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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： xiao Liang Xingping Quan xiaorui Geng Yujing Huang Yonghua zhao Lei Xi Zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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基于以太网的发电机组集中监控系统设计

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移动电源与车辆 2016年第2期47卷 1-5,19页

作者：张爱军孙晓静薛朝辉海军指挥自动化工作站北京100841 兰州电源车辆研究所有限公司兰州730050 甘肃省内燃机电站工程技术研究中心兰州730050

介绍了一种基于Modbus-RTU规约,通过RS-485串口/以太网转换器实现对两台电站四台发电机组以太网集中监控的设计方法。该方法已在产品中得到了应用。实践证明:使用方便,性能可靠。

关键词：发电机组控制器 Modbus-RTU协议串口/以太网转换器

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Maximum Entropy Method for Analyses of Fluorescence Correlation Spectra of Oligonucleotide Intra-chain Collision

Maximum Entropy Method for Analyses of Fluorescence Correlat...

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第一届全国生物物理化学会议暨生物物理化学发展战略研讨会

作者： YIN Yan-Dong,ZHOU xiao-xue,zhao Xin-Sheng~* Beijing National Laboratory for Molecular Sciences,State Key Laboratory for Structural Chemistry of Unstable and Stable Species,and Department of Chemical Biology,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,P.R.China

＜正＞It has been a challenge to accurately extract dynamic information from experimental fluorescence correlation spectroscopy（FCS） *** Maximum Entropy Method （MEMExp） which is model-free to fit the exponential f... 详细信息

关键词： Maximum entropy method Fluorescence correlation spectroscopy Oligonucleotides

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin xiao Fangqing zhao Jing-Dong J.Han Qi Liu xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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Multi-source Data-driven Identification of Urban Functional Areas:A Case of Shenyang,China

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Chinese Geographical Science 2023年第1期33卷 21-35页

作者： xue Bing xiao xiao LI Jingzhong zhao Bingyu FU Bo Institute of Applied Ecology Chinese Academy of SciencesShenyang 110016China Key Lab for Environmental Computation and Sustainability of Liaoning Province Shenyang 110016China University of Chinese Academy of Sciences Beijing 100049China College of Urban Planning and Architecture Xuchang UniversityXuchang 461000China

Urban functional area(UFA)is a core scientific issue affecting urban *** current knowledge gap is mainly reflected in the lack of multi-scale quantitative interpretation methods from the perspective of human-land *** this paper,based on multi-source big data include 250 m×250 m resolution cell phone data,1.81×105 Points of Interest(POI)data and administrative boundary data,we built a UFA identification method and demonstrated empirically in Shenyang City,*** argue that the method we built can effectively identify multi-scale multi-type UFAs based on human activity and further reveal the spatial correlation between urban facilities and human *** empirical study suggests that the employment functional zones in Shenyang City are more concentrated in central cities than other single functional *** are more mix functional areas in the central city areas,while the planned industrial new cities need to develop comprehensive functions in *** have scale effects and human-land interaction *** suggest that city decision makers should apply multi-sources big data to measure urban functional service in a more refined manner from a supply-demand perspective.

关键词： human-land relationship multi-source big data urban functional area identification method Shenyang City

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Analysis of energy consumption for lump coal degradation in melting gasifier

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Journal of Iron and Steel Research International 2017年第8期24卷 770-777页

作者： Qi-hang Liu xiao-ming Li Jun-xue zhao School of Metallurgical Engineering Xi'an University of Architecture and TechnologyXi'an 710055ShaanxiChina

The volume hypothesis,a theory about the energy scale of comminution,was adopted to analyze the degradation behavior of lump coal under different heating *** breakage energy of chars was determined by a compression test,and the results show that the ultimate strength of chars decreased at the early stage during the heating process,resulting in a decrease of the char breakage *** the late stage during the heating process,the char breakage energy increased with the increase of heating *** power consumption coefficients CKof different chars were determined by a drum experiment,and then the char degradation behavior under different power consumptions was *** addition,agasification experiment was conducted to determine the gasification activation energy（with CO_2）of lump coal heated for different *** results show that the gasification activation energy increased greatly at the early stage during the heating process,which showed opposite change to the breakage energy of ***,the internal temperature and heat changes of the bonded coal briquette were calculated by using an unsteady heat conduction *** large difference between the surface and the center temperatures of coal and the large amount of heat absorption at the early stage during the heating process may have a negative effect on the breakage energy of chars.

