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Prevalence of Helicobacter pylori infection in Chinese military personnel:A cross-sectional,multicenter-based study

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World Journal of Gastroenterology 2025年第3期31卷 42-49页

作者： Han-Chen Min Chun-Yan Zhang Fang-yu Wang xiao-Hui yu Shan-Hong Tang Hong-Wu zhu Ya-Gang Zhao Ji-Luo Liu Jian Wang Jing-Han Guo xiao-Mei Zhang yun-Sheng Yang Chinese People’s Liberation Army Medical School Chinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology and Hepatology The First Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Sixth Healthcare Department The Second Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina Department of Gastroenterology General Hospital of Western Theater CommandChengdu 610011Sichuan ProvinceChina Department of Gastroenterology General Hospital of Southern Theater CommandGuangzhou 510010Guangdong ProvinceChina Department of Epidemiology Naval Medical UniversityShanghai 200433China School of Medicine Nankai UniversityTianjin 300071China National Clinical Research Center for Geriatric Diseases Chinese People’s Liberation Army General HospitalBeijing 100853China

BACKGROUND Helicobacter pylori(***)infection is a prevalent disease encountered in military internal medicine and recognized as the main cause of dyspepsia,gastritis,and peptic ulcer,which are common diseases in military *** guidelines in China state all patients with evidence of active infection with *** are offered ***,the prevalence of *** infection and its regional distribution in the military population remain unclear,which hinders effective prevention and treatment *** the prevalence of *** infection in the military population will aid in the development of customized strategies to better manage this infectious *** To investigate the prevalence of *** infection in the Chinese military population in different geographic *** This multicenter,retrospective study included 22421 individuals from five tertiary hospitals located in north,east,southwest,and northwest cities of *** infection was identified using the urea breath test,which had been performed between January 2020 and December *** Of the 22421 military service members,7416(33.1%)were urea breath *** highest prevalence of *** was in the 30-39 years age group for military personnel,with an infection rate of 34.9%.The majority of infected subjects were younger than 40-years-old,accounting for 70.4%of the infected *** individuals serviced in Lanzhou and Chengdu showed a higher infection prevalence than those in Beijing,Nanjing,and Guangzhou,with prevalence rates of 44.3%,37.9%,29.0%,31.1%,and 32.3%,*** *** infection remains a common infectious disease among military personnel in China and has a relatively high prevalence rate in northwest China.

关键词： Helicobacter pylori Prevalence Military personnel Urea breath test Multicenter study

掺CH_4的SiCOH低介电常数薄膜结构与介电性能研究

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物理学报 2005年第11期54卷 5417-5421页

作者：俞笑竹王婷婷叶超宁兆元苏州大学物理科学与技术学院江苏省薄膜材料重点实验室苏州215006

以十甲基环五硅氧烷和甲烷作为反应气体,采用电子回旋共振等离子体化学气相沉积(ECR-CVD)方法制备了k=2.45,485℃下的热稳定性优良的SiCOH低介电常数薄膜.通过薄膜结构的FTIR谱分析,比较了十甲基环五硅氧烷(D5)液态源和不同甲烷流量下... 详细信息

以十甲基环五硅氧烷和甲烷作为反应气体,采用电子回旋共振等离子体化学气相沉积(ECR-CVD)方法制备了k=2.45,485℃下的热稳定性优良的SiCOH低介电常数薄膜.通过薄膜结构的FTIR谱分析,比较了十甲基环五硅氧烷(D5)液态源和不同甲烷流量下制备的薄膜的键结构差异,发现在沉积过程中甲烷含量的增大,一方面有利于D5源环结构的保留,另一方面有利于薄膜中形成高密度的CHn基团.高密度碳氢大分子基团的存在降低了薄膜密度,结合薄膜中形成的本构孔隙、低极化率Si—C键以及—OH键减少的共同作用,导致薄膜介电常数的降低.

关键词： SiCOH薄膜介电常数碳氢掺杂电子回旋共振等离子体化学气相沉积热稳定性键结构

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基于复合胞化空间的图胞映射方法

物理学报 2008年第7期57卷 4021-4028页

作者：贺群徐伟李爽肖玉柱西北工业大学理学院成用数学系西安710072

为了提高计算的准确性和效率,通过引入复合胞化空间概念,构建了一种迭代的图胞映射方法.该方法能够对任意感兴趣的空间区域进行细化处理,细化过程采用代数运算完成不会额外增加计算机内存且能保持细化前后图动力系统性质不变.为了便于... 详细信息

为了提高计算的准确性和效率,通过引入复合胞化空间概念,构建了一种迭代的图胞映射方法.该方法能够对任意感兴趣的空间区域进行细化处理,细化过程采用代数运算完成不会额外增加计算机内存且能保持细化前后图动力系统性质不变.为了便于计算机实施,也给出了相应的有效算法.通过对典型例子Henon映射的应用分析,证实了该方法的有效性.

