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Early embryonic failure caused by a novel mutation in the TUBB8 gene:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2092-2098页

作者： xiao-yu zhang Xing-Xing zhang Lei Wang Department of Reproductive Center Zaozhuang Maternal and Child Healthcare HospitalZaozhuang 277000Shandong ProvinceChina

BACKGROUND This study aimed to explore the relationship between gene mutations and early embryonic development arrest and to provide more possibilities for the diagnosis and treatment of repeated implantation *** SUMMARY Here,we collected and described the clinical data of a patient with early embryonic development stagnation after repeated in vitro fertilization attempts for primary infertility at the Department Reproductive Center of Zaozhuang Maternal and Child Healthcare *** also detected the whole-exon gene of the patient's spouse and parents,and conducted bioinformatics analysis to determine the pathogenesis of the *** A novel mutant of the TUBB8 gene[c.602G>T(p.C201F)]was identified,and this mutant provided new data on the genotype-phenotype relationships of related diseases.

关键词： Genes Mutation Embryonic development Fertilization in vitro Intracytoplasmic sperm injection Case report

Quantum support vector machine for multi classification

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Communications in Theoretical Physics 2024年第7期76卷 57-62页

作者： Li Xu xiao-yu zhang Ming Li Shu-qian Shen College of Science China University of PetroleumQingdao 266580China

Classical machine learning algorithms seem to be totally incapable of processing tremendous data,while quantum machine learning algorithms could deal with big data unhurriedly and provide exponential acceleration over classical *** this paper,we propose two quantum support vector machine algorithms for multi *** is the quantum version of the directed acyclic graph support vector *** other one is to use the Grover search algorithm before measurement,which amplifies the amplitude of the phase storing of the classification *** k classification,the former provides quadratic reduction in computational complexity when *** latter accelerates the training speed significantly and more importantly,the classification result can be read out with a probability of at least 50%using only one *** conduct numerical simulations on two algorithms,and their classification success rates are 96%and 88.7%,respectively.

关键词： quantum support vector machine quantum feature mapping Grover search algorithm

Network Pharmacology-Based Dissection of the Bioactive Compounds and Pharmacological Mechanisms of Yiqi Fumai Lyophilized Injection for the Treatment of Heart Failure

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 75-82页

作者： yu-Xi Huang Jing-Jing Fan Lu-Lu Xu Rong yu Yi Kuang yue Chai Rui Zheng xiao-yu zhang Hong-Cai Shang Xue Qiao Min Ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijingChina Key Laboratory of Chinese Internal Medicine of Ministry of Education Dongzhimen HospitalBeijing University of Chinese MedicineBeijingChina yunnan Baiyao International Medical Research Center Peking UniversityBeijingChina Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education Peking UniversityBeijingChina

Objective:Yiqi Fumai Lyophilized Injection(YQFM),a Chinese medicine injection,has been widely used for the treatment of cardiovascular diseases,especially heart failure(HF).However,bioactive compounds and underlying mechanisms of YQFM in treating HF remain poorly *** and Methods:Network pharmacology was employed to investigate the bioactive compounds and mechanisms of YQFM.A compound-target network was constructed to screen bioactive compounds based on contribution index ***,an adriamycin-induced HF rat model was established to evaluate the cardio-protective effects of YQFM by hematoxylin and eosin staining and enzyme-linked immunosorbent ***:Network pharmacology indicated that YQFM may alleviate HF through 36 compounds and 109 ***,ginsenosides Rb1,Rg1,Re,Rf,Rb2,Rh1,schisandrin,and ginsenoside Rc were indicated as the top contributors of YQFM in treating *** was predicted to act on multiple targets such as vascular endothelial growth factor A,interleukin-2(IL-2),IL-6,and IL-1β,as well as to regulate signaling pathways such as hypoxia-inducible factor 1,tumor necrosis factor,VEGF,and *** pharmacological study suggested that YQFM could attenuate cardiac injury and up-regulate plasma concentrations of VEGFR-1 and NO in HF *** Rb1,as the major contributor from network pharmacology analysis,also showed a cardioprotective effect and up-regulation of VEGFR-1 in ***:Ginsenosides and schisandrin were predicted as the most important contributors to the cardioprotective effect of *** Rb1 was proved to alleviate HF and increase the plasma concentration of VEGFR-1.

