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Assessment of Wet Season Precipitation in the Central United States by the Regional Climate Simulation of the WRFG Member in NARCCAP and Its Relationship with Large-Scale Circulation Biases

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Advances in Atmospheric Sciences 2024年第4期41卷 619-638页

作者： yating ZHAO Ming XUE Jing JIANG xiao-Ming hu Anning huANG School of Atmospheric Sciences Nanjing UniversityNanjing 210023China Center for Analysis and Prediction of Storms and School of Meteorology The University of OklahomaNorman 73072U.S.A

Assessment of past-climate simulations of regional climate models(RCMs)is important for understanding the reliability of RCMs when used to project future regional ***,we assess the performance and discuss possible causes of biases in a WRF-based RCM with a grid spacing of 50 km,named WRFG,from the North American Regional Climate Change Assessment Program(NARCCAP)in simulating wet season precipitation over the Central United States for a period when observational data are *** RCM reproduces key features of the precipitation distribution characteristics during late spring to early summer,although it tends to underestimate the magnitude of *** dry bias is partially due to the model’s lack of skill in simulating nocturnal precipitation related to the lack of eastward propagating convective systems in the *** in reproducing large-scale circulation and environmental conditions is another contributing *** too weak simulated pressure gradient between the Rocky Mountains and the Gulf of Mexico results in weaker southerly winds in between,leading to a reduction of warm moist air transport from the Gulf to the Central Great *** simulated low-level horizontal convergence fields are less favorable for upward motion than in the NARR and hence,for the development of moist convection as ***,a careful examination of an RCM’s deficiencies and the identification of the source of errors are important when using the RCM to project precipitation changes in future climate scenarios.

关键词： NARCCAP Central United States precipitation low-level jet large-scale environment diurnal variation

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Clinical value of precise rehabilitation nursing in management of cerebral infarction

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World Journal of Clinical Cases 2024年第1期12卷 24-31页

作者： ya-Na Xu Xiu-Zhen Wang xiao-Rong Zhang Department of Neurology Wuhan Fourth HospitalWuhan 430030Hubei ProvinceChina Department of Neurosurgery The First People's Hospital of Jiangxia DistrictWuhan City(Union Jiangnan Hospital of Huazhong University of Science and Technology)Wuhan 430200Hubei ProvinceChina

BACKGROUND Cerebral infarction,previously referred to as cerebral infarction or ischemic stroke,refers to the localized brain tissue experiencing ischemic necrosis or softening due to disorders in brain blood supply,ischemia,and *** precision rehabilitation nursing model for chronic disease management is a continuous,fixed,orderly,and efficient nursing model aimed at standardizing the clinical nursing process,reducing the wastage of medical resources,and improving the quality of medical *** To analyze the value of a precise rehabilitation nursing model for chronic disease management in patients with cerebral *** Patients(n=124)admitted to our hospital with cerebral infarction between November 2019 and November 2021 were enrolled as the study *** random number table method was used to divide them into a conventional nursing intervention group(n=61)and a model nursing intervention group(n=63).Changes in the nursing index for the two groups were compared after conventional nursing intervention and precise rehabilitation intervention nursing for chronic disease *** Compared with the conventional intervention group,the model intervention group had a shorter time to clinical symptom relief(P<0.05),lower Hamilton Anxiety Scale and Hamilton Depression Scale scores,a lower incidence of total complications(P<0.05),a higher disease knowledge mastery rate,higher safety and quality,and a higher overall nursing satisfaction rate(P<0.05).CONCLUSION The precision rehabilitation nursing model for chronic disease management improves the clinical symptoms of patients with cerebral infarction,reducing the incidence of total complications and improving the clinical outcome of patients,and is worthy of application in clinical practice.

关键词： Precise rehabilitation nursing model for chronic disease management Cerebral infarction Knowledge of disease Safety and quality

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RNF187 governs the maintenance of mouse GC-2 cell development by facilitating histone H3 ubiquitination at K57/80

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Asian Journal of Andrology 2024年第3期26卷 272-281页

作者： Bing-ya Xu Xiang-Ling Yu Wen-Xin Gao Ting-Ting Gao Hao-Yue hu Tian-Tian Wu Cong Shen xiao-yan huang Bo Zheng Yi-Bo Wu human Reproductive and Genetic Center Affiliated Hospital of Jiangnan UniversityWuxi 214122China State Key Laboratory of Reproductive Medicine Department of Histology and EmbryologySchool of Basic Medical SciencesNanjing Medical UniversityNanjing 211166China Changzhou Maternal and Child Health Care Hospital Changzhou Medical CenterNanjing Medical UniversityChangzhou 213000China State Key Laboratory of Reproductive Medicine Center for Reproduction and GeneticsSuzhou Municipal HospitalThe Affiliated Suzhou Hospital of Nanjing Medical UniversityGusu SchoolNanjing Medical UniversitySuzhou 215002China