关键词：图胞映射方法迭代方法 Henon映射

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基于镜像激励的结构动力学系统的设计点激励

工程力学 2015年第10期32卷 233-238页

作者：任丽梅刘建民肖玉柱长安大学理学院陕西西安710064

在随机振动及结构可靠性研究中,动力学系统的设计点激励有着不可替代的作用,但非线性动力学系统设计点激励的计算方法仍是当今研究者的焦点之一。该文利用振子自由振动响应的镜像激励,给出了高斯白噪声激励下非线性系统的设计点激励,并... 详细信息

在随机振动及结构可靠性研究中,动力学系统的设计点激励有着不可替代的作用,但非线性动力学系统设计点激励的计算方法仍是当今研究者的焦点之一。该文利用振子自由振动响应的镜像激励,给出了高斯白噪声激励下非线性系统的设计点激励,并将其应用到首穿失效概率估计问题中,与原始的蒙特卡罗模拟相比较,两者体现了高度的一致性。为进一步说明该文方法的正确性,针对线性系统,利用解析方法获得设计点激励的准确值,利用镜像方法所得近似值,将其均应用到首穿失效概率的计算中,数值例子显示,两种方法所得设计点激励稍有不同,但在计算首穿失效概率时,展现出同样的有效性。

关键词：结构动力学设计点激励镜像激励首穿失效概率自由振动响应

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QTLs for Rice Leaf Chlorophyll Content Under Low N Stress

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Pedosphere 2004年第2期14卷 145-150页

作者： FANGPing yuxiao-Min zhuRi-Qing WUPing CollegeofEnvironmentalandResourceSciences ZhejiangUniversityHangzhou310029（China）.E-mail：pfang@*** CollegeofLifeSciences ZhejiangUniversityHangzhou310029（China）

Quantitative trait loci (QTLs) for chlorophyll content of a rice leaf weremapped on to the molecular marker linkage map of a double-haploid (DH) population derived from across between two rice varieties 'IR64' and 'Azucena' in both nutrient solutionand soil cultureexperiments to detect rice nitrogen nutrition status under low N stress A chlorophyll meter was usedto measure the soil plant analysis development (SPAD) value of the topmost fully expanded leaf asthe index of chlorophyll content thatexpressed nitrogen status in rice plants. Totally 3 QTLs forSPAD values, two on chromosome 3 located at interval RG179-CDO337 and RG348-RZ329, respectively, andone on chromosome 10 at interval RZ500-RG134, were detected under stressed conditions of low N inthe soil and/or nutrient solution culture experiments. One QTL located at interval RG179-GDO337 onchromosome 3 associated with a relative change in SPAD value from a high N level to a low N level inthe soil culture experiment was also *** on the different responses to low N stressbetween the two parents, it was supposed that the QTLs identified in this study associated withnitrogen efficiency in rice at low N levels might be useful in applying marker technology to ricebreeding programs.

关键词： chlorophyll meter nitrogen efficiency QTLs rice (Oryza sativa L.) SPADvalue

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan yu xiao-Li Li xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie zhu xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Multiparameter magnetic resonance imaging-based radiomics model for the prediction of rectal cancer metachronous liver metastasis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 62-72页

作者： Zhi-Da Long xiao yu Zhi-Xiang Xing Rui Wang Department of Hepatobiliary and Pancreaticosplenic Surgery Jingzhou Hospital Affiliated to Yangtze UniversityJingzhou 434100Hubei ProvinceChina

