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睡眠纺锤波与噪声干扰敏感性慢性睡眠障碍的干预方法选择

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中国临床神经科学 2024年第3期32卷 275-283页

作者：郎莹蒋晓江叶清林毛丹丹陈向阳张远凤陆军军医大学大坪医院神经内科全军神经内科专科中心重庆400042 重庆西区医院重庆400052 陆军军医大学大坪医院医学心理科重庆400042

目的探讨睡眠纺锤波能否对噪声干扰易感慢性睡眠障碍患者实施认知行为治疗(CBT-I)疗效起到预测作用,以期实现对该类患者的临床个体化精准治疗目标。方法选择在夜间睡眠时段(22∶00~06∶00)公路、铁道旁及飞机航线附近噪音暴露环境相对固... 详细信息

目的探讨睡眠纺锤波能否对噪声干扰易感慢性睡眠障碍患者实施认知行为治疗(CBT-I)疗效起到预测作用,以期实现对该类患者的临床个体化精准治疗目标。方法选择在夜间睡眠时段(22∶00~06∶00)公路、铁道旁及飞机航线附近噪音暴露环境相对固定(50~60分贝,每次持续时间10~15 s)条件下的居民为观察对象,采用匹兹堡睡眠质量指数(PSQI)量表和多导睡眠监测(PSG)检查进行主观及客观睡眠情况评估。根据结果分为睡眠正常(26例)组和睡眠障碍(30例)组,采用焦虑自评量表(SAS)、抑郁自评量表(SDS)评估两组的情绪状态。根据PSQI量表筛选睡眠障碍患者,对失眠患者开展PSG并根据结果中睡眠期纺锤波情况再分为:纺锤波偏高组(12例)和纺锤波偏低组(18例),同期进行8周的团体认知行为治疗。结果睡眠正常组的PSQI量表、SAS及SDS量表评分低于睡眠障碍组(P0.05)。睡眠障碍组经团体认知行为治疗后,纺锤波偏高组睡眠情况改善,PSQI量表评分、SAS及SDS量表评分较治疗前降低,睡眠潜伏期缩短、N2和N3期睡眠时间延长、睡眠期纺锤波次数增加(均P0.05)。纺锤波指数偏低者的睡眠情况较治疗前无明显变化,PSQ量表评分、SAS及SDS程度、睡眠结构参数与治疗前比较差异均无显著性(均P>0.05)。结论噪声干扰睡眠,睡眠期纺锤波指数与机体抗噪能力相关,睡眠期纺锤波指数偏低者对认知行为治疗效果较差,睡眠期纺锤波可作为预测睡眠障碍患者实施CBT-I临床疗效的生物学标志。

关键词：睡眠障碍睡眠纺锤波噪声认知行为治疗

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Science China(Technological Sciences) 2014年第12期57卷 2418-2425页

作者： WANG De Dong yuan Zhi Gang DENG xiao Hua ZHOU Meng HUANG Shi Yong LI Ming LI Hui Min LI Hai Meng RAITA Tero PANG Ye School of Electronic Information Wuhan University Institute of Space Science and Technology Nanchang University Sodankyl Geophysical Observatory University of Oulu

With coordinated observations of the NOAA 15 satellite and OUL magnetometer station in Finland, we report that the elec- tromagnetic ion cyclotron （EMIC） waves which were stimulated by the compression of the magnetosphere drive relativistic electron precipitation in geoquiescence on 1 Jan 2007. After an enhancement of solar wind dynamic pressure （SWDP）, a day- side Pcl pulsation was observed by the OUL station. Such a Pcl pulsation is caused by an EMIC wave which propagates from the generation source to lower altitudes. Simultaneously, the NOAA 15 satellite registered an enhancement of precipitating electron count rates with energies 〉3 MeV within the anisotropic zone of protons. This phenomenon is coincident with the quasi-linear theoretical calculation presented in this paper. Our observations suggest that after a positive impulse of solar wind, the compression-related EMIC waves can drive relativistic electrons precipitation and play a pivotal role in the dynamic of ra- diation belts.

