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All-optical Quantitative Framework for Bioluminescence Tomography with Non-contact Measurement

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International Journal of Automation and computing 2012年第1期9卷 72-80页

作者： Xue-Li Chen Heng Zhao xiao-Chao Qu Duo-Fang Chen xiao-rui wang Ji-Min Liang Life Sciences Research Center School of Life Sciences and Technology Xidian University Xi＇an 710071 PRC School of Technical Physics Xidian University Xi＇an 710071 PRC

In this contribution, we present an all-optical quantitative framework for bioluminescence tomography with non-contact measurement. The framework is comprised of four indispensable steps： extraction of the geometrical structures of the subject, light flux reconstruction on arbitrary surface, calibration and quantification of the surface light flux and internal bioluminescence reconstruction. In particular, the geometrical structures are retrieved using a completely optical method and captured under identical viewing conditions with the bioluminescent images. As a result, the proposed framework avoids the utilization of computed tomography or magnetic resonance imaging to provide the geometrical structures. On the basis of experimental measurements, we evaluate the performance of the proposed all-optical quantitative framework using a mouse shaped phantom. Preliminary result reveals the potential and feasibility of the proposed framework for bioluminescence tomography.

关键词： All-optical biol tomography quantitative framework non-contact surface extraction.

Electronic Structure and Chemical Bond of Titanium Diboride

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Journal of Wuhan University of Technology(Materials Science) 2003年第2期18卷 11-14页

作者：闵新民 Wuhan University of Technology

Titanium diboride was calculated by the density function and discrete variational (DFT-DVM) method to study the relation between structure and *** and its first-nearest boron atoms form a strong covalent bond,so TiB 2 has high melting point,hardness and chemical *** atom releases two electrons to form Ti 2+ ions,and a boron atom gets one electron to come into B- ion.B- takes the sp2 hybrid and forms σ bonds to link other boron atoms in the same *** other one 2p z orbital of every B- ion in the same layer interacts each other to form the π molecular orbital,so TiB 2 has fine electrical *** calculated density of state is close to the result of XPS experiment of TiB *** Ti3d and B2p atomic orbitals contribute the total DOS near the Fermi level.

关键词： titanium diboride property calculation electronic structure chemical bond

Comparison of healing patterns of different side-cut angulations after FS-LASIK

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International Journal of Ophthalmology(English edition) 2021年第3期14卷 430-435页

作者： Wei Wei Xi-Yu Sun Di Shen xiao-rui wang Yu-Qiang Ji Chang-Ning Zhang Xi'an No.1 Hospital Shaanxi Institute of OphthalmologyShaanxi Key Laboratory of OphthalmologyClinical Research Center for Ophthalmology Diseases of Shaanxi ProvinceFirst Affliliated Hospital of Northwestem UniversityXi'an 710002Shaanxi ProvinceChina

AIM: To investigate and evaluate healing patterns around flaps made with different side-cut angulations after femtosecond laser in situ keratomileusis(FS-LASIK).METHODS: Thirty-four patients(68 eyes) received a 90° side-cut(n=34) or a 120° side-cut flaps(n=34) made with a femtosecond laser. One day, 1 wk, 1 and 3 mo postoperatively, side-cut scar was evaluated under slit-lamp photography according to a new grading system(Grade 0=transparent scar, 1=faint healing opacity, and 2=evident healing opacity). In vivo corneal confocal microscopy and anterior segment optical coherence tomography(AS-OCT) were used to observe wound-healing patterns around flap margin in the two groups. Sirius Scheimpflug Analyzer was also used to analyze higher order aberrations 3 mo after ***: There were no significant differences in flap wound-healing patterns at each follow up between the two groups(P>0.05). Three months after surgery, the flap edge scar classified as Grade 0 had excellent apposition and rapid nerve regeneration. At 3 mm and 5 mm pupil diameters, there were significant differences in trefoil aberrations between the two groups(P0.05).CONCLUSION: Flap edge scars classified as Grade 0 have excellent apposition and rapid nerve regeneration, and 120° side-cut angle flaps induce less trefoil aberrations after FS-LASIK.

