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Association of serum gamma-glutamyl transferase with treatment outcome in chronic hepatitis B patients

World Journal of Gastroenterology 2015年第34期21卷 9957-9965页

作者： Rui Huang Chen-Chen Yang Yong Liu Juan Xia Ran Su Ya-Li Xiong Gui-Yang Wang Zhen-Hua Sun xiao-Min Yan shan Lu Chao Wu Department of Infectious Diseases Nanjing Drum Tower HospitalNanjing University Medical School Department of Infectious Diseases Qidong People’s Hospital Department of Laboratory Medicine Nanjing Drum Tower HospitalNanjing University Medical School Department of Medicine University of Massachusetts Medical School

AIM:To investigate the association of serum gammaglutamyl transferase(GGT) levels with chronic hepatitis B infection and hepatitis B e antigen(HBe Ag) ***:A retrospective study was performed on clinical data collected from patients who had been positive for hepatitis B surface antigen for > 6 mo and who were antiviral-treatment na?ve(n = 215) attending the Hepatitis Clinic at Nanjing Drum Tower Hospital between August 2010 and December 2013. Healthy individuals without liver disease(n = 83) were included as controls. Patients were categorized into four groups based on disease status as recommended by the European Association for the Study of the Liver:immune tolerance(IT; n = 47),HBe Ag-positive hepatitis(EPH; n = 93),HBe Ag-negative hepatitis(ENH;n = 20),and inactive carrier(IC; n = 55). Prediction of complete response(CR) based on serum GGT was also examined in EPH patients(n = 33) treated for 48 wk with nucleos(t)ide analogue(NA) therapy,including lamivudine plus adefovir combination therapy(n = 20) or entecavir monotherapy(n = 13). CR was defined as a serum hepatitis B virus DNA level < 500 copies/m L and HBe Ag seroconversion by 48 wk of treatment. RESULTS:Serum GGT levels were significantly increased in EPH and ENH patients relative to the IT,IC,and healthy control groups(P < 0.01 for all). However,no significant difference in serum GGT levels was found between the EPH and ENH groups. Baseline serum GGT levels were significantly higher in patients who achieved CR(7/33; 21.2%) compared to patients in the non-CR group(26/33; 78.8%; P = 0.011). In addition,the decline in serum GGT was greater in CR patients compared to non-CR patients after 24 wk and 48 wk of treatment(P = 0.012 and P = 0.008,respectively). The receiver operating characteristic curve yielded a sensitivity of 85.71% and a specificity of 61.54% at a threshold value of 0.89 times the upper limit of normal for baseline serum GGT in the prediction of CR following NA therapy. CONCLUS

关键词： Gamma-glutamyl transferase Hepatitis B e antigen H

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移植排斥反应中趋化因子及其受体表达的研究进展

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第二军医大学学报 2007年第6期28卷 659-661页

作者：肖亮傅宏丁国善第二军医大学长征医院器官移植科肝移植部上海200003

器官移植术后急、慢性排斥反应是导致移植物功能丧失的重要原因之一。趋化因子在器官移植早期表达异常活跃.它们特异性募集T细胞和抗原提呈细胞到移植组织内,激发并加剧炎症发展,致使移植物功能损害。因此.动态监测趋化因子及其受体的... 详细信息

器官移植术后急、慢性排斥反应是导致移植物功能丧失的重要原因之一。趋化因子在器官移植早期表达异常活跃.它们特异性募集T细胞和抗原提呈细胞到移植组织内,激发并加剧炎症发展,致使移植物功能损害。因此.动态监测趋化因子及其受体的表达状况可成为判断急、慢性排斥反应发生的重要依据;筛选出一个或多个特异性趋化因子或受体作为抗排斥治疗的新靶点对提高器官移植术后疗效有很重要的意义。本文就近年来这一领域的研究进展作一综述。

关键词：趋化因子类受体趋化因子器官移植移植物排斥

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Geographical characteristics of China’s wetlands derived from remotely sensed data

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Science China Earth Sciences 2009年第6期52卷 723-738页

