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Chinese Physics Letters 2020年第11期37卷 87-92页

作者： xiao-ran wang Cui-Xian Guo Qian Du Su-Peng Kou Center for Advanced Quantum Studies Department of PhysicsBeijing Normal UniversityBeijing 100875China

Breakdown of bulk-boundary correspondence in non-Hermitian(NH)topological systems with generalized inversion symmetries is a controversial *** non-Bloch topological invariants determine the existence of edge states,but fail to describe the number and distribution of defective edge states in non-Hermitian topological *** state-dependent topological invariants,instead of a global topological invariant,are developed to accurately characterize the bulk-boundary correspondence of the NH systems,which is very different from their Hermitian *** the same time,we obtain the accurate phase diagram of the one-dimensional non-Hermitian Su–Schrieffer–Heeger model with a generalized inversion symmetry from the state-dependent topological ***,these results will be helpful for understanding the exotic topological properties of various non-Hermitian systems.

关键词： topological invariants correspondence

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New cancer suppressor gene for colorectal adenocarcinoma:Filamin A

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World Journal of Gastroenterology 2015年第7期21卷 2199-2205页

作者： Zi-Qiang Tian Jian-Wei Shi xiao-ran wang Zhong Li Gui-Ying wang Department of Thoracic Surgery Fourth Hospital of Hebei Medical University Department of Surgical Oncology Affiliated Hospital of Hebei University Department of the Second General Surgery Fourth Hospital of Hebei Medical University

AIM:To determine the expression and significance of filamin A(FLNa)in colorectal adenocarcinoma ***:The expression of FLNa in 46 colorectal cancer tissues and normal tissues was detected by immunohistochemistry,reverse transcription polymerase chain reaction(RT-PCR)and Western blotting,and its relationship with clinical parameters and prognosis was ***:The positive expression of FLNa in cancer tissues was lower than that in normal mucosa,and the difference was statistically *** expression of FLNa correlated with liver metastasis,lymph node metastasis and rectal invasion depth,regardless of sex,age,tumor location,tumor size,gross shape and histological type of colorectal *** analysis showed that FLNa was an independent risk factor for postoperative survival of patients with colorectal ***,survival analysis showed that the expression level of FLNa was closely related with survival of patients with colorectal *** results of RT-PCR and Western blotting were consistent with those of ***:FLNa showed low expression in colorectal adenocarcinoma,high correlation with the incidence and development of colorectal cancer,and was considered an indicator of prognosis.

关键词： Colorectal carcinoma Filamin A Immunohistochemistr

Low concentration of sodium hyaluronate temporarily elevates the tear film lipid layer thickness in dry eye patients with lipid deficiency

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International Journal of Ophthalmology(English edition) 2018年第3期11卷 389-394页

作者： Yan Li Xuan Sang Liu Yang xiao-ran wang Jia-Hui Liu Xiong-Jun He Ying Liu xiao-He Lu Zhi-Chong wang State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 Guangdong Province China Department of Ophthalmology Zhujiang Hospital of Southem Medical University Guangzhou 510282 Guangdong Province China

AIM： To investigate the effects of different concentrations of artificial tears on lipid layer thickness （LLT） and blink rate （BR） in dry eye patients. METHODS： This study included 106 eyes of 58 patients with dry eye. The lipid deficiency type was defined as the LLT baseline 〈75 nm. The LLT and BR were measured at baseline and 1, 5 and 15min after the instillation of 0.1% or 0.3% sodium hyaluronate （SH） eye drops by using the LipiView ocular surface interferometer. RESULTS： In the lipid deficiency group, the LLT increased from baseline at 1rain post instillation. The LLT after the instillation of 0.1% SH was significantly higher than that after the instillation of 0.3% SH （P〈0.001）. The LLT returned to baseline at 15min post instillation of 0.1% SH and at 5min post instillation of 0.3% SH. In the non-lipid deficiency group, the LLT decreased from baseline at lmin and returned to baseline at 5rain for both treatments. The BRs were not significantly different at different time points for both treatments. CONCLUSION： SH eye drops induce a short-term increase in LLT of patients with lipid deficiency. A low concentration of artificial tears have a stronger effect than a high concentration of artificial tears on the increase in LLT. in comparison, SH eye drops induce a transient and slight decrease in LLT of patients without lipid deficiency. A low concentration of artificial tears might be better for patients with lipid deficiency.

