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World Journal of Clinical Cases 2021年第31期9卷 9577-9583页

作者： Guo-Feng Liu xiao-ze wang Xue-Feng Luo Department of Gastroenterology and Hepatology Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal CancerWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Hepatic encephalopathy(HE)is a frequent and debilitating complication of chronic liver *** HE is strongly linked with spontaneous portosystemic shunts(SPSSs).Intrahepatic arterioportal fistulas(IAPFs)occur rarely but pose a major clinical challenge and may lead to or worsen portal ***,we present a rare case of recurrent HE secondary to a SPSS combined with an *** SUMMARY A 63-year-old female with primary biliary cirrhosis presented with recurrent disturbance of consciousness for 4 *** communicating the superior mesenteric vein with the inferior vena cava and IAPF linking the intrahepatic artery with the portal vein were found on contrast-enhanced abdominal computed *** patient did not respond well to medical ***,simultaneous embolization of SPSS and IAPF was *** embolization,the symptoms of HE showed obvious *** The presence of liver vascular disorders should not be neglected in patients with chronic liver disease,and interventional therapy is a reasonable choice in such patients.

关键词： Spontaneous portosystemic shunts Intrahepatic arterioportal fistula Endovascular embolization Hepatic encephalopathy Liver disease Case report

Clinical utility of two-dimensional shear-wave elastography in monitoring disease course in autoimmune hepatitis-primary biliary cholangitis overlap syndrome

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World Journal of Gastroenterology 2022年第18期28卷 2021-2033页

作者： Yu-Ling Yan Xian Xing Yi wang xiao-ze wang Zhi wang Li Yang Department of Gastroenterology and Hepatology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Sichuan University University of Oxford Huaxi Joint for Gastrointestinal Cancer CentreChengdu 610207Sichuan ProvinceChina

BACKGROUND Autoimmune hepatitis-primary biliary cholangitis(AIH-PBC)overlap syndrome has a worse prognosis than AIH or PBC ***,accurately staging liver fibrosis and dynamically monitoring disease progression are *** To investigate the performance of two-dimensional shear-wave elastography(2DSWE)for noninvasively staging liver fibrosis and assessing the clinical utility of repeated 2D-SWE for monitoring treatment response in AIH-PBC overlap *** A total of 148 patients diagnosed with AIH-PBC overlap syndrome were retrospectively *** them,82 patients had a 2D-SWE follow-up time of more than 1 *** Scheuer scoring system was used to evaluate stages of hepatic inflammation and liver *** performance of 2D-SWE for staging liver fibrosis was evaluated with the liver *** in liver stiffness(LS)measured by 2D-SWE in patients with or without complete biochemical remission were *** LS value was strongly correlated with liver fibrosis stage(Spearman r=0.84,P<0.0001).The areas under the receiver operating characteristic curves of LS for diagnosing significant fibrosis(≥S2),severe fibrosis(≥S3),and cirrhosis(S4)were 0.91,0.97,and 0.96,*** with complete biochemical remission had a considerable decrease in LS values(P<0.0001).More importantly,the declined LS in patients with S0-S2 was significantly lower than that in patients with S3-S4(P=0.0002).In contrast,patients who failed to achieve biochemical remission had a slight but not significant decrease in LS(P=0.37).CONCLUSION LS measured by 2D-SWE is an accurate and reliable method in assessing liver fibrosis,especially for diagnosing severe fibrosis(≥3)and monitoring treatment response in patients with AIH-PBC overlap syndrome.

关键词： Liver fibrosis Liver biopsy Diagnostic tests Autoimmune hepatitis Primary biliary cholangitis Inflammation

Teaching Chinese to English Tour Guide Interpreting

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Sino-US English Teaching 2012年第5期9卷 1181-1185页

作者： wang xiao-yan wang ze-xia Changchun University Changchun China

In the present study, some junior students of the English major were asked to verbalize or write their thoughts after interpreting. Besides, students＇ errors were also identified through observations by the researchers. As a result some of the mistakes made by students were found： lacking humor and variety in their interpreting, little vocabulary and variation in expression, etc.. Reasons were also analyzed which included that students were generally not familiar with some of the often-used sentence patterns for tour guide interpretation, and teachers are not using the suitable ways of teaching tour guide interpreting. To conclude, ways to solve these problems were recommended for readers＇ reference.