作者： NIU Zhenguo GONG Peng CHENG xiao guo JianHong WANG Lin HUANG HuaBing SHEN ShaoQing WU YunZhao WANG xiaoFeng WANG XianWei YING Qing LIANG Lu ZHANG LiNa WANG Lei YAO Qian YANG ZhenZhong guo ZiQi DAI YongJiu State Key Laboratory of Remote Sensing Science Jointly Sponsored by Institute of Remote Sensing ApplicationsChinese Academy of Sciencesand Beijing Normal UniversityBeijing 100101China School of Geography Beijing Normal UniversityBeijing 100875China

In this paper, we report the first wetland mapping of the entire China using Landsat enhanced thematic mapper plus (ETM+) data. These data were obtained from the Global Land Cover Facility at the University of Maryland spanning from 1999 to 2002. A total of 597 scenes of Landsat images were georeferenced and mosaiced. Manual image interpretation of satellite images was aided with elevation data, soil data, land cover/land use data and Google Earth. The minimum mapping unit is 10 pixel × 10 pixel, equivalent to 9 ha. The aim of our first round of mapping was only targeted at the boundary delineation of any type of wetland except those wetlands that are under agricultural use (i.e., paddy fields), which has already been well mapped by others. Our interpretation results indicate that a total of 359478 km2 of wetlands are of non-agricultural use. Among our preliminarily mapped wetland, 339353 km2 are inland wetland, 2786 km2 are non-agricultural artificial wetland, and 17609 km2 are coastal wetland. Because low-tide is rarely captured in satellite images, an under-estimation of coastal wetland is inevitable. We conducted some statistics based on our mapped wetlands and compared them with those previously obtained from a number of sources including a land cover/land use map made with satellite images during the late 1990s and early 2000s, a marshland map developed in approximately the same period, survey data of coastal wetland in early 1980s, and area data for approximately 400 larger patches of marshland in China compiled in 1996. Because some inconsistencies exist in the guidelines of those different wetland surveys, difference in area is expected. Some further comparison indicates that the wetland distributions derived from the preliminary wetland map are reasonable and more objective than other sources. The mapping process also indicated that the method adopted by us was efficient and cost-effective. We also found that in order to ensure comparability of the wetland

关键词： China wetlands remote sensing wetland mapping

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Global antimicrobial resistance:a system-wide comprehensive investigation using the Global One Health Index

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Infectious Diseases of Poverty 2022年第4期11卷 94-95页

作者： Nan Zhou Zile Cheng xiaoxi Zhang Chao Lv Chaoyi guo Haodong Liu Ke Dong Yan Zhang Chang Liu Yunfu Chang Sheng Chen xiaokui guo xiao-Nong Zhou Min Li Yongzhang Zhu Department of Animal Health and Food Safety School of Global HealthChinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghai 200025China 不详

Background:Antimicrobial resistance(AMR)is one of the top ten global public health ***,given the lack of a comprehensive assessment of worldwide AMR status,our objective is to develop a One Health-based system-wide evaluation tool on global ***:We have further developed the three-hierarchical Global One Health Index(GOHI)-AMR indicator scheme,which consists of five key indicators,17 indicators,and 49 sub-indicators,by incorporating 146 countries'data from diverse authoritative databases,including WHO's Global Antimicrobial Resistance and Use Surveillance System(GLASS)and the European *** investigated the overall-or sub-rankings of GOHI-AMR at the international/regional/national levels for data preprocessing and score calculation utilizing the existing GOHI ***,a correlation analysis was conducted between the GOHI-AMR and other socioeconomic ***:The average GOHI-AMR score for 146 countries is *** expected,high-income countries(HICs)outperform the other three income groups on overall rankings and all five key indicators of GOHI-AMR,whereas lowincome countries unexpectedly outperform upper-middle-income countries and lower-middle-income countries on the antibiotics-resistant key indicator(ARR)and ARR-subordinate indicators,including carbapenem-,β-lactam-,and quinolone resistance,and even HICs on aminoglycoside *** were no significant differences among the four groups on the environmental-monitoring indicator(P>0.05).GOHI-AMR was positively correlated with gross domestic product,life expectancy,and AMR-related publications,but negatively with natural growth rate and chronic respiratory *** contrast to Cyprus,the remarkably lower prevalence of"ESKAPE pathogens"in high-scoring Sweden and Denmark highlights Europe's huge *** and Russia outperformed the other three BRICS countries on all key indicators,particularly India's ARR and Brazil's AMR laboratory network and coordination capac

