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Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children

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World Journal of Pediatrics 2024年第9期20卷 901-914页

作者： Ying-Shuo Wang Yun-Lian Zhou Guan-Nan Bai Shu-Xian Li Dan Xu Li-Na Chen Xing Chen xiao-Yan Dong Hong-Min Fu Zhou Fu Chuang-Li Hao Jian-Guo Hong En-Mei Liu Han-Min Liu xiao-Xia Lu Zheng-Xiu Luo Lan-Fang Tang Man Tian Yong Yin xiao-bo zhang Jian-Hua zhang Hai-Lin zhang De-Yu Zhao Shun-Ying Zhao Guo-Hong Zhu Ying-Xue Zou Quan Lu Yuan-Yuan zhang Zhi-Min Chen Department of Pulmonology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Child Health Care Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Pediatric Pulmonology and Immunology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Pediatrics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China Department of Pulmonology Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Department of Pulmonary and Critical Care Medicine Kunming Children’s HospitalKunming 650034China Department of Respiratory Medicine Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Pulmonology Children’s Hospital of Soochow UniversitySuzhou 215003China Department of Pediatrics Shanghai General Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200080China Department of Respiratory Medicine Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China Department of Respiratory Medicine Children’s Hospital of Nanjing Medical UniversityNanjing 210008China Department of Respiratory Medicine Shanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Respiratory Medicine Children’s Hospital of Fudan UniversityShanghai 201102China Department of Pediatric Pulmonology Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 201102China Department of Pediatric Respiratory Medicine The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027China National Clinical Research Center for Respiratory Diseases Beijing Children’s HospitalCapital Medical UniversityBeijing 100045China Departmen

Background Mycoplasma pneumoniae(***)is a significant contributor to community-acquired pneumonia among *** 1968,when a strain of *** resistant to macrolide antibiotics was initially reported in Japan,macrolide-resistant ***(MRMP)has been documented in many countries worldwide,with varying incidence *** infections lead to a poor response to macrolide antibiotics,frequently resulting in prolonged fever,extended antibiotic treatment,increased hospitalization,intensive care unit admissions,and a significantly higher proportion of patients receiving glucocorticoids or second-line *** 2000,the global incidence of MRMP has gradually increased,especially in East Asia,which has posed a serious challenge to the treatment of *** infections in children and attracted widespread attention from ***,there is still no global consensus on the diagnosis and treatment of MRMP in *** We organized 29 Chinese experts majoring in pediatric pulmonology and epidemiology to write the world’s first consensus on the diagnosis and treatment of pediatric MRMP pneumonia,based on evidence *** evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,CNKI,Medline,and the Cochrane *** used variations in terms for“macrolide-resistant”,“Mycoplasma pneumoniae”,“MP”,“***”,“pneumonia”,“MRMP”,“lower respiratory tract infection”,“Mycoplasma pneumoniae infection”,“children”,and“pediatric”.Results Epidemiology,pathogenesis,clinical manifestations,early identification,laboratory examination,principles of antibiotic use,application of glucocorticoids and intravenous immunoglobulin,and precautions for bronchoscopy are *** and rapid identification of gene mutations associated with MRMP is now available by polymerase chain reaction and fluorescent probe techniques in respiratory *** the resistance rate to mac

关键词： Child Macrolide-resistant Mycoplasma pneumoniae Recommendation Diagnosis Treatment

Effect of Ag Addition on Microstructure,Mechanical and Corrosion Properties of Mg-Nd-Zn-Zr Alloy for Orthopedic Application

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Acta Metallurgica Sinica(English Letters) 2023年第2期36卷 295-309页

作者： Yu-Jin Nie Jian-Wei Dai xiao-bo zhang School of Materials Science and Engineering Nanjing Institute of TechnologyNanjing211167China Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology Nanjing211167China

The as-extruded Mg-3Nd-0.2Zn-0.4Zr-xAg(x=0,0.2,0.5,1 wt%)alloys were prepared for biomedical *** electron microscope,electron backscattered diffraction,X-ray diffraction,tensile test machine,electrochemical workstation,and immersion experiments were used to study microstructures,mechanical properties,and corrosion behavior of the as-extruded *** results indicate that the microstructures of all the as-extruded alloys are composed of coarse undynamic recrystallized grains,fine equiaxed recrystallized grains,and precipitated *** element plays a positive role in promoting dynamic recrystallization and grain *** during the extrusion,all the four alloys generate a //ED fiber *** the increase of Ag element,the volume fraction of Mg_(12)Nd phase increases and then decreases *** increasing Ag addition,both yield strength and ultimate tensile strength of the as-extruded alloys reduce first and then improve,and the elongation improves gradually from 9.4 to 12.7%.More importantly,the addition of Ag accelerates corrosion of the as-extruded alloys in simulated body fluid,and all the as-extruded alloys show uniform corrosion mode.

