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Laparoscopic management of gastric gastrointestinal stromal tumors: A retrospective 10-year single-center experience

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World Journal of Gastroenterology 2017年第19期23卷 3522-3529页

作者： Guan-qun Liao Tao Chen xiao-long qi Yan-feng Hu Hao Liu Jiang Yu Guo-Xin Li Department of General Surgery Nanfang Hospital Southern Medical University Department of General Surgery Foshan Hospital affiliated to Southern Medical University

AIM To determine the feasibility,safety,and oncological outcome of laparoscopic resection of gastric gastrointestinal stromal tumors(GISTs)based on favorable or unfavorable *** Our hospital database included 207 patients who underwent laparoscopic removal of gastric GISTs from January 2004 to September *** demographics,clinical presentation,surgery,histopathology,postoperative course,and oncological outcomes were reviewed and *** Gastric GIST in favorable locations was present in81/207(39.1%)cases,and in unfavorable locations in 126/207(60.9%)*** mean tumor size was 3.28±1.82 *** conversions occurred,and complete R0 resection was achieved in 207(100%)*** were three incidences of iatrogenic tumor *** feasibility and safety of laparoscopic surgery were comparable in both groups with no statistical difference between unfavorable and favorable location groups,respectively:for operative time:83.86±44.41 vs 80.77±36.46 min,P=0.627;conversion rate:0%vs 0%;estimated blood loss:27.74±45.2vs 29.59±41.18 m L,P=0.780;tumor rupture during surgery:0.90%vs 2.82%,P=0.322;or postoperative complications:3.74%vs 7.04%,P=*** follow-up period recurrence rate was 1.89%with no significant differences between the two groups(3.03%vs 0%,P=0.447).Overall 5-year survival rate was98.76%and survival rates were similar between the two groups:98.99%vs 98.39%,P=0.623(unfavorable vs favorable,respectively).CONCLUSION The laparoscopic approach for gastric GISTs is safe and feasible with well-accepted oncological surgical *** for laparoscopic resection should be selected according to the location and size of the *** treatment of gastric GISTs in unfavorable locations should not be restricted in gastrointestinal centers.

关键词： Laparoscopic Gastrointestinal stromal tumors Gastrectomy Minimally invasive surgery

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Safety and immunogenicity of COVID-19 vaccination among liver transplant recipients in China

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 605-608页

作者： qiu-Ju Tian Man Xie Ji-Tao Wang Yi Wang Bei Zhang Jin-Zhen Cai xiao-long qi Wei Rao Division of Hepatology Liver Disease CenterThe Affiliated Hospital of Qingdao UniversityQingdao 266000China Department of Organ Transplantation The Affiliated Hospital of Qingdao UniversityQingdao 266000China Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdao 266000China CHESS-COVID-19 Group Xingtai People’s HospitalXingtai 054000China Department of Clinical Laboratory The Affiliated Hospital of Qingdao UniversityQingdao 266000China Department of Immunology Qingdao University Medical CollegeQingdao 266000China CHESS Center Institute of Portal HypertensionThe First Hospital of Lanzhou UniversityLanzhou 730000China

To the Editor:During the ongoing coronavirus disease 2019(COVID-19)pan-demic globally,patients with chronic liver diseases(CLD),par-ticularly cirrhosis,hepatobiliary malignancies,candidates for liver transplantation(LT),and immunosuppressed LT recipients appear to be at increased risk of infections,which leads to an increase in mortality[1-6].Apart from physical distancing,quarantine and isolation,vaccination is crucial for the restraining of the epidemic and the protection from severe acute respiratory syndrome coron-avirus 2(SARS-CoV-2)infection and aggravation of COVID-19[7,8].A recent prospective,multicenter,open-label study in China has demonstrated the safety of inactivated whole-virion SARS-CoV-2 vaccines in patients with CLD.

关键词： vaccination liver mortality

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Artificial intelligence empowers the second-observer strategy for colonoscopy:a randomized clinical trial

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Gastroenterology Report 2023年第1期11卷 216-223页

作者： Pu Wang xiao-Gang Liu Min Kang Xue Peng Mei-Ling Shu Guan-Yu Zhou Pei-Xi Liu Fei Xiong Ming-Ming Deng Hong-Fen Xia Jian-Jun Li xiao-qi long Yan Song Liang-Ping Li Department of Gastroenterology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanP.R.China Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuanP.R.China Department of Gastroenterology Xinqiao HospitalThird Military Medical UniversityChongqingP.R.China Department of Gastroenterology Suining Central HospitalSuiningSichuanP.R.China

