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Optimal decision-making in relieving global high temperature-related disease burden by data-driven simulation

Infectious Disease Modelling 2024年第2期9卷 618-633页

作者： xin-Chen Li Hao-Ran Qian Yan-Yan zhang Qi-Yu zhang Jing-Shu Liu Hong-Yu Lai Wei-Guo Zheng Jian Sun Bo Fu xiao-Nong Zhou xiao-xi zhang School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiPeople's Republic of China Institute of One Health Shanghai Jiao Tong UniversityShanghaiPeople's Republic of China School of Public Health Shanghai Jiao Tong University School of MedicineShanghaiPeople's Republic of China School of Data Science Fudan UniversityShanghaiPeople's Republic of China

The rapid acceleration of global warming has led to an increased burden of high temperature-related diseases(HTDs),highlighting the need for advanced evidence-based management *** have developed a conceptual framework aimed at alleviating the global burden of HTDs,grounded in the One Health *** framework refines the impact pathway and establishes systematic data-driven models to inform the adoption of evidence-based decision-making,tailored to distinct *** collected extensive national-level data from authoritative public databases for the years 2010–*** burdens of five categories of disease causes–cardiovascular diseases,infectious respiratory diseases,injuries,metabolic diseases,and non-infectious respiratory diseases–were designated as intermediate outcome *** cumulative burden of these five categories,referred to as the total HTD burden,was the final outcome *** evaluated the predictive performance of eight models and subsequently introduced twelve intervention measures,allowing us to explore optimal decision-making strategies and assess their corresponding *** model selection results demonstrated the superior performance of the Graph Neural Network(GNN)model across various *** simulations driven by the GNN model,we identified a set of optimal intervention strategies for reducing disease burden,specifically tailored to the seven major regions:East Asia and Pacific,Europe and Central Asia,Latin America and the Caribbean,Middle East and North Africa,North America,South Asia,and Sub-Saharan *** mitigation and adaptation measures,acting upon our categories of Infrastructure&Community,Ecosystem Resilience,and Health System Capacity,exhibited particularly strong performance for various regions and *** out of twelve interventions were included in the optimal intervention package for each region,including raising low-carbon energy use,increasing energy intensity,improving

关键词： High temperature-related diseases Data-driven simulation Optimal intervention Disease burden Graph neural network Global warming

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Towards an actionable One Health approach

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贫困所致传染病(英文) 2024年第2期13卷 1-6页

作者： zhang xiao-xi Lederman Zohar Han Le-Fei Schurer Janna M. xiao Li-Hua zhang Zhi-Bing Chen Qiu-Lan Pfeiffer Dirk Ward Michael P. Sripa Banchob Gabri?l Sarah Dhama Kuldeep Acharya Krishna Prasad Robertson Lucy J. Deem Sharon L. Aenishaenslin Cécile Dantas-Torres Filipe Otranto Domenico Grace Delia Wang Yang Li Peng Fu Chao Poeta Patrícia Rahman Md. Tanvir Kassegne Kokouvi Zhu Yong-zhang Yin Kun Liu Jiming Wang Zhao-Jun Guo xiao-Kui Gong Wen-Feng Schwartl?nder Bernhard Ren Ming-Hui Zhou xiao-Nong School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai People’s Republic of China Institute of One Health Shanghai Jiao Tong University Shanghai People’s Republic of China Medical Ethics and Humanities Unit Hong Kong University Hong Kong People’s Republic of China Center for One Health University of Global Health Equity Butaro Rwanda College of Veterinary Medicine South China Agricultural University Guangzhou People’s Republic of China School of Ecology and Environment Hainan University Haikou Hainan People’s Republic of China Branch of animal and vector-borne diseases Division of Infectious Disease Control Chinese Center for Disease Control and Prevention Beijing People’s Republic of China Centre for Applied One Health Research and Policy Advice Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life Sciences City University of Hong Kong Hong Kong SAR People’s Republic of China Department of Pathobiology and Population Sciences Royal Veterinary College London United Kingdom Sydney School of Veterinary Science The University of Sydney Camden Australia Tropical Disease Research Center Department of Tropical Medicine Faculty of Medicine Khon Kaen University Khon Kaen Thailand Laboratory of foodborne parasitic zoonoses Department of translational physiology infectiology and public health Chair Faculty Committee on Internationalisation Faculty of Veterinary Medicine Ghent University Merelbeke Belgium Division of Pathology ICAR-Indian Veterinary Research Institute (IVRI) Bareilly Uttar Pradesh India Department of Livestock Services Animal Quarantine Office-Kathmandu Budhanilkantha Kathmandu Nepal Parasitology Department of Paraclinical Sciences Faculty of Veterinary Medicine Norwegian University of Life Sciences ?s Norway One Government Drive Saint Louis Zoo Institute for Conservation Medicine St. Louis USA Groupe de Recherche en épidémi