关键词： Magnesium alloy Hot extrusion Mechanical properties Corrosion resistance

Effect of Solution Treatment on Microstructure and Corrosion Properties of Mg–4Gd–1Y–1Zn–0.5Ca–1Zr Alloy

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Acta Metallurgica Sinica(English Letters) 2018年第8期31卷 865-872页

作者： Jian-Wei Dai xiao-bo zhang Yang Fei zhang-Zhong Wang Huai-Ming Sui School of Materials Science and Engineering Nanjing Institute of TechnologyNanjing 211167China Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology Nanjing 211167China Yangzhou Fengming Optronic New Material Co. LtdYangzhou 225117China

The as-cast multi-element Mg–4Gd–1Y–1Zn–0.5Ca–1Zr alloy with low rare earth additions was prepared, and the solution treatment was applied at different temperatures. The microstructural evolution of the alloy was characterized by optical microscopy and scanning electron microscopy, and corrosion properties of the alloy in 3.5% NaCl solution were evaluated by immersion and electrochemical tests. The results indicate that the as-cast alloy is composed of the a-Mg matrix,lamellar long-period stacking-ordered（LPSO） structure and eutectic phase. The LPSO structure exists with more volume fraction in the alloy solution-treated at 440 °C, but disappears with the increase in the solution temperature. For all the solution-treated alloys, the precipitated phases are detected. The corrosion rates of the alloys decrease first and then increase slightly with the increase in the solution temperature, and the corrosion resistance of the solution-treated alloys is more than four times as good as that of the as-cast alloy. In addition, the alloy solution-treated at 480 °C for 6 h shows the best corrosion property.

关键词： Magnesium alloy Solution treatment Microstructure Corrosion properties

Clinical features of postinfectious bronchiolitis obliterans in children undergoing long-term nebulization treatment

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World Journal of Pediatrics 2018年第5期14卷 498-503页

作者： xiao-Mei zhang Ai-Zhen Lu Hao-Wei Yang Li-Ling Qian Li-bo Wang xiao-bo zhang Respiratory Department Children's Hospital of Fudan University399 Wan Yuan RdShanghaiChina Radiology Department Children's Hospital of Fudan University399 Wan Yuan RdShanghaiChina

Background Limited data are available in relation to the clinical features of PIbo undergoing prolonged nebulization treat-ment with budesonide, terbutaline and ipratropium bromide. This retrospective study aimed to outline the features of clini-cal, high-resolution computed tomography (HRCT) and pulmonary function test (PFT) of PIbo, undergoing maintenance therapy utilizing a triple nebulization treatment and to determine the factors associated with prognosis. Methods Children diagnosed with PIbo were followed up between April 2014 and March 2017. The clinical features after maintenance nebulization treatment for 12 months were thereafter summarized. Results Thirty patients, 21 boys and 9 girls, were enrolled in the study. The median age of patients was 17.4 months, with a range between 3.0 and 33 months. Persistent coughing and wheezing were detected whilst wheezing and crackles were the common manifestations presented. HRCT scans revealed patchy ground and glass opacity, while PFT showed fixed airway obstruction in all patients. Four patients were lost during follow-up. After treatment, the clinical symptoms were improved greatly in all patients (Pbo, due to its efficacy as indicated in the improved clinical symptoms, pulmonary functions and CT manifesta-tions identified in the children. New prospective and controlled studies are required to confirm this proposition.

