolution transmission electron microscopy （HRTEM）, and diffuse reflectance spectroscopy （DRS）. The as-prepared photocatalysts were found to be tetragonal crystal structure and lamellar plate morphology. Their band gaps were between 3.44 and 2.83 eV. The effect of light response on the photocatalytic activity of BiOClxBrl-x was investigated by degradation of Rhodamine B （RhB）. Complete removal of RhB from water was realized under simulated sunlight irradiation for 50 min with BiOC10.5Br0.5. Mechanism studies showed that photo- generated holes and superoxide anion radicals played important roles in RhB photodegradation. The results of chemical oxygen demand （COD） confirmed RhB mineralization. The effect of light response on the activity of BiOClxBr1-x was further investigated under monochromatic light irradiation, and BiOCl0.5Br0.5 catalyst exhibited the highest activity. Furthermore, BiOC10.5Br0.5 exhibited high stability, suggesting its practical application for the removal of RhB pollutant from water.

关键词： photocatalysts photocatalytic activity light response degradation organic pollutants

Current clinical trials on gastric cancer surgery in China

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World Journal of Gastrointestinal Oncology 2024年第11期16卷 4369-4382页

作者： Shun Zhang Ren-Hao Hu Xi-mao Cui chun Song xiao-Hua Jiang Department of Gastrointestinal Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

Gastric cancer(GC)is the leading diagnosed malignancy worldwide,especially in *** surgery is the cornerstone of GC *** reviewed previous clinical trials and aimed to provide an update on the factors related to the surgical treatment of *** number of registered clinical trials in the field of GC surgery is rapidly *** the development and popularization of endoscopic,laparoscopic,and robotic techniques,GC surgery has gradually entered a new era of precise minimally invasive *** quality of life has become a major issue in addition to surgical oncological *** great progress has been made in clinical research on GC in China,there are still *** studies enrolled large numbers of patients,but the research data were not of high *** characteristics of GC in China include a high incidence,large population,and large proportion of patients with advanced GC,which provides sufficient reason for studying this *** is still a need for well-designed,large,randomized clinical trials to improve our knowledge of the surgical treatment of GC.

关键词： Gastric cancer Clinical trial Surgery China Minimally invasive surgery Quality of life

Review of precipitation strengthening in ultrahigh-strength martensitic steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 256-269页

作者： Zhihao Tian chunlei Shang Chaolei Zhang xiaoye Zhou Honghui Wu Shuize Wang Guilin Wu Junheng Gao Jiaming Zhu Xinping mao Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China Institute of Steel Sustainable Technology Liaoning Academy of MaterialsShenyang 110004China Department of Materials Science and Engineering Shenzhen MSU-BIT UniversityShenzhen 518172China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China School of Civil Engineering Shandong UniversityJinan 250061China

Martensite is an important microstructure in ultrahigh-strength steels,and enhancing the strength of martensitic steels often involves the introduction of precipitated phases within the martensitic *** considerable research efforts devoted to this area,a systematic summary of these advancements is *** review focuses on the precipitates prevalent in ultrahigh-strength martensitic steel,primarily carbides(e.g.,MC,M_(2)C,and M_(3)C)and intermetallic compounds(e.g.,Ni Al,Ni_(3)X,and Fe_(2)Mo).The precipitation-strengthening effect of these precipitates on ultrahigh-strength martensitic steel is discussed from the aspects of heat treatment processes,microstructure of precipitate-strengthened martensite matrix,and mechanical ***,a perspective on the development of precipitation-strengthened martensitic steel is presented to contribute to the advancement of ultrahigh-strength martensitic *** review highlights significant findings,ongoing challenges,and opportunities in the development of ultrahigh-strength martensitic steel.

