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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai yuan Zhuang Shenghua Lu Qianqian Ge Hao Li yu Deng Hongbin wu xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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Increased circulating of myeloid-derived suppressor cells in myelodysplastic syndrome

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Chinese Medical Journal 2013年第13期126卷 2582-2584页

作者： JIANG Hui-juan FU Rong WANG Hua-quan LI Li-juan QU Wen LIANG Yong WANG Guo-jin WANG xiao-ming wu yu-hong LIU Hong SONG Jia GUAN Jing X1NG Li-min RUAN Er-bao SHAO Zong-hong Department of Hematology General Hospital of Tianjin Medical University Tianjin 300052 China

Myelodysplastic syndrome （MDS） is a group of clonal .hematopoietic stem cell disorders, characterizedby varying degrees ot peripheral cytopema caused by ineffective dysplasia of the myeloid lineages. MDS also has a high risk of progression to acute myeloid leukemia. But the role of immune abnormalities in the pathogenesis of MDS is still not clear. Myeloid-derived suppressor cells （MDSCs） constitute a heterogeneous population of immature cells derived from the bone marrow. In the recent years, MDSCs were reported to play an important role in suppressing lymphocytes in tumor-bearing animal models and cancer patients. This could be one of the mechanisms on tumor immune evasion, which aggravates the development and growth of tumors. In a mice model, MDSCs are characterized by co- expression of GR1 and CDllb. In humans, the phenotype of MDSCs was accepted as Lin- HLA-DR- CD33＋.l In the present study, we investigated the level of circulating MDSCs （Lin- HLA-DR- CD33＋） in patients with MDS and evaluated the association between MDSCs and malignancy in MDS. METHODS Patients Thirty-five patients with MDS （24 men and 11 women, median age 59 years （age range 21-83）, including refractory anemia （n=3）; refractory anemia with ringed sideroblasts （n=3）; refractory cytopenia with multilineage dysplasia （n=9）; refractory anemia with excess blast-I （n=4）; refractory anemia with excess blast-II （n=16））, and without other systemic diseases, were enrolled in the present study. All the patients underwent diagnosis in the Department of Hematology, General Hospital of Tianjin Medical University from March 2011 to April 2012, according to the diagnostic criteria of MDS proposed between 2007 and 2008. After treatment for three months, 14 MDS patients were investigated again for their MDSCs changes. Twenty normal healthy individuals were selected as controls （9 men and 11 women, median age 34 years （age range 26-82））. The study was approved by the Ethics Committee of Tianjin Medical Universit

关键词： myeloid-derived suppressor cells myelodysplastic syndrome CD34+ cells

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Design high-performance narrowband emitters for blue light-emitting diodes through manipulating resonance structure of aromatic heterocycles

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Science China Chemistry 2025年

作者： yue yu Lei Xu Wenle Tan yuyu Pan Jiyin xiao Bohan Wang Guangjun Tian yuguang Ma Lei Ying Institute of Polymer Optoelectronic Materials and Devices Guangdong Basic Research Center of Excellence for Energy and Information Polymer Materials State Key Laboratory of Luminescent Materials and Devices South China University of Technology School of Petrochemical Engineering Shenyang University of Technology Key Laboratory for Microstructural Material Physics of Hebei Province School of Science Yanshan University

Narrowband light-emitting materials play critical roles in improving the color gamut and energy consumption of electroluminescence. Herein we demonstrated that by regulating the ground state resonance structure form of emitters with polycyclic aromatic heterocycles, the high-energy vibration of the C–C bond can be effectively suppressed, resulting in narrow emission like classical cyanine dyes. The designed compounds consist of twist and planar conformation, while having differences in the orientation of the positioning electron-donating(nitrogen) and electron-accepting(carbonyl) groups in the polycyclic aromatic hydrocarbon skeleton. The resulting compound Ac-Ph-Ac with a dominated zwitterionic resonance structure exhibits a relatively wide electroluminescent profile with the full width at half maximum(FWHM) of 42 nm and moderate device performance. In contrast, the “soliton transition” of 2AcPh based on the cyanine limit character effectively suppresses C–C stretching vibration in the polycyclic aromatic heterocycle skeleton, leading to a narrow electroluminescent profile with FWHM of 30 nm(0.16 eV)associated with an impressively high external quantum efficiency of 28.52%, which is among the highest efficiencies of so far reported non-sensitized organic light-emitting diodes.

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基于Intel SGX的Ansible安全增强

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计算机系统应用 2017年第10期26卷 67-72页

作者：杨骁于佳耕武延军中国科学院软件研究所基础软件国家工程研究中心北京100190 中国科学院大学北京100049

Ansible是当今最主流的云平台自动化运维工具之一,通常拥有大量集群的管理员账号信息来批量执行运维任务,这些账号信息一般明文存储在配置文件中.但在云计算环境中这种机制具有较大的安全隐患,因为Ansible的配置信息的机密性和完整性依... 详细信息

Ansible是当今最主流的云平台自动化运维工具之一,通常拥有大量集群的管理员账号信息来批量执行运维任务,这些账号信息一般明文存储在配置文件中.但在云计算环境中这种机制具有较大的安全隐患,因为Ansible的配置信息的机密性和完整性依赖云服务厂商提供的基础软件的安全性.因此,加强Ansible配置信息管理机制的安全性至关重要.本文基于Intel近年推出的安全机制SGX(Software Guard e Xtensions)开发了Ansible的配置管理模块,它可以独立地在可信的执行环境(Trusted Execution Environment,TEE)内管理Ansible的配置信息,从而保证了Ansible配置信息不被外界读取和修改,同时其安全性不再依赖于底层基础软件.实验评估显示,本文方案更加安全可靠,性能的额外开销也在接受范围之内,而且可以进一步扩展成通用的配置管理组件集成到Open Stack等云平台中.

关键词： Intel SGX 云计算安全运维 Ansible

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银川市郊蔬菜温棚作业者泌尿生殖系统健康现况调查

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环境与职业医学 2017年第6期34卷 521-526页

作者：植小玉吴冰董立军赵吉杨惠芳宁夏医科大学公共卫生与管理学院宁夏回族自治区银川750004 宁夏国龙医院办公室宁夏回族自治区银川750004

[目的]了解银川市郊蔬菜温棚作业者泌尿生殖系统健康现状,并分析其影响因素。[方法]采用随机整群抽样法,于2015年4—5月采用问卷调查的方式,收集银川市三区两县460名蔬菜温棚作业者的相关信息,运用logistic回归分析作业者泌尿生殖系统... 详细信息

[目的]了解银川市郊蔬菜温棚作业者泌尿生殖系统健康现状,并分析其影响因素。[方法]采用随机整群抽样法,于2015年4—5月采用问卷调查的方式,收集银川市三区两县460名蔬菜温棚作业者的相关信息,运用logistic回归分析作业者泌尿生殖系统健康现况的影响因素。[结果]本次研究最终调查对象448名,问卷回收率97.4%,其中女性207人,男性241人。女性泌尿生殖系统疾病患病率高达75.8%,多因素分析结果显示:随意增加喷药次数(OR=3.683,95%CI:1.261~10.760)、喷药时闲聊(OR=2.532,95%CI:1.056~6.068)是影响其患病率的危险因素;使用阿维菌素(OR=0.311,95%CI:0.132~0.730)是保护因素。男性泌尿生殖系统疾病患病率为14.1%,多因素分析结果显示:年龄大(OR=1.048,95%CI:1.007~1.091)、农药的暴露分级高(OR=5.11,95%CI:1.313~19.890)、混配农药的种类多(OR=3.275,95%CI:1.186~9.042)及混配农药使用所占的比例高(OR=3.243,95%CI:1.056~9.959)是影响其患病率的危险因素;每周食用肉类次数多(OR=0.697,95%CI:0.491~0.989)是保护因素。[结论]银川市郊女性温棚作业者泌尿生殖系统疾病发病率较高,缺乏农药的正确使用及防护知识是影响该类疾病的主要影响因素。

关键词：温棚作业者泌尿生殖系统患病率农药暴露农药防护

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乳腺导管的X线解剖研究及临床意义

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实用放射学杂志 2000年第11期16卷 662-663页

作者：郁武殷国玮章龙蛟范晓彧吴雪梅上海市长宁区中心医院放射科!上海200336 上海市长宁区妇幼保健院放射科

目的 :探讨乳腺导管的X线解剖形态 ,进一步提高对乳腺导管系统疾病的诊断与治疗水平。方法 :作者回顾 2 5 4例3 69支乳腺导管造影资料。结果 :乳腺导管的X线解剖形态大致可分为 4型 ,即全支型、多支型、少支型和单支型。以多支型和少支... 详细信息

目的 :探讨乳腺导管的X线解剖形态 ,进一步提高对乳腺导管系统疾病的诊断与治疗水平。方法 :作者回顾 2 5 4例3 69支乳腺导管造影资料。结果 :乳腺导管的X线解剖形态大致可分为 4型 ,即全支型、多支型、少支型和单支型。以多支型和少支型最为多见 ,而全支型及单支型较为少见。结论 :了解乳腺导管的X线解剖形态对导管系统疾病的诊断与治疗很有价值。

关键词：乳腺导管 X线解剖乳腺导管造影

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Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

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Science China Life Sciences 2025年第1期68卷 116-129页

作者： Jiangpeng wu Siyu Xia Wenting Ye Yan Sun Jing Cai Fubing yu Haiping Wen Xiuwei Yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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乳酸脱氢酶A促进人脉络膜黑色素瘤细胞的生长

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眼科新进展 2018年第6期38卷 519-522页

作者：刘园园朱晓雨吴亚更刘莹徐小洁刘丹锦州医科大学附属第一医院辽宁省锦州市121000 寿县县医院安徽省寿县232200 军事医学科学院北京市100850

目的成功构建带有Flag标签的人乳酸脱氢酶A(lactate dehydrogenase A,LDHA)的真核表达载体,初步检测LDHA基因对人脉络膜黑色素瘤(choroidal melanoma,CM)MUM-2B细胞生长功能的影响。方法将军事科学院传代培养的人CM系随机分为实验组和... 详细信息

目的成功构建带有Flag标签的人乳酸脱氢酶A(lactate dehydrogenase A,LDHA)的真核表达载体,初步检测LDHA基因对人脉络膜黑色素瘤(choroidal melanoma,CM)MUM-2B细胞生长功能的影响。方法将军事科学院传代培养的人CM系随机分为实验组和对照组,实验组MUM-2B细胞瞬时转染构建成功带有Flag标签的人LDHA重组质粒(Flag-LDHA),对照组MUM-2B细胞瞬时转染Flag空载质粒;以带有GST标签的Flag-LDHA为模板,采用聚合酶链反应(PCR)技术扩增LDHA基因,并将其插入到Flag载体,应用菌液PCR、双酶切和测序方法鉴定重组质粒,鉴定成功后瞬时转染人CM,通过Western blot鉴定其表达;CCK8法检测并绘制生长曲线。结果PCR技术扩增得到长约1000 bp的LDHA基因的编码区序列,并成功克隆至Flag载体上;与对照组相比,实验组菌液PCR结果为阳性,双酶切鉴定结果为切开两条长约4000 bp的Flag载体和1000 bp的LDHA基因条带,测序鉴定结果为插入的序列与LDHA基因的编码序列完全一致。Western blot检测结果显示,与对照组相比,实验组MUM-2B细胞成功表达LDHA蛋白;CCK8法检测结果显示,实验组MUM-2B细胞较对照组MUM-2B细胞生长快。结论成功构建了Flag-LDHA真核表达载体,并发现LDHA基因能够促进人CM MUM-2B细胞的生长,为研究LDHA在人CM的发生发展中的功能奠定基础。

关键词：乳酸脱氢酶A 真核表达人脉络膜黑色素瘤MUM-2B细胞克隆

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Comparative analysis of empirical and deep learning models for ionospheric sporadic E layer prediction

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Earth and Planetary Physics 2025年第1期9卷 10-19页

作者： BingKun yu PengHao Tian XiangHui Xue Christopher JScott HaiLun Ye JianFei wu Wen Yi TingDi Chen XianKang Dou Institute of Deep Space Sciences Deep Space Exploration LaboratoryHefei 230088China CAS Key Laboratory of Geospace Environment School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China Department of Meteorology University of ReadingReading RG66BBUK

Sporadic E(Es)layers in the ionosphere are characterized by intense plasma irregularities in the E region at altitudes of 90-130 *** they can significantly influence radio communications and navigation systems,accurate forecasting of Es layers is crucial for ensuring the precision and dependability of navigation satellite *** this study,we present Es predictions made by an empirical model and by a deep learning model,and analyze their differences comprehensively by comparing the model predictions to satellite RO measurements and ground-based ionosonde *** deep learning model exhibited significantly better performance,as indicated by its high coefficient of correlation(r=0.87)with RO observations and predictions,than did the empirical model(r=0.53).This study highlights the importance of integrating artificial intelligence technology into ionosphere modelling generally,and into predicting Es layer occurrences and characteristics,in particular.

关键词： ionospheric sporadic E layer radio occultation ionosondes numerical model deep learning model artificial intelligence

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Unveiling the relationship between Fabry-Perot laser structures and optical field distribution via symbolic regression

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Optoelectronics Letters 2025年第3期21卷 149-154页

作者： LI Wenqiang wu Min LI Weijun HAO Meilan yu Lina Ann Lab Institute of Semiconductors Chinese Academy of Sciences School of Electronic Electrical and Communication Engineering & School of Integrated Circuits University of Chinese Academy of Sciences Beijing Key Laboratory of Semiconductor Neural Network Intelligent Sensing and Computing Technology

In recent years, machine learning (ML) techniques have been shown to be effective in accelerating the development process of optoelectronic devices. However, as"black box"models, they have limited theoretical interpretability. In this work, we leverage symbolic regression (SR) technique for discovering the explicit symbolic relationship between the structure of the optoelectronic Fabry-Perot (FP) laser and its optical field distribution, which greatly improves model transparency compared to ML. We demonstrated that the expressions explored through SR exhibit lower errors on the test set compared to ML models, which suggests that the expressions have better fitting and generalization capabilities.

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