Background Despite the increasing focus on strengthening One Health capacity building on global level, challenges remain in devising and implementing real-world interventions particularly in the Asia-Pacific region. Recognizing these gaps, the One Health Action Commission (OHAC) was established as an academic community for One Health action with an emphasis on research agenda setting to identify actions for highest *** text This viewpoint describes the agenda of, and motivation for, the recently formed OHAC. Recognizing the urgent need for evidence to support the formulation of necessary action plans, OHAC advocates the adoption of both bottom-up and top-down approaches to identify the current gaps in combating zoonoses, antimicrobial resistance, addressing food safety, and to enhance capacity building for context-sensitive One Health *** By promoting broader engagement and connection of multidisciplinary stakeholders, OHAC envisions a collaborative global platform for the generation of innovative One Health knowledge, distilled practical experience and actionable policy advice, guided by strong ethical principles of One Health.

关键词： One Health Global Health One Health Action Commission Research agenda

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Variational Neural Inference Enhanced Text Semantic Communication System

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China Communications 2024年第7期21卷 50-64页

作者： zhang xi zhang Yiqian Li Congduan Ma xiao School of Electronics and Communication Engineering Sun Yat-Sen UniversityShenzhen 518107China Guizhou University State Key Laboratory of Public Big Data Guiyang 550025China Shenzhen Key Laboratory of Navigation and Communication Integration Shenzhen 518107China School of Computer Science and Engineering Sun Yat-Sen UniversityGuangzhou 510006China

Recently,deep learning-based semantic communication has garnered widespread attention,with numerous systems designed for transmitting diverse data sources,including text,image,and speech,*** efforts have been directed toward improving system performance,many studies have concentrated on enhancing the structure of the encoder and ***,this often overlooks the resulting increase in model complexity,imposing additional storage and computational burdens on smart ***,existing work tends to prioritize explicit semantics,neglecting the potential of implicit *** paper aims to easily and effectively enhance the receiver's decoding capability without modifying the encoder and decoder *** propose a novel semantic communication system with variational neural inference for text ***,we introduce a simple but effective variational neural inferer at the receiver to infer the latent semantic information within the received *** information is then utilized to assist in the decoding *** simulation results show a significant enhancement in system performance and improved robustness.

关键词： deep learning semantic communication variational neural inference

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Decoupling methods of MIMO antenna arrays for 5G applications: a review

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Frontiers of Information Technology & Electronic Engineering 2020年第1期21卷 62-71页

作者： xiao-xi zhang Ai-di REN Ying LIU Science and Technology on Antenna and Microwave Laboratory Xidian UniversityXi’an 710071China Department of Electronic and Digital Technologies Polytech NantesUniversity of NantesNantes 44306France

Multiple-input multiple-output(MIMO)technique is a key technique for communication in the *** can effectively enhance channel *** future fifth-generation(5G)terminals,it is still a challenging task to realize desirable isolation within a compact *** achieve an acceptable isolation level,many decoupling methods have been *** review the most recent research on decoupling methods,including the employment of external decoupling structures,orthogonal modes,and reduction of ground effect,and discuss the development trends of the MIMO array in 5G smartphones.

关键词： MIMO array 5G smartphone Decoupling methods

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Role of biochar in raising blue carbon stock capacity of salt marshes

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Pedosphere 2024年第1期34卷 19-22页

作者： Yuzhou HUANG xi xiao Ocean College Zhejiang UniversityZhoushan 316021China Key Laboratory of Marine Ecological Monitoring and Restoration Technologies of the Ministry of Natural Resources of China Shanghai 201306China Donghai Laboratory Zhoushan 316021China Ocean Academy Zhejiang UniversityZhoushan 316021China Key Laboratory of Watershed Non-point Source Pollution Control and Water Eco-security of Ministry of Water Resources College of Environmental and Resources SciencesZhejiang UniversityHangzhou 310058China

Salt marshes are an important blue carbon ecosystem, with surprisingly fast carbon accumulation rates that are 40 times higher than those of terrestrial forests. In recent decades, salt marshes have suffered great degradation and loss all over the world. The idea to enhance carbon stock in salt marshes(so-called blue carbon) using biochar (so-called black carbon) has recently been proposed. Although experiments and observations remain limited, significant enhancements in soil organic carbon and plant growth have been documented in most case studies. However, due to the limited number of observations and their relatively short time window ranging from months to less than one year, there still exists a knowledge gap regarding the process, mechanism, and effect of biochar in enhancing carbon stock in salt marshes. Future research is urgently needed in the following perspectives:1) exploring the relationship between carbon stock enhancement efficiency and biochar properties, 2) optimizing the physical and chemical properties of biochar to boost its efficiency, and 3)studying the in-situ responses of complex carbon pools to biochar addition, especially under tidal conditions and over a longer period of time.