关键词： Global antimicrobial resistance Global One Health Index Antimicrobial resistance surveillance networks

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Compound heterozygous p.L483P and p.S310G mutations in GBA1 cause type 1 adult Gaucher disease:A case report

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World Journal of Clinical Cases 2022年第36期10卷 13426-13434页

作者： xiao-Ling Wen Yao-Zi Wang Xia-Lin Zhang Jia-Qiang Tu Zhi-Juan Zhang Xia-Xia Liu Hai-Yan Lu guo-Ping Hao xiao-Huan Wang Lin-Hua Yang Rui-Juan Zhang Department of Hematology The First People’s Hospital of YibinYibin 644000Sichuan ProvinceChina Department of Hematology The Second Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Hematology The Third Hospital of Shanxi Medical UniversityThe Shanxi Bethune HospitalThe Shanxi Academy of Medical SciencesThe Tongji Shanxi HospitalThe Shanxi Medical UniversityTaiyuan 030032Shanxi ProvinceChina Department of Hematology The Children’s Hospital of ShanxiTaiyuan 030006Shanxi ProvinceChina

BACKGROUND Gaucher disease(GD)is caused by a GBA1 gene mutation that leads to decreased acidβ-glucosidase activity[glucocerebrosidase(GCase)].This study aimed to identify and characterise compound heterozygous mutations in GBA1 in a patient with type 1 *** SUMMARY Here,we report a rare adult-onset type 1 GD in a 46-year-old female patient with clinical manifestations of giant spleen,thrombocytopenia,and bone pain,diagnosed by enzymatic and genetic *** and whole exome sequencing revealed heterozygous missense mutations in exon 10 c.1448T>C(p.L483P)and exon 7 c.928A>G(p.S310G)of *** latter was first reported in patients with *** modelling showed that p.S310G and p.L483P were distant from the GCase active *** p.S310G mutation in domain 1 may decrease stability between theα2 andα3 helices of *** p.L483P mutation in domain 2 reduced the van der Waals force of the side chain and disrupted the C-terminalβ-*** patient was treated with imiglucerase replacement therapy,and her condition was *** The p.L483P/p.S310G novel compound heterozygous mutation underlies type 1 GD and likely affects GCase protein *** is the first description of p.S310G being associated with mild type 1 GD in the context of a coinherited p.L483P mutation.

关键词： Gaucher disease Parkinson’s disease Lipid metabolism Molecular mechanism Case report

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Growth inhibitory effect of 4-phenyl butyric acid on human gastric cancer cells is associated with cell cycle arrest

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World Journal of Gastroenterology 2012年第1期18卷 79-83页

作者： Long-Zhu Li Hong-Xia Deng Wen-Zhu Lou Xue-Yan Sun Meng-Wan Song Jing Tao Bing-Xiu xiao Jun-Ming guo Department of Biochemistry and Molecular Biology NingboUniversity School of Medicine Ningbo 315211 Zhejiang Prov-ince China Li LZ performed the research and draft-ed the paper Deng HX Lou WZ Sun XY Song MW and Tao Jassisted in the research and revision of the paper xiao BX pro-vided advice regarding the performance of the research guo JMdesigned the research and revised and contributed to the writingof the paper.

AIM: To investigate the growth effects of 4-phenyl butyric acid (PBA) on human gastric carcinoma cells and their mechanisms. METHODS: Moderately-differentiated human gastric carcinoma SGC-7901 and lowly-differentiated MGC-803 cells were treated with 5, 10, 20, 40, and 60 μmol/L PBA for 1-4 d. Cell proliferation was detected using the MTT colorimetric assay. Cell cycle distributions were examined using flow ***: The proliferation of gastric carcinoma cells was inhibited by PBA in a doseand time-dependent fashion. Flow cytometry showed that SGC-7901 cells treated with low concentrations of PBA were arrested at the G0/G1 phase, whereas cells treated with high concentrations of PBA were arrested at the G2/M phase. Although MGC-803 cells treated with low concentrations of PBA were also arrested at the G0/G1 phase, cells treated with high concentrations of PBA were arrested at the S phase. CONCLUSION: The growth inhibitory effect of PBA on gastric cancer cells is associated with alteration of the cell cycle. For moderately-differentiated gastric cancer cells, the cell cycle was arrested at the G0/G1 and G2/M phases. For lowly-differentiated gastric cancer cells, the cell cycle was arrested at the G0/G1 and S phases.