关键词： radiation belt Solar wind dynamic pressure (SWDP) electromagnetic ion cyclotron (EMIC) waves precipitation rela-tivistic electron

The Influence of Fluctuated Soil Moisture on Growth Dynamic of Winter Wheat

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Agricultural Sciences in China 2002年第1期1卷 56-63页

作者： CHEN xiao-yuan and LUO yuan-pei( Institute of Resources and Environments, China Agricultural University, Beijing 100094 Agrometeorology Institute, Chinese Academy of Agricultural Sciences, Beijing 100081 ) Institute of Resources and Environments China Agricultural University Beijing 100094 Agrometeorology Institute Chinese Academy of Agricultural Sciences Beijing 100081

Glasshouse and laboratory tests were carried out in 1996 - 1998 using winter wheat cultivars Beinong 6 as materials. The growth dynamics of the whole-wheat plant were analysed under constant and fluctuated soil water condition. The results revealed that water stress made the starting time of crop greatest growth phase(STCGGP) in advance, prolonged crop greatest growth phase(CGGP), decreased the rate of crop greatest growth (CGGR or CGRm), and as a result, the rate of dry matter accumulation was reduced and the growth of the crop was slowed down. Rewatering delayed STCGGP, shortened CGGP, increased CGGR, thus, the rate of dry matter accumulation had been boosted and the growth of the crop was accelerated. The growth rate, dry matter weight and grains yield of winter wheat were almost equal to the well-watered controls if they were rewatered under the condition of moderate water stress during the jointing stage.

关键词： Winter wheat Soil moisture Growth dynamics

Epigenetic regulation in metabolic diseases:mechanisms and advances in clinical study

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1434-1460页

作者： Yan-Lin Wu Zheng-Jun Lin Chang-Chun Li xiao Lin Su-Kang Shan Bei Guo Ming-Hui Zheng Fuxingzi Li Ling-Qing yuan Zhi-hong Li National Clinical Research Center for Metabolic Disease Department of Metabolism and EndocrinologyThe Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Department of Orthopaedics The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Hunan Key Laboratory of Tumor Models and Individualized Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China

Epigenetics regulates gene expression and has been confirmed to play a critical role in a variety of metabolic diseases,such as diabetes,obesity,non-alcoholic fatty liver disease(NAFLD),osteoporosis,gout,hyperthyroidism,hypothyroidism and *** term‘epigenetics’was firstly proposed in 1942 and with the development of technologies,the exploration of epigenetics has made great *** are four main epigenetic mechanisms,including DNA methylation,histone modification,chromatin remodelling,and noncoding RNA(ncRNA),which exert different effects on metabolic *** and non-genetic factors,including ageing,diet,and exercise,interact with epigenetics and jointly affect the formation of a *** epigenetics could be applied to diagnosing and treating metabolic diseases in the clinic,including epigenetic biomarkers,epigenetic drugs,and epigenetic *** this review,we introduce the brief history of epigenetics as well as the milestone events since the proposal of the term‘epigenetics’.Moreover,we summarise the research methods of epigenetics and introduce four main general mechanisms of epigenetic ***,we summarise epigenetic mechanisms in metabolic diseases and introduce the interaction between epigenetics and genetic or non-genetic ***,we introduce the clinical trials and applications of epigenetics in metabolic diseases.

关键词： diseases clinical mechanisms

The association between metabolic syndrome and advanced prostate cancer in Chinese patients receiving radical prostatectomy

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Asian Journal of Andrology 2015年第5期17卷 839-844,I0011页

作者： Gui-Ming zhang Yao Zhu Da-Hai Dong Cheng-Tao Han Cheng-yuan Gu Wei-Jie Gu xiao-Jian Qin Li-Jiang Sun Ding-Wei Ye Department of Urology Fudan University Shanghai Cancer Center Shanghai China Department of Oncology Shanghai Medical College Fudan University Shanghai China Department of Urology The Affiliated Hospital of Qingdao University Qingdao Shandong China