Background:In colonoscopy screening for colorectal cancer,human vision limitationsmay lead to highermiss rate of lesions;artificial intelligence(AI)assistance has been demonstrated to improve polyp ***,there still lacks direct evidence to demonstrate whether AI is superior to trainees or experienced nurses as a second observer to increase adenoma detection during *** this study,we aimed to compare the effectiveness of assistance fromAI and human observer during ***:A prospective multicenter randomized study was conducted from 2 September 2019 to 29 May 2020 at four endoscopy centers in *** patients were randomized to either computer-aided detection(CADe)-assisted group or observer-assisted *** primary outcome was adenoma per colonoscopy(APC).Secondary outcomes included polyp per colonoscopy(PPC),adenoma detection rate(ADR),and polyp detection rate(PDR).We compared continuous variables and categorical variables by using R studio(version 3.4.4).Results:A total of 1,261(636 in the CADe-assisted group and 625 in the observer-assisted group)eligible patients were ***(0.42 vs 0.35,P=0.034),PPC(1.13 vs 0.81,P<0.001),PDR(47.5%vs 37.4%,P<0.001),ADR(25.8%vs 24.0%,P=0.464),the number of detected sessile polyps(683 vs 464,P<0.001),and sessile adenomas(244 vs 182,P=0.005)were significantly higher in the CADe-assisted group than in the observer-assisted *** detections of the CADe system were lower than those of the human observer(122 vs 191,P<0.001).Conclusions:Compared with the human observer,the CADe system may improve the clinical outcome of colonoscopy and reduce disturbance to routine practice(*** No.:ChiCTR1900025235).

关键词： artificial intelligence colon cancer screening adenoma early detection computer-aided detection

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A novel nomogram individually predicting disease-specific survival after D2 gastrectomy for advanced gastric cancer

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Cancer Communications 2018年第1期38卷 254-262页

作者： Wei Wang Zhe Sun Jing-Yu Deng xiao-long qi Xing-Yu Feng Cheng Fang Xing-Hua Ma Zhen-Ning Wang Han Liang Hui-Mian Xu Zhi-Wei Zhou Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine651 Dongfeng East RoadGuangzhou 510060GuangdongP.R.China Department of Surgical Oncology The First Affiliated Hospital of China Medical UniversityShenyang 110000LiaoningP.R.China Department of Gastric Cancer Surgery Tianjin Medical University Cancer HospitalTianjin 300000P.R.China Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhou 510515GuangdongP.R.China Department of Gastroenterology Surgery Guangdong General HospitalGuangzhou 510030GuangdongP.R.China Department of Preventive Medicine School of Public HealthSun Yat-sen UniversityGuangzhou 510275GuangdongP.R.China

Background:Few studies have shown nomograms that may predict disease-specific survival(DSS)probability after curative D2 gastrectomy for advanced gastric cancer(AGC),particularly among Chinese *** study sought to develop an elaborative nomogram that predicts long-term DSS for AGC in Chinese ***:A retrospective study was conducted on 6753 AGC patients undergoing D2 gastrectomy between January 1,2000 and December 31,2012 from three large medical hospitals in *** assigned patients from Sun Yat-sen University Cancer Center to the training set,and patients from the First Affiliated Hospital of China Medical University and Tianjin Medical University Cancer Hospital to two separate external validation sets.A multivariate survival analysis was performed using Cox proportional hazards regression model in a training set,and a nomogram was ***’s C-index was used to evaluate discrimination and calibration plots were used to validate similarities between survival probabilities predicted by the nomogram model and actual survival rates in two validation ***:The multivariate Cox regression model identified age,tumor size,location,Lauren classification,lymphatic/venous invasion,depth of invasion,and metastatic lymph node ratio as covariates associated with *** the training set,the nomogram exhibited superior discrimination power compared with the 8th American Joint Com-mittee on Cancer TNM classification(Harrell’s C-index,0.82 vs.0.74;P<0.001).In two validation sets,the nomogram’s discrimination power was also excellent relative to TNM classification(C-index,0.83 vs.0.75 and 0.81 vs.0.74,respec-tively;P<0.001 for both).After calibration,the nomogram produced survival predictions that corresponded closely with actual survival ***:The established nomogram was able to predict 3-,5-,and 10-year DSS probabilities for AGC *** revealed that this nomogram exhibited excellent discrimination and calibrat

关键词： Advanced gastric cancer Disease-specific survival Prognostic nomogram

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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan long xiao Gao Zhengwei Wang Zhizhong Guan xiaolan qi Wei Hong Yan xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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Clinical practice of transarterial chemoembolization for hepatocellular carcinoma:consensus statement from an international expert panel of International Society of Multidisciplinary Interventional Oncology(ISMIO)

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Hepatobiliary Surgery and Nutrition 2021年第5期10卷 661-671页

