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Isolation and characterization of three pairs of verrucosidin epimers from the marine sediment‑derived fungus Penicillium cyclopium and confguration revision of penicyrone A and related analogues

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Marine Life Science & Technology 2023年第2期5卷 223-231页

作者： Yan-He Li Attila Mándi Hong-Lei Li xiao-Ming Li Xin Li Ling-Hong Meng Sui-Qun Yang xiao-shan shi Tibor Kurtán Bin-Gui Wang CAS and shandong Province Key Laboratory of Experimental Marine Biology Institute of OceanologyChinese Academy of Sciencesand Laboratory of Marine Biology and Biotechnology at the Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China School of Marine Science University of Chinese Academy of SciencesBeijing 100049China Department of Organic Chemistry University of DebrecenEgyetem Tér 1Debrecen 4032Hungary Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China

Verrucosidins,a methylatedα-pyrone class of polyketides rarely reported upon,have been implicated in one or more neurological *** the signifcance of verrucosidins as neurotoxins,the absolute confgurations of most of the derivatives have not been accurately characterized *** this study,three pairs of C-9 epimeric verrucosidin derivatives,including the known compounds penicyrones A and B(1a/1b)and 9-O-methylpenicyrones A and B(2a/2b),the new compounds 9-O-ethylpenicyrones A and B(3a/3b),together with the related known derivative verrucosidin(4),were isolated and identifed from the culture extract of Penicillium cyclopium SD-413,which was obtained from the marine sediment collected from the East China *** structures were established based on an in-depth analysis of nuclear magnetic resonances(NMR)and mass spectroscopic *** of the absolute confgurations of these compounds was accomplished by Mosher’s method and time-dependent density functional theory(TDDFT)calculations of electronic circular dichroism(ECD)and optical rotation(OR).The confgurational assignment of penicyrone A demonstrated that the previously reported C-6 absolute confguration of verrucosidin derivatives needs to be revised from(6S)to(6R).The 9R/9S epimers of compounds 1–3 were found to exhibit growth inhibition against some pathogenic bacteria,indicating that they have potential as lead compounds for the creation of antimicrobial agents.

关键词： Marine-derived fungus Penicillium cyclopium Verrucosidin derivatives TDDFT-ECD calculations Mosher’s method Antimicrobial activity

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Influence of Dispersion Character of Rock Electric Parameters on Archie＇s Formulas and Waxman-Smits Model

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石油地球物理勘探 2009年第A2期44卷 114-117页

作者： xiao Zhan-shan Zhu shi-he Ma Jing Wang Dong Wang Zhi-qiang Min Zhi-qiang Sang Jiu-bo GWDC Holewire Services Company Panjin Liaoning Province 124011China

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Resistance of caprock to hydraulic fracturing due to CO2 injection into sand lens reservoirs

Resistance of caprock to hydraulic fracturing due to CO2 inj...

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中国科学院地质与地球物理研究所2013年度（第13届）学术年会

作者： Zhen-Dong Cui Da-An Liu Rong-Shu Zeng Jing-Rui Niu Hong-Jian Wang xiao-shan shi Key Laboratory of Engineering Geomechanics Institute of Geology and GeophysicsChinese Academy of Sciences

The geomechanical stability of caprock is critical to the long-term safety of geologic storage of CO in depleted oil *** on the theory of rock fracture mechanics in deep formations,we propose a quantitative assessment framework for the resistance of caprock to hydraulic fracturing due to CO injection and storage in a sand lens *** simplifying the sand lens reservoir as a lenticular crack model,we developed a formula for the Mode-I stress intensity factor at the crack tip(pinch-out tip of the sand lens reservoir) and the in situ fracture toughness of the surrounding *** then established a preliminary threshold for assessing the resistance of caprock to hydraulic *** on this threshold,the critical hydraulic fracturing pressure at the pinch-out tip of a sand lens reservoir and the allowable injection pressure at the bottom hole of an injection well can be *** quantitative assessment framework has been verified for use in sand lens reservoirs with a case study of the Daqingzijing CO storage site in the Jilin oil field,*** results provide important implications for assessing the resistance to hydraulic fracturing in similar reservoirs with stratigraphic pinch-outs in impermeable formations,preventing caprock fracturing and water or gas channeling during CO injection.

关键词： Caprock CO2 storage Hydraulic fracturing In situ fracture toughness Sand lens reservoir

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Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao xiao Chaoyang Chu Zhicheng Lin Tianyuan Fang Yuyu Zhou Chuxia Zhang Jianghui shan shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

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多酶组合水解甘蔗渣及利用甘蔗渣水解液发酵丁二酸

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食品与发酵工业 2014年第9期40卷 12-16页

作者：陶生涛郑璞肖石山江南大学生物工程学院工业生物技术教育部重点实验室江苏无锡214112

以甘蔗渣为原料,研究了甘蔗渣水解液的制备与利用琥珀酸放线杆菌发酵生产丁二酸的主要工艺参数。甘蔗渣经过1%NaOH预处理后,用纤维素酶、木聚糖酶、β-葡聚糖酶和果胶酶共同水解,在底物质量浓度为75 g/L时,水解液的还原糖质量浓度为65.6... 详细信息

以甘蔗渣为原料,研究了甘蔗渣水解液的制备与利用琥珀酸放线杆菌发酵生产丁二酸的主要工艺参数。甘蔗渣经过1%NaOH预处理后,用纤维素酶、木聚糖酶、β-葡聚糖酶和果胶酶共同水解,在底物质量浓度为75 g/L时,水解液的还原糖质量浓度为65.6 g/L,甘蔗渣中总纤维素水解率达到90%。以还原糖质量浓度为55g/L的甘蔗渣水解液为碳源,在3 L发酵罐中分批发酵29 h产39.9 g/L丁二酸,丁二酸对甘蔗渣水解液中还原糖的得率为0.82 g/g,对甘蔗渣的得率为0.46 g/g。反映了以甘蔗渣为原料发酵生产丁二酸的可行性。

关键词：甘蔗渣预处理酶解丁二酸

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Graphene Aerogel Composites with Self‑Organized Nanowires‑Packed Honeycomb Structure for Highly Efficient Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第2期17卷 533-547页

作者： xiao You Huiying Ouyang Ruixiang Deng Qiuqi Zhang Zhenzhong Xing xiaowu Chen Qingliang shan Jinshan Yang Shaoming Dong State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Key Laboratory of Inorganic Coating Materials CAS Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Structural Ceramics and Composites Engineering Research Center Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210People’s Republic of China School of Materials Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China University of Chinese Academy of Sciences Beijing 100039People’s Republic of China

With vigorous developments in nanotechnology,the elaborate regulation of microstructure shows attractive potential in the design of electromagnetic wave ***,a hierarchical porous structure and composite heterogeneous interface are constructed successfully to optimize the electromagnetic loss *** macro–micro-synergistic graphene aerogel formed by the ice template‑assisted 3D printing strategy is cut by silicon carbide nanowires(SiC_(nws))grown in situ,while boron nitride(BN)interfacial structure is introduced on graphene *** unique composite structure forces multiple scattering of incident EMWs,ensuring the combined effects of interfacial polarization,conduction networks,and magnetic-dielectric ***,the as-prepared composites present a minimum reflection loss value of−37.8 dB and a wide effective absorption bandwidth(EAB)of 9.2 GHz(from 8.8 to 18.0 GHz)at 2.5 ***,relying on the intrinsic high-temperature resistance of SiC_(nws) and BN,the EAB also remains above 5.0 GHz after annealing in air environment at 600℃ for 10 h.

关键词： Hierarchical porous structure Interface High-temperature resistance Graphene aerogel composites Electromagnetic wave absorption

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ITP患者外周血树突状细胞亚群变化及其临床意义

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遵义医学院学报 2010年第1期33卷 26-28,31页

作者：肖仕珊袁钟遵义医学院附属医院血液内科贵州遵义563000

目的探讨特发性血小板减少性紫癜(ITP)患者外周血树突状细胞(DC)亚群的变化及其临床意义。方法用流式细胞技术检测29例初治ITP患者及15例健康人外周血CD11c+树突状细胞(DC1)、CD123+树突状细胞(DC2)亚群的数量。以上29例患者按1mg/kg.d... 详细信息

目的探讨特发性血小板减少性紫癜(ITP)患者外周血树突状细胞(DC)亚群的变化及其临床意义。方法用流式细胞技术检测29例初治ITP患者及15例健康人外周血CD11c+树突状细胞(DC1)、CD123+树突状细胞(DC2)亚群的数量。以上29例患者按1mg/kg.d的泼尼松常规治疗两周,分析ITP患者外周血树突状细胞亚群数量变化与短期疗效的相关性。结果与正常对照组比较,29例ITP患者外周血CD123+DC比例及绝对数有明显降低(P0.05)。29例ITP患者中经泼尼松常规治疗两周后有效的患者有16例,无效的有13例,将这两组治疗前的外周血DC亚群与健康对照组比较发现,有效组的CD123+DC有明显下降(P0.05)。而无效组CD123+DC及CD11c+DC均无明显差异(P>0.05)。结论树突状细胞亚群的异常可能与部分ITP的发病有关。DC2下降的ITP患者经糖皮质激素治疗后的短期疗效可能更好。

关键词：特发性血小板减少性紫癜树突状细胞亚群

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VcR-CAP方案治疗初治性套细胞淋巴瘤138例

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中国新药与临床杂志 2017年第9期36卷 525-529页

作者：肖仕珊周昌娟朱红倩贵州省人民医院血液内科贵州贵阳550002

目的研究Vc R-CAP方案(硼替佐米+利妥昔单抗+环磷酰胺+多柔比星+泼尼松)治疗初治性套细胞淋巴瘤(MCL)的临床疗效及不良反应。方法初治性MCL患者138例,根据套细胞淋巴瘤国际预后指数(MIPI)评分分为低危组、中危组和高危组。给予Vc R-CAP... 详细信息

目的研究Vc R-CAP方案(硼替佐米+利妥昔单抗+环磷酰胺+多柔比星+泼尼松)治疗初治性套细胞淋巴瘤(MCL)的临床疗效及不良反应。方法初治性MCL患者138例,根据套细胞淋巴瘤国际预后指数(MIPI)评分分为低危组、中危组和高危组。给予Vc R-CAP方案治疗,每疗程21 d,利妥昔单抗375 mg·m^(-2)(第1日),环磷酰胺750 mg·m^(-2)(第1日),多柔比星50 mg·m^(-2)(第1日),泼尼松100 mg·m^(-2)(第1~5日),硼替佐米1.3 mg·m^(-2)(第1、4、8、11日),共6个疗程。评价临床疗效,进行临床特征与生存分析,观察不良反应。结果低危组总有效率为70%(47/67),中危组为50%(21/42),高危组为34%(10/29)。年龄≥60岁、Ann Arbor分期Ⅲ~Ⅳ期、出现侵袭及乳酸脱氢酶升高的患者无进展生存期和总生存期较年龄<60岁、Ann Arbor分期Ⅰ~Ⅱ期、无侵袭及乳酸脱氢酶正常的患者短,低危组、中危组、高危组的生存期存在显著差异(均P<0.05)。化疗引起的不良反应以贫血、血小板减少、中性粒细胞减少、恶心/呕吐为主,程度以1~2级为主,未影响治疗进展。结论 Vc R-CAP方案对初治性MCL患者安全有效。

关键词：硼替佐米利妥昔单抗抗肿瘤联合化疗方案套细胞淋巴瘤

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调控A20对NF-κB表达及Jurkat细胞的影响

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中国实验血液学杂志 2020年第4期28卷 1144-1151页

作者：王哲肖仕珊丁倩王清周胜楠李哲朱红倩贵州省人民医院血液科贵州贵阳550002

目的:探讨在急性T淋巴细胞白血病糖皮质激素耐药Jurkat细胞株中,调控A20对NF-κB表达以及Jurkat细胞生物学特性的影响。方法:CCRF CEM和Jurkat细胞中分别加入100、10、1、0.1、0.01和0.001μmol/L地塞米松(DEX),培养24、48和72 h,应用CC... 详细信息

目的:探讨在急性T淋巴细胞白血病糖皮质激素耐药Jurkat细胞株中,调控A20对NF-κB表达以及Jurkat细胞生物学特性的影响。方法:CCRF CEM和Jurkat细胞中分别加入100、10、1、0.1、0.01和0.001μmol/L地塞米松(DEX),培养24、48和72 h,应用CCK-8检测细胞增殖抑制的变化。构建A20质粒,设计并合成A20-siRNA,分别通过脂质体转染Jurkat细胞,CCK-8检测不同浓度DEX处理组、不同浓度DEX联合A20质粒和A20-siRNA处理组的Jurkat细胞增殖率。应用RT-qPCR检测NF-κB的m RNA表达水平,Western bolt检测蛋白表达水平,采用流式细胞术检测Jurkat细胞凋亡。结果:不同浓度地塞米松(DEX)对CCRF CEM细胞生长的抑制作用呈显著的时间依赖性(r=0.984,P0.05)。结论:Jurkat细胞对DEX耐药,A20过表达联合DEX可增加对DEX耐药细胞的敏感性,降低Jurkat细胞增殖率;下调Jurkat细胞中NF-κB的表达水平,促进Jurkat细胞的凋亡。

关键词： A20 NF-κB T淋巴细胞白血病耐药 RNA干扰

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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu xiao-Li Li xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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