关键词： Contribution index heart failure network pharmacology traditional Chinese medicine yiqi fumai lyophilized injection

Construction of N-doped copper metal–organic frameworks for promoting photocatalytic carbon dioxide reduction to ethylene

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Science China Chemistry 2024年

作者： Fan Guo Zong-Zheng He Peng Wang xiao-yu zhang Hongjian yu Qin-Chao Wang Wei-Yin Sun School of Chemistry and Chemical Engineering Yangzhou University Coordination Chemistry Institute State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Nanjing National Laboratory of Microstructures Collaborative Innovation Center of Advanced Microstructures Nanjing University

Engineering nonmetallic atom-doped metal-organic framework （MOF） catalyst to promote C-C coupling and realize conversion of CO2into C2 multi-carbon hydrocarbon products is still ***,with 2-methylimidazole as a dopant of N element,an N-doped NH2-CuBDC catalyst was obtained via a facile and simple stirring *** illumination,compared with catalytic CO2reduction to C1 product of CO by original MOF,N-doped NH2-CuBDC can motivate generation of C2H4,which is difficult to achieve in photocatalytic system by MOF-based *** transfer rates of photo-generated charges have been expedited due to the high electron density around Cu catalytic sites after *** importantly,C–C coupling intermediate CO–CHO*was identified by in situ Fourier transform infrared spectroscopy during the catalytic CO2reduction reaction process,which further indicates the presence of Cu–N sites in the NH2-CuBDC can facilitate the formation of *** work uncovers a new paradigm to design photocatalysts for enhancing the reduction of CO2to C2 products.

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Periampullary duodenal neuroendocrine tumor in a patient with neurofibromatosis-1:A case report

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World Journal of Clinical Oncology 2024年第9期15卷 1222-1231页

作者： xiao-yu zhang Jian-Fa yu Yang Li Ping Li The First Central Hospital Clinical School Tianjin Medical UniversityTianjin 300192China Department of Hepatobiliary Surgery Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjin 300192China Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China

BACKGROUND Patients with neurofibromatosis type 1(NF1)are exposed to a higher risk of developing neuroendocrine tumors(NETs).Periampullary neuroendocrine neoplasms(NENs)in NF1 patients primarily affect the duodenum and periampullary *** SUMMARY A 50-year-old male patient was admitted to our hospital due to progressive skin and scleral yellowing for over 6 *** abdominal contrast-enhanced computed tomography scan revealed a tumor in the periampullary region,which measured 1.2 cm×1.4 cm in size and showed a progressive *** resonance cholangiopancreatography indicated the dilation of intrahepatic and extrahepatic bile *** patient was diagnosed with an ampullary tumor with the possibility of malignancy.A Whipple procedure was ***,the duodenum tumor was found to invade the mucosa,sphincter,and muscular layer of the duodenal *** hematoxylin and eosin staining confirmed the presence of duodenal G1 ***,a bibliometric analysis was performed to evaluate the state of NEN *** about periampullary NENs showed an annual increase,with most of them focusing on the treatment and diagnosis of *** This article reported a case of periampullary duodenal NET in a patient with NF1,and a bibliometric analysis was conducted.

关键词： Neuroendocrine tumor Neurofibromatosis-1 Endocrine carcinoma Bibliometric analysis Case report

Research on the development methodology for clinical practice guidelines for organic integration of traditional Chinese medicine and Western medicine

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Military Medical Research 2024年第3期11卷 313-322页

作者： Ying-Hui Jin Yan-Ping Wang Ying-Lan Xie Gui-Hua Tian xiao-yu zhang Nan-Nan Shi Ke-Hu Yang Xin Sun Yao-Long Chen Da-Rong Wu Xin-Feng Guo Long Ge Chen Zhao Cheng Lu Yin Jiang Jing Guo Si-yu Yan Yong-Bo Wang Qiao Huang Xiang-Ying Ren Ying-yue Rao yun-yun Wang Meng-Qian yuan Xian-Tao Zeng Hong-Cai Shang Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China China Center for Evidence Based Traditional Chinese Medicine Beijing 100029China Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan 430074China Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou 730000China China Center for Evidence-Based Medicine West China Hospital of Sichuan UniversityChengdu 610041China State Key Laboratory of Dampness Syndrome of Chinese Medicine the Second Affliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Evidence-based Medicine Team Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhou 510120China Nanjing University of Chinese Medicine Nanjing 210023China Jiangsu Province Hospital of Chinese Medicine Nanjing 210029China