关键词： Histone deacetylase inhibitor 4-phenyl butyric acid Gastric carcinoma Anticancer effect Cell cycle MGC-803 SGC-7901

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Genetic variability in serine/threonine kinase 11(STK11) is associated with the risk of coronary artery disease in type 2 diabetes in a Chinese Han population

Genetic variability in serine/threonine kinase 11(STK11) is ...

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中华医学会糖尿病学分会第十六次全国学术会议

作者： BAI Ge MA xiao-wei HUANG Lin-juan ZHANG Jian-wei DENG Rui-fen DING shan GU Nan guo xiao-hui Peking University First Hospital Beijing Hospital

Objective Recent studies indicated that the LKB 1 is a key regulator of the AMP-activated protein kinase (AMPK),which plays a crucial role in protecting cardiac muscle from damage during *** study aimed to investigate whether genetic variations in the STK 11 gene encoding LKBl affect the risk of coronary artery disease

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Kinetics and fractionation of hydrogen isotopes during gas formation from representative functional groups

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Petroleum Science 2021年第4期18卷 1021-1032页

作者： Shuang-Fang Lu guo-Qi Feng Ming-Li Shao Ji-Jun Li Hai-Tao Xue Min Wang Fang-Wen Chen Wen-Biao Li xiao-Ting Pang aResearch Institute of Unconventional Oil&Gas and New Energy China University of PetroleumQingdaoShandong 266580China Exploitation and Development Research Institude of Jilin Oilfield Company CNPCSongyuanJilin138000China

A gold tube simulation device was used to study the cleavage of representative compounds into *** goal of this study is to investigate hydrogen isotope composition change of gaseous hydrocarbons during *** chromatography and isotopic analyses were conducted to determine how the yield of natural gas components and their hydrogen isotopic composition were related to experimental temperature and heating rate.A chemical kinetic model for the generation of each component of the natural gas and for the hydrogen isotopic fractionation was established and calibrated based on the *** indicate that the hydrogen isotopic fractionation during the evolution of various gas-forming organic materials can be satisfactorily described by chemical kinetic *** regular methane generation,the reactions at low-activation-energy region had a greater contribution than the high-activation-energy *** the reactions with high-activation-energy region had greater contribution of deuterium-rich *** with carbon isotope fractionation,this results in a greater hydrogen isotopic fractionation,which is more sensitive to changes in *** study lays a foundation for further investigations of genesis and maturity of natural gas provided by hydrogen isotopic *** also provides fundamental knowledge for investigating the filling history of natural gas reservoir and for identifying.

关键词： Gas-forming compounds Pyrolysis Hydrogen isotopes Fractionation Chemical kinetics

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Melatonin attenuates radiation-induced cortical bone-derived stem cells injury and enhances bone repair in postradiation femoral defect model

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Military Medical Research 2022年第3期9卷 319-330页

作者： Wei Hu Jia-Wu Liang Song Liao Zhi-Dong Zhao Yu-Xing Wang xiao-Fei Mao Si-Wei Hao Yi-Fan Wang Heng Zhu Bin guo Medical School of Chinese People’s Liberation Army(PLA) Beijing100853China Department of Stomatology the First Medical CentreChinese PLA General HospitalBeijing100853China Beijing Key Laboratory for Radiobiology Beijing Institute of Radiation MedicineBeijing100840China

