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Science China(Life Sciences) 2024年第6期67卷 1302-1304页

作者： Zhuo-Yu An xiao-Hui zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Collaborative Innovation Center of Hematology Peking UniversityBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China

Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is an important medical development in treating hematological ***,the risk of acute graft-versus-host disease(a GVHD)severely limits its use.a GVHD is a sev... 详细信息

关键词： hematopoietic graft artificial

Increased Expression of Serum Monocyte Chemoattractant Protein-1,Chemokine(C-C motif)Ligand 3,and Interleukins in Patients With Vitiligo

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International Journal of Dermatology and Venereology 2024年第1期7卷 40-43页

作者： xiao-Ling Zhao ya-Lan Li Zi-Han Li xiao-Chong zhang Li-Hui An Yu-Jiao Sun Deng-Xiang Liu Fang Cheng Cancer Laboratory Xingtai People’s HospitalXingtaiHebei 054001China Endocrine Department Xingtai People’s HospitalXingtaiHebei 130500China Dermatological Department Xingtai People’s HospitalXingtaiHebei 054001China

Objective:Vitiligo is a chronic,acquired depigmentation of the skin,which can be divided into active and stable *** stable and active stages are not immutable and often *** of internal markers would help to diagnose the active stage of vitiligo,and the purpose of this study was to find potential active markers in the progression of ***:We compared 30 healthy controls to 60 patients with vitiligo(30 with active disease and 30 with stable disease)regarding the expression of serum monocyte chemoattractant protein(MCP)-1,chemokine(C-C motif)ligand(CCL)3,CCL5,CCL21,interleukin(IL)-6,and *** were collected from May 2017 to December *** detection was carried out by enzyme-linked immunosorbent *** difference between groups was compared by Kruskal-Wallis H test and Mann-Whitney U ***:We found that the serum levels of MCP-1,CCL3,IL-6,and IL-17 were significantly higher in patients with vitiligo than in healthy controls(P<0.01)and that IL-17 was higher in patients with active vitiligo than in those with stable vitiligo(P<0.01).After 3months of treatment,the serum IL-17 level of patients with active vitiligo was not significantly different from that before treatment(P=0.526);after 6months of treatment,however,the serum IL-17 level had significantly decreased(P<0.01).Conclusion:These findings suggest that the serum IL-17 level can be used as a marker of vitiligo disease activity giving it certain guiding significance for clinical treatment.

关键词： clinical marker serum cytokines vitiligo

IR-YOLO: Real-Time Infrared Vehicle and Pedestrian Detection

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Computers, Materials & Continua 2024年第2期78卷 2667-2687页

作者： xiao Luo Hao Zhu Zhenli zhang Department of Electrical Engineering and Automation Jiangxi University of Science and TechnologyGanzhou341000China Jiangxi Provincial Key Laboratory of Maglev Technology Ganzhou341000China Graduate School of Information Production and SystemsWaseda UniversityKitakyushu-shiFukuoka808-0135Japan

Road traffic safety can decrease when drivers drive in a low-visibility *** application of visual perception technology to detect vehicles and pedestrians in infrared images proves to be an effective means of reducing the risk of *** tackle the challenges posed by the low recognition accuracy and the substan-tial computational burden associated with current infrared pedestrian-vehicle detection methods,an infrared pedestrian-vehicle detection method A proposal is presented,based on an enhanced version of You Only Look Once version 5(YOLOv5).First,A head specifically designed for detecting small targets has been integrated into the model to make full use of shallow feature information to enhance the accuracy in detecting small ***,the Focal Generalized Intersection over Union(GIoU)is employed as an alternative to the original loss function to address issues related to target overlap and category ***,the distribution shift convolution optimization feature extraction operator is used to alleviate the computational burden of the model without significantly compromising detection *** test results of the improved algorithm show that its average accuracy(mAP)reaches 90.1%.Specifically,the Giga Floating Point Operations Per second(GFLOPs)of the improved algorithm is only *** contrast,the improved algorithms outperformed the other algorithms on similar GFLOPs,such as YOLOv6n(11.9),YOLOv8n(8.7),YOLOv7t(13.2)and YOLOv5s(16.0).The mAPs that are 4.4%,3%,3.5%,and 1.7%greater than those of these algorithms show that the improved algorithm achieves higher accuracy in target detection tasks under similar computational resource *** the other hand,compared with other algorithms such as YOLOv8l(91.1%),YOLOv6l(89.5%),YOLOv7(90.8%),and YOLOv3(90.1%),the improved algorithm needs only 5.5%,2.3%,8.6%,and 2.3%,respectively,of the *** improved algorithm has shown significant advancements in balancing accuracy and computati

