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Intelligent Vascularized 3D/4D/5D/6D‑Printed Tissue Scaffolds

纳微快报:英文版 2023年第12期15卷 376-418页

作者： xiaoyu Han Qimanguli Saiding xiaolu Cai Yi xiao Peng Wang Zhengwei Cai Xuan Gong Weiming Gong Xingcai Zhang Wenguo cui Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of Medicine197 Ruijin 2nd RoadShanghai 200025People’s Republic of China Department of Orthopedics Jinan Central HospitalShandong First Medical University and Shandong Academy of Medical Sciences105 Jiefang RoadLixia DistrictJinan 250013ShandongPeople’s Republic of China Department of Biomedical Engineering College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074HubeiPeople’s Republic of China School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA University of Texas Southwestern Medical Center DallasTX 75390‑9096USA

Blood vessels are essential for nutrient and oxygen delivery and waste ***-repairing materials with functional vascular networks are widely used in bone tissue *** manufacturing is a manufacturing technology that creates three-dimensional solids by stacking substances layer by layer,mainly including but not limited to 3D printing,but also 4D printing,5D printing and 6D *** can be effectively combined with vascularization to meet the needs of vascularized tissue scaffolds by precisely tuning the mechanical structure and biological properties of smart vascular ***,the development of neovascularization to vascularization to bone tissue engineering is systematically discussed in terms of the importance of vascularization to the ***,the research progress and future prospects of vascularized 3D printed scaffold materials are highlighted and presented in four categories:functional vascularized 3D printed scaffolds,cell-based vascularized 3D printed scaffolds,vascularized 3D printed scaffolds loaded with specific carriers and bionic vascularized 3D printed ***,a brief review of vascularized additive manufacturing-tissue scaffolds in related tissues such as the vascular tissue engineering,cardiovascular system,skeletal muscle,soft tissue and a discussion of the challenges and development efforts leading to significant advances in intelligent vascularized tissue regeneration is presented.

关键词： Intelligent Additive manufacturing Tissue engineering Vascularization Osteogenesis

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SAPO-11分子筛的粒度调控

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无机化学学报 2013年第3期29卷 565-570页

作者：韩磊崔晓刘欣梅中国石油大学(华东)重质油加工国家重点实验室青岛266580

采用干凝胶法,通过向合成体系中添加适量的十六烷基三甲基溴化铵(CTAB)或氟化氢(HF)控制SAPO-11分子筛的粒度。采用SEM、XRD、IR、MAS NMR、TPD、TEM、TG-DSC以及低温N2吸附脱附对产物进行表征。结果表明,CTAB或HF的加入不仅能够减小分... 详细信息

采用干凝胶法,通过向合成体系中添加适量的十六烷基三甲基溴化铵(CTAB)或氟化氢(HF)控制SAPO-11分子筛的粒度。采用SEM、XRD、IR、MAS NMR、TPD、TEM、TG-DSC以及低温N2吸附脱附对产物进行表征。结果表明,CTAB或HF的加入不仅能够减小分子筛的粒度,而且能调控分子筛骨架元素组成、表观形貌、孔道结构及酸性质等。其中,CTAB的加入有利于Si进入分子筛骨架,增加产物的酸量;HF的加入使样品由不规则的微米级颗粒调控为500 nm左右的棒状单晶,增强了分子筛的稳定性,但阻止了硅进入骨架,降低产物的酸量。

关键词：干凝胶法 SAPO—11 超细分子筛

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Application of LC-MS based glutathione-trapped reactive metabolites in the discovery of toxicity of traditional Chinese medicine

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TMR Modern Herbal Medicine 2018年第4期1卷 209-219页

作者： xiao-Mei Liu Hong Lv xiao-Ming Wang ya-Qing Guo Ting-Ting Li Gui-Xiang Pan Tianjin State Key Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese Medicine Tianjin China. Second Affiliated hospital of Tianjin University of Traditional Chinese Medicine Tianjin China.