关键词： tear film lipid layer thickness dry eye artificialtears ocular surface interferometer sodium hyaluronate

Lipid layer thickness and tear meniscus height measurements for the differential diagnosis of evaporative dry eye subtypes

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International Journal of Ophthalmology(English edition) 2018年第9期11卷 1496-1502页

作者： Xuan Sang Yan Li Liu Yang Jia-Hui Liu xiao-ran wang Chao-Yang Li Ying Liu Chen-Jie wang Xiong-Jun He Shou-Bi wang Zhi-Chong wang State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina Department of Ophthalmology Zhujiang Hospital of Southem Medical UniversityGuangzhou 510060Guangdong ProvinceChina

AIM： To explore a new diagnostic index for differentiating the evaporative dry eye（EDE） subtypes by analysis of their respective clinical characteristics. METHODS： A cross-sectional study of 139 patients（139 eyes） with EDE who were enrolled and classified as obstructive meibomian gland dysfunction（MGD）（n=81） and non-obstructive MGD（n=58） EDE. All patients completed a Standard Patient Evaluation of Eye Dryness（SPEED） questionnaire and were evaluated for average lipid layer thickness（LLT）, tear meniscus height measurements（TMH）, tear break-up time（TBUT）, ocular surface staining score, Schirmer I test（SIT）, lid margin abnormalities, and meibomian gland function and morphology. RESULTS： Age, average LLT, TMH, scores of lid margin abnormalities, meibum quality, meibomian gland loss（MGL）（all P≤0.001）, and TBUT（P=0.03） were all significantly different between obstructive MGD EDE patients and nonobstructive MGD EDE patients. Average LLT in obstructive MGD EDE was correlated with meibomian expressibility（r=-0.541, P≤0.001）, lid margin abnormalities were marginally not significant（r=0.197, P=0.077）, and TMH was correlated with MGL（total MGL： r=0.552, P≤0.001; upper MGL： r=0.438, P≤0.001; lower MGL： r=0.407, P≤0.001）. Average LLT in non-obstructive MGD EDE, was correlated with meibomian expressibility and Oxford staining（r=-0.396, P=0.002; r=-0.461, P≤0.001）. The efficiency of combining average LLT and TMH was optimal, with a sensitivity of 80.2% and a specificity of 74.1%. Obstructive MGD EDE patients had an average LLT≥69 nm and TMH≥0.25 mm, while non-obstructive MGD EDE patients had an average LLT〈69 nm and TMH〈0.25 ***： Obstructive MGD EDE and nonobstructive MGD EDE have significantly different clinical characteristics. Combining average LLT and TMH measurements enhanced their reliability for differentiating these two subtypes and provided guidance for offering more precise treatments for EDE subtypes.

关键词： evaporative dry eye lipid layer thickness tear meniscus height

Efficacy and safety of fecal microbiota transplantation for treatment of ulcerative colitis:A post-consensus systematic review and metaanalysis

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World Journal of Clinical Cases 2024年第21期12卷 4691-4702页

作者： Jin-Tao Zhang Nan Zhang Xue-Tao Dong xiao-ran wang Hong-Wen Ma Yan-Di Liu Mu-ran Li Department of Clinical Medicine School of MedicineNankai UniversityTianjin 300071China Department of Gastroenterology Tianjin Union Medical CenterTianjin 300122China

BACKGROUND Numerous studies have assessed the efficacy and safety of fecal microbiota transplantation(FMT)as a therapy for ulcerative colitis(UC).However,the treatment processes and outcomes of these studies *** To evaluate the efficacy and safety of FMT for treating UC by conducting a systematic *** The inclusion criteria involved reports of adult patients with UC treated with FMT,while studies that did not report clinical outcomes or that included patients with infection were *** remission(CR)and endoscopic remission(ER)were the primary and secondary outcomes,*** We included nine studies retrieved from five electronic *** FMT group had better CR than the control group[relative risk(RR)=1.53;95%confidence interval(CI):1.19-1.94;Prandomized clinical trials are still needed before the widespread use of FMT can be ***,standardizing the FMT process is urgently needed for improved safety and efficacy.

关键词： Fecal microbiota transplantation randomized clinical trials Remission Ulcerative colitis Meta-analysis

Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

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Neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan wang Yuanyuan ran Zihan Li Tianyuan Zhao Fangfang Zhang Juan wang Zongjian Liu Xuechai Chen Beijing International Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHDF2

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面向数据密集型应用的细粒度内存管理方案

北京邮电大学学报 2017年第3期40卷 91-96,103页

作者：郝晓冉倪茂王力玉陈岚中国科学院微电子研究所EDA中心北京100029

提出并实现了一种细粒度内存管理方案.该方案以用户数据对象为粒度对内存进行管理,当需要将部分内存数据换出以获得空闲内存空间时,不再像传统操作系统以页为单位换出,而是将多个冷数据对象换出到底层存储设备中,最大限度地保证了被换... 详细信息

提出并实现了一种细粒度内存管理方案.该方案以用户数据对象为粒度对内存进行管理,当需要将部分内存数据换出以获得空闲内存空间时,不再像传统操作系统以页为单位换出,而是将多个冷数据对象换出到底层存储设备中,最大限度地保证了被换出的数据近期内不会再次被访问,从而有效减少了额外的I/O开销.测试结果表明,本方案与操作系统页交换机制相比,系统响应速度平均提高了37.5%.