Integrated traditional Chinese medicine(TCM)and Western medicine(WM)is a new medical science grounded in the knowledge bases of both TCM and WM,which then forms a unique modern medical system in *** TCM and WM has a long history in China,and has made important achievements in the process of clinical diagnosis and ***,the methodological defects in currently published clinical practice guidelines(CPGs)limit its *** organic integration of TCM and WM is a deeper integration of TCM and *** realize the progression of"integration"to"organic integration",a targeted and standardized guideline development methodology is ***,the purpose of this study is to establish a standardized development procedure for clinical practice guidelines for the organic integration of TCM and WM to promote the systematic integration of TCM and WM research results into clinical practice guidelines in order to achieve optimal results as the whole is greater than the sum of the parts.

关键词： Methodology Traditional Chinese medicine Western medicine Organic integration Clinical practice guidelines(CPGs)

Dual-atom catalysts:controllable synthesis and electrocatalytic applications

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Science China Chemistry 2021年第11期64卷 1908-1922页

作者： Shengbo zhang Yanfen Wu yu-xiao zhang Zhiqiang Niu Department of Chemical Engineering Tsinghua UniversityBeijing100084China

Electrocatalysis,as the nexus for energy storage and environmental remediation,requires developing low-cost and highperforming heterogeneous *** with the single atom catalysts(SACs),dual-atom catalysts(DACs)are attracting ever-increasing interest due to their higher metal loading,more versatile active sites and unique ***,controlled synthesis of DACs remains a great challenge,and their electrocatalytic applications are still in *** review first discusses the synthesis of DACs by highlighting several synthetic ***,we exemplify the unique reactivities of DACs in electrocatalytic applications including water splitting,oxygen reduction,carbon dioxide reduction and nitrogen *** structure-activity relations of DACs are specifically discussed in comparison with that of SACs,on the basis of experimental and theoretical ***,the opportunities and challenges of DACs are summarized in terms of rational design,controlled synthesis,characterization,and applications.

关键词： dual-atom catalysts controlled synthesis electrocatalytic applications structure-activity relationship

Numerical Evaluation of External Effects on Interspecific Interacting Populations

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International Journal of Automation and computing 2016年第2期13卷 133-141页

作者： xiao-yu zhang Qing Fang Department of Mathematics College of ScienceBeijing Forestry University Department of Mathematical Sciences Faculty of ScienceYamagata University

In this paper, effects of environmental and hunting parameters on the interspecific interacting populations are considered by applying the Rosenzweig-MacArthur model with the Holling type II functional response. Attenuating functions of the carrying capacity are introduced with a concern on the hunting parameters. We carry out numerical study to investigate how the population densities behave when environmental quantities change. We obtain the Hopf bifurcation diagrams from numerical results.

关键词： Interspecific interaction predator-prey system carrying capacity hunting effect Hopf bifurcation.

Drying and preheating processes of iron ore pellets in a traveling grate

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International Journal of Minerals,Metallurgy and Materials 2010年第5期17卷 535-540页

作者： Jun-xiao Feng yu zhang Hai-wei Zheng xiao-yan Xie Cai zhang School of Mechanical Engineering University of Science and Technology B~ijing Beijing 100083 China

A mathematical model of drying and preheating processes in a traveling grate was presented based on the laws of mass, momen- tum, heat transfer, and drying semiempirical relations. A field test was systematically carried out in a traveling grate. The effects of pellet diameter, moisture, grate velocity, and inlet gas temperature on the pellet bed temperature were studied. The average relative error between actual measurements and simulations is less than 7.97%, indicating the validity of the model.

关键词： iron ores pelletizing drying preheating numerical methods field test