关键词： Traffic safety infrared image pedestrians and vehicles focal GIoU distributed shift convolution

Development and validation of a predictive model for acute-onchronic liver failure after transjugular intrahepatic portosystemic shunt

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1301-1310页

作者： Wei zhang ya-Ni Jin Chang Sun xiao-Feng zhang Rui-Qi Li Qin Yin Jin-Jun Chen Yu-Zheng Zhuge Department of Gastroenterology Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210000Jiangsu ProvinceChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510000Guangdong ProvinceChina Co-first authors:Wei Zhang and Ya-Ni Jin

BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)is a cause of acute-onchronic liver failure(ACLF).AIM To investigate the risk factors of ACLF within 1 year after TIPS in patients with cirrhosis and construct a prediction *** In total,379 patients with decompensated cirrhosis treated with TIPS at Nanjing Drum Tower Hospital from 2017 to 2020 were selected as the training cohort,and 123 patients from Nanfang Hospital were included in the external validation *** and multivariate logistic regression analyses were performed to identify independent *** prediction model was established based on the Akaike information *** and external validation were conducted to assess the performance of the *** Age and total bilirubin(TBil)were independent risk factors for the incidence of ACLF within 1 year after *** developed a prediction model comprising age,TBil,and serum sodium,which demonstrated good discrimination and calibration in both the training cohort and the external validation *** Age and TBil are independent risk factors for the incidence of ACLF within 1 year after TIPS in patients with decompensated *** model showed satisfying predictive value.

关键词： Acute-on-chronic liver failure Transjugular intrahepatic portosystemic shunt Influencing factor analysis Risk prediction model Nomogram

Controlling secondary flow in high-lift low-pressure turbine using boundary-layer slot suction

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Chinese Journal of Aeronautics 2024年第3期37卷 21-33页

作者： xiao QU Liunan LI Yingjie zhang Xingen LU Junqiang ZHU yanfeng zhang School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China Key Laboratory of Light-Duty Gas-Turbine Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China School of Aeronautics and Astronautics University of Chinese Academy of SciencesBeijing 100190China

The design of high-lift Low-Pressure Turbines(LPTs)causes the separation of the boundary layer on the suction side of the blade and leads to a strong secondary *** present study aims to minimize secondary losses through endwall slot suction and incoming wakes in a front-loaded high-lift LPT cascade with Zweifel of 1.58 under low Reynolds number of *** slotted schemes for the boundary layer of the endwall were designed(Plan A and Plan B),and the effects of suction mass flow on secondary flow were *** underlying physics of the endwall boundary layer of the suction and secondary flow under unsteady wakes was *** results show that slot suction at the endwall boundary layer can significantly suppress the secondary flow by removing low-momentum *** A and B significantly reduced the secondary kinetic energy by 44.2%and 36.9%,respectively,compared with the baseline cascade at the suction mass flow ratios of 1%.With an increase in the mass flow ratio of suction,the secondary flow was gradually reduced in both Plans A and *** is more beneficial to control the secondary flow to destroy the intersection of the pressure side and suction side of the horseshoe vortex before it develops into a passage *** unsteady wakes,the combined effects of incoming wakes and endwall boundary layer suction can further suppress the secondary flow at the suction mass flow ratios of 2%for Plan A,because the positive and negative vorticity inside upstream wakes accelerated the mixing of the main flow and secondary flow and thus increased the energy of secondary vortices.