关键词：计算机系统结构页交换数据密集型应用虚拟内存管理物理内存管理

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Electrochemical conversion of methane to bridge the gap in the artificial carbon cycle

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Journal of Energy Chemistry 2025年第1期100卷 286-308页

作者： Yuhao Peng Yuefeng Song Ihar Razanau Juanxiu xiao Wei xiao Di Hu Guoxiong wang College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power Sources Wuhan University State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Dalian Institute of Chemical Physics Chinese Academy of Sciences Laboratory of Physical-Chemical Technologies SSPA Scientific and Practical Materials Research Centre of NAS of Belarus State Key Laboratory of Marine Resources Utilization in South China Sea Collaborative Innovation Center of Marine Science and Technology School of Marine Science and Engineering Hainan University Department of Chemical and Environmental Engineering University of Nottingham Ningbo China

Methane, an abundant one-carbon（C1） resource, is extensively used in the industrial production of vital fuels and value-added chemicals. However, current industrial methane conversion technologies are energy-and carbon-intensive, mainly due to the high activation energy required to break the inert C–H bond, low selectivity, and problematic side reactions, including CO2emissions and coke deposition. Electrochemical conversion of methane（ECM） using intermittent renewable energy offers an attractive solution, due to its modular reactor design and operational flexibility across a broad spectrum of temperatures and pressures. This review emphasizes conversion pathways of methane in various reaction systems, highlighting the significance and advantages of ECM in facilitating a sustainable artificial carbon cycle. This work provides a comprehensive overview of conventional methane activation mechanisms and delineates the complete pathways of methane conversion in electrolysis contexts. Based on surface/interface chemistry, this work systematically analyzes proposed reaction pathways and corresponding strategies to enhance ECM efficiency towards various target products, including syngas, hydrocarbons, oxygenates, and advanced carbon materials. The discussion also encompasses opportunities and challenges for the ECM process, including insights into ECM pathways, rational electrocatalyst design, establishment of benchmarking protocols, electrolyte engineering, enhancement of CH4conversion rates, and minimization of CO2emission.

关键词： Activation energy

Unmasking Social Robots’Camouflage:A GNN-random Forest Framework for Enhanced Detection

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Computers, Materials & Continua 2025年第1期82卷 467-483页

作者： Weijian Fan Chunhua wang xiao Han Chichen Lin School of Data Science and Intelligent Media Communication University of ChinaBeijing100024China School of Computer and Cyber Sciences Communication University of ChinaBeijing100024China Institute of Communication Studies Communication University of ChinaBeijing100024China State Key Laboratory of Media Convergence and Communication Communication University of ChinaBeijing100024China

The proliferation of robot accounts on social media platforms has posed a significant negative impact,necessitating robust measures to counter network anomalies and safeguard content *** robot detection has emerged as a pivotal yet intricate task,aimed at mitigating the dissemination of misleading *** graphbased approaches have attained remarkable performance in this realm,they grapple with a fundamental limitation:the homogeneity assumption in graph convolution allows social robots to stealthily evade detection by mingling with genuine human *** unravel this challenge and thwart the camouflage tactics,this work proposed an innovative social robot detection framework based on enhanced HOmogeneity and random Forest(HORFBot).At the core of HORFBot lies a homogeneous graph enhancement strategy,intricately woven with edge-removal techniques,tometiculously dissect the graph intomultiple revealing ***,leveraging the power of contrastive learning,the proposed methodology meticulously trains multiple graph convolutional networks,each honed to discern nuances within these tailored *** culminating stage involves the fusion of these feature-rich base classifiers,harmoniously aggregating their insights to produce a comprehensive detection *** experiments on three social robot detection datasets have shown that this method effectively improves the accuracy of social robot detection and outperforms comparative methods.

关键词： Social robot detection graph neural networks random forest homophily heterophily

Design of a cationic accelerator enabling ultrafast ion diffusion kinetics in aqueous zinc-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 377-384页

作者： Yawei xiao Qianqian Gu Haoyu Li Mengyao Li Yude wang National Center for International Research on Photoelectric and Energy Materials School of Materials and Energy Yunnan University Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources School of Chemistry and Chemical Engineering Hainan University College of Chemical Engineering Fuzhou University Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon Technologies Yunnan University

Aqueous zinc-ion batteries are highly favored for grid-level energy storage owing to their low cost and high safety,but their practical application is limited by slow ion *** address this,a strategy has been developed to create a cation-accelerating electric field on the surface of the cathode to achieve ultrafast Zn2+diffusion *** employing electrodeposition to coat MoS2on the surface of BaV6O16·3H2O nanowires,the directional built-in electric field generated at the heterointerface acts as a cation accelerator,continuously accelerating Zn2+diffusion into the active *** optimized Zn2+diffusion coefficient in CC@BaV-6O16·3H2O@MoS2(7.5×10～8cm2s-1) surpasses that of most reported V-based ***,MoS2serving as a cathodic armor extends the cycling life of the Zn-CC@BaV6O16·3H2O@MoS2full batteries to over 10000 *** work provides valuable insights into optimizing ion diffusion kinetics for high-performance energy storage devices.

关键词： Zinc alloys