检索结果-南通市图书馆

Maternal inappropriate calcium intake aggravates dietary-induced obesity in male offspring by affecting the differentiation potential of mesenchymal stem cells

引用

World Journal of Stem Cells 2022年第10期14卷 756-776页

作者： Ping Li Yang Wang Pei Li yuan-Lin Liu Wei-Jiang Liu xiao-Yu Chen Tian-Tian Tang Ke-Min Qi Yi zhang Laboratory of Nutrition and Development Key Laboratory of Major Diseases in Children's Ministry of EducationBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Experimental Hematology and Biochemistry Beijing Institute of Radiation MedicineBeijing 100085China Department of Pediatrics General Hospital of Tianjin Medical UniversityTianjin Medical UniversityTianjin 300070China

BACKGROUND The effects of inappropriate dietary calcium intake in early life on later obesity have not been fully *** To raise the mechanism of maternal calcium intake on the multi-differentiation potential of mesenchymal stem cells among their male *** Four-week-old female C57BL/6N mice were fed by deficient,low,normal and excessive calcium reproductive diets throughout pregnancy and *** MSCs(BMSCs)were obtained from 7-day-old male offspring to measure the adipogenic differentiation potential by the Wnt/β-catenin signaling *** other weaning male pups were fed a high-fat diet for 16 wk,along with normalfat diet as the *** the serum was collected for the measurement of biochemical ***,the adipose tissues were excised to analyze the adipocyte sizes and inflammatory *** the target gene expressions on the adipogenic differentiation and Wnt/β-catenin signaling pathway in the adipose tissues and BMSCs were determined by real-time reverse transcription polymerase chain *** Compared with the control group,maternal deficient,low and excessive calcium intake during pregnancy and lactation aggravated dietary-induced obesity,with larger adipocytes,more serious inflammatory infiltration and higher serum metabolism indicators by interfering with higher expressions of adipogenic differentiation(PPARγ,C/EBPα,Fabp4,LPL,Adiponectin,Resistin and/or Leptin)among their male offspring(P<0.05).And there were significantly different expression of similar specific genes in the BMSCs to successfully polarize adipogenic differentiation and suppress osteogenic differentiation in vivo and in vitro,respectively(P<0.05).Meanwhile,it was accompanied by more significant disorders on the expressions of Wnt/β-catenin signaling pathway both in BMSCs and adulthood adipose tissues among the offspring from maternal inappropriate dietary calcium intake *** Early-life abnormal dietary calcium intak

关键词： Calcium Obesity Bone mesenchymal stem cells Wnt/β-catenin signaling pathway Adipogenic differentiation Male offspring

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

潜流人工湿地处理农田退水的温室气体排放特征研究

引用

湿地科学与管理 2024年第3期20卷 13-19页

作者：吴嘉彬周筱妍郭伟杰赵伟华阮英卢秋如长江科学院流域水环境研究所湖北武汉430010 流域水资源与生态环境科学湖北省重点实验室湖北武汉430010 云南省水利水电科学研究院云南昆明650228 武汉市青山区水务和湖泊局湖北武汉430080

人工湿地作为一种生态、低耗的污水处理技术,在去除污染物的同时,也产生和排放温室气体。本研究基于处理农田退水的中型人工湿地系统,探讨了不同运行方式、湿地构型和水力停留时间等因素对温室气体排放的影响。结果表明:运行方式对温室... 详细信息

人工湿地作为一种生态、低耗的污水处理技术,在去除污染物的同时,也产生和排放温室气体。本研究基于处理农田退水的中型人工湿地系统,探讨了不同运行方式、湿地构型和水力停留时间等因素对温室气体排放的影响。结果表明:运行方式对温室气体排放的影响受到水力停留时间的制约。水力停留时间1d时,连续运行的潜流湿地的CH4排放通量[-0.062mg/(m^(2)·h)]显著高于间歇运行的潜流湿地[-0.225mg/(m^(2)·h)](P<0.01),间歇运行的潜流湿地N_(2)O排放通量略高于连续运行的潜流湿地。水力停留时间1—3d时,水平潜流湿地的CH4排放通量和N_(2)O排放通量均显著高于垂直潜流湿地的CH4排放通量和N_(2)O排放通量(P<0.01);水力停留时间与温室气体排放通量呈正相关。研究结果可为降低人工湿地的温室气体排放提供参考。