关键词： femtosecond laser side-cut confocal microscopy scar healing

Combination of fruquintinib with venetoclax for the treatment of colorectal cancer

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Oncology research 2025年第1期33卷 225-234页

作者： Wei Zhang Weicheng wang rui wang xiao Han Lijun Zhu Wenjie Guo Yanhong Gu Department of Oncology The First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China. Department of Oncology The Affiliated Taizhou People's Hospital of Nanjing Medical University Taizhou 225300 China. State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University Nanjing 210023 China.

Background:As a novel blocker of vascular endothelial growth factor receptor (VEGFR), fruquintinib has been approved for treating colorectal cancer (CRC). However, its dosage and therapeutic efficacy are limited by its widespread adverse reactions. Venetoclax, recognized as the initial inhibitor of B-cell lymphoma protein 2 (BCL2), has shown potential in boosting the effectiveness of immunotherapy against CRC. This study investigated the efficacy and mechanisms of fruquintinib combined with venetoclax in treating CRC.Methods and Materials:We developed a colon cancer mouse model with the CT26 colon cell line to demonstrate fruquintinib and venetoclax's efficacy against tumors. Then we employed various techniques to evaluate different aspects of the experimental outcomes. Immunohistochemistry was used to detect cell proliferation and angiogenesis in tumor tissues. Western blot analysis was utilized to examine the occurrence of cell apoptosis, and flow cytometry to quantitate immune cells within the tumor tissues. Moreover, immunofluorescence was employed to measure cytokine levels.Results:The strongest inhibition on tumor growth was achieved by the combination of fruquintinib with venetoclax, as opposed to individual drug use. Venetoclax was found to amplify the impact of fruquintinib, leading to decreased cancer cell proliferation, increased cancer cell apoptosis, lowered angiogenesis, better vascular structure normalization, and improved immune cell infiltration.Conclusion:Our findings indicate that the addition of venetoclax enhances the impact of fruquintinib on vascular normalization and modulation of the tumor immune microenvironment. Our study presents the justification for utilizing the fruquintinib and venetoclax combination in treating CRC. Venetoclax holds promise in being assimilated into anticancer medications for CRC.

关键词： Anti-angiogenesis B-cell lymphoma protein 2 (BCL2) Colorectal cancer (CRC) Fruquintinib Immunotherapy Vascular endothelial growth factor receptor (VEGFR) Venetoclax

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基于多智能体模拟的流行病消息传播研究

系统仿真学报 2008年第23期20卷 6511-6513,6518页

作者：龚晓光王瑞瑞华中科技大学管理学院武汉430074

设计了并实现了消息传播多智能体模拟模型(ENS),研究了个人的社会联系数量、对流行病消息的信任度和传播网络结构对流行病消息传播的影响。研究发现,随着社会联系数量的增加,流行病消息传播速度迅速增加,而直接听到消息的比例减少;随着... 详细信息

设计了并实现了消息传播多智能体模拟模型(ENS),研究了个人的社会联系数量、对流行病消息的信任度和传播网络结构对流行病消息传播的影响。研究发现,随着社会联系数量的增加,流行病消息传播速度迅速增加,而直接听到消息的比例减少;随着信任度的增加,流行病消息的传播速度迅速增加,而直接听到消息的比例变化不显著;在小世界网络结构下,流行病消息的传播和遗忘速度比随机网络中慢。

关键词：多智能体模拟信息传播小世界网络流行病

Electrochemical conversion of methane to bridge the gap in the artificial carbon cycle

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Journal of Energy Chemistry 2025年第1期100卷 286-308页

作者： Yuhao Peng Yuefeng Song Ihar Razanau Juanxiu xiao Wei xiao Di Hu Guoxiong wang College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power Sources Wuhan University State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Dalian Institute of Chemical Physics Chinese Academy of Sciences Laboratory of Physical-Chemical Technologies SSPA Scientific and Practical Materials Research Centre of NAS of Belarus State Key Laboratory of Marine Resources Utilization in South China Sea Collaborative Innovation Center of Marine Science and Technology School of Marine Science and Engineering Hainan University Department of Chemical and Environmental Engineering University of Nottingham Ningbo China