We summarized the discovery of liquid chromatography mass spectrometry （LC-MS） based glutathione （GSH） capture of reactive metabolites in traditional Chinese medicine （TCM）, which provides scientific basis for further research and clinical application of Chinese medicine toxicity discovery. This dissertation overviews relevant literatures of GSH capture of reactive metabolites in recent years. And then we review the principles and methods of LC-MS based GSH capture of reactive metabolites, as well as the research progress in the discovery of toxicity of TCM including pyrrolizidine alkaloids, furans and quinoid species. The review shows that the representative compounds of TCM includes adonifoline, lasiocarpine, diosbulbin B and safrol are well dctected by LC-MS based GSH capture technique. And the main analytic systems of LC-MS are triple quadrupole and Q-Trap mass spectrometer. Constant neutral loss scan （CNLS）, precursor ion scan （PIS） and multiple reaction monitor （MRM） are main detection methods to monitor the characteristic GSH conjugate fragmentations. The approach of LC-MS based GSH-trapped metabolites has a good application prospect in the discovery of toxic components of TCM.

关键词： glutathione conjugation Liquid Chromatography Mass Spectrometry Reactive metabolites Toxicity traditional Chinese medicine

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聚降冰片烯/聚乳酸共混物形状记忆效应的研究

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高分子学报 2018年第3期28卷 402-409页

作者：肖雅曲明史新妍青岛科技大学高分子科学与工程学院橡塑材料与工程教育部重点实验室青岛266042

将聚降冰片烯(PNB)和聚乳酸(PLA)按照PNB/PLA(80/20)、(70/30)、(60/40)、(50/50)4种不同质量配比进行共混,采用X射线衍射(XRD)、动态力学分析(DMA)、示差扫描量热分析(DSC)等对共混物基本性能进行表征,同时采用DMA-Q800对其形状记忆效... 详细信息

将聚降冰片烯(PNB)和聚乳酸(PLA)按照PNB/PLA(80/20)、(70/30)、(60/40)、(50/50)4种不同质量配比进行共混,采用X射线衍射(XRD)、动态力学分析(DMA)、示差扫描量热分析(DSC)等对共混物基本性能进行表征,同时采用DMA-Q800对其形状记忆效应进行探究.结果显示:4种共混物均有明显屈服现象,随着PLA含量的增加,屈服现象越明显;PNB/PLA共混物出现2个玻璃化转变温度(T_g),且不随共混物配比变化而变化;4种共混物均在2θ=18.45o附近出现特征衍射峰,且其结晶度随PNB含量的减少而降低;随PNB含量的增多4种共混物的形状记忆性能提高.对于PNB/PLA(80/20),在双重形状记忆中,其形状固定率为99.88%,形状恢复率为81.04%;在三重形状记忆中,总固定率和恢复率分别为98.83%和94.26%.

关键词：聚降冰片烯聚乳酸形状记忆应力松弛结晶

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Significant longevity-extending effects of rbGrx on Caenorhabditis elegans

Significant longevity-extending effects of rbGrx on Caenorha...

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2017第七届泛环渤海生物化学与分子生物学会学术交流会

作者： LI Fang cui xiao-Dong WANG Zhuan-Hua Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of BiotechnologyShanxi University

According to the free radical theory of aging,one of the main causes of aging is composed of biological molecular damage by reactive oxygen species *** means that any can reduce the ROS factor are likely to delay ***(Grxs)are ubiquitous thioltransferases and members of the thioredoxin(Trx)fold *** have multiple functions in cells including oxidative stress responses and cell *** have identified,cloned,and purified a novel glutaredoxin from buckwheat(rbGrx)with higher catalytic *** evaluate benefits of rbGrx for health and longevity,antioxidant activity and anti-aging effects were studied in vitro and in a Caenorhabditis elegans(***)model *** vitro,rbGrx can scavenge DPPH radicals in the concentration range of 2-20μg/mL and demonstrate a mass-dependent ***,rbGrx showed the ability to scavenge·OH free radicals with a clear dose-response relationship in the range of rbGrx concentrations(2.5-15μg/mL).These indicated that rbGrx has high oxidative capacity and can interrupt the lipid peroxidation chain *** vivo,we have found that rbGrx extended Caenorhabditis elegans *** treatment with rbGrx,the mean lifespan of the nematodes was extended by 9.09%,15.59%,and 18.08%treated with 12.5,25 and 50μg/mL rbGrx,***,to confirm the underlying mechanisms of the enhanced lifespan,we examined the effect of rbGrx on the intracellular ROS levels of rbGrx-treated *** with control nematodes,the accumulation of ROS was decreased in nematodes treated with *** together,these findings suggest that significant longevity-extending effects of rbGrx on Caenorhabditis elegans were responsible for the attenuation of intracellular ROS levels in part.

