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Room-temperature ionic conductivity of Ba,Y,Al co-doped Li_(7)La_(3)Zr_(2)O_(12)solid electrolyte after sintering

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Rare Metals 2021年第8期40卷 2301-2306页

作者： xiao-zhen liu Lei Ding Yu-Ze liu Li-Ping Xiong Jie Chen xiao-Long Luo School of Chemical and Environmental Engineering Shanghai Institute of TechnologyShanghai201418China College of Economic and Management Beijing Forestry UniversityBeijing100083China Regenia AB Stockholm10691Sweden

The Ba,Y and A1 co-doped Li_(7)La_(3)Zr_(2)O_(12)(LLZO)was prepared by the solid-state reaction *** of sintering on the crystallographic structure,morphology,total conductivity,relative density and contractibility rate of the prepared solid electrolyte was studied,*** sintered samples were characterized by X-ray diffractometer(XRD),scanning electron microscopy(SEM),electrochemical impedance spectra(EIS)and inductively coupled plasma atomic emission spectrometry(ICP-AES)techniques,*** cubic garnet phase Ba,Y and Al co-doped LLZO is obtained,and the room-temperature total conductivity of the Ba,Y and Al co-doped LLZO solid electrolyte is improved significantly by eliminating the grain boundary resistances and improving the densifications with controlling sintering temperature(T)and time(t),*** at 1160-1190℃for 12 h and at 1190℃for6-15 h,respectively,the Ba,Y and Al co-doped LLZO solid electrolytes are cubic garnet *** at1180-1190℃for 12 h and at 1190℃for 12-18 h,respectively,SEM images of the cross section of the Ba,Y and Al co-doped LLZO solid electrolytes exhibit the distinctively flattened morphology without any noticeable grain *** total conductivity,relative density and contractibility rate of Li_(6.52)La_(2.98)-Ba_(0.02)Zr_(1.9)Y_(0.1)Al_(0.2)O_(12)solid electrolyte are 2.96×10^(-4) S·cm^(-1),94.19%and 18.61%,respectively.

关键词： Solid electrolyte Ionic conductivity Sintering Li_(7)La_(3)Zr_(2)O_(12) Garnet

An Improved and Convenient Procedure for the Synthesis of Ozagrel

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Chinese Chemical Letters 2006年第2期17卷 180-182页

作者： Chun GUO xiao Dan liu zhen Gang XIE Chu Jun LI School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016

A novel approach to the synthesis of ozagrel is described. The target compound is conveniently prepared from the commercially available material, 1,1-carboxyldiimidazole （CDI） through the condensation and hydrolyzat... 详细信息

关键词： Ozagrel synthesis 1 1-carboxyldiimidazole.

Boundary Stabilization of Stochastic Delay Reaction-Diffusion Systems 36

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Boundary Stabilization of Stochastic Delay Reaction-Diffusio...

A new method for inversion of hydroxyl group of carbocyclic nucleosides

第36届中国控制会议

作者： xiao-zhen liu xiao-Hua Ding Kai-Ning Wu Department of Mathematics Harbin Institute of Technology at Weihai

ISBN: (纸本)9781538629185

This paper considers the boundary stabilization of stochastic delay reaction-diffusion systems（SDRDSs）.We present the integral-form Lyapunov stability lemma for SDRDSs which provides the foundation of stability analysis for stochastic reaction-diffusion systems. Then, we design a boundary controller and obtain a criterion to guarantee the globally stochastically asymptotical stability of SDRDSs with Neumann boundary conditions. In addition, when the external disturbances enter in a given systems, we design a boundary controller and get the sufficient condition for the mean-square H∞ performance. Two numerical examples verifying the validity of the results are obtained in this paper.

关键词： Stochastic Reaction-Diffusion Systems Delay Boundary Control Stabilization H Infinity Performance

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cnki会议

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Chinese Chemical Letters 2007年第11期18卷 1339-1341页

作者： xiao zhen liu Fei Wang Dong Dong Luo Xing Guo Guang Qing Lei Research Institute of Chemical Defense Beijing 102205 China College of Chemistry and Material Science South-Central University for Nationalities （SCUFN） Wuhan 430074 China

The hydroxyl group of carbocyclic nucleosides was inversed when the compounds were treated with Me3SiCl, KCN and a catalytic mount of NaI in DMF/CH3CN.

关键词： Carbocyclic nucleosides Inversion Hydroxyl groups

Modeling of Strain-Induced Precipitation Kinetics and Evolution of Austenite Grains in Nb Microalloyed Steels

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Journal of Iron and Steel Research International 2008年第3期15卷 65-69页

作者： ZHOU xiao-guang liu zhen-yu YUAN Xiang-qian WU Di WANG Guo-dong liu Xiang-hua State Key Laboratory of Rolling Technology and Automation Northeastern University Shenyang 110004 Liaoning China

Considering the effect of strain and chemical composition onprecipitation behavior, new models for the start and end time of Nb（C,N） precipitation in austenite under the conditions of different temperatures and strains have been investigated for Nb microalloyed steel. The value of n in the precipitation kinetic equation has been determined by using the available experimental data in literature, which indicated that n is a constant and independent of temperature. The values of the start and end time of the predicted precipitation are compared with the experimental values. Calculated results are in good agreement with the experimental results. Also, the evolution of austenite grains before ferrite transformation is simulated by taking the effect of precipitation into consideration. The measured austenite grain size is in good agreement with predicted one prior to ferrite transformation.