The global incidence of metabolic syndrome （MetS） is dramatically increasing. Considerable interest has been devoted to the relationship between MetS and prostate cancer （PCa） risk. However, few studies have examined the association between MetS and PCa progression. This retrospective study consisted of 1016 patients with PCa who received radical prostatectomy. The association between MetS and pathological features was evaluated using logistic regression analysis. Compared with patients without MetS, those with MetS indicated an increased risk of prostatectomy Gleason score （GS）≥8 （odds ratio [OR] =1.670, 95% confidence interval （CI） 1.096-2.545, P = 0.017）, and a 1.5-fold increased risk of pT3-4 disease （OR = 1.583, 95% CI 1.106-2.266, P = 0.012）. The presence of MetS was an independent predictor of lymph node involvement （OR = 1.751, 95% CI 1.038-2.955, P = 0.036）. Furthermore, as the number of MetS components accumulated, the risk of a GS ≥ 8 increased. The present study indicates a significant association between MetS and advanced PCa. The results need to be evaluated in large-scale prospective cohorts.

关键词： Gleason score metabolic syndrome pathology prostate cancer

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基于多元素分析的贵州绿茶产地鉴别研究

食品安全质量检测学报 2024年第1期15卷 20-28页

作者：罗玉航况晓宇周绍均袁付明刘桂岚阁世媚遵义市产品质量检验检测院食品农产品检验部遵义563000 国家茶及茶制品质量检验检测中心(贵州) 遵义563000

目的探究以多元素统计对贵州不同产地绿茶判别分析的有效性和可行性,筛选产地间差异性元素。方法采用电感耦合等离子体发射光谱法(inductively coupled plasma emission spectrometry,ICP-OES)和电感耦合等离子体质谱法(inductively cou... 详细信息

目的探究以多元素统计对贵州不同产地绿茶判别分析的有效性和可行性,筛选产地间差异性元素。方法采用电感耦合等离子体发射光谱法(inductively coupled plasma emission spectrometry,ICP-OES)和电感耦合等离子体质谱法(inductively coupled plasma mass spectrometry,ICP-MS)对贵州4个产地63个绿茶样品中47种元素进行定量分析,结合正交偏最小二乘法判别分析(orthogonal partial least squares discriminant analysis,OPLS-DA)建立贵州绿茶的产地判别模型。结果4个产地的绿茶中元素含量有明显的差异;K、P、Ca、Mg、Mn、Al和Fe元素含量规律相同,说明4个产地的茶叶对土壤中部分高含量元素的富集能力具有一致性;4个产地的污染物Pb、Cu、Cd、As和Cr的含量均低于茶叶相关标准的限量要求。基于元素含量建立的6组OPLS-DA分析模型可以有效区分产地,其中黔西南州与铜仁市模型(QXN-TR)参数最优,该模型用50.3%的变量可解释93.8%的组间差异,模型预测能力也能达到89.7%;6组模型中共筛选出20种差异性元素,在6组产地判别模型中未找到共有元素;稀土元素在4个产地的判别上贡献有限。结论综合结果表明,以多元素分析和统计学模型针对贵州不同产地的绿茶样本进行判别分析是可行的,整体区分效果良好;不同产地的绿茶间元素含量的差异不同;为贵州绿茶产地区分提供了思路和研究基础。

关键词：绿茶微量元素产地判别差异性元素正交偏最小二乘法判别分析

Characterizing Human Collective Behaviors During COVID-19 — Hong Kong SAR, China, 2020

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China CDC weekly 2023年第4期5卷 71-75,I0001-I0003页

作者： zhanwei Du xiao zhang Lin Wang Sidan Yao yuan Bai Qi Tan xiaoke Xu Sen Pei Jingyi xiao Tim K.Tsang Qiuyan Liao Eric H.YLau Peng Wu Chao Gao Benjamin J.Cowling WHO Collaborating Centre for Infectious Disease Epidemiology and Control School of Public HealthLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Laboratory of Data Discovery for Health Hong Kong Science and Technology ParkNew TerritoriesHong Kong Special Administrative RegionChina Department of Genetics University of CambridgeCambridgeCB23EHUK Institute of High Performance Computing(IHPC) Agency for ScienceTechnology and Research(A*STAR)Singapore College of Information and Communication Engineering Dalian Minzu UniversityDalian CityLiaoning ProvinceChina Department of Environmental Health Sciences Mailman School of Public HealthColumbia UniversityNew York CityNYUSA School of Artificial Intelligence Opticsand Electronics(iOpen)Northwestern Polytechnical UniversityXi’an CityShaanxi ProvinceChina