RING finger 187(RNF187),a ubiquitin-ligating(E3)enzyme,plays a crucial role in the proliferation of cancer ***,it remains unclear whether RNF187 exhibits comparable functionality in the development of germline *** investigate thepotential involvement of RNF187 in germ cell development,we conducted interference and overexpression assays using GC-2 cells,a mouse spermatocyte-derived cell *** findings reveal that the interaction between RNF187 and histone H3 increases theviability,proliferation,and migratory capacity of GC-2 ***,we provide evidence demonstrating that RNF187 interactswith H3 and mediates the ubiquitination of H3 at lysine 57(K57)or lysine 80(K80),directly or indirectly resulting in increasedcellular *** is a study to report the role of RNF187 in maintaining the development of GC-2 cells by mediatinghistone H3 ubiquitination,thus highlighting the involvement of the K57 and K80 residues of H3 in the epistatic regulation of *** discoveries provide a new theoretical foundation for further comprehensive investigations into the functionof RNF187 in the reproductive system.

关键词： GC-2 cell histone H3 RNF187 ubiquitination

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Treg Immunomodulation Contributes to the Anti-atherosclerotic Effects of huxin Formula in ApoE^(-/-)Mice

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Chinese Journal of Integrative Medicine 2024年第10期30卷 896-905页

作者： OU xiao-min CAI Jing hu xiao-yue ZENG Qiao-huang LAN Tao-hua JIANG Wei The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510405China Department of Cardiology Guangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510020China Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases Guangzhou510020China

Objective:To explore the effects of huxin formula(HXF)in curtailing atherosclerosis and its underlying ***:According to random number table method,24 specific pathogen free male ApoE^(-/-)mice were randomly divided into model group,HXF low-dose(HXF-L)group(8.4 g/kg daily),HXF high-dose(HXF-H)group(16.8 g/kg daily),and pravastatin(8 mg/kg daily)group in ExperimentⅠ(n=6 per group).C57BL/6J mice served as the control group(n=6).ApoE^(-/-)mice in HXF-L,HXF-H,pravastatin groups were fed a Western diet and administered continuously by gavage for 12 weeks,while C57BL/6J mice in the control group were fed conventional lab mouse chow for 12 ***,Tregs were depleted by weekly intraperitoneal injection of purified anti-mouse CD25 antibody(PC61,250μg per mouse)for 4 weeks in ExperimentⅡ(n=6 per group).Oil Red O and Masson staining were used to evaluate the plaque area and aortic root *** CD4^(+)CD25^(+)Foxp3^(+)Treg counts in the lymph nodes and spleen cells were detected using flow cytometric *** transforming growth factor-β1(TGF-β1),interleukin(IL)-10,and IL-6 serum levels were examined by MILLIPLEX?MAP *** real-time reverse transcription PCR(qRT-PCR)and Western blot were utilized to assess the expression of TGF-βmRNA and protein in the *** expression of CD4^(+)T lymphocytes,macrophages and smooth muscle cells in the aortic root were detected by immunofluorescence ***:HXF reduced plaque area in ApoE^(-/-)mice(P0.05).Also,HXF upregulated the expression of TGF-βmRNA and protein in the aorta(P<0.05).Additionally,HXF attenuated CD4^(+)T lymphocytes,macrophages and smooth muscle cells in aortic root plaque(P<0.01).Furthermore,the depletion of Tregs with CD25

关键词： atherosclerosis huxin Formula Tregs immune responses inflammation

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Copper Metabolism and Cuproptosis:Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases

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Current Medical Science 2024年第1期44卷 28-50页

作者： xiao-xia BAN Hao WAN Xin-xing WAN ya-ting TAN Xi-min hu Hong-xia BAN Xin-yu CHEN Kun huANG Qi ZHANG Kun XIONG Department of human Anatomy and Neurobiology School of Basic Medical ScienceCentral South UniversityChangsha 430013China Department of Endocrinology Third Xiangya HospitalCentral South UniversityChangsha 430013China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 430013China Affiliated Hospital Inner Mongolia Medical UniversityHohhot 010050China Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikou 571199China hunan Key Laboratory of Ophthalmology Changsha 430013China

Copper is an essential trace element,and plays a vital role in numerous physiological processes within the human *** normal metabolism,the human body maintains copper *** deficiency or excess can adversely affect cellular ***,copper homeostasis is stringently *** studies suggest that copper can trigger a specific form of cell death,namely,cuproptosis,which is triggered by excessive levels of intracellular *** induces the aggregation of mitochondrial lipoylated proteins,and the loss of iron-sulfur cluster *** neurodegenerative diseases,the pathogenesis and progression of neurological disorders are linked to copper *** review summarizes the advances in copper homeostasis and cuproptosis in the nervous system and neurodegenerative *** offers research perspectives that provide new insights into the targeted treatment of neurodegenerative diseases based on cuproptosis.

