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Transcriptional identification of differentially expressed genes associated with division of labor in Apis cerana cerana

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Insect Science 2021年第2期28卷 457-471页

作者： Yi-Jie Chen Ying-Jiao Li Shuang Wu Wen-Chao Yang Jing miao Shao-Hua Gu Jiang-Hong Li xiao-qing miao Xianchun Li College of Bee Science Fujian Agriculture and Forestry UniversityFuzhouChina State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijingChina Department of Entomology and BI05 Institute University of ArizonaTucsonAZUSA

Workers of Apis cerana cerana undergo an in-hive nursing to outdoor foraging transition,but the genes underlying this age-related transition remain largely ***,we sequenced the head transcriptomes of its 7-day-old normal nurses,18-and 22-day-old normal foragers,7-day-old precocious foragers and 22-day-old over-aged nurses to unravel the genes associated with this *** of the sequence reads to Apis mellifera genome showed that the three types of foragers had a greater percentage of reads from annotated exons and intergenic regions,whereas the two types of nurses had a greater percentage of reads from ***-and group-wise comparisons of the five transcriptomes revealed 59 uniquely expressed genes(18 in nurses and 41 in foragers)and 14 nurse-and 15 forager-upregulated *** uniquely expressed genes are usually low-abundance long noncoding RNAs,transcription factors,transcription coactivators,RNA-binding proteins,kinases or phosphatases that are involved in signaling and/or regulation,whereas the nurse-or forager-upregulated genes are often high-abundance downstream genes that directly perform the tasks of nurses or *** together,these results suggest that the nurse-forager transition is coordinated by a social signal-triggered epigenetic shift from introns to exons/intergenic regions and the resulting transcriptional shift between the nurse-and forager-associated genes.

关键词： behavioral transition epigenetic shift IncRNA over-aged nurses precocious foragers signaling genes

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Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： xiao-xiao Zhang Li Jia Xiu-Jun Zhan Charity Ngina qing-Rui Zhang xiao-Ge Li Qi-Bao Jiang Shi Bai miao-miao Jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

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LASIK术后角膜上皮内生的处理

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国际眼科杂志 2015年第5期15卷 931-933页

作者：陈玄之苗晓晴全雄湛江中心人民医院眼科中国广东省湛江市524037

目的：分析准分子激光原位角膜磨镶术（ LASIK）后角膜上皮植入及内生发生的原因,总结治疗经验。方法：回顾性分析2008-01/2012-12于我院行LASIK患者1256例2256眼,术后发生角膜上皮植入及内生18例30眼的临床资料。对所有患眼进行治疗... 详细信息

目的：分析准分子激光原位角膜磨镶术（ LASIK）后角膜上皮植入及内生发生的原因,总结治疗经验。方法：回顾性分析2008-01/2012-12于我院行LASIK患者1256例2256眼,术后发生角膜上皮植入及内生18例30眼的临床资料。对所有患眼进行治疗后,对治疗前后患者整体视觉质量评分进行分析。结果：行LASIK术后角膜上皮植入及内生18例30眼,发生率为1.3%。18例30眼患者中12眼为术后外伤致角膜瓣移位上皮内生,12眼为术中多次角膜瓣下冲洗,2眼为术中制作角膜瓣出现不规则瓣,4眼术中无特殊。30眼角膜上皮内生的程度：I级11例18眼,Ⅱ级4例8眼,Ⅲ级3例4眼。 I-Ⅱ级者予妥布霉素地塞米松滴眼液点眼并辅予降眼压药物治疗为主,Ⅲ级者先予药物治疗,若情况无好转,则予手术治疗。治疗后11例18眼I级者中8例13眼内生均消失,3例5眼植入上皮灶缩小；4例8眼Ⅱ级者中2例4眼上皮植入消失,2例4眼上皮植入程度减轻至I级；3例4眼Ⅲ级者中2例2眼角膜缘1 mm处瓣缘有0.5-1mm宽瓣下浅灰白色带,视力0.8-1.2,1例2眼患者予刮除植入角膜上皮及内生上皮,随访无复发。治疗后18例角膜上皮内生患者整体视觉质量评分低于治疗前（Hc=10.511,P〈0.01）。结论：规范手术操作、术后及早发现并予积极治疗是对预防和治疗LASIK 术后并发症有重要意义。

关键词：准分子激光原位角膜磨镶术上皮内生视觉质量

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显微外路和传统外路手术治疗视网膜脱离的临床比较

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国际眼科杂志 2015年第4期15卷 666-668页

作者：陈玄之黄文婕苗晓晴湛江中心人民医院中国广东省湛江市524037

目的:观察显微外路和传统外路手术治疗裂孔源性视网膜脱离的疗效。方法:裂孔源性视网膜脱离患者46例46眼,其中26例行显微外路视网膜脱离手术(显微组),20例行传统外路视网膜脱离手术(传统组),由同一手术者完成。回顾分析其临床资料,对比... 详细信息