Summary What is already known about this topic?People are likely to engage in collective behaviors online during extreme events,such as the coronavirus disease 2019(COVID-19)crisis,to express awareness,take action,and... 详细信息

关键词： collective likely extreme

The Stimulating Effects of Rewatering on Leaf Area of Winter Wheat Suffering Water Stress

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Agricultural Sciences in China 2002年第2期1卷 177-183页

作者： LIU xiao-ying, LUO yuan-pei and SHI yuan-chun( Institute of Resources and Environments , China Agricultural University, Beijing 100094 Institute of Agrometeorology, CAAS , Beijing 100081) Institute of Resources and Environments China Agricultural University Beijing 100094 Institute ofAgrometeorology CAAS Beijing 100081

After water stress at various levels and durations at different growth stages, rewatering could greatly stimulate the leaf area development of winter wheat. The results showed that the stimulation effect changed with water stress time, degree and duration. Rewatering under earlier stress had greater stimulation effect on leaf area than that under later stress. Higher stimulation effect was observed under severe water stress than that under moderate stress. Longer duration of stress resulted in low stimulation effect. In spite of the greater stimulation effect under severe and longer stress, the final leaf area in these situations was lower than that under moderate stress and shorter duration. Whenever the stress occurred, the stimulating effect was due to the increase of the leaf area of the tillers. Once the leaf on the main stem emerged during stress period, rewatering had no effect on its size, and consequently its leaf area. The stimulation of rewateirng on leaf area contributed to the final grain yield by 45% under moderate stress, and 67% under severe stress. Although the stimulation partly compensated for the loss during stress, the final leaf area and the grain yield could not reach the level without water stress.

关键词： Water stress Rewatering Winter wheat Stimulation Leaf area Yield

Feasibility of hyperspectral analysis for discrimination of rabbit liver VX2 tumor

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World Journal of Gastrointestinal Oncology 2019年第1期11卷 1-8页

作者： Feng Duan Jing yuan Xuan Liu Li Cui Yan-Hua Bai xiao-Hui Li Huang-Rong Xu Chen-Yang Liu Wei-Xing Yu Department of Interventional Radiology the General Hospital of Chinese People's Liberation Army Department of Pathology the General Hospital of Chinese People's Liberation Army Key Laboratory of Spectral Imaging Technology of Chinese Academy of Sciences Xi'an Institute of Optics and Precision Mechanics Chinese Academy of Sciences

BACKGROUND Hepatocellular carcinoma is one of the most common malignant tumors worldwide. Currently, the most accurate diagnosis imaging modality for hepatocellular carcinoma is enhanced magnetic resonance imaging. However, it is still difficult to distinguish cirrhosis lesions, and novel diagnosis modalities are still *** To investigate the feasibility of hyperspectral analysis for discrimination of rabbit liver VX2 *** In this study, a rabbit liver VX2 tumor model was established. After laparotomy,under direct view, VX2 tumor tissue and normal liver tissue were subjected to hyperspectral *** The spectral signature of the liver tumor was clearly distinguishable from that of the normal tissue, simply from the original spectral curves. Specifically, two absorption peaks at 600-900 nm wavelength in normal tissue disappeared but a new reflection peak appeared in the tumor. The average optical reflection at the whole waveband of 400-1800 nm in liver tumor was higher than that of the normal *** Hyperspectral analysis can differentiate rabbit VX2 tumors. Further research will continue to perform hyperspectral imaging to obtain more information for differentiation of liver cancer from normal tissue.

关键词： Hyperspectral analysis VX2 tumor Liver cancer Diagnosis Animal experiment