关键词： Melting gasifier Lump coal Degradation Volume hypothesis Heat absorption

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Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： xiao-Yu zhao Juan-Han Yu Yi-Hua Wang Yi-Xin Liu Lu Xu Lin Fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

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Ko⁃LLaMA:基于LLaMA的朝鲜语大语言模型

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外语学刊 2025年第1期 1-8页

作者：庞杰闫晓东赵小兵中央民族大学北京100081 国家语言资源监测与研究民族语言中心北京100081 民族语言智能与安全治理教育部重点实验室北京100081

在本文中,我们通过扩展LLaMA现有的词表,增加额外的20,000个朝鲜语Token,从而提高其对朝鲜语的编码和语义理解的能力;并且进一步使用朝鲜语数据进行继续预训练,使用朝鲜语指令微调数据集对模型进行SFT(Supervised Fine⁃Tuning),并分析... 详细信息

在本文中,我们通过扩展LLaMA现有的词表,增加额外的20,000个朝鲜语Token,从而提高其对朝鲜语的编码和语义理解的能力;并且进一步使用朝鲜语数据进行继续预训练,使用朝鲜语指令微调数据集对模型进行SFT(Supervised Fine⁃Tuning),并分析不同数据量对指令精调效果的影响,经过继续预训练和指令微调后的模型显著提高了理解和遵循朝鲜语指令的能力。实验结果表明,新提出的模型Ko⁃LLaMA显著提高了原版LLaMA在理解和生成朝鲜语内容方面的能力。此外,在朝鲜语文本分类数据集YNAT上对Ko⁃LLaMA与擅长少数民族语言的CINO模型及CINO的多种模型组合以及原版LLaMA和GPT⁃3.5进行了效果对比。结果表明,Ko⁃LLaMA的朝鲜语文本分类能力远超CINO和CINO的组合模型以及LLaMA和GPT⁃3.5等未经过朝鲜语语料进行词表扩充和继续预训练的大语言模型。

关键词：朝鲜语大语言模型词表扩充继续预训练指令微调

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Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia zhao Taixi Feng Guimin Lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

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DLM/FD SIMULATION OF CHANNEL FLOW WITH FENE POLYMER CHAIN SUSPENSION

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Journal of Hydrodynamics 2005年第6期17卷 677-680页

作者： SHAO xue-ming CHENG xiao-yin YU zhao-sheng Department of Mechanics State Key Laboratory of Fluid Power Transmisson and Control Zhejiang University Hangzhou 310027 China Institute of Textiles and Clothing. The Hongkong Polytechnic University Hongkong China Departmcnt of Mechanics Zhejiang University Hangzhou 310027 China

Distributed Lagrange Multiplier/Fictitious Domain （DLM/FD） method was employed to simulate the channel flow with polymer suspension. The polymer molecules were modeled as Finitely Extensible Nonlinear Elastic （FENE） chains and FENE chain cluster. The coiled stretched transition of FENE chains was examined and the change in configuration of FENE chains was presented. The average velocity profile of the fully developed channel flow with 64 FENE chains was given and fitted well with the power-law curve. The change of chain cluster configuration was also simulated. These simulations show that DLM/FD method is capable of simulating the motion of not only FENE chain, but also FENE chain cluster.

关键词： Distributed Lagrange Multiplier/Fictitious Domain (DLM/FI)) method Finitely Extensible Nonlinear Elastic (FENE) polymer chain channel flow

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