关键词： Aging Glutaredoxins Oxidative stress

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Distribution of Metabolites in Root Barks of Seven Tree Peony Cultivars for Quality Assessment Using NMR-based Metabolomics

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Chinese Herbal Medicines 2017年第1期9卷 31-41页

作者： Pei Wang Ze-ming Rong cui-xia Ma Xin-feng Zhao Chao-ni xiao xiao-hui Zheng Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of Education College of Life Sciences Northwest University Xi'an 710069 China

Objective To determine the distribution of metabolites in the root barks of different tree peony cultivars for quality assessment. Methods Seven tree peony phenotypic cultivars with different colors were systematically analyzed using NMR-based metabolomics. Results A total of 16 metabolites from their methanol extracts were simultaneously identified and quantified, including one primary metabolite （sucrose） and 15 secondary ones （acetophenones, phenolics, monoterpene glycosides, flavonoids, and unsaturated fatty acids）. The quantitative data indicated that sucrose （90-180 mg/g） and acetophenones （15-100 mg/g）, and non-phenolics, monoterpene glycosides, flavonoids, and unsaturated fatty acids （2-15 mg/g） were the major metabolites in these tree peony cultivars. The significantly increasing levels of paeonoside with bioactivity were observed in ＂Xiangyu＂, ＂Wujinyaohui＂, ＂Roufurong＂, ＂yaohuang＂, ＂Zhaofen＂, ＂Doulu＂, and ＂Yingrihong＂ in order. Opposite trends in the levels of paeonoside and paeonol were observed in ＂Xiangyu＂ and ＂Yingrihong＂, suggesting that the changes of the secondary metabolites in plants were influenced by primary metabolites, such as sucrose/glucose, and the different physiological processes occurred in different tree peony cultivars. Conclusion ＂Yingrihong＂ with red flower has the highest medicine quality whereas ＂Xiangyu＂ with white flower has the worst one based on the content of paeonoside.

关键词： metabolomics NMR quality assessment tree peony

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多波长消荧光拉曼光谱仪的研制及应用研究

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光谱学与光谱分析 2022年第1期42卷 86-92页

作者：赵迎李晓鹏崔飞鹏刘佳李小佳钢铁研究总院北京100081 钢研纳克检测技术股份有限公司北京100081

拉曼光谱技术作为探究分子、晶体及其结构特征的有力手段,具有快速、无损、样品用量小、无需前处理且适应性强等优点,已被广泛应用于食品安全、石油化工等领域。但在拉曼光谱应用中,常常受到荧光背景干扰,导致拉曼信号降低,严重的情况... 详细信息

拉曼光谱技术作为探究分子、晶体及其结构特征的有力手段,具有快速、无损、样品用量小、无需前处理且适应性强等优点,已被广泛应用于食品安全、石油化工等领域。但在拉曼光谱应用中,常常受到荧光背景干扰,导致拉曼信号降低,严重的情况下拉曼信号甚至会淹没在荧光背景中。为解决拉曼技术在实际应用中荧光背景干扰的问题,从仪器角度出发,采用二色镜对多波长拉曼光谱进行光路耦合设计,研制了近红外拉曼光谱与移频差分拉曼复合一体的多波长消荧光拉曼光谱检测系统,其中近红外拉曼光谱采用1064 nm激光光源设计,移频差分拉曼光谱选取784.5和785.5 nm两组激光光源进行时分复用,在移频差分拉曼光谱检测的同时,亦可获得两组单波长拉曼光谱数据。通过对比同步测试和分时逐次测试的强度及峰位稳定性,验证了多波长消荧光拉曼光谱仪的同步测试性能;选取了多种荧光背景强弱不同的样品,进行了单波长拉曼、近红外拉曼及移频差分拉曼光谱的对比分析。针对丙酮、乙腈等荧光背景较弱的样品,可采用单波长拉曼光谱对样品进行定量及定性分析;针对食用油、红色塑胶微粒等荧光背景与拉曼信号强度相当的样品,可采用近红外拉曼光谱对样品进行定量及定性分析;针对红酒、棕色塑胶微粒等荧光背景较强的样品,需结合近红外拉曼光谱和差分拉曼光谱对样品进行定性分析。研究表明:通过多波长消荧光拉曼光谱检测系统的研制,在常规单波长拉曼光谱技术的基础上,将两种抑制荧光干扰技术有机结合,有效扩充了应用领域及样品检测范围。