关键词： ultrahigh-strength martensitic steel precipitation strengthening mechanical property carbide intermetallic compound

A comparison between novel Gd_(2)Zr_(2)O_(7)and Gd_(2)Zr_(2)O_(7)/YSZ thermal barrier coatings fabricated by plasma spray-physical vapor deposition

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Rare Metals 2021年第8期40卷 2244-2253页

作者： Ren-Bo Zhu Jian-Peng Zou Jie mao Zi-Qian Deng xiao-Feng Zhang chun-Ming Deng Min Liu School of Materials Science and Engineering University of New South WalesSydneyNSW2052Australia State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083China National Engineering Laboratory for Modern Materials Surface Engineering Technology and Key Laboratory of Guangdong for Modern Surface Engineering Technology Guangdong Institute of New MaterialsGuangzhou510651China

Spherical Gd_(2)Zr_(2)O_(7)hollow powders with a mean size of 8.8μm were fabricated as feedstock for thermal barrier coatings(TBCs)by *** single-ceramic-layer(SCL)Gd_(2)Zr_(2)O_(7)TBCs and double-ceramic-layer(DCL)Gd_(2)Zr_(2)O_(7)/YSZ TBCs with quasicolumnar structure were successfully fabricated by plasma spray-physical vapor deposition(PS-PVD).Tensile and water-quenching tests were applied to evaluate TBCs *** results show that adhesion strength of SCL Gd_(2)Zr_(2)O_(7)TBCs and DCL Gd_(2)Zr_(2)O_(7)/YSZ TBCs is36.5 MPa and 15.4 MPa,*** delamination of SCL Gd_(2)Zr_(2)O_(7)TBCs and DCL Gd_(2)Zr_(2)O_(7)/YSZ TBCs in the tensile test takes place at the middle and bottom of Gd_(2)Zr_(2)O_(7)layer,respectively,due to relatively lower fracture toughness of Gd_(2)Zr_(2)O_(7)*** 40 cycles of water-quenching test,DCL Gd_(2)Zr_(2)O_(7)/YSZ TBC surface keeps relatively intact,while SCL Gd_(2)Zr_(2)O_(7)TBC surface shows 20%visible destroyed regions,which demonstrates that DCL Gd_(2)Zr_(2)O_(7)/YSZ TBCs have a better thermal shock resistance than SCL Gd_(2)Zr_(2)O_(7)*** cracks in the SCL system propagate near thermally grown oxide(TGO)due to thermal mismatch and TGO growing stress,while cracks in the DCL system propagate in the Gd_(2)Zr_(2)O_(7)layer due to its relatively lower fracture toughness.

关键词： Plasma spray-physical vapor deposition Thermal barrier coatings Gd_(2)Zr_(2)O_(7) Thermal shock resistance Adhesion strength

Preparation of β-SiC by combustion synthesis in a large-scale reactor

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International Journal of Minerals,Metallurgy and Materials 2009年第3期16卷 322-326页

作者： Yu-qiong Liu Li-feng Zhang Qing-zhi Yan xiao-dong mao Qiao Feng Chang-chun Ge Laboratory of Special Ceramics and Powder Metallurgy University of Science and Technology Beijing Beijing 100083 China Beijing chunshu Rectifier Co. Ltd. Beijing 100040 China

The feasibility of 5 kg β-SiC synthesized in one batch was demonstrated through igniting the mixture of Si, C-black and polytetrafluoroethylene （PTFE） under different nitrogen pressures. The effect of experimental parameters, including the contents of PTFE, nitrogen pressure, preheating, and raw materials distribution forms were investigated. The results show that the products are β-SiC with equiaxed grains. The average grain size is less than 200 nm. The powders loaded loosely promote reaction heat dispersing, resulting in small grains. High purity β-SiC powders are obtained when the PTFE content is as low as 5wt%, which simplifies the process and decreases the cost effectively. The ceramic sintered from the obtained β-SiC powders presents the hardness of 22.20 GPa, the bending strength as high as 715.15 MPa and the fracture toughness of 8.179 MPa·m^1/2, which are higher than those of ceramics fabricated with α-SiC produced by combustion synthesis.

关键词： silicon carbide combustion synthesis β-SiC reaction parameter large-scale reactor self-propagating high-temperature synthesis

Anick Resolution and the Minimal Projective Resolution of U_(q)+(C_(3))

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Acta Mathematica Sinica,English Series 2023年第6期39卷 1022-1052页

作者： Ling Ling mao xiao Long XIN School of Mathematics Northwest UniversityXi'an 710127P.R.China School of Science Xi'an Polytechnic UniversityXi'an 710048P.R.China

In this paper,from the Anick’s resolution and Grobner-Shirshov basis for quantized enveloping algebra of type C_(3),we compute the minimal projective resolution of the trivial module U_(q)+(C_(3))and as an applicatio... 详细信息

关键词： Anick resolution minimal projective resolution Grobner-Shirshov basis global dimension