BACKGROUND The liver,as the main target organ for hematogenous metastasis of colorectal cancer,early and accurate prediction of liver metastasis is crucial for the diagnosis and treatment of ***,this study aims to investigate the application value of a combined machine learning(ML)based model based on the multiparameter magnetic resonance imaging for prediction of rectal metachronous liver metastasis(MLM).AIM To investigate the efficacy of radiomics based on multiparametric magnetic resonance imaging images of preoperative first diagnosed rectal cancer in predicting MLM from rectal *** We retrospectively analyzed 301 patients with rectal cancer confirmed by surgical pathology at Jingzhou Central Hospital from January 2017 to December *** participants were randomly assigned to the training or validation queue in a 7:3 *** first apply generalized linear regression model(GLRM)and random forest model(RFM)algorithm to construct an MLM prediction model in the training queue,and evaluate the discriminative power of the MLM prediction model using area under curve(AUC)and decision curve analysis(DCA).Then,the robustness and generalizability of the MLM prediction model were evaluated based on the internal validation set between the validation queue *** Among the 301 patients included in the study,16.28%were ultimately diagnosed with MLM through pathological *** analysis showed that carcinoembryonic antigen,and magnetic resonance imaging radiomics were independent predictors of ***,the GLRM prediction model was developed with a comprehensive nomogram to achieve satisfactory *** prediction performance of GLRM in the training and validation queue was 0.765[95%confidence interval(CI):0.710-0.820]and 0.767(95%CI:0.712-0.822),*** with GLRM,RFM achieved superior performance with AUC of 0.919(95%CI:0.868-0.970)and 0.901(95%CI:0.850-0.952)in the training and validation queue,respect

关键词： Rectal cancer Metachronous liver metastases Magnetic resonance imaging Radiomics Machine learning

O_2掺杂对SiCOH低k薄膜结构与电学性能的影响

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物理学报 2007年第2期56卷 1172-1176页

作者：卫永霞钱晓梅俞笑竹叶超宁兆元梁荣庆苏州大学物理科学与技术学院江苏省薄膜材料实验室苏州215006 复旦大学现代物理研究所上海200433

以十甲基环五硅氧烷(D5)和氧气(O2)作为反应气体,采用电子回旋共振等离子体化学气相沉积(ECR-CVD)方法制备了k=2.62的SiCOH薄膜.研究了O2掺杂对薄膜结构与电学性能的影响.结果表明,采用O2掺杂可以在保持较低介电常数的前提下极大地降低... 详细信息

以十甲基环五硅氧烷(D5)和氧气(O2)作为反应气体,采用电子回旋共振等离子体化学气相沉积(ECR-CVD)方法制备了k=2.62的SiCOH薄膜.研究了O2掺杂对薄膜结构与电学性能的影响.结果表明,采用O2掺杂可以在保持较低介电常数的前提下极大地降低薄膜的漏电流,提高薄膜的绝缘性能,这与薄膜中Si-O立体鼠笼、Si-OH结构含量的提高有关.

关键词： SiCOH薄膜 O2掺杂介电性能键结构

Dermatitis bullosa caused by the immune checkpoint inhibitor camrelizumab:A case report

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World Journal of Clinical Cases 2025年第8期13卷 15-21页

作者： yuan-Jing Jiang Lu Wu xiao Yang yu Pu Bing-Jie Ning Na Peng xiao-Ju zhu Cancer Center Daping HospitalArmy Medical UniversityChongqing 400042China

BACKGROUND Since the advent of the 20th century,alongside the progression of medical science and technological advancements,immunotherapy has emerged as a pivotal thera-peutic approach for tumor patients subsequent to undergoing radiotherapy and ***(camrelizumab),a flagship drug in the realm of immuno-therapy,functions as a monoclonal antibody specifically targeting the progra-mmed death protein 1(PD-1).This drug engages with the human PD-1 receptor,effectively inhibiting the PD-1/programmed death ligand 1 signaling *** inhibition results in the restoration of T cell activity and the induction of an anti-tumour ***,it is noteworthy that such interference could lead to immune-related adverse events resembling autoimmune *** grow-ing availability and clinical use of immune checkpoint inhibitors have raised sig-nificant clinical concerns regarding their *** instances of immune-related adverse reactions and the associated management strategies have been extensively *** identification and diagnosis,coupled with multidi-sciplinary consultation and the prompt administration of immunosuppressants,can effectively address severe immune-related adverse *** SUMMARY Arimab(camrelizumab),a monoclonal antibody targeting programmed death protein 1(PD-1),disrupts the PD-1/programmed death ligand 1(PD-L1)inter-action,reactivating T cell function and triggering anti-tumor ***,this disruption may trigger immune-mediated adverse events akin to autoim-mune *** 2.8%of such events manifest as immune-related dermatologic reactions,with 0.7%classified as grade 3,which are infrequently ***,this study describes a case of grade 3 bullous dermatitis occur-ring 15 days after initiating camrelizumab *** patient,a 67-year-old male with oesophageal squamous cell carcinoma,received camrelizumab plus paclitaxel alongside chemotherapy and radiotherapy in early ***

关键词： Camrelizumab Anti-programmed cell death protein-1 blockade Skin-related adverse events Immune-related dermatitis Case report