关键词：拉曼光谱移频差分拉曼近红外拉曼

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论“三个务必”的中华优秀传统文化底蕴

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北京社会科学 2023年第8期 16-24页

作者：崔晓丹北京科技大学马克思主义学院

习近平“三个务必”重大论断的孕育生成既是马克思主义中国化时代化的理论结晶,也是对中华优秀传统文化继承发展的精神积淀。中华优秀传统文化是中华民族的根和魂,其蕴含的思想观念、道德规范、人文精神、思维方式等,是揭示“三个务必... 详细信息

习近平“三个务必”重大论断的孕育生成既是马克思主义中国化时代化的理论结晶,也是对中华优秀传统文化继承发展的精神积淀。中华优秀传统文化是中华民族的根和魂,其蕴含的思想观念、道德规范、人文精神、思维方式等,是揭示“三个务必”思想源泉和精髓要义的文化基因。通过对“民为邦本、本固邦宁”的民本思想,“谦恭虚己、奋发图强”的行为规范,“敢作敢为、有勇有谋”的斗争精神等进行深刻阐释,充分彰显了“三个务必”的中华优秀传统文化底蕴,使其成为诠释“三个务必”的坚实支撑。

关键词： “三个务必” 中华优秀传统文化马克思主义中国化中华民族党的建设

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Current developments, problems and solutions in the non-surgical treatment of pancreatic cancer

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World Journal of Gastrointestinal Oncology 2013年第2期5卷 20-28页

作者： xiao-Zhong Guo Zhong-Min cui Xu Liu Department of Gastroenterology the General Hospital of Shenyang Military Command

Pancreatic cancer is a common malignant neoplasm of the pancreas with an increasing incidence, a low early diagnostic rate and a fairly poor prognosis. To date, the only curative therapy for pancreatic cancer is surgical resection, but only about 20% patients have this option at the time of diagnosis and the mean 5-year survival rate after resection is only 10%-25%. Therefore, developing new treatments to improve the survival rate has practical significance for patients with this disease. This review deals with a current unmet need in medical oncology: the improvement of the treatment outcome of patients with pancreatic cancer. We summarize and discuss the latest systemic chemotherapy treatments (including adjuvant, neoadjuvant and targeted agents), radiotherapy, interventional therapy and immunotherapy. Besides discussing the current developments, we outline some of the main problems, solutions and prospects in this field.

关键词： Treatment Pancreatic cancer Survival rate Systemic chemotherapy Radiotherapy Interventional therapy Immunotherapy

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Trypsin inhibitor rBTI extends life span of C. elegans by inducing the change of ROS

Trypsin inhibitor rBTI extends life span of C. elegans by in...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Jiao Li xiao-dong cui Zhuan-hua Wang Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of Biotechnology Shanxi University

At present, in many studies of drugs on the prevention of aging, extendedlifespan is associated with reducing the accumulation of free radicals such as quercetin,resveratrol, etc..Accumulation of free radicals in the organism mainly is double impactedby the rate of metabolism and antioxidant defense system. When there is an imbalance,the excess of ROS damages physiologically important cellular macromolecules like lipids,proteins as well as DNA and leads to the loss of cellular integrity and functionality. Variousmetabolic reactions in vivo are the main source of the production of endogenous free radicals,the low rate of metabolic generates less ROS, otherwise produce more ***, we have shown that rBTI, a recombinent buckwheat trypsin inhibitor, can extendthe lifespan by enhancing the capability of anti-oxidative stress in fruit flies. Here, inorder to understand the mechanism, we studied anti-aging effect of rBTI in the multicellularmodel organism Caenorhabditis elegans. We found that exposing wild-type(N2) nematodesto rBTI at 10μM throughout adult life leads to an increase in median lifespan andmaximal lifespan(31.23%)under normal culture conditions. The ROS levels increased 60%after exposing nematodes to rBTI at 10μM for one day. Thereafter, ROS levels decreasedgradually, reached the lowest point on the third day. Furthermore, we found that daf-16 transcription was upregulated, the components of IIS transcription was significantlydown-regulated, and the activities of glycolysis and the citric acid decreased. Taken together,we presume that rBTI might extends life span of C. elegans by inducing a transient ROS signal to inhibite insulin/IGF-1 pathway.

关键词： Trypsin inhibitor lifespan C.elegans

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