关键词： soil stock char

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Pyruvate kinase M in germ cells is essential for sperm motility and male fertility but not spermatogenesis

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Asian Journal of Andrology 2024年第2期26卷 212-219页

作者： Gao-Qing Qian xiao-Chen Wang xi zhang Bin Shen Qiang Liu State Key Laboratory of Reproductive Medicine and Offspring Health Nanjing Medical UniversityNanjing 211166China Shanghai Key Laboratory of Reproductive Medicine Department of HistoembryologyGenetics and Developmental BiologyShanghai Jiao Tong University School of MedicineShanghai 200025China State Key Laboratory of Molecular Biology Shanghai Key Laboratory of Molecular AndrologyShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China

Male germ cells employ specific metabolic pathways throughout their developmental *** a previous study,we discovered heightened expression of pyruvate kinase M(PKM),a pivotal glycolytic enzyme,in spermatogonia and *** gain deeper insights into PKM's roles in spermatogenesis,sperm function,and male fertility,we engineered a conditional-knockout mouse model(Pkm-vkO mice)to selectively disrupt the Pkm gene within germ *** maintaining regular testicular histology and sperm morphology,the male Pkm-vko mice were infertility,characterized by significant impairments in sperm motility and adenosine triphosphate(ATP)*** addition,Pkm-null spermatozoa exhibited similar deficits in protein tyrosine phosphorylation linked to capacitation,as well as compromised performance in in vitro fertilization *** conclude,PKM's presence is not obligatory for the entirety of spermatogenesis in male germ cells;however,it emerges as a critical factor influencing sperm motility and overall male fertility.

关键词： glycolysis male fertility pyruvate kinase M sperm motility spermatogenesis

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Hydraulic characteristics of a siphon-shaped overflow tower in a long water conveyance system: CFD simulation and analysis

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Journal of Hydrodynamics 2016年第4期28卷 564-575页

作者：余康程永光张晓曦 State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University State Key Laboratory of Hydroscience and Engineering Tsinghua University

The siphon-shaped overflow tower is a new type of pressure-suppressing structure used in long water conveyance systems,and it plays a crucial role in guaranteeing the system＇s stability and safety during hydraulic transient *** flow in the tower is characteristic of weir flow in a closed duct,and is thus a complex air-water two-phase *** studies of the flow patterns,the pressure pulsations,and the discharge capacity are necessary for better understanding of the flow processes and for the purpose of *** this paper,we simulate the flow in a siphon-shaped overflow tower under both steady and unsteady flow *** a steady-flow field simulation,the relationship between the overflow discharge and the pressure in the connected pipeline is analyzed and an empirical formula for evaluating the discharge capacity is *** a transient-flow field simulation,the negative-pressure distributions on the weir crest,the pressure pulsations on the crest and in the falling pond,and the transformation of the air-water two-phase flow in the downstream outlet pipe are ***,the major influencing factors of the flow patterns,especially,the sectional area of the air vents,are *** is indicated that the siphon-shaped overflow tower can regulate the pressure surge during hydraulic transients and guarantee the safety and stability of the pipeline system,if the shape and the vents are properly designed.

关键词： tower shaped downstream pipeline hydraulic falling crest unsteady outlet guarantee

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Achieving structurally stable O3-type layered oxide cathodes through site-specific cation-anion co-substitution for sodium-ion batteries

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Journal of Energy Chemistry 2024年第6期93卷 411-418,I0011页

作者： Yihao Shen Chen Cheng xiao xia Lei Wang xi Zhou Pan Zeng Jianrong Zeng Liang zhang Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123JiangsuChina Institute for Advanced Study School of Mechanical EngineeringChengdu UniversityChengdu 610106SichuanChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow UniversitySuzhou 215123JiangsuChina