作者： Jian Lu Ming Zhao Yasuaki Arai Bin-Yan Zhong Hai-Dong Zhu xiao-long qi Thierry de Baere Uei Pua Hyun Ki Yoon David C.Madoff Gao-Jun Teng International Society of Multidisciplinary Interventional Oncology(ISMIO) Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjingChina State Key Laboratory of Oncology in Southern China GuangzhouChina Minimally Invasive&Interventional Department Cancer CenterSun Yat-sen UniversityGuangzhouChina Department of Diagnostic Radiology National Cancer CenterTokyoJapan Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySuzhouChina CHESS Frontier Center First Hospital of Lanzhou UniversityLanzhouChina Gustave Roussy-Cancer Campus VillejuifFrance Department of Radiology Tan Tock Seng HospitalNational University of SingaporeSingaporeSingapore Department of Radiology and Research Institute of Radiology University of Ulsan College of MedicineAsan Medical CenterSeoulKorea Department of Radiology and Biomedical Imaging Section of Interventional Radiology and Department of Internal MedicineSection of Medical OncologyYale School of MedicineNew HavenCTUSA 不详

Importance:Transarterial chemoembolization(TACE)has been associated with a wide range of practice variations for hepatocellular carcinoma(HCC)between the East and the *** considerable ambiguity may lead to the heterogeneous quality in treatment and have a negative impact on the role of TACE in the overall multidisciplinary HCC treatment ***:It may be a good start to establish a guideline worldwide to have this consensus from experts who represent east and west,although it does not cover all aspects of *** Review:An international expert panel on TACE is convened to cluster the expert’s opinions and summary a standard *** panel committee consist of leading physicians in TACE on HCC from USA,France,Japan,Singapore,Korea,China,and so *** first-round face-to-face consensus meeting was held during in Nanjing,China in October *** second-round conference for revision of the consensus was held during the Annual Meeting of Chinese College of Interventionalists in August 2020 by a hybrid format of a Webinar and roundtable *** several on-line revisions,the final manuscript was approved by all members of the panel in June ***:The consensus statements were organized into the following categories:patients’selection,performing the procedure,TACE outcomes,repeat TACE,TACE failure/refractory,and TACE-based combination *** and Relevance for Reviews:More and more evidences have showed the better outcomes with strategy of combined TACE with other local therapies such as *** most-recently developing strategy of combined TACE with PD-1/PD-L1 plus tyrosine kinase inhibitor(TKI)agents has shined a light to the HCC patients,especially to those with high risk of tumor recurrence after treatment or TACE failure/refractory.

关键词： Transarterial chemoembolization(TACE) hepatocellular carcinoma(HCC) consensus

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Multiparameter magnetic resonance imaging-based radiomics model for the prediction of rectal cancer metachronous liver metastasis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 62-72页

作者： Zhi-Da long xiao Yu Zhi-Xiang Xing Rui Wang Department of Hepatobiliary and Pancreaticosplenic Surgery Jingzhou Hospital Affiliated to Yangtze UniversityJingzhou 434100Hubei ProvinceChina

BACKGROUND The liver,as the main target organ for hematogenous metastasis of colorectal cancer,early and accurate prediction of liver metastasis is crucial for the diagnosis and treatment of ***,this study aims to investigate the application value of a combined machine learning(ML)based model based on the multiparameter magnetic resonance imaging for prediction of rectal metachronous liver metastasis(MLM).AIM To investigate the efficacy of radiomics based on multiparametric magnetic resonance imaging images of preoperative first diagnosed rectal cancer in predicting MLM from rectal *** We retrospectively analyzed 301 patients with rectal cancer confirmed by surgical pathology at Jingzhou Central Hospital from January 2017 to December *** participants were randomly assigned to the training or validation queue in a 7:3 *** first apply generalized linear regression model(GLRM)and random forest model(RFM)algorithm to construct an MLM prediction model in the training queue,and evaluate the discriminative power of the MLM prediction model using area under curve(AUC)and decision curve analysis(DCA).Then,the robustness and generalizability of the MLM prediction model were evaluated based on the internal validation set between the validation queue *** Among the 301 patients included in the study,16.28%were ultimately diagnosed with MLM through pathological *** analysis showed that carcinoembryonic antigen,and magnetic resonance imaging radiomics were independent predictors of ***,the GLRM prediction model was developed with a comprehensive nomogram to achieve satisfactory *** prediction performance of GLRM in the training and validation queue was 0.765[95%confidence interval(CI):0.710-0.820]and 0.767(95%CI:0.712-0.822),*** with GLRM,RFM achieved superior performance with AUC of 0.919(95%CI:0.868-0.970)and 0.901(95%CI:0.850-0.952)in the training and validation queue,respect