关键词： TAP (think-aloud protocol) the teaching of tour guide interpreting training approaches

充填不同气体相对论返波管特性的PIC-MCC模拟

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物理学报 2008年第7期57卷 4613-4622页

作者：李小泽王建国童长江张海西北核技术研究所西安市69信箱5室西安710024

讨论了PIC-MCC方法的基本原理以及在UNIPIC软件中的编程实现,并用该软件模拟了充填不同种类气体在不同气压下相对论返波管的气体电离过程,讨论了所产生的等离子体对电子束的传输以及波束相互作用的影响.给出了返波管输出功率、频率和起... 详细信息

讨论了PIC-MCC方法的基本原理以及在UNIPIC软件中的编程实现,并用该软件模拟了充填不同种类气体在不同气压下相对论返波管的气体电离过程,讨论了所产生的等离子体对电子束的传输以及波束相互作用的影响.给出了返波管输出功率、频率和起振时间随气体种类和气压等参数的变化情况.模拟结果表明,电离产生的阳离子是返波管性能改善的原因,而腔内滞留的低能电子是破坏返波管振荡而引起脉宽缩短的重要因素.

关键词：蒙特卡罗碰撞粒子模拟高功率微波相对论返波管

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen Jie wang xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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一种基于单片机技术的家用电器远程控制系统的设计

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电工材料 2017年第1期 37-39页

作者：蒋萧泽王艳新朱莉东北林业大学哈尔滨150040

远程控制是未来家电控制系统的发展趋势,而如今电话已经走进千家万户,利用电话网进行各种远程控制开始进入人们的生活中。基于这样的思想,本设计采用了以单片机为主控制器的远程电话控制系统,以电话网络为媒介的电话家电控制器。通过电... 详细信息

远程控制是未来家电控制系统的发展趋势,而如今电话已经走进千家万户,利用电话网进行各种远程控制开始进入人们的生活中。基于这样的思想,本设计采用了以单片机为主控制器的远程电话控制系统,以电话网络为媒介的电话家电控制器。通过电话网络传输语言和数字,家庭端控制部分接收DTMF信号进行解码处理,最终将信号送给单片机以此来完成对家用电器的控制。

关键词：单片机控制家用电器远程控制电话网络

Isolation of a Plasmalemma Aquaporin Encoding Gene StPIP1 from Solanum tuberosum L. and Its Expression in Transgenic Tobacco

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Agricultural Sciences in China 2009年第10期8卷 1174-1186页

作者： WU wang-ze PENG xiao-li wang Di Crop Research Institute Academy of Agri-Science Anhui Province Hefei 230031 P.R.China College of Agronomy Gansu Agricultural University Lanzhou 730070 P.R. China Gansu Key Lab of Crop Improvement ＆ Germplasm Enhancement Lanzhou 730070 P.R. China School of Biotechnology and Food Engineering Hefei University of Technology Hefei 230009 P.R.China