目的:观察显微外路和传统外路手术治疗裂孔源性视网膜脱离的疗效。方法:裂孔源性视网膜脱离患者46例46眼,其中26例行显微外路视网膜脱离手术(显微组),20例行传统外路视网膜脱离手术(传统组),由同一手术者完成。回顾分析其临床资料,对比两组的临床情况及疗效。结果:显微组和传统组患者手术方式选择、冷凝反应、裂孔封闭情况和一次手术视网膜复位情况的差异均无统计学意义(P>0.05)。显微组患者术后1mo的最佳矫正视力情况较术前改善,其术后视力提高率较对照组高(P<0.05)。结论:显微外路视网膜脱离手术与传统外路视网膜脱离手术治疗裂孔源性视网膜脱离的手术效果相近,显微外路视网膜脱离手术在改善患者视力方面略有优势。

关键词：显微外路手术传统外路手术裂孔源性视网膜脱离

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角膜后弹力层脱离30例临床分析

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国际眼科杂志 2013年第7期13卷 1459-1461页

作者：曾朝霞全雄陈荟郦苗小晴湛江中心人民医院眼科中国广东省湛江市524000

目的:探讨引起角膜后弹力层脱离的原因,提出处理方法及预防方法。方法:回顾性分析30例30眼角膜后弹力层脱离患者,行前房注气术,术后随访6mo,观察角膜透明度及视力等情况。结果:白内障及青光眼术后是引起角膜后弹力层脱离的常见原因,前... 详细信息

目的:探讨引起角膜后弹力层脱离的原因,提出处理方法及预防方法。方法:回顾性分析30例30眼角膜后弹力层脱离患者,行前房注气术,术后随访6mo,观察角膜透明度及视力等情况。结果:白内障及青光眼术后是引起角膜后弹力层脱离的常见原因,前房注气后30例患者中25例视力明显改善,27例角膜恢复透明。结论:角膜后弹力层脱离对角膜影响较大,应及时处理,否则易造成角膜持续性损伤。

关键词：角膜后弹力层脱离前房注气术角膜失代偿

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杜仲保健面条的研制

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食品科技 2003年第3期28卷 80-81页

作者：宗留香康怀斌毛薇肖青苗河南科技大学洛阳471003

介绍了杜仲保健面条的制作工艺、操作要点。

关键词：杜仲保健面条研制杜仲浸提液制作工艺配方

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miR-483-3p增强胰腺癌对吉西他滨敏感性及分子机制研究

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大连理工大学学报 2025年第1期65卷 30-37页

作者：刘青肖桂山大连理工大学化工学院辽宁大连116024

吉西他滨耐药限制了其对胰腺癌的治疗效果,而传统化学药物无法有效克服吉西他滨对胰腺癌的耐药.研究表明,microRNA(miRNA)的异常表达与肿瘤发生、发展和化疗耐药性有关.对miR-483-3p在胰腺癌吉西他滨耐药中的作用和潜在机制进行了研究.q... 详细信息

吉西他滨耐药限制了其对胰腺癌的治疗效果,而传统化学药物无法有效克服吉西他滨对胰腺癌的耐药.研究表明,microRNA(miRNA)的异常表达与肿瘤发生、发展和化疗耐药性有关.对miR-483-3p在胰腺癌吉西他滨耐药中的作用和潜在机制进行了研究.qPCR结果显示miR-483-3p在胰腺癌耐药细胞中显著下调.miR-483-3p minics瞬时转染显著提高了耐药细胞内miR-483-3p的表达水平,显著减弱了耐药细胞的增殖、迁移、转移和侵袭能力,恢复了吉西他滨的反应性.Western blot结果显示miR-483-3p抑制PI3K和p-AKT蛋白的表达水平,抑制Bcl2蛋白表达,促进Bax、Bad和cleaved-Caspase-3蛋白表达,促进细胞凋亡进程.总之,研究结果表明miR-483-3p通过抑制PI3K/AKT信号通路促进细胞凋亡,增加胰腺癌对吉西他滨的敏感性,miR-483-3p可能是吉西他滨耐药胰腺癌患者的潜在治疗策略.

关键词： miR-483-3p 胰腺癌吉西他滨耐药性 miRNA

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普通刺猬的解剖学研究(三)内脏

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实验动物科学与管理 2000年第4期17卷 1-6页

作者：肖青苗庞有志邓雯宗留香洛阳农业高等专科学校洛阳471003

:对 2 8只 (♀ 1 6,♂ 1 2 )成年普通刺猬 (Erinaceuseuropaeus)的内脏进行了大体解剖学研究。普通刺猬口腔容积大 ,口裂长 ,舌大而灵活 ,食虫型牙齿 ,单室胃、单乳头肾、双角子宫、无肓肠、无阴囊 ,有乳腺 5对 ,大小肠分化不明显 ,肠... 详细信息

:对 2 8只 (♀ 1 6,♂ 1 2 )成年普通刺猬 (Erinaceuseuropaeus)的内脏进行了大体解剖学研究。普通刺猬口腔容积大 ,口裂长 ,舌大而灵活 ,食虫型牙齿 ,单室胃、单乳头肾、双角子宫、无肓肠、无阴囊 ,有乳腺 5对 ,大小肠分化不明显 ,肠长相当于体长的 5～ 6倍 ,肝 7叶 ,肺 4叶 ,肝、脾、肾、胰、心脏和肺分别占体重的 4 1 2 %～ 5 2 3% ,0 2 9%～ 0 51 % ,0 42 %～ 0 53% ,0 45%～ 0 65% ,0 36%～ 0 51 %和0 42 %～ 0 60 % ,血液和褐色脂肪分别占体重的 7 7%～ 8 2 %和 0 75%～ 0 87% ,脑较小 ,大脑表面无沟回 ,雌雄刺猬除生殖器官重量有差异外 ,其它各脏器组分均无性别差异。普通刺猬的内脏特征。

关键词：刺猬解剖学内脏消化系统呼吸系统

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Adsorption and sensing characteristics of insulating gas C4F7N on 3d late transition metal-phthalocyanine:Theoretical and experimental study

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High Voltage 2024年第4期9卷 870-878页

作者： Dachang Chen Ziang Zheng Cong Zhang Yi Luo Song xiao qing miao Ke Liu Beibei xiao School of Electrical and Electronic Engineering Wuhan Polytechnic UniversityWuhanChina Beijing International S&T Cooperation Base for Plasma Science and Energy Conversion Institute of Electrical EngineeringChinese Academy of SciencesBeijingChina School of Electrical Engineering and Automation Wuhan UniversityWuhanChina School of Energy and Power Engineering Jiangsu University of Science and TechnologyZhenjiangChina

Heptafluoroisobutyronitrile(C_(4)F_(7)N)is being considered as a promising alternative to the greenhouse gas SF6 in the electrical ***,its biotoxicity necessitates the development of gas sensing technology to detect leaked C_(4)F_(7)N.A combination of density functional theory and experiments was employed to evaluate the adsorption and sensing performance of different metal-phthalocyanines as potential sensing materials for C_(4)F_(7)N *** study included exploring adsorption configurations with adsorption energies,electron transfer,and adsorption distance,as well as comparisons of electronic properties,electron distribution,and density of states(DOS)among the ***,gas sensing experiments were conducted using different MPcs to detect 25-100 ppm C_(4)F_(7)*** results revealed that Mn-Pc,Fe-Pc,Co-Pc,and Zn-Pc exhibited considerable chemical interactions,while Ni-Pc and Cu-Pc showed weaker adsorption *** findings were further elucidated based on the electron density and DOS of atomic ***,gas sensing experiments indicated that Co-Pc demonstrated a higher response compared to Fe-Pc at the same concentration of C_(4)F_(7)***,the theoretical and experimental insights offer valuable guidance for C_(4)F_(7)N detection and provide a systematic approach to screen and explore organometallic polymer-based gas sensors applicable in various fields.

关键词： adsorption phthalocyanine Adsorption

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Relationship between nutrient pollutants and suspended sediments in upper reaches of Yangtze River

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Water Science and Engineering 2015年第2期8卷 121-126页

作者： xiao-qing Wang Zhao-cun Liu Ji-lun miao Ning Zuo Southwest Research Institute of Water Transport Engineering Chongqing Jiaotong University

In order to study the relationship between nutrient pollutants and suspended sediments（SS） in the upper reaches of the Yangtze River and two tributaries, water samples were collected from September 1, 2010 to September 30, 2011 at the Zhutuo, Cuntang, Beibei, Wulong, qingxichang,Wanxian, and Fengjie cross-sections. In the laboratory, the SS concentration and the concentration of SS whose particle size was smaller than0.02 mm were measured. The phosphorus（P）, nitrogen（N）, and permanganate index（CODMn） concentrations in the natural water sample, the settled water sample, and two types of filtered water samples obtained through filter membranes with pore sizes of 0.02 mm and 0.45 mm were monitored synchronously. The results show that there are strong relationships between the P and CODMnconcentrations and the SS concentration. P mainly exists in particulate form, while N mainly exists in dissolved form. SS whose particle size is smaller than 0.02 mm accounts for a high proportion of sediments in the Yangtze River and has a strong effect on water quality. At the seven cross-sections, the amounts of P, N, and CODMnin particulate form in the wet season are higher than in the dry season and the adsorption amounts of P, N, and CODMnper unit mass of sediment are higher in the dry season than in the wet season.

关键词： Suspended sediment Phosphorus Nitrogen Permanganate index

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