Background:The healing of bone defects can be challenging for clinicians to manage,especially after exposure to ionizing *** this regard,radiation therapy and accidental exposure to gamma(o inhibit bone formation and increase the risk of *** bone-derivγ)-ray radiation have been shown ted stem cells(CBSCs)are reportedly essential for osteogenic lineages,bone maintenance and *** study aimed to investigate the effects of melatonin on postradiation CBSCs and bone defect ***:CBSCs were extracted from C57BL/6 mice and were identified by flow *** CBSCs were subjected to 6 Gyγ-ray radiation followed by treatment with various concentrations of *** effects of exogenous melatonin on the self-renewal and osteogenic capacity of postradiation CBSCs in vitro were *** underlying mechanisms involved in genomic stability,apoptosis and oxidative stress-related signaling were further analyzed by Western blotting,flow cytometry and immunofluorescence ***,postradiation femoral defect models were established and treated with Matrigel and *** effects of melatonin on postradiation bone healing in vivo were evaluated by micro-CT and pathological ***:The decrease in radiation-induced self-renewal and osteogenic capacity were partially reversed in postradiation CBSCs treated with melatonin(P<0.05).Melatonin maintained genomic stability,reduced postradiation CBSC apoptosis and intracellular oxidative stress,and enhanced expression of antioxidant-related enzymes(P<0.05).Western blotting validated the anti-inflammatory effects of melatonin by downregulating interleukin-6(IL-6)and tumor necrosis factor alpha(TNF-α)levels via the extracellular regulated kinase(ERK)/nuclear factor erythroid 2-related factor 2(NRF2)/heme oxygenase-1(HO-1)signaling *** was also found to exhibit antioxidant effects via NRF2 *** vivo experiments demonstrated that the newly formed bone in th

关键词： Melatonin Stem cells Ionizing radiation Bone regeneration

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Jiedu Recipe,a compound Chinese herbal medicine,inhibits cancer stemness in hepatocellular carcinoma via Wnt/β-catenin pathway under hypoxia

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Journal of Integrative Medicine 2023年第5期21卷 474-486页

作者： Bing-jie guo Yi Ruan Ya-jing Wang Chu-lan xiao Zhi-peng Zhong Bin-bin Cheng Juan Du Bai Li Wei Gu Zi-fei Yin School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China Department of Gastroenterology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200433China PLA Naval Medical Center Shanghai 200052China Department of Traditional Chinese Medicine the 920th Hospital of Joint Logistics Support ForceKunming 650000Yunan ProvinceChina Department of Rehabilitation Changhai HospitalNaval Medical UniversityShanghai 200433China

Objective Jiedu Recipe(JR),a Chinese herbal remedy,has been shown to prolong overall survival time and decrease recurrence and metastasis rates in patients with hepatocellular carcinoma(HCC).This work investigated the mechanism of JR in HCC *** The chemical constituents of JR were detected using liquid chromatography-mass *** potential anti-HCC mechanism of JR was screened using network pharmacology and messenger ribonucleic acid(mRNA)microarray chip assay,followed by experimental validation in human HCC cells(SMMC-7721 and Huh7)in vitro and a nude mouse subcutaneous transplantation model of HCC in *** cell characteristics of proliferation,migration and invasion under hypoxic setting were investigated using thiazolyl blue tetrazolium bromide,wound healing and Transwell assays,***-i^(TM)Hypoxia Reagent was added to reveal hypoxic *** cell sphere formation assay was used to detect the ***-mesenchymal transition(EMT)markers like E-cadherin,vimentin andα-smooth muscle actin,and pluripotent transcription factors including nanog homeobox,octamer-binding transcription factor 4,and sex-determining region Y box protein 2 were analyzed using Western blotting and real-time polymerase chain *** blot was performed to ascertain the anti-HCC effect of JR under hypoxia involving the Wnt/β-catenin *** According to network pharmacology and mRNA microarray chip analysis,JR may potentially act on hypoxia and inhibit the Wnt/β-catenin *** vitro and in vivo experiments showed that JR significantly decreased hypoxia,and suppressed HCC cell features of proliferation,migration and invasion;furthermore,the hypoxia-induced increases in EMT and stemness marker expression in HCC cells were inhibited by *** based on the co-administration of JR and an agonist(LiCl)or inhibitor(IWR-1-endo)verified that JR suppressed HCC cancer stem-like properties under hypoxia by blocking the Wnt/β-ca

关键词： Jiedu Recipe Chinese medicine Hepatocellular carcinoma Hypoxia Cancer stemness Wnt/β-cateninpathway

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