Methane, an abundant one-carbon（C1） resource, is extensively used in the industrial production of vital fuels and value-added chemicals. However, current industrial methane conversion technologies are energy-and carbon-intensive, mainly due to the high activation energy required to break the inert C–H bond, low selectivity, and problematic side reactions, including CO2emissions and coke deposition. Electrochemical conversion of methane（ECM） using intermittent renewable energy offers an attractive solution, due to its modular reactor design and operational flexibility across a broad spectrum of temperatures and pressures. This review emphasizes conversion pathways of methane in various reaction systems, highlighting the significance and advantages of ECM in facilitating a sustainable artificial carbon cycle. This work provides a comprehensive overview of conventional methane activation mechanisms and delineates the complete pathways of methane conversion in electrolysis contexts. Based on surface/interface chemistry, this work systematically analyzes proposed reaction pathways and corresponding strategies to enhance ECM efficiency towards various target products, including syngas, hydrocarbons, oxygenates, and advanced carbon materials. The discussion also encompasses opportunities and challenges for the ECM process, including insights into ECM pathways, rational electrocatalyst design, establishment of benchmarking protocols, electrolyte engineering, enhancement of CH4conversion rates, and minimization of CO2emission.

关键词： Activation energy

Intelligent optimization of the structure of the large section highway tunnel based on improved immune genetic algorithm

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Journal of Pharmaceutical Analysis 2009年第3期21卷 163-166页

作者： Hai-tao Bo1,xiao-feng Jia2,xiao-rui wang11.School of Civil Engineering and Mechanics,Huazhong University of Science and Technology, Wuhan 430074 2.Department of Chemistry and Bioengineering,Nanyang Institute of Technology,Nanyang 473004,China. School of Civil Engineering and Mechanics Huazhong University of Science and Technology Wuhan 430074 China Department of Chemistry and Bioengineering Nanyang Institute of Technology Nanyang 473004 China

As in the building of deep buried long tunnels,there are complicated conditions such as great deformation,high stress,multi-variables,high non-linearity and so on,the algorithm for structure optimization and its application in tunnel engineering are still in the starting stage. Along with the rapid development of highways across the country,it has become a very urgent task to be tackled to carry out the optimization design of the structure of the section of the tunnel to lessen excavation workload and to reinforce the support. Artificial intelligence demonstrates an extremely strong capability of identifying,expressing and disposing such kind of multiple variables and complicated non-linear relations. In this paper,a comprehensive consideration of the strategy of the selection and updating of the concentration and adaptability of the immune algorithm is made to replace the selection mode in the original genetic algorithm which depends simply on the adaptability value. Such an algorithm has the advantages of both the immune algorithm and the genetic algorithm,thus serving the purpose of not only enhancing the individual adaptability but maintaining the individual diversity as well. By use of the identifying function of the antigen memory,the global search capability of the immune genetic algorithm is raised,thereby avoiding the occurrence of the premature phenomenon. By optimizing the structure of the section of the Huayuan tunnel,the current excavation area and support design are adjusted. A conclusion with applicable value is arrived at. At a higher computational speed and a higher efficiency,the current method is verified to have advantages in the optimization computation of the tunnel project. This also suggests that the application of the immune genetic algorithm has a practical significance to the stability assessment and informationization design of the wall rock of the tunnel.

关键词： immune genetic algorithm tunnel super-large section optimization

Intelligent direct analysis of physical and mechanical parameters of tunnel surrounding rock based on adaptive immunity algorithm and BP neural network

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Journal of Pharmaceutical Analysis 2009年第1期21卷 22-30页

作者： xiao-rui wang1,2, Yuan-han wang1, xiao-feng Jia31.School of Civil Engineering and Mechanics,Huazhong University of Science and Technology, Wuhan 430074,China 2.Department of Civil Engineering,Nanyang Institute of Technology,Nanyang 473004,China 3.Department of Chemistry and Bioengineering,Nanyang Institute of Technology,Nanyang 473004,China. School of Civil Engineering and Mechanics Huazhong University of Science and Technology Wuhan 430074 China Department of Civil Engineering Nanyang Institute of Technology Nanyang 473004 China Department of Chemistry and Bioengineering Nanyang Institute of Technology Nanyang 473004 China