关键词： strain-induced precipitation start time precipitation static recrystallization grain size

Persistence and intergenerational transmission of differentially expressed genes in the testes of intracytoplasmic sperm injection conceived mice

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第5期14卷 372-381页

作者： Li-ya WANG Ning WANG Fang LE Lei LI Le-jun LI xiao-zhen liu Ying-ming zhenG Hang-ying LOU Xiang-rong XU xiao-ming ZHU Yi-min ZHU He-feng HUANG Fan JIN Key Laboratory of Reproductive Genetics (Zhejiang) Ministry of Educationand Centre of Reproductive Medicine Women's HospitalSchool of MedicineZhejiang University Department of Gynecologic Oncology Henan Cancer Hospital

Intracytoplasmic sperm injection (ICSI) is commonly used to solve male infertility problems. Previous studies showed that early environmental exposure of an embryo may influence postnatal development. To detect whether ICSI operations affect the reproductive health of a male or his offspring, we established assisted reproductive technologies (ART) conceived mouse models, and analyzed gene expression profiles in the testes of both ICSI and naturally conceived (NC) newborn F1 mice using micro-array analysis. Among the differentially expressed genes, we focused on the expression of eight male reproduction-related genes. Quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) was used to analyze the expression of these genes in the testes of both adult and old F1 generation mice and adult F2 generation mice. Our results showed that down-regulated and somatic cell-expressed genes in newborn mice retained their differential expression patterns in adult and old F1 generation individuals, implying the persistence and fetal origin of the alteration in the expression of these genes. The intergenerational transmission of differential gene expression was observed, but most changes tended to be reduced in adult F2 generations. Controlled ovarian hyperstimulation (COH) and in vitro fertilization (IVF) mice models were added to explore the precise factors contributing to the differences in ICSI offspring. The data demonstrated that superovulation, in vitro culture, and mechanical stimulation involved in ICSI had a cumulative effect on the differential expression of these male reproductive genes.

关键词： Intracytoplasmic sperm injection Testis Intergenerational transmission

Simultaneous expression of two pathogenic genes in four Chinese patients affected with inherited retinal dystrophy

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International Journal of Ophthalmology(English edition) 2020年第2期13卷 220-230页

作者： xiao-zhen liu Tian-Chang Tao Hong Qi Shan-Na Feng Ning-Ning Chen Lin Zhao Zhi-Zhong Ma Gen-Lin Li Li-Ping Yang Department of Ophthalmology Peking University Third HospitalBeijing Key Laboratory of Restoration of Damaged Ocular NerveBeijing 100191China Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Sciences Key LabBeijing 100730China

●AIM:To describe the complex,overlapping phenotype of four Chinese patients with inherited retinal dystrophies(IRDs)who harbored two pathogenic genes simultaneously.●METHODS:This retrospective study included 4 patients affected with *** and ophthalmic histories were obtained,and clinical examinations were performed.A specific Hereditary Eye Disease Enrichment Panel(HEDEP)based on exome capture technology was used for genetic screening.●RESULTS:Four patients were identified to harbor disease-causing variants in two different *** retinitis pigmentosa(RP)01-II:1 exhibited both classical ABCA4-induced Stargardt disease(STGD)1 and USH2 Aassociated RP,patient RP02-III:2 exhibited both classical ABCA4-induced STGD1 and CDH23-associated RP,patient RP03-II:1 exhibited both USH2 A-induced autosomal recessive retinitis pigmentosa(arRP)syndrome and SNRNP200-induced autosomal dominant retinitis pigmentosa(adRP),and patient RP04-II:2 exhibited USH2 Ainduced arRP syndrome and EYS-induced arRP at the same time.●CONCLUSION:Our study demonstrates that genotype–phenotype correlations and comprehensive genetic screening is crucial for diagnosing IRDs and helping family planning for patients suffering from the disease.

关键词： inherited retinal dystrophies Hereditary Eye Disease Enrichment Panel retinitis pigmentosa Stargardt disease two pathogenic genes

A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： xiao Liang Xingping Quan xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi zhen Yuan Ping Wang Bin liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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医疗损害鉴定一元化实证研究

现代法学 2014年第4期36卷 176-183页

作者：肖柳珍南方医科大学人文与管理学院广东广州510515

医疗损害鉴定二元化一直是医疗损害案件司法实践中的难题。法官在选择医学会还是司法鉴定机构进行鉴定时没有顺位偏好。在涉及医疗损害鉴定意见专业性与中立性评价中,法官优先考虑中立性。鉴于二者的痼疾,即医学会行业保护以及司法鉴定... 详细信息

医疗损害鉴定二元化一直是医疗损害案件司法实践中的难题。法官在选择医学会还是司法鉴定机构进行鉴定时没有顺位偏好。在涉及医疗损害鉴定意见专业性与中立性评价中,法官优先考虑中立性。鉴于二者的痼疾,即医学会行业保护以及司法鉴定机构趋利性,重新整合相关资源成立唯一的医疗损害鉴定机构就成为了大多数法官对一元化制度建构的优先选择。一元化的关键是鉴定标准的一元化。立法部门或其他主管部门应制定医疗过错分类、因果关系判断及损伤参与度认定的统一标准,并对鉴定程序特别是听证程序和鉴定次数、鉴定专家库以及鉴定人员的准入进行一元化制度设计。

关键词：医疗损害鉴定侵权责任法一元化医学会司法鉴定