关键词： Clinical features Nebulization treatment Post-infectious bronchiolitis obliterans Prognosis

Generation of a Plasma Waveguide with Slow-Wave Structure

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Chinese Physics Letters 2021年第4期38卷 61-66页

作者： xiao-bo zhang Xin Qiao Ai-Xia zhang Ju-Kui Xue College of Physics and Electronics Engineering Northwest Normal UniversityLanzhou 730070China

Using the particle-in-cell simulations,we report an efficient scheme to generate a slow wave structure in the electron density of a plasma waveguide,based on the array laser-plasma *** spatial distribution of the electron density of the plasma waveguide is modulated via effective control of the super-Gaussian index and array pattern code of the lasers.A complete overview of the holding time,and the bearable laser’s intensity of the electron density structure of the plasma waveguide,is *** addition,the holding time of the slow wave structure of the plasma waveguide is also controlled by adjusting the frequency of the array laser ***,effects due to ion motion are discussed in detail.

关键词： interaction. structure wave

The association between demodex infestation and ocular surface manifestations in meibomian gland dysfunction

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International Journal of Ophthalmology(English edition) 2018年第4期11卷 589-592页

作者： xiao-bo zhang Ying-Hui Ding Wei He Shenyang He Eye Hospital Liaoning He UniversityShenyang 110034Liaoning ProvinceChina Eye Institute of Xiamen University Xiamen 361005FujianProvinceChina Department of Ophthalmology the People's Hospital ofBozhouBozhou 236800Anhui ProvinceChina

AIM： To investigate the association between ocular demodex folliculorum infestation and ocular surface manifestations in meibomian gland dysfunction（MGD）.METHODS： Eight-six patients with MGD were enrolled. All enrolled subjects were tested in the following sequence： ocular surface disease index（OSDI）, slit-lamp biomicroscope examination, corneal surface regularity index（SRI） and surface asymmetry index（SAI）, tear fluid collection, fluorescein tear film break-up time（F-BUT）, corneal fluorescein staining（CFS）, Schirmer I test（SIT） and demodex folliculorum counting. Tear matrix metalloproteinase（MMP）-9 activity was assessed using MMP-9 activity assay ***： Among 86 MGD patients, 40 were positive for demodex. The ocular demodex-positive group showed significantly increased scores of OSDI（25.96±13.74 vs 18.07±11.55, P=0.01）, lid margin abnormality（2.38±0.87 vs 1.98±0.91, P=0.04） and CFS（1.28±2.00 vs 0.94±1.36, P=0.01） compared to the ocular demodex-free group. The tear MMP-9 activity was higher in the ocular demodex-positive group（102.9±32.4 ng/mL） than the ocular demodex-free group（46.2±19.2 ng/mL, P=0.03）. There was no significant difference in meibum quality and expressibility, SRI, SAI, F-BUT and SIT between the two groups（P〉0.05 for each）. No significant correlation was noted between the number of demodex and ocular surface parameters in demodexpositive MGD group（P〉0.05 for each）.CONCLUSION： Ocular demodex folliculorum infestation may be associated with ocular discomfort and ocular surface damage in MGD.

关键词： demodex meibomian gland dysfunction ocular surface

Effects of chloride on electrochemical and stress corrosion cracking behavior of 9Cr ferritic-martensitic steel

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Journal of Iron and Steel Research International 2020年第6期27卷 719-731页

作者： Zhen zhang Zheng-fei Hu Liang He xiao-bo zhang Xin-xian Fang Bao-sen zhang Zhi-xin Ba Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology Nanjing 211167JiangsuChina School of Materials Science and Engineering Nanjing Institute of TechnologyNanjing 211167JiangsuChina School of Materials Science and Engineering Tongji UniversityShanghai 201804China School of Materials Science and Engineering Georgia Institute of TechnologyAtlanta 30332-0620USA

The electrochemical and stress corrosion cracking behavior of 9Cr ferritic-martensitic steel is investigated in the chloride environment by using the traditional electrochemical method, the scanning vibrating electrode technique and the slow strain rate test (SSRT). Results of the static corrosion tests and corrosion morphology show that the prior austenite grain boundaries and martensite lath boundaries are the preferred sites for pit nucleation and growth in chloride environment. Results of SSRT coupled with insitu electrochemical test show that the transition from pitting corrosion to uniform corrosion, as well as the nucleation of stress corrosion crack, is the synergistic effects of the chloride and applied load. Stress corrosion cracking of the steel in the chloride environment can be divided into three different regions as follows: fast and uniform corrosion activ-ity, microcrack nucleation and propagation, and active crack growth regions.

关键词： 9Cr ferritic-martensitic steel Chloride In situ electrochemical test Scanning vibrating electrode technique Stress corrosion cracking

Is mild erectile dysfunction associated with severe psychological symptoms in Chinese patients with moderate-to-severe chronic prostatitis/chronic pelvic pain syndrome?

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Asian Journal of Andrology 2021年第3期23卷 319-324页

作者： Xiu-Cheng Li xiao-bo zhang zhang-Cheng Liao Zheng-Yan Tang Dong-Jie Li Departm ent of Urology Xiangya HospitalCentral South UniversityChangsha 410008China Xiangya International Medical Center Department of Geriatric UrologyXiangya HospitalCentral South UniversityChangsha 410008China Provincial Laboratory for Diagnosis and Treatment of Genitourinary System Disease Changsha 410008China Department of Clinical Pharmacology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Pharmacogenetics Institute of Clinical PharmacologyCentral South UniversityChangsha 410078China National Clinical Research Center for Geriatric Disorders Changsha 410008China

This study aimed to assess the association between psychological disorders and erectile dysfunction(ED)in patients with different degrees of chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS).This was a retrospective study conducted from June 2017 to October 2019 and included 182 *** were interviewed using the Structured Interview on Erectile Dysfunction(SIEDY)for pathogenic *** National Institutes of Health-Chronic Prostatitis Symptom Index(NIH-CPSI)and the International Index of Erectile Function-5(IIEF-5)were used for the evaluation of CP/CPPS and *** Generalized Anxiety Disorder-7(GAD-7)and Patient Health Questionnaire-9(PHQ-9)were used to assess anxiety symptoms and depressive *** number of patients with mild CP/CPPS and mild ED,mild CP/CPPS and moderate-to-severe ED,moderate-to-severe CP/CPPS and mild ED,and moderate-to-severe CP/CPPS and moderate-to-severe ED was 69(37.9%),36(19.8%),35(19.2%),and 42(23.1%),*** corresponding PHQ-9 scores of the four groups were 6.22,7.19,10.69,and 7.71,*** corresponding GAD-7 scores of the four groups were 5.26,6.31,8.77,and 6.36,*** patients with moderate-to-severe CP/CPPS,the PHQ-9 and GAD-7 scores of the moderate-to-severe ED group were significantly lower than those of the mild ED group(P=0.007 and P=0.010,respectively).The prevalence of ED and premature ejaculation(PE)in patients with moderate-to-severe CP/CPPS was significantly higher than that in patients with mild CP/CPPS(P=0.001 and P=0.024,respectively).Our findings proved that the severity of ED was negatively associated with psychological symptoms in outpatients with moderate-to-severe CP/CPPS.

关键词： anxiety association chronic prostatitis/chronic pelvic pain syndrome depression erectile dysfunction

Synthesis and Crystal Structure of N-cyclopropyl-9 -(3,4-dicholophenyl)-1,2,3,4,5,6,7,8,9,10-decahydroacridine -1,8-dione under Microwave Irradiation

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Chinese Journal of Structural Chemistry 2005年第12期24卷 1457-1461页

作者： FENG You-Jian JIA Run-Hong TU Shu-Jiang zhang xiao-Jin JIANG bo zhang Yan zhang Jun-Yong Department of Chemistry Xuzhou Normal University Key Laboratory of Biotechnology on Medical Plant Xuzhou Jiangsu 221116 China

The N-cyclopropyl-9-（3,4-dicholophenyl）- 1,2,3,4,5,6,7,8,9,10-decahydroacri- dine-1,8-dione was synthesized by the reaction of 1,3-cyclohexanedione, N-cyclopropylamine and 3,4-dicholoaldehyde in water and glycol under microwave irradiation. Its crystal structure was determined by single-crystal X-ray diffraction analysis. It possesses P212121 space group, with a = 9.9103（5）, b = 13.3597（8）, c = 14.5633（8）A, V= 1928.16（18）A3 ,Mr = 402.30, Z = 4, Dc= 1.386 g/cm^3, 2 = 0.7107A,μ（MoKα）=0.354mm^-1 and F （000） = 840. The structure was refined to R = 0.0280 and wR = 0.0757. In the structure, the pyridine ring adopts a boat conformation.

关键词： acridine synthesis microwave irradiation crystal structure