O3-type layered oxides have garnered great attention as cathode materials for sodium-ion batteries because of their abundant reserves and high theoretical ***,challenges persist in the form of uncontrollable phase transitions and intricate Na^(+)diffusion pathways during cycling,resulting in compromised structural stability and reduced capacity over *** study introduces a special approach employing site-specific Ca/F co-substitution within the layered structure of O_(3)-NaNi_(0.5)Mn_(0.5)O_(2) to effectively address these ***,the strategically site-specific doping of Ca into Na sites and F into O sites not only expands the Na^(+)diffusion pathways but also orchestrates a mild phase transition by suppressing the Na^(+)/vacancy ordering and providing strong metal-oxygen bonding strength,*** as-synthesized Na_(0.95)Ca_(0.05)Ni_(0.5)Mn_(0.5)O_(1.95)F_(0.05)(NNMO-CaF)exhibits a mild O3→O3+O'3→P3 phase transition with minimized interlayer distance variation,leading to enhanced structural integrity and stability over extended *** a result,NNMO-CaF delivers a high specific capacity of 119.5 mA h g^(-1)at a current density of 120 mA g^(-1)with a capacity retention of 87.1%after 100 *** study presents a promising strategy to mitigate the challenges posed by multiple phase transitions and augment Na^(+)diffusion kinetics,thus paving the way for high-performance layered cathode materials in sodium-ion batteries.

关键词： Sodium-ion batteries O3-type layered oxides Site-specific co-doping Phase transition

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Cost dynamics of onshore wind energy in the context of China's carbon neutrality target

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Environmental Science and Ecotechnology 2024年第3期19卷 109-117页

作者： Shi Chen Youxuan xiao Chongyu zhang xi Lu Kebin He Jiming Hao School of Environment State Key Joint Laboratory of Environment Simulation and Pollution ControlTsinghua UniversityBeijing100084China Beijing Laboratory of Environmental Frontier Technologies Tsinghua UniversityBeijing100084China Institute for Carbon Neutrality Tsinghua UniversityBeijing100084China

Wind energy has become one of the most important measures for China to achieve its carbon neutrality *** spatial and temporal evolvement of economic competitiveness for wind energy becomes an important concern in shaping the decarbonization pathway in *** has been an urgent need in power system planning to model the future dynamics of cost decline and supply potential for wind power in the context of carbon neutrality until *** studies often fail to capture the rapid decline in the cost of wind power generation in recent years,and the prediction of wind power cost decline is more conservative than the *** study constructs an integrated model to evaluate the cost-competitiveness and grid parity potential of China's onshore wind electricity at fine spatial resolution with updated *** indicate that the total onshore wind potential amounts to 54.0 *** average levelized cost of wind power is expected to decline from CNY 0.39 kWh^(-1)in 2020 to CNY 0.30 and CNY 0.21 kWh^(-1)in 2030 and 2060.28.3%,67.6%,and 97.6%of the technical potentials hold power costs lower than coal power in 2020,2030,and 2060.

关键词： Wind power Carbon neutrality Electricity potential Economic competitiveness Grid parity

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A review of the neurotransmitter system associated with cognitive function of the cerebellum in Parkinson's disease

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Neural Regeneration Research 2024年第2期19卷 324-330页

作者： xi Chen Yuhu zhang Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Shantou University Medical College ShantouGuangdong ProvinceChina

The dichotomized brain system is a concept that was generalized from the‘dual syndrome hypothesis’to explain the heterogeneity of cognitive impairment,in which anterior and posterior brain systems are independent but partially *** dopaminergic system acts on the anterior brain and is responsible for executive function,working memory,and *** contrast,the cholinergic system acts on the posterior brain and is responsible for semantic fluency and visuospatial *** from dopaminergic/cholinergic imaging or functional neuroimaging has shed significant insight relating to the involvement of the cerebellum in the cognitive process of patients with Parkinson’s *** research has reported evidence that the cerebellum receives both dopaminergic and cholinergic ***,whether these two neurotransmitter systems are associated with cognitive function has yet to be fully ***,the precise role of the cerebellum in patients with Parkinson’s disease and cognitive impairment remains ***,in this review,we summarize the cerebellar dopaminergic and cholinergic projections and their relationships with cognition,as reported by previous studies,and investigated the role of the cerebellum in patients with Parkinson’s disease and cognitive impairment,as determined by functional *** findings will help us to understand the role of the cerebellum in the mechanisms underlying cognitive impairment in Parkinson’s disease.

关键词： anterior brain system cerebellum cholinergic cognitive impairment dopaminergic dual syndrome hypothesis neuroimage neurotransmitter Parkinson’s disease posterior brain system therapeutic targets

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