关键词：潜流人工湿地温室气体运行方式湿地构型水力停留时间

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

预制装配式型钢混凝土梁抗剪承载力的智能模型研究

引用

建筑钢结构进展 2024年第3期26卷 12-20页

作者：刘坚招渝刘长江马宏伟邢增林周观根肖海鹏彭林苗任达陈原童华炜戚玉亮杨勤鹏张专涛广州大学土木工程学院广州510006 广州大学广东省复杂钢结构工程技术研究中心广州510006 华南理工大学土木与交通学院广州510641 广东省建筑设计研究院有限公司广州510010 浙江东南网架股份有限公司杭州311209 广州建筑产业研究院有限公司广州510653 杭萧钢构(广东)有限公司广东珠海519055

通过建立计算预制装配式型钢混凝土(PSRC)梁抗剪承载力的智能模型,在一定程度上提高了计算精度与适用性。基于BP人工神经网络算法,通过对影响PSRC梁抗剪承载力的相关参数进行梳理,选取14个主要影响参数作为输入层,以试算法确定隐含层节... 详细信息

通过建立计算预制装配式型钢混凝土(PSRC)梁抗剪承载力的智能模型,在一定程度上提高了计算精度与适用性。基于BP人工神经网络算法,通过对影响PSRC梁抗剪承载力的相关参数进行梳理,选取14个主要影响参数作为输入层,以试算法确定隐含层节点数为5,初步构建了3层结构人工神经网络系统;以收集的76组试验数据作为学习样本,对构建的神经网络系统进行训练,建立了对PSRC梁及SRC梁抗剪承载力计算的N14-5-1智能模型。使用智能模型对6个PSRC梁构件及6个SRC梁构件进行抗剪承载力计算,并通过与规范公式计算结果、试验结果的对比分析,证明了智能模型具有良好的计算精度及较好的泛化能力,具有一定的工程参考意义。运用Garson算法对输入参数进行敏感性分析,结果表明箍筋间距、型钢屈服强度、箍筋屈服强度、型钢腹板含钢率对抗剪承载力影响较大。随着研究试验的开展,在收集更多具有代表性的试验数据以扩充学习样本后,可对智能模型进一步优化。

关键词：预制装配式型钢混凝土梁 BP人工神经网络抗剪承载力智能模型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gastrointestinal-type chemotherapy prolongs survival in an atypical primary ovarian mucinous carcinoma: A case report

引用

World Journal of Clinical Cases 2021年第11期9卷 2533-2541页

作者： Qi Wang xiao-Yan Niu Hui Feng Jie Wu Wen Gao Zai-Xian zhang Yu-Wei Zou Bi-yuan zhang Hai-Ji Wang Department of Radiation Oncology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Ultrasound The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Pathology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Radiology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Primary ovarian mucinous carcinoma is a rare histologic subtype of epithelial ovarian carcinoma and exhibits considerable morphologic overlap with secondary *** is hard to differentiate primary from metastatic ovarian mucinous carcinoma by morphological and immunohistochemical *** of the histologic similarity between primary ovarian mucinous carcinoma and metastatic gastrointestinal carcinoma,it has been hypothesized that ovarian mucinous carcinomas might respond better to non-gynecologic ***,the standard treatment of advanced ovarian mucinous carcinoma has not reached a *** SUMMARY A 56-year-old postmenopausal woman presented with repeated pain attacks in the right lower quadrant abdomen,accompanied by diarrhoea,anorexia,and weight loss for about 3 *** patient initially misdiagnosed as having gastrointestinal carcinoma because of similar pathological *** on the physical examination,tumour markers,imaging tests,and genetic tests,the patient was clinically diagnosed with ovary mucinous *** gastrointestinal-type chemotherapy or gynecologic chemotherapy was a favourable choice for patients with advanced ovarian mucinous cancer had not been *** patient received a chemotherapy regimen based on the histologic characteristics rather than the tumour *** patient received nine cycles of FOLFOX and *** was followed by seven cycles of bevacizumab maintenance therapy for 9 *** therapeutic efficacy was *** The genetic analysis might be used in the differential diagnosis of primary ovarian mucinous carcinoma and non-gynecologic mucinous ***,primary ovarian mucinous carcinoma patients could benefit from gastrointestinal-type chemotherapy.

关键词： Ovarian mucinous cancer Chemotherapy Pathology Next-generation sequencing Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

智慧教学环境赋能地域性医家文化传承融入高等中医院校中医护理课程教学与考评研究

引用

齐齐哈尔医学院学报 2024年第15期45卷 1471-1476页

作者：袁亚美施慧郝书婕宋海洋时潇王杰方向明安徽中医药大学护理学院安徽合肥230012 安徽中医药大学中医学院安徽合肥230012

目的探讨智慧教学环境赋能地域性医家文化传承融入高等中医院校中医护理课程中运用的效果。方法选择本校2021级护理学本科两个自然班101名护生作为研究对象,护理2班51名护生为实验组、护理4班50名护生为对照组。对照组以传统教学模式融... 详细信息