关键词： cuproptosis copper metabolism copper homeostasis neurodegeneration neurodegenerativedisease

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Genetic source,migration and accumulation of helium under deep thermal fluid activities:A case study of Ledong diapir area in Yinggehai Basin,South China Sea

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Petroleum Exploration and Development 2024年第3期51卷 753-766页

作者： FENG Ziqi HAO Fang hu Lin hu Gaowei ZHANG yazhen LI yangming WANG Wei LI Hao xiao Junjie TIAN Jinqiang State Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao 266580China School of Geosciences China University of Petroleum(East China)Qingdao 266580China Laboratory for Marine Mineral Resources Qingdao Marine Science and Technology CenterQingdao 266237China Hainan Branch of CNOOC(China)Co. Ltd.Haikou 570312China

Based on the geochemical parameters and analytical data,the heat conservation equation,mass balance law,Rayleigh fractionation model and other methods were used to quantify the in-situ yield and external flux of crust-derived helium,and the initial He concentration and thermal driving mechanism of mantle-derived helium,in the Ledong Diapir area,the Yinggehai Basin,in order to understand the genetic source,migration and accumulation mechanisms of helium under deep thermal fluid *** average content of mantle-derived He is only 0.0014%,the ^(3)He/^(4)He value is(0.002–2.190)×10^(−6),and the R/Ra value ranges from 0.01 to 1.52,indicating the contribution of mantle-derived He is 0.09%–19.84%,while the proportion of crust-derived helium can reach over 80%.Quantitative analysis indicates that the crust-derived helium is dominated by external input,followed by in-situ production,in the Ledong diapir *** crust-derived helium exhibits an in-situ 4 He yield rate of(7.66–7.95)×10^(−13)cm^(3)/(a·g),an in-situ 4 He yield of(4.10–4.25)×10^(−4)cm^(3)/g,and an external 4 He influx of(5.84–9.06)×10^(−2)cm^(3)/*** results may be related to atmospheric recharge into formation fluid and deep rock-water *** ratio of initial mole volume of 3 He to enthalpy(W)is(0.004–0.018)×10^(−11) cm^(3)/J,and the heat contribution from the deep mantle(X_(M))accounts for 7.63%–36.18%,indicating that deep hot fluid activities drive the migration of mantle-derived 3 *** primary helium migration depends on advection,while the secondary migration is controlled by hydrothermal degassing and gas-liquid *** deep to shallow layers,the CO_(2/3) He value rises from 1.34×10^(9)to 486×10^(9),indicating large amount of CO_(2)has *** the influence of deep thermal fluid,helium migration and accumulation mechanisms include:deep heat driven diffusion,advection release,vertical hydrothermal degassing,shallow lateral migration,accumulation in traps far from faults,

关键词： deep thermal fluid helium genetic source migration and accumulation mechanism Yinggehai Basin

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Effects of stigma on the quality of lifein patients with epilepsy

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Acta Epileptologica 2024年第2期7卷 110-118页

作者： Chunmei hu Yuping Zhao Zheng xiao Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityNO.1 Youyi Rd.ChongqingYuzhong District 400016China Department of Neurology The People’s Hospital of NanchuanChongqing 408400China

Background This study was aimed to evaluate the stigma and quality of life(QoL)in adult patients with epilepsy(PWEs)and explore the relationship between stigma and *** Two hundred and ninety-eight PWEs admitted to the Epilepsy Center of the First Affiliated Hospitalof Chongqing Medical University during September 2020 and March 2021 were enrolled in this *** participantscompleted self-reported questionnaires including the Stigma Scale for Epilepsy and the Quality of Life in EpilepsyInventory-31(QOLIE-31).Results A total of 146(49%)PWEs reported an experience of *** total score of QOLIE-31 and the individualscores of seven subscales(worry about new seizures,emotion,well-being,energy and fatigue,cognitive impairment,medication effect,and social function)were significantly decreased in these patients(P<0.001).Multivariate stepwiselinear regression analysis showed that the annual household income per capita,the number of antiseizure medica-tions and stigma had statistically significant effects on QoL(P<0.05).Among them,stigma had the most significantnegative *** Nearly half of PWEs have experienced ***,lower household income per capita,and polyp-harmacy treatment are associated with poorer *** has the most obvious negative impact.