关键词： Low-pressure turbine Secondary flow Flow control Boundary-layer suction Incoming wake

Alleviating the anisotropic microstructural change and boosting the lithium ions diffusion by grain orientation regulation for Ni-rich cathode materials

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Journal of Energy Chemistry 2024年第1期88卷 213-222,I0005页

作者： Xinyou He Shilin Su Bao zhang Zhiming xiao Zibo zhang Xing Ou Engineering Research Center of the Ministry of Education for Advanced Battery Materials School of Metallurgy and EnvironmentCentral South UniversityChangsha 410083HunanChina Zhejiang Power New Energy Co.Ltd Zhuji 311899ZhejiangChina

Generally,layered Ni-rich cathode materials exhibit the morphology of polycrystalline secondary sphere composed of numerous primary *** the arrangement of primary particles plays a very important role in the properties of Ni-rich *** disordered particle arrangement is harmful to the cyclic performance and structural stability,yet the fundamental understanding of disordered structure on the structural degradation behavior is ***,we have designed three kinds of LiNi_(0.83)Co_(0.06)Mn_(0.11)O_(2) cathode materials with different primary particle orientations by regulating the precursor coprecipitation *** finite element simulation and in-situ characterization,the Li^(+)transport and structure evolution behaviors of different materials are ***,the smooth Li^(+)diffusion minimizes the reaction heterogeneity,homogenizes the phase transition within grains,and mitigates the anisotropic microstructural change,thereby modulating the crack evolution ***,the optimized structure evolution ensures radial tight junctions of the primary particles,enabling enhanced Li^(+)diffusion during dynamic ***-loop bidirectional enhancement mechanism becomes critical for grain orientation regulation to stabilize the cyclic *** precursor engineering with particle orientation regulation provides the useful guidance for the structural design and feature enhancement of Ni-rich layered cathodes.

关键词： Ni-rich cathode Grain orientation regulation Anisotropic microstructural change Precursor engineering Li~+-ions diffusion

Highly Improved Creep Resistance in Polypropylene Through Thermally Reduced Graphene Oxide and Its Creep Lifetime Prediction

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Chinese Journal of Polymer Science 2024年第2期42卷 256-266,I0010页

作者： Can-Can zhang Jun-Long yang ya-Jiang Huang Guang-Xian Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering of ChinaSichuan UniversityChengdu610065China

Polypropylene(PP) exhibits suboptimal creep resistance due to the presence of methyl groups on its main chain, leading to irregular chain segment distribution, diminished inter-chain interaction, and crystallinity. This structural feature causes chain slippage in PP under stress,significantly constraining its service lifetime. In this study, thermally reduced graphene oxide(TrGO) nanosheets were incorporated into the PP matrix, yielding a nanocomposite with exceptional creep resistance performance. Results demonstrated that at a stress of 25 MPa, a 2.0 wt% TrGO content could enhance the creep failure lifetime of PP by 21.5 times compared to neat PP. Rheology, transmission electron microscopy(TEM),and scanning electron microscopy(SEM) characterization techniques were employed to analyze the mechanism of TrGO's influence on PP's creep behavior. It was observed that when TrGO content exceeded 1.0 wt%, an effective particle network structure formed within the PP matrix. This homogeneously dispersed TrGO-formed particle network structure restricted the migration and rearrangement of PP molecular chains, enabling prolonged stress resistance without structural failure. By combining the time-strain superposition method with the critical failure strain as a criterion, generalized creep compliance curves for PP and its composites were established, facilitating the prediction of material creep failure lifetimes, with a strong agreement between experimental and predicted lifetime values. This research proposes a novel strategy aimed at developing polypropylene materials and products with enhanced long-term stability and durability, thus extending service life, reducing failure risk, and broadening their potential across various application domains.

关键词： Thermally reduced graphene oxide Polypropylene Creep failure and lifetime prediction

Bending Analysis of Circular Piezoelectric Semiconductor Plates Incorporating Flexoelectricity

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Acta Mechanica Solida Sinica 2024年第4期37卷 613-621页

作者： Liang Sun Zhengguang xiao Chunli zhang Weiqiu Chen Department of Engineering Mechanics Zhejiang UniversityHangzhou310027China Department of Basic Courses Naval University of EngineeringWuhan430033China Huanjiang Laboratory Zhuji311816China

Based on the three-dimensional(3D)basic equations of piezoelectric semiconductors(PSs),we establish a two-dimensional(2D)deformation-polarization-carrier coupling bending model for PS structures,taking flexoelectricity into *** analytical solutions to classical flexure of a clamped circular PS thin plate are *** the derived analytical model,we numerically investigate the distributions of electromechanical fields and the concentration of electrons in the circular PS thin plate under an upward concentrated *** effect of flexoelectricity on the multi-field coupling responses of the circular PS plate is *** obtained results provide theoretical guidance for the design of novel PS devices.

关键词： Piezoelectric semiconductor Plate model Flexoelectricity Multi-field coupling

pH Induced Self-assembly of AIE Fluorescent Probe for Tumor Imaging

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Chinese Journal of Polymer Science 2024年第1期42卷 7-13,I0005页

作者： Jing-Yuan Xiang Wen-Long zhang He-Ting Li ya-Ning He Department of Chemical Engineering Key Laboratory of Advanced Materials(MOE)Tsinghua UniversityBejing 100084China

This work reported an AIE fluorescent probe for tumor imaging based on the p H induced self-assembly strategy. The fluorescent probe was composed of an acid-responsive soluble copolymer PEG-b-PAMA-DMMA with a maleic acid amide group and an anionic soluble aggregation-induced emission fluorogen(AIEgen) TPE-2SO_(3)^(-). The polymer could be transformed into a protonated amine-containing polymer after the hydrolysis of maleic acid amide in acidic tumor microenvironment, which would be further self-assembled with TPE-2SO_(3)^(-)to form aggregated nanoparticles. The transition of TPE-2SO_(3)^(-)from dispersed state to aggregated state led to an obvious increase in fluorescence intensity due to its AIE characteristics.

关键词： p H-responsive Self-assembly Fluorescent probe AIE Tumor imaging

Diminishing the Perception Bias in the Working Environment Using a Network Generation-Based Framework

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Tsinghua Science and Technology 2024年第3期29卷 671-683页

作者： Jun Qian Tongda zhang xiao Sun Yueting Chai Department of Automation Tsinghua UniversityBeijing 100084China Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055Chinaand with Systems Optimization LaboratoryStanford UniversityPalo AltoCA 94305USA

Income inequality is widespread in human society and has important implications for human ***’s perception of the environment bridges income inequality and individual behavioral *** research suggests that social income inequality is usually biased,either overestimated or ***,such phenomena have not been fully explored with quantitive prove,especially in the working environment based on performance data of actual *** fact,the correct perception of people is the basis of a fair environment for their production ***,the perception bias may weaken the adaptability and competitiveness of a company in the *** paper first confirms the prevalence of individual perception bias of income inequality within the working environment based on actual production *** results show that people tend to underestimate income inequity around them,and this underestimation grows with the real unfairness of the working ***,this paper proposes a network generation-based framework with a three-layer structure to correct perception bias using a cooperative network reengineering *** the framework,a homophily-based generative network model is proposed as the key *** simulation results show that our proposed framework effectively reduces individuals’perception bias of income inequality.

关键词： income inequality perception bias Gini coefficient factory production cooperative networkreengineering homophily-based generative network model