Because of complexity and non-predictability of the tunnel surrounding rock, the problem with the determination of the physical and mechanical parameters of the surrounding rock has become a main obstacle to theoretical research and numerical analysis in tunnel engineering. During design, it is a frequent practice, therefore, to give recommended values by analog based on experience. It is a key point in current research to make use of the displacement back analytic method to comparatively accurately determine the parameters of the surrounding rock whereas artificial intelligence possesses an exceptionally strong capability of identifying, expressing and coping with such complex non-linear relationships. The parameters can be verified by searching the optimal network structure, using back analysis on measured data to search optimal parameters and performing direct computation of the obtained results. In the current paper, the direct analysis is performed with the biological emulation system and the software of Fast Lagrangian Analysis of Continua (FLAC3D. The high non-linearity, network reasoning and coupling ability of the neural network are employed. The output vector required of the training of the neural network is obtained with the numerical analysis software. And the overall space search is conducted by employing the Adaptive Immunity Algorithm. As a result, we are able to avoid the shortcoming that multiple parameters and optimized parameters are easy to fall into a local extremum. At the same time, the computing speed and efficiency are increased as well. Further, in the paper satisfactory conclusions are arrived at through the intelligent direct-back analysis on the monitored and measured data at the Erdaoya tunneling project. The results show that the physical and mechanical parameters obtained by the intelligent direct-back analysis proposed in the current paper have effectively improved the recommended values in the original prospecting data. This is of p

关键词： adaptive immunity algorithm BP neural network physical and mechanical parameters surrounding rock direct-back analysis

Efficacy of Pudilan xiaoyan Oral Liquid in the treatment of pneumonia induced by drug-resistant Pseudomonas aeruginosa

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Infectious Diseases Research 2024年第3期5卷 22-29页

作者： Jing Ma Yan-Yan Bao xiao-rui wang Kuok Kuantai Leong-Man Chon xiao-Lan Cui Ju-Ying Zhong Yu-Jing Shi Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Conde S.Januário Hospital(CHCSJ) pharmacy departmentMacao 999078China Lin Fong Charities Traditional Chinese Medicine Treatment Centre Macao 999078China Experimental Research Center China Academy of Chinese Medical SciencesBeijing 100700China

Background:Pudilan xiaoyan Oral Liquid(PDL)is a Chinese patent medicine with notable pharmacological properties,including anti-inflammatory and antibacterial ***-resistant Pseudomonas aeruginosa infection is a common and refractory bacterial infection in clinical *** to its high drug resistance,it brings great challenges to *** study aimed to assess the therapeutic efficacy of PDL in a murine model of pneumonia induced by drug-resistant Pseudomonas ***:Three different doses of PDL(11 mL/kg/d,5.5 mL/kg/d,2.75 mL/kg/d)were used to observe lung tissue pathology and inflammatory cytokine levels in pneumonia mouse models induced by multidrug-resistant Pseudomonas aeruginosa(MDR-PA).Additionally,the protective efficacy of PDL against mortality in infected mice was evaluated using a death model caused by *** sub-MIC concentration of levofloxacin was used to induce drug-resistant mice pneumonia model to evaluate the role of PDL in reversing drug *** data are expressed as mean±standard *** significance was determined by one-way analysis of variance followed by Tukey’s multiple-comparisons ***:Treatment effect of PDL on MDR-PA pneumonia:the medium and small doses of PDL can significantly reduce the lung index of multi-drug resistant bacteria infected pneumonia model mice(P<0.05),the lung index inhibition rates for these groups were 55.09%and 58.43%,and improve the degree of lung tissue lesions of mice;The expression of serum cytokines keratinocyte chemoattractant,tumor necrosis factor-αand monocyte chemoattractant protein-1 could be decreased in the three dosage groups of PDL(P<0.01).PDL treatment not only lowered the mortality but also extended the survival duration in mice infected with *** was found after sub-MIC concentration of levofloxacin induced resistance of Pseudomonas aeruginosa to pneumonia in *** with the model group,the lung index of mice in high

关键词： pudilan Pseudomonas aeruginosa drug resistance mice model