目的探讨智慧教学环境赋能地域性医家文化传承融入高等中医院校中医护理课程中运用的效果。方法选择本校2021级护理学本科两个自然班101名护生作为研究对象,护理2班51名护生为实验组、护理4班50名护生为对照组。对照组以传统教学模式融入课程思政相关内容,实验组开展新安医家文化传承+多端口平台联合+进阶式教学,课程中对护生学习成绩进行过程性评价与终结性评价、护生文化素养能力、共情能力评分以及护生对教学的过程和课程改革的总体满意度进行评价。结果过程性评价成绩理论课程中,实验组护生MOOC学习、课堂合作以及课后作业得分均高于对照组,差异有统计学意义(P<0.05);实训课程中,实验组护生虚拟平台操作与微平台视频质量评分均高于对照组,差异有统计学意义(P<0.05);终结性评价成绩期末理论考核中,实验组护生中医护理学相关课程期末理论成绩优于对照组,差异有统计学意义(P<0.05);实训考核中,实验组护生中医护理学实训考核成绩优于对照组,差异有统计学意义(P<0.05);实验组护生文化素养的新安医学文化知识、人文关怀意识、专业认同感、地域性医学文化自信、中医护理思辨能力、职业素养得分均高于对照组,差异有统计学意义(P<0.05);实验组护生对教学过程满意度的教学内容、课程思政设计、理论和实训设计、重难点、教学态度及平台使用等情况评价得分均高于对照组,差异有统计学意义(P<0.05);实验组护生对课程的课程思政有效性、课程问题解决情况、新安医学文化融合度以及课程考核方式评价评分均高于对照组,差异有统计学意义(P<0.05);实验组护生的观点采择、换位思考、情感护理共情能力得分均高于对照组,差异有统计学意义(P<0.05)。结论以智慧教学环境赋能的智慧教学模式下的新安地域医家文化传承融入高等中医院校中医护理课程中,能够以思想、文化激活护生历史使命感,提升护生的文化传承意识及社会服务的自主性,解决护生传承意识淡薄,新安医学文化底蕴差、专业信念不强、中医护理信念不坚定等问题。

关键词：智慧教学系统新安医家文化传承中医护理课程

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Human hair follicle-derived mesenchymal stem cells:Isolation,expansion,and differentiation

引用

World Journal of Stem Cells 2020年第6期12卷 462-470页

作者： Bo Wang xiao-Mei Liu Zi-Nan Liu yuan Wang Xing Han Ao-Bo Lian Ying Mu Ming-Hua Jin Jin-Yu Liu Department of Toxicology School of Public HealthJilin UniversityChangchun 130021Jilin ProvinceChina Research Center for Analytical Instrumentation Institute of Cyber-Systems and ControlState Key Laboratory of Industrial Control TechnologyZhejiang UniversityHangzhou 310000Zhejiang ProvinceChina

Hair follicles are easily accessible skin appendages that protect against cold and potential *** follicles contain various pools of stem cells,such as epithelial,melanocyte,and mesenchymal stem cells(MSCs)that continuously self-renew,differentiate,regulate hair growth,and maintain skin ***,MSCs derived from the dermal papilla or dermal sheath of the human hair follicle have received attention because of their accessibility and broad differentiation *** this review,we describe the applications of human hair follicle-derived MSCs(hHF-MSCs)in tissue engineering and regenerative *** have described protocols for isolating hHF-MSCs from human hair follicles and their culture condition in *** also summarize strategies for maintaining hHF-MSCs in a highly proliferative but undifferentiated state after repeated in vitro passages,including supplementation of growth factors,3D suspension culture technology,and 3D aggregates of *** addition,we report the potential of hHF-MSCs in obtaining induced smooth muscle cells and tissue-engineered blood vessels,regenerated hair follicles,induced red blood cells,and induced pluripotent stem *** summary,the abundance,convenient accessibility,and broad differentiation potential make hHF-MSCs an ideal seed cell source of regenerative medical and cell therapy.

关键词： Human hair follicle Regenerative therapy Mesenchymal stem cell Tissue engineering Cell differentiation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

硅基槽波导级联多模干涉耦合器型偏振分束器

引用

红外与毫米波学报 2015年第5期34卷 583-587,592页

作者：王嘉源肖金标孙小菡东南大学光传感/通信综合网络国家地方联合工程研究中心江苏南京210096

提出了一种基于硅基槽波导的级联多模干涉(MMI)耦合器型偏振分束器,由锥形及矩形结构MMI耦合器构成.级联结构使器件长度无需为两偏振模自镜像长度的公倍数,不仅能有效减小器件尺寸,而且提高设计灵活性.同时,利用槽波导的高双折射特性及... 详细信息

提出了一种基于硅基槽波导的级联多模干涉(MMI)耦合器型偏振分束器,由锥形及矩形结构MMI耦合器构成.级联结构使器件长度无需为两偏振模自镜像长度的公倍数,不仅能有效减小器件尺寸,而且提高设计灵活性.同时,利用槽波导的高双折射特性及MMI耦合器的锥形结构,可进一步缩短器件尺寸.分析结果表明,所提器件能够有效实现偏振束分离,两级MMI工作区总长度仅为42μm,准TE与准TM模的偏振消光比分别为29.8和31.4d B,1.55μm波长下的插入损耗分别为0.395和0.699 d B,偏振消光比大于20 d B时光带宽为43 nm,覆盖整个C波段.最后,详细分析了器件关键参数的制造误差对器件性能的影响.

关键词：光学偏振分束器槽波导多模干涉耦合器

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Criteria-specific long-term survival prediction model for hepatocellular carcinoma patients after liver transplantation

引用

World Journal of Gastroenterology 2014年第31期20卷 10900-10907页

作者： Fei Teng Gui-Hua Wang Yi-Feng Tao Wen-yuan Guo Zheng-Xin Wang Guo-Shan Ding xiao-Min Shi Zhi-Ren Fu Organ Transplantation Institute of Changzheng Hospital Second Military Medical University

AIM: To establish a model to predict long-term survival of hepatocellular carcinoma (HCC) patients after liver transplantation (MHCAT).

关键词： Criteria Hepatocellular carcinoma Liver transplantation MHCAT Survival model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Distinguishing Rectal Cancer from Colon Cancer Based on the Support Vector Machine Method and RNA-sequencing Data

引用

Current Medical Science 2021年第2期41卷 368-374页

作者： Yan zhaNG yuan WU Zi-ying GONG Hai-dan YE xiao kai zhaO Jie-yi LI xiao-mei zhaNG Sheng LI Wei ZHU Mei WANG Ge-yu LIANG Yun LIU Xin GUAN Dao-yun zhaNG Bo SHEN Jiangsu Cancer Hospital Jiangsu Institute of Cancer ResearchThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Shanghai Yunying Medical Technology Co LtdShanghai 201612China Jiaxing Yunying Medical Inspection Co LtdJiaxing 314000China School of Medicine Jiangsu UniversityZhenjiang 212013China School of Public Health Southeast UniversityNanjing 211189China

Colorectal cancer (CRC) is the third most commonly diagnosed cancer *** studies have indicated that rectal cancer is significantly different from colon cancer interms of treatment, prognosis, and metastasis. Recently, the differential mRNA expression of coloncancer and rectal cancer has received a great deal of attention. The current study aimed to identifysignificant differences between colon cancer and rectal cancer based on RNA sequencing (RNA-seq)data via support vector machines (SVM). Here, 393 CRC samples from the The Cancer GenomeAtlas (TCGA) database were investigated, including 298 patients with colon cancer and 95 withrectal cancer. Following the random forest (RF) analysis of the mRNA expression data, 96 genessuch as HOXB13, PR4C, and BCLAFI were identified and utilized to build the SVM classificationmodel with the Leave-One-Out Cross-validation (LOOCV) algorithm. In the training (n= 196)and the validation cohorts (n=197), the accuracy (82. 1 % and 82.2 %, respectively) and the AUC(0.87 and 0.91, respectively) indicated that the established optimal SVM classification modeldistinguished colon cancer from rectal cancer reasonably. However, additional experiments arerequired to validate the predicted gene expression levels and functions.

关键词： colon cancer rectal cancer support vector machine classification gene selection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高校计算机应用基础课程教考新模式的改革与探索

引用

煤炭技术 2011年第2期30卷 226-228页

作者：赵晓春黑龙江科技学院哈尔滨150027

针对目前高等院校《计算机应用基础》课程的教学模式、考核方式现状及产生的原因,提出了改革教学模式、改革考试方式与成绩评定方法(网络考试方式)的具体措施,并在实践应用中取得了较好的效果。文章通过高校计算机应用基础课程考核现状... 详细信息

针对目前高等院校《计算机应用基础》课程的教学模式、考核方式现状及产生的原因,提出了改革教学模式、改革考试方式与成绩评定方法(网络考试方式)的具体措施,并在实践应用中取得了较好的效果。文章通过高校计算机应用基础课程考核现状的分析,探讨如何使用现有的信息技术及各高校校园网络现状对计算机应用基础课程进行网络化、无纸化考试,提出自己的观点与构思。

关键词：计算机应用基础教学改革网络考试系统应用

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：