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On Impulsive Control for Synchronization and Its Application to Matsumoto-Chua-Kobayashi （MCK） Circuit

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Communications in Theoretical Physics 2007年第2X期48卷 275-278页

作者： LI Yang LIAO xiao-Feng LI chuan-dong WANG Yong College of Computer Science and Engineering Chongqing University Chongqing 400030 China

The issue of impulsive control theory for synchronization of the MCK circuit is developed. We propose an impulsive control scheme for the complete synchronization of the MCK circuit including chaotic systems. A sufficient condition for the impulsive control is derived, with an easily calculated maximum impulsive interval. The proposed impulsive control scheme is applied to the MCK circuit and the simulation result demonstrates the effectiveness of the method.

关键词： chaos impulsive control MCK circuit

Clinicopathological Features and Prognostic Value of KRAS/NRAS/BRAF Mutations in Colorectal Cancer Patients of Central China

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Current Medical Science 2021年第1期41卷 118-126页

作者： xiao-na CHANG Fu-mei SHANG Hong-yu JIANG Chen CHEN Zhe-yan ZHAO Sheng-he DENG Jun FAN xiao-chuan dong Ming YANG Yan LI Kai-lin CAI Li LIU Hong-li LIU Xiu NIE Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Epidemiology and Biostatistics the Ministry of Education Key Lab of Environment and HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

The incidence of colorectal cancer(CRC)is increasing in China,with high ***,we aimed to evaluate the latest clinicopathological features and prognostic value of the KRAS/NRAS/BRAF mutation status in CRC patients in Central *** clinical data of 1549 CRC patients with stage I-IV disease diagnosed at Union Hospital,Tongji Medical College of Huazhong University of Science and Technology from 2015 to 2017 were collected and analyzed ***/NRAS/BRAF mutations were detected by real-time quantitative polymerase chain reaction(q-PCR)in 410 CRC patients,with mutation frequencies of KRAS,NRAS and BRAF of 47.56%,2.93%and 4.15%,*** gene mutation status and clinicopathological characteristics of 410 patients with CRC who underwent qPCR were *** KRAS and BRAF gene mutations were related to the pathological differentiation and number of metastatic lymph *** BRAF gene mutation was also associated with cancer thrombosis in blood *** regression analysis showed that there was no statistically significant difference in the overall survival(OS)between patients with KRAS,NRAS mutants and wild-type CRC patients,while the BRAF gene mutation was negatively correlated with the OS rate of CRC *** is suggested that the BRAF gene mutation may be an independent risk factor for the prognosis of CRC.

关键词： colorectal cancer KRAS mutation NRAS mutation BRAF mutation prognosis

2-D nano-positioning system for AFM based on H_∞ control

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Journal of Shanghai University(English Edition) 2010年第5期14卷 359-364页

作者：孙鑫金小平程传东唐沈键 School of Mechatronics Engineering and Automation Shanghai University

Nano-manipulation technology is an emerging field in the development of modern science and technology. Atomic force microscope （AFM）, a sharp weapon for nano imaging and nanomanipulation, which is honored as ＂eye＂ and ＂hand＂ of nano-technology. However, due to the hysteresis, creep and other nonlinearity of piezoelectric ceramics tube （PZT） as well as the probe＇s tip deviations caused by cantilever deformation, AFM has larger error of relative displacement between probe and sample, which creates enormous inconvenience to the nano-manipulation and repositioning. As to improve positioning accuracy, this dissertation presents a novel AFM＇s X-Y dimensional nano-positioning control system with large-scale based on H∞ control. Through careful research on variety of influence factors on AFM＇s precise nano-manipulation, a composite control strategy based on feedforward compensation control of cantilever probe tip＇s offset and H∞ control of piezoelectric scanner is presented in this paper. In the end, simulation results can also testify the tracking ability and better nano-positioning performance of the system.

关键词： atomic force microscope (AFM) nano-manipulation nano-reposition H∞ control

Revolutionizing photothermal CO_(2)hydrogenation with ceria-based catalysts

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Nano Research 2025年第1期18卷 30-49页

作者： Zhaorui Zhang xiao Han Junhong Zhang Yunyun dong Jinsheng Zhao Qian Xu ingqiang Zhang School of Chemistry and Chemical Engineering Liaocheng UniversityLiaocheng 252059China Institute for Catalysis Hokkaido UniversityN-21W-10Sapporo 001-0021Japan National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China

In the context of achieving carbon neutrality,CO_(2)catalytic conversion technologies are effective in reducing atmospheric CO_(2)concentrations while simultaneously producing renewable *** approach is seen as a viable method for constructing a new carbon cycle,thereby effectively addressing the issue of global *** CO_(2)conversion has recently emerged as a promising research focus due to its high energy utilization efficiency,superior CO_(2)conversion,excellent product selectivity,mild operating conditions,low energy consumption and minimal operating *** oxide(CeO_(2))has been widely used in photothermal catalysis due to its unique chemical properties,particularly when used as a support material with supported metals,creating distinctive interfacial sites for catalytic *** an emerging star support in photothermal CO_(2)conversion,its contributions are equally significant and should not be ***,to our knowledge,there has been no comprehensive review of CeO_(2)applications in catalytic hydrogenation of CO_(2).In this paper,we summarize and discuss CeO_(2)-based materials for photothermal CO_(2)conversion to value-added *** research particularly focuses on the synthesis methods of CeO_(2)-supported catalysts,the history of CeO_(2)in photothermal catalysis,types of photothermal catalytic reactors,unique characterization methods for the photothermal catalysts and the photothermal CO_(2)hydrogenation reactions by CeO_(2)-based *** related to further challenges and future directions for photothermal CO_(2)hydrogenation are also provided.

关键词： CO_(2)neutrality hydrogenation photothermal catalysis ceria C1 chemistry

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： Ling-xiao Yi Hui Ren Woon Genevieve Saw Li Zeng Eng King Tan Zhi dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin dong Bin Duan Feiyang Xing Jun Wu Minmin xiao Fangqing Zhao Jing-dong J.Han Qi Liu xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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湄洲湾北部海底地貌特征研究与分析

海洋科学 2016年第8期40卷 61-69页

作者：宫士奇阎军马小川栾振东陈长安中国科学院海洋研究所中科院海洋地质与环境重点实验室山东青岛266071 中国科学院大学北京100049

为对湄洲湾北部海底地形地貌特征及其影响因素进行系统的研究,作者利用多波束系统对湄洲湾北部海底地形进行探测,结合研究区内沉积物及潮流特征,对该区域海底地貌特征及其成因进行分析。研究区呈现中部低、南北高的地形格局,其中中部深... 详细信息

为对湄洲湾北部海底地形地貌特征及其影响因素进行系统的研究,作者利用多波束系统对湄洲湾北部海底地形进行探测,结合研究区内沉积物及潮流特征,对该区域海底地貌特征及其成因进行分析。研究区呈现中部低、南北高的地形格局,其中中部深水区又为近岸深、中间浅的特征,中轴为潮汐水道,水道两侧发育浅滩的海底地貌特征。研究区沉积物组分以砂和粉砂为主,由于研究区大部分表层沉积物中细粒沉积物占主要组分,沉积物具有较强的黏性,而实测资料显示潮流流速较小,因此研究区在常态水动力条件下,海底沉积物很难被冲刷,海底地形变化受潮流影响较小。通过将2012年与2013年研究区的调查结果进行对比发现,研究区海底地形整体变化不大,个别区域地形起伏变化较大,据推测可能是由于人为的挖沙、港口疏浚等因素造成的。因此,短期内影响研究区海底地形变化的主要因素为人为因素。

关键词：湄洲湾海底地形地形变化影响因素

Graphene Aerogel Composites with Self‑Organized Nanowires‑Packed Honeycomb Structure for Highly Efficient Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第2期17卷 533-547页

作者： xiao You Huiying Ouyang Ruixiang Deng Qiuqi Zhang Zhenzhong Xing xiaowu Chen Qingliang Shan Jinshan Yang Shaoming dong State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Key Laboratory of Inorganic Coating Materials CAS Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Structural Ceramics and Composites Engineering Research Center Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210People’s Republic of China School of Materials Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China University of Chinese Academy of Sciences Beijing 100039People’s Republic of China

With vigorous developments in nanotechnology,the elaborate regulation of microstructure shows attractive potential in the design of electromagnetic wave ***,a hierarchical porous structure and composite heterogeneous interface are constructed successfully to optimize the electromagnetic loss *** macro–micro-synergistic graphene aerogel formed by the ice template‑assisted 3D printing strategy is cut by silicon carbide nanowires(SiC_(nws))grown in situ,while boron nitride(BN)interfacial structure is introduced on graphene *** unique composite structure forces multiple scattering of incident EMWs,ensuring the combined effects of interfacial polarization,conduction networks,and magnetic-dielectric ***,the as-prepared composites present a minimum reflection loss value of−37.8 dB and a wide effective absorption bandwidth(EAB)of 9.2 GHz(from 8.8 to 18.0 GHz)at 2.5 ***,relying on the intrinsic high-temperature resistance of SiC_(nws) and BN,the EAB also remains above 5.0 GHz after annealing in air environment at 600℃ for 10 h.

关键词： Hierarchical porous structure Interface High-temperature resistance Graphene aerogel composites Electromagnetic wave absorption

Enhanced solid-electrolyte interface efficiency for practically viable hydrogen-air fuel cell systems

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Journal of Energy Chemistry 2025年第1期100卷 356-368页

作者： Venkitesan Sakthivel dong Jin Yoo Graduate School Department of Energy Storage/Conversion Engineering (BK21 FOUR) Hydrogen and Fuel Cell Research Center Jeonbuk National University Jeonju Department of Life Science Jeonbuk National University

Proton exchange membrane fuel cells （PEMFCs） provide an appealing sustainable energy system,with the solid-electrolyte membrane playing a crucial role in its overall ***,sulfonated poly（1,4-phenylene ether-ether sulfone）(SPEES),an aromatic hydrocarbon polymer,has garnered considerable attention as an alternative to Nafion ***,the long-term durability and stability of SPEES present a significant *** this context,we introduce a potential solution in the form of an additive,specifically a core–shell-based amine-functionalized iron titanate （A–Fe2TiO5）,which holds promise for improving the lifetime,proton conductivity,and power density of SPEES in *** modified SPEES/A–Fe2TiO5composite membranes exhibited notable characteristics,including high water uptake,enhanced thermomechanical stability,and oxidative ***,the SPEES membrane loaded with 1.2 wt%of A–Fe2TiO5demonstrates a maximum proton conductivity of 155 mS cm-1,a twofold increase compared to the SPEES membrane,at 80°C under 100%relative humidity （RH）.Furthermore,the 1.2 wt%of A–Fe2TiO5/SPEES composite membranes exhibited a maximum power density of 397.37 mW cm-2and a current density of 1148 mA cm-2at 60°C under 100%RH,with an opencircuit voltage decay of 0.05 m V/h during 103 h of continuous *** study offers significant insights into the development and understanding of innovative SPEES nanocomposite membranes for PEMFC applications.

关键词： Acid-base Hybrid membrane Proton conductivity Polymer electrolyte fuel cell Single-cell performance