关键词： Perceived stigma Epilepsy Quality of life

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Mixed-decomposed convolutional network:A lightweight yet efficient convolutional neural network for ocular disease recognition

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CAAI Transactions on Intelligence Technology 2024年第2期9卷 319-332页

作者： xiaoqing Zhang xiao Wu Zunjie xiao Lingxi hu Zhongxi Qiu Qingyang Sun Risa Higashita Jiang Liu Research Institute of Trustworthy Autonomous Systems and Department of Computer Science and Engineering Southern University of Science and TechnologyShenzhenChina Tomey Corporation NagoyaJapan Guangdong Provincial Key Laboratory of Brain‐inspired Intelligent Computation Department of Computer Science and EngineeringSouthern University of Science and TechnologyShenzhenChina Singapore Eye Research Institute SingaporeSingapore

Eye health has become a global health concern and attracted broad *** the years,researchers have proposed many state-of-the-art convolutional neural networks(CNNs)to assist ophthalmologists in diagnosing ocular diseases efficiently and ***,most existing methods were dedicated to constructing sophisticated CNNs,inevitably ignoring the trade-off between performance and model *** alleviate this paradox,this paper proposes a lightweight yet efficient network architecture,mixeddecomposed convolutional network(MDNet),to recognise ocular *** MDNet,we introduce a novel mixed-decomposed depthwise convolution method,which takes advantage of depthwise convolution and depthwise dilated convolution operations to capture low-resolution and high-resolution patterns by using fewer computations and fewer *** conduct extensive experiments on the clinical anterior segment optical coherence tomography(AS-OCT),LAG,University of California San Diego,and CIFAR-100 *** results show our MDNet achieves a better trade-off between the performance and model complexity than efficient CNNs including MobileNets and ***,our MDNet outperforms MobileNets by 2.5%of accuracy by using 22%fewer parameters and 30%fewer computations on the AS-OCT dataset.

关键词： artificial intelligence deep learning deep neural networks image analysis image classification medical applications medical image processing

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Transcatheter arterial chemoembolization combined with PD-1 inhibitors and Lenvatinib for hepatocellular carcinoma with portal vein tumor thrombus

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World Journal of Gastroenterology 2024年第8期30卷 843-854页

作者： Hong-xiao Wu xiao-yan Ding ya-Wen Xu Ming-hua Yu xiao-Mi Li Na Deng Jing-Long Chen Cancer Center Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

BACKGROUND Hepatocellular carcinoma(HCC)patients complicated with portal vein tumor thrombus(PVTT)exhibit poor prognoses and treatment *** To investigate efficacies and safety of the combination of PD-1 inhibitor,transcatheter arterial chemoembolization(TACE)and Lenvatinib in HCC subjects comorbid with *** From January 2019 to December 2020,HCC patients with PVTT types Ⅰ-Ⅳ were retrospectively enrolled at Beijing Ditan *** were distributed to either the PTL or TACE/Lenvatinib(TL)*** median progression-free survival(mPFS)was set as the primary endpoint,while parameters like median overall survival,objective response rate,disease control rate(DCR),and toxicity level served as secondary *** Forty-one eligible patients were finally recruited for this study and divided into the PTL(n=18)and TL(n=23)*** a median follow-up of 21.8 months,the DCRs were 88.9%and 60.9%in the PTL and TL groups(P=0.046),***,mPFS indicated significant improvement(HR=0.25;P<0.001)in PTL-treated patients(5.4 months)compared to TL-treated(2.7 months)*** were no treatment-related deaths or differences in adverse events in either *** A triplet regimen of PTL was safe and well-tolerated as well as exhibited favorable efficacy over the TL regimen for advanced-stage HCC patients with PVTT types Ⅰ-Ⅳ.

关键词： Hepatocellular carcinoma Transcatheter arterial chemoembolization Lenvatinib PD-1 inhibitor Portal vein tumor thrombus

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Understanding the Impact of H_(2) Diffusion Energy on the Formation Efficiency of H_(2) on the Interstellar Dust Grain Surface

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Research in Astronomy and Astrophysics 2024年第9期24卷 190-198页

作者： xiaoying Guo Wasim Iqbal Qiang Chang xiao-hu Li School of Physics and Optoeletronic Engineering Shandong University of TechnologyZibo 255000China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Key Laboratory of Radio Astronomy Chinese Academy of SciencesUrumqi 830011China

We use microscopic Monte Carlo simulation techniques to investigate the impact of H_(2)diffusion energy on the recombination efficiency of H_(2)on interstellar dust grain surfaces under diffuse and translucent cloud *** constructed five models representing different possible conditions encountered by adsorbed H and H_(2)on interstellar dust *** implemented adsorption sites with multiple binding energies for surface species;the Encounter-Desorption mechanism was also *** study focused on silicate surfaces in diffuse clouds and water ice surfaces in translucent *** results show that the recombination efficiency of H_(2)on dust surfaces decreases as H_(2)diffusion energy *** interesting finding of this work is that considering different binding sites for H and H_(2)gives rise to multiple steady phases,during which the recombination efficiency remains constant with a change in H_(2)diffusion energy.

关键词： astrochemistry atomic processes ISM:molecules

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