关键词： Rectal cancer Metachronous liver metastases Magnetic resonance imaging Radiomics Machine learning

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X区块随钻堵漏钻井液研究

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化学工程师 2016年第10期30卷 34-36,24页

作者：戚小龙长江大学湖北武汉430100

井漏是油气井钻井过程中遇到的最麻烦而复杂的情况之一,它严重的制约了油气井的钻采进度,大大的增加了油气开采成本。针对X区块裂缝性地层地质特征,展开了室内的一系列的裂缝性地层堵漏模拟实验研究,通过实验优选出了最佳的随钻堵漏钻... 详细信息

井漏是油气井钻井过程中遇到的最麻烦而复杂的情况之一,它严重的制约了油气井的钻采进度,大大的增加了油气开采成本。针对X区块裂缝性地层地质特征,展开了室内的一系列的裂缝性地层堵漏模拟实验研究,通过实验优选出了最佳的随钻堵漏钻井液配方,并在X区块后续所钻井的应用中取得了很好的效果。

关键词：井漏复杂堵漏钻井液

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利用对话模型引导的对话生成推荐

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东北大学学报（自然科学版） 2022年第10期43卷 1397-1404页

作者：齐孝龙韩东红高翟乔百友东北大学计算机科学与工程学院辽宁沈阳110169

对话推荐技术旨在通过与用户的对话交互完成高质量的信息推荐.针对已有研究存在的对话目标预测准确性不高的问题,提出一种利用对话模型引导的对话生成推荐(dialogue guided recommendation of dialogue generation,DGRDG)模型.首先,利... 详细信息

对话推荐技术旨在通过与用户的对话交互完成高质量的信息推荐.针对已有研究存在的对话目标预测准确性不高的问题,提出一种利用对话模型引导的对话生成推荐(dialogue guided recommendation of dialogue generation,DGRDG)模型.首先,利用对话模型生成对话目标,通过经典的Seq2Seq模型融合输入的对话历史、用户画像以及知识信息来生成对话目标;其次,提出目标重规划策略(goal replan policy,GRP)来修正生成的对话目标,以提高对话目标预测的准确率.在DuRecDial数据集上进行实验的结果表明,对话目标生成模块在引入目标重规划策略后,对话目标预测的准确率提高了3.93%;总体模型在BLEU,DISTINCT,F1以及人工评价指标上具有较好的效果.

关键词：对话推荐对话生成对话目标规划管道模型对话策略

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纤维蛋白原和血小板联合检测在胃癌诊断和预后中的价值分析

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标记免疫分析与临床 2019年第4期26卷 585-591页

作者：李敏綦晓龙西南医科大学附属医院胃肠外科四川泸州646000

目的探讨纤维蛋白原、血小板联合检测对胃癌诊断及预后的临床价值。方法回顾性研究2008年1月至2014年4月在我科住院并手术的胃癌患者,共1023例符合纳入标准。根据ROC曲线确定纤维蛋白原和血小板的最佳截断值,根据最佳截断值及评分标准对... 详细信息

目的探讨纤维蛋白原、血小板联合检测对胃癌诊断及预后的临床价值。方法回顾性研究2008年1月至2014年4月在我科住院并手术的胃癌患者,共1023例符合纳入标准。根据ROC曲线确定纤维蛋白原和血小板的最佳截断值,根据最佳截断值及评分标准对F-PLT进行评分,分为F-PLT 0分、1分、2分三组;运用独立样本t检验及卡方检验分析FIB、PLT、F-PLT与年龄、性别、病理类型、淋巴结转移、浸润深度、是否远处转移、临床分期的关系。并用Cox进行生存分析。结果 (1) FIB与年龄、浸润深度、淋巴结转移、远处转移、临床分期密切相关,差异具有统计学意义(P <0.05),与性别、病理类型无显著差异(t=-0.687、0.344,P=0.495、0.734);(2)PLT与浸润深度、病理类型、淋巴结转移、远处转移、临床分期密切相关,差异具有统计学意义(P <0.05),与性别、年龄无显著差异(t=-0.372、0.358,P=0.711、0. 721);(3) F-PLT评分与浸润深度、病理类型、淋巴结转移、远处转移、临床分期密切相关,差异具有统计学意义(P <0. 05),与性别、年龄无显著差异(X^2=2.078、0. 445,P=0.085、0. 274);(4) F-PLT 2分4年生存率显着低于F-PLT 0-1分的患者(P <0.05)。结论血浆FIB、PLT水平对诊断胃癌及判断预后具有一定的临床意义,值得临床参考应用。

关键词：纤维蛋白原血小板 F-PLT 胃癌预后

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