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Integrated ribosome and proteome analyses reveal insights into sevoflurane-induced long-term social behavior and cognitive dysfunctions through ADNP inhibition in neonatal mice

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Zoological Research 2024年第3期45卷 663-678页

作者： Li-Rong Liang Bing Liu Shu-Hui Cao You-Yi Zhao Tian Zeng Mei-Ting Zhai Ze Fan Dan-Yi He San-Xin Ma xiao-tong shi Yao Zhang Hui Zhang State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Engineering Research Center for Dental Materials and Advanced ManufactureDepartment of AnesthesiologySchool of StomatologyAir Force Medical UniversityXi’anShaanxi 710032China Department of Anesthesiology 986th Air Force HospitalAir Force Medical UniversityXi’anShaanxi 710032China

A growing number of studies have demonstrated that repeated exposure to sevoflurane during development results in persistent social abnormalities and cognitive ***,an active fragment of the activity-dependent neuroprotective protein(ADNP),has been implicated in social and cognitive ***,the potential of davunetide to attenuate social deficits following sevoflurane exposure and the underlying developmental mechanisms remain poorly *** this study,ribosome and proteome profiles were analyzed to investigate the molecular basis of sevoflurane-induced social deficits in neonatal *** neuropathological basis was also explored using Golgi staining,morphological analysis,western blotting,electrophysiological analysis,and behavioral *** indicated that ADNP was significantly down-regulated following developmental exposure to *** adulthood,anterior cingulate cortex(ACC)neurons exposed to sevoflurane exhibited a decrease in dendrite number,total dendrite length,and spine ***,the expression levels of Homer,PSD95,synaptophysin,and vglut2 were significantly reduced in the sevoflurane ***-clamp recordings indicated reductions in both the frequency and amplitude of miniature excitatory postsynaptic currents(mEPSCs).Notably,davunetide significantly ameliorated the synaptic defects,social behavior deficits,and cognitive impairments induced by *** analysis revealed that loss of ADNP led to dysregulation of Ca^(2+)activity via the Wnt/β-catenin signaling,resulting in decreased expression of synaptic *** of Wnt signaling was restored in the davunetide-treated ***,ADNP was identified as a promising therapeutic target for the prevention and treatment of neurodevelopmental toxicity caused by general *** study provides important insights into the mechanisms underlying social and cognitive disturbances caused by sevoflurane exposure in neonatal

关键词： Davunetide Sevoflurane Abnormal social behaviors ADNP Neurotoxicity

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Fast nuclear-spin gates and electrons−nuclei entanglement of neutral atoms in weak magnetic fields

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Frontiers of physics 2024年第2期19卷 179-203页

作者： xiao-Feng shi School of Physics Xidian UniversityXi’an 710071China

We present a novel class of Rydberg-mediated nuclear-spin entanglement in divalent atoms with global laser ***,we show a fast nuclear-spin controlled phase gate of an arbitrary phase realizable either with two laser pulses when assisted by Stark shifts,or with three ***,we propose to create an electrons−nuclei-entangled state,which is named a super bell state(SBS)for it mimics a large Bell state incorporating three small Bell ***,we show a protocol to create a three-atom electrons-nuclei entangled state which contains the three-body W and Greenberger−Horne−Zeilinger(GHZ)states *** protocols possess high intrinsic fidelities,do not require single-site Rydberg addressing,and can be executed with large Rydberg Rabi frequencies in a weak,Gauss-scale magnetic *** latter two protocols can enable measurement-based preparation of Bell,hyperentangled,and GHZ states,and,specifically,SBS can enable quantum dense coding where one can share three classical bits of information by sending one particle.

关键词： nuclear-spin qubit electrons−nuclei entanglement super Bell state Greenberger−Horne−Zeilinger state Rydberg-mediated entanglement quantum dense coding

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A survey on federated learning:a perspective from multi-party computation

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Frontiers of Computer Science 2024年第1期18卷 93-103页

作者： Fengxia LIU Zhiming ZHENG Yexuan shi Yongxin tong Yi ZHANG Institute of Artificial Intelligence and Key Laboratory of Mathematics Informatics Behavioral Semantics Beihang UniversityBeijing 100191China State Key Laboratory of Software Development Environment and Advanced Innovation Center for Future Blockchain and Privacy Computing Beihang UniversityBeijing 100191China Pengcheng Laboratory Shenzhen 518055China Zhongguancun Laboratory Beijing 100190China Institute for Mathematical Sciences and Engineering Research Center of Financial Computing and Digital Engineering Renmin University of ChinaBeijing 100872China

Federated learning is a promising learning paradigm that allows collaborative training of models across multiple data owners without sharing their raw *** enhance privacy in federated learning,multi-party computation can be leveraged for secure communication and computation during model *** survey provides a comprehensive review on how to integrate mainstream multi-party computation techniques into diverse federated learning setups for guaranteed privacy,as well as the corresponding optimization techniques to improve model accuracy and training *** also pinpoint future directions to deploy federated learning to a wider range of applications.

关键词： sfederated learning multi-party ycomputation privacy-preserving data mining distributed learning

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Statistical Process Monitoring Based on Ensemble Structure Analysis

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1889-1891页

作者： Likang shi Chudong tong Ting Lan Xuhua shi Faculty of Electrical Engineering and Computer Science Ningbo UniversityNingbo 315211China

Dear Editor,This letter presents a novel process monitoring model based on ensemble structure analysis(ESA).The ESA model takes advantage of principal component analysis(PCA),locality preserving projections(LPP),and multi-manifold projections(MMP)models,and then combines the multiple solutions within an ensemble result through Bayesian *** the developed ESA model,different structure features of the given dataset are taken into account simultaneously,the suitability and reliability of the ESA-based monitoring model are then illustrated through ***:The requirement for ensuring safe operation and improving process efficiency has led to increased research activity in the field of process monitoring.

关键词： ensemble preserving letter

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Chord length sampling correction analysis for dispersion fuel in Monte Carlo simulation

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Nuclear Science and Techniques 2024年第4期35卷 57-64页

作者： Zhao-Yu Liang Ding She Yu-tong Wen Lei shi Institute of Nuclear and New Energy Technology(INET) Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of EducationTsinghua UniversityBeijing 100084China

Dispersion fuels,knowned for their excellent safety performance,are widely used in advanced reactors,such as hightemperature gas-cooled *** with deterministic methods,the Monte Carlo method has more advantages in the geometric modeling of stochastic *** explicit modeling method has high computational accuracy and high computational *** chord length sampling(CLS)method can improve computational efficiency by sampling the chord length during neutron transport using the matrix chord length?s probability density *** study shows that the excluded-volume effect in realistic stochastic media can introduce certain deviations into the CLS.A chord length correction approach is proposed to obtain the chord length correction factor by developing the Particle code based on equivalent transmission *** numerical analysis against reference solutions from explicit modeling in the RMC code,it was demonstrated that CLS with the proposed correction method provides good accuracy for addressing the excludedvolume effect in realistic infinite stochastic media.

关键词： Stochastic media Monte Carlo Chord length sampling Excluded-volume effect Chord length correction

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Density peak clustering using tensor network

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Science China(Information Sciences) 2024年第3期67卷 321-322页

作者： xiao shi Yun SHANG Institute of Mathematics Academy of Mathematics and Systems ScienceChinese Academy of Sciences School of Mathematical Sciences University of Chinese Academy of Sciences National Center for Mathematics and Interdisciplinary Sciences Key Laboratory of ManagementDecision and Information SystemsAcademy of Mathematics and Systems ScienceChinese Academy of Sciences

Tensor networks have been a powerful tool in simulating many-body physics and have recently gained recognition in the machine learning community due to their remarkable representation capabilities. However, using tens... 详细信息

关键词： Tensors

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Network Evolution Analysis of Vehicle Road-Driving Behavior Strategies and Design of Information Guidance Algorithm

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Journal of Social Computing 2024年第1期5卷 58-87页

作者： tong Lyu Lefeng shi Weijun He College of Economics and Management China Three Gorges UniversityYichang 443002China National Center for Applied Mathematics in Chongqing Chongqing Normal UniversityChongqing 401331China

By analyzing the influence of time and safety factors on the behavior strategies of vehicles on the road,a network game evolution model between drivers that considers the behavior strategies of the driving vehicle itself and its neighbors is constructed,and the competition relationship between different types of cars is *** influence of the proportion of driving vehicle types on the potential risk of the road is also *** paper presents a guidance algorithm for vehicle dynamic behavior preference *** correctness of the algorithm is verified by an *** shows:The choice of behavior strategies,such as speeding and lane changing,is related to the expected benefits of time,safety,and neighboring vehicle strategies,and the critical value of payable benefits is *** higher the proportion of aggressive vehicles on the road,the greater the potential risk on the *** there is a vehicle in the adjacent lane of the driving vehicle will affect the type of driving *** guidance helps to stabilize the state of vehicles on the road,and the policy transition probability also helps stabilize the form of vehicles cars on the ***,information guidance has a more significant impact on the transition of vehicle ***,the guidance strategy of managers is given when the road is smooth and congested.

关键词： user portrait information guidance network game risk appetite

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A highly sensitive multiple-mode optical thermometer designed in Eu^(2+)/^(3+)and Li^(+)co-doped polymorphism compound LaSc_(3)(BO_(3))_(4)

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Journal of Advanced Ceramics 2024年第6期13卷 821-833页

作者： Nan Yang Zhuo Li Tingxia Zhou Ziwang Zhang Wen shi Yexiang tong Jianxin shi School of Chemistry IGCMESun Yat-sen UniversityGuangzhou 510006China MOE of the Key Laboratory of Bioinorganic and Synthetic Chemistry IGCMEThe Key Lab of Low-Carbon Chemistry&Energy Conservation of Guangdong ProvinceSun Yat-sen UniversityGuangzhou 510006China

Noncontact optical thermometers have attracted widespread attention,but existing problems such as single-mode and low-sensitivity thermometers still urgently need to be ***,a novel multiple-mode thermometer was designed for the polymorphism LaSc_(3)(BO_(3))_(4):Eu^(2+/3+),Li^(+).X-ray diffraction(XRD)patterns revealed a slight transition betweenα-andβ-phases with the concentrations of the dopants,which is further proved by structure refinements and first-principles *** coexistence of Eu^(2+)and Eu^(3+)in the phosphors and their relative percentages were confirmed by X-ray absorption near-edge structure(XANES)*** from appropriate emissions from Eu^(2+)and Eu^(3+)without obvious energy transfer and their opposite changing trends with temperatures under 307 nm excitation,a triple-mode optical thermometer is obtained for this material within the temperature range of 150–450 *** highest sensitivities of 27.65,14.05,and 7.68%·K^(−1)are achieved based on two fluorescence intensity ratio(FIR)modes of Eu^(2+)and Eu^(3+)(5d–4f/^(5)D_(0)–^(7)F_(2,4))and the fluorescence lifetime(FL)mode of Eu^(2+),*** the best of our knowledge,the former is almost the highest in Eu^(2+)and Eu^(3+)co-doped *** results indicate that this material may be used as an excellent multiple-mode optical thermometer.

关键词： phase transition europium(Eu)ions multiple-mode optical thermometer thermal quenching properties fluorescence intensity ratio(FIR) fluorescence lifetime(FL)

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A privacy-preserving method for publishing data with multiple sensitive attributes

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 222-238页

作者： tong Yi Minyong shi Wenqian Shang Haibin Zhu School of Computer Science and Engineering Guangxi Normal UniversityGuilinChina School of Computer Science Communication University of ChinaBeijingChina Department of Computer Science and Mathematics Nipissing UniversityNorth BayOntarioCanada

The overgeneralisation may happen because most studies on data publishing for multiple sensitive attributes(SAs)have not considered the personalised privacy ***,sensitive information disclosure may also be caused by these personalised *** address the matter,this article develops a personalised data publishing method for multiple *** to the requirements of individuals,the new method partitions SAs values into two categories:private values and public values,and breaks the association between them for privacy *** the private values,this paper takes the process of anonymisation,while the public values are released without this *** algorithm is designed to achieve the privacy mode,where the selectivity is determined by the sensitive value frequency and undesirable *** experimental results show that the proposed method can provide more information utility when compared with previous *** theoretic analyses and experiments also indicate that the privacy can be guaranteed even though the public values are known to an *** overgeneralisation and privacy breach caused by the personalised requirement can be avoided by the new method.

关键词： data privacy data publishing

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High-dimensional uncertainty quantification of projectile motion in the barrel of a truck-mounted howitzer based on probability density evolution method

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Defence Technology（防务技术） 2024年第2期32卷 209-221页

作者： Mingming Wang Linfang Qian Guangsong Chen tong Lin Junfei shi shijie Zhou Nanjing University of Science and Technology Nanjing 210094JiangsuChina Northwest Institute of Mechanical and Electrical Engineering Xianyang 712099ShaanxiChina Nanjing Vocational University of Industry Technology Nanjing 210023JiangsuChina

This paper proposed an efficient research method for high-dimensional uncertainty quantification of projectile motion in the barrel of a truck-mounted ***,the dynamic model of projectile motion is established considering the flexible deformation of the barrel and the interaction between the projectile and the ***,the accuracy of the dynamic model is verified based on the external ballistic projectile attitude test ***,the probability density evolution method(PDEM)is developed to high-dimensional uncertainty quantification of projectile *** engineering example highlights the results of the proposed method are consistent with the results obtained by the Monte Carlo Simulation(MCS).Finally,the influence of parameter uncertainty on the projectile disturbance at muzzle under different working conditions is *** results show that the disturbance of the pitch angular,pitch angular velocity and pitch angular of velocity decreases with the increase of launching angle,and the random parameter ranges of both the projectile and coupling model have similar influence on the disturbance of projectile angular motion at muzzle.

关键词： Truck-mounted howitzer Projectile motion Uncertainty quantification Probability density evolution method

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