Aquaporin （AQP） belongs to a highly conserved group of membrane proteins considered as major intrinsic proteins, which facilitate water transport across biological membranes. The discovery of AQPs in plants has resulted in a paradigm shift in the understanding of plant-water relations, however, the potential relationship between the role of aquaporins in regulating plant water balance and drought tolerance still remains elusive. In this study, the gene encoding potato AQP cDNA, StPIP1 （GenBank accession no. DQ999080）, was cloned from the leaf of potato cultivar Gannongshu 2 by reverse transcription-PCR （RT-PCR）. Sequence alignment was made by BLASTn in GenBank, the phylogenetic analysis was conducted using PHYLIPWY, the 3D structure was predicted in Swiss-Model server. Subcellular localization of StPIP1 was performed by constructing CaMV35S-StPIP1-GFP and rd29A-StPIP1-GFP fusion proteins and transient expression in onion epidermis. To understand StPIP1 physiological functions in potato under various stress conditions, the StPIP1 gene in a reverse orientation was transformed into tobacco driven by the Cauliflower mosaic virus （CMV） 35S promoter. The expression levels of transgenic and wild-type plants were assessed under various abiotic stress conditions using semi-quantitative RT-PCR, and the morphological and physiological responses of transgenic plants to different stress conditions were investigated. The expression of StPIP1 mRNA decreased in transgenic plants under non-stress and stress conditions, however, the reduction was more severer under drought stress. In both non-stress and stress conditions, StPIP1 was expressed predominantly in root. The morphological and physiological investigation showed no significant differences in growth rate, germination rate, and root fresh weight （FW） between transgenic and wild-type plants when grown under favorable conditions. In contrast, under drought stress, the reduction in StPIPI expression leads to a delay in seed germi

关键词： aquaporin Solanum tuberosum L. drought stress gene cloning sequence analysis gene expression

Effect of Butyl α-Hydroxymethyl Acrylate Monomer Structure on the Morphology Produced via Aqueous Emulsion Polymerization-induced Self-assembly

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Chinese Journal of Polymer Science 2020年第1期38卷 9-16,I0005页

作者： Shou-Kuo Man xiao wang Jin-Wen Zheng ze-Sheng An Institute of Nanochemistry and Nanobiology College of Environmental and Chemical EngineeringShanghai UniversityShanghai200444China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China

Polymerization-induced self-assembly(PISA) is an efficient and versatile method to afford polymeric nano-objects with polymorphic morphologies. Compared to dispersion PISA syntheses based on soluble monomers, the vast majority of emulsion PISA formulations using insoluble monomers leads to kinetically-trapped spheres. Herein, we present aqueous emulsion PISA formulations generating worms and vesicles besides spheres. Two monomers with different butyl groups, n-butyl(n BHMA) and tert-butyl(t BHMA) α-hydroxymethyl acrylate, and thus possessing different water solubilities were synthesized via Baylis-Hillman reaction. Photoinitiated aqueous emulsion polymerizations of n BHMA and t BHMA employing poly(ethylene glycol) macromolecular chain transfer agents(macro-CTAs, PEG45-CTA, and PEG113-CTA) at 40 °C were systematically investigated to evaluate the effect of monomer structure and solubility on the morphology of the generated block copolymer nano-objects. Higher order morphologies including worms and vesicles were readily accessed for t BHMA, which has a higher water solubility than that of n BHMA. This study proves that plasticization of the core-forming block by water plays a key role in enhancing chain mobility required for morphological transition in emulsion PISA.

关键词： Block copolymer α-Hydroxymethyl acrylate RAFT emulsion polymerization Polymerization-induced self-assembly

The universal characteristic water content of aqueous solutions

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Chinese Physics B 2019年第6期28卷 16-19页

作者： xiao Huang ze-Xian Cao Qiang wang Institute of Physics Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China

Raman measurements at room temperature reveal a characteristic concentration for a series of aqueous solutions of electrolytes, through which O–H stretching vibration of H2 O or dilute HDO obviously changes their concentration dependence. This characteristic concentration is very consistent with another, through which the solutions undergo an abrupt change in their glass-forming ability. Interestingly, the molar ratio of water to solute at these two consistent concentration points is almost solute-type independent and about twice the hydration number of solutes. We suggest that just when the concentration increases above this characteristic concentration, bulk-like free water disappears in aqueous solutions and all water molecules among closely-packed hydrated solutes exhibit the characteristics of confined water.

关键词： aqueous solutions stretching vibration of water concentration dependence hydration number

Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li Kang Yi Jiang Hua-Wei Zhang xiao-Mei Song Yu-ze Li Wen-Li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC