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Surgical intervention combined with weight-bearing walking training improves neurological recoveries in 320 patients with clinically complete spinal cord injury:a prospective self-controlled study

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Neural Regeneration Research 2021年第5期16卷 820-829页

作者： Yansheng Liu Jia-Xin Xie Fang Niu Zhexi xu Pengju Tan Caihong Shen Hongkun Gao Song Liu Zhengwen Ma Kwok-Fai So Wutian Wu Chen Chen Sujuan Gao xiao-ming xu Hui Zhu Kunming International Spine and Spinal Cord Injury Treatment Center Kunming Tongren HospitalKunmingYunnan ProvinceChina Clinical Center for Spinal Cord Injury Kunming General Hospital of Chengdu Military CommandKunmingYunnan ProvinceChina Department of Laboratory Animal Sciences Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Guangdong-Hongkong-Macao Institute for Central Nervous System Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina Re-Stem Biotechnology Co.Ltd.SuzhouJiangsu ProvinceChina Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Biostatistics Indiana University School of MedicineIndianapolisINUSA

Although a large number of trials in the SCI field have been conducted,few proven gains have been realized for *** the present study,we determined the efficacy of a novel combination treatment involving surgical intervention and long-term weight-bearing walking training in spinal cord injury(SCI)subjects clinically diagnosed as complete or American Spinal Injury Association Impairment Scale(AIS)Class A(AIS-A).A total of 320 clinically complete SCI subjects(271 male and 49 female),aged 16–60 years,received early(≤7 days,n=201)or delayed(8–30 days,n=119)surgical interventions to reduce intraspinal or intramedullary *** days post-surgery,all subjects received a weight-bearing walking training with the“Kunming Locomotion Training Program(KLTP)”for a duration of 6 *** neurological deficit and recovery were assessed using the AIS scale and a 10-point Kunming Locomotor Scale(KLS).We found that surgical intervention significantly improved AIS scores measured at 15 days post-surgery as compared to the pre-surgery baseline *** improvement of AIS scores was detected at 3 and 6 months and the KLS further showed significant improvements between all pair-wise comparisons of time points of 15 days,3 or 6 months indicating continued improvement in walking scores during the 6-month *** conclusion,combining surgical intervention within 1 month post-injury and weight-bearing locomotor training promoted continued and statistically significant neurological recoveries in subjects with clinically complete SCI,which generally shows little clinical recovery within the first year after injury and most are permanently *** study was approved by the Science and Research Committee of Kunming General Hospital of PLA and Kunming Tongren Hospital,China and registered at ***(Identifier:NCT04034108)on July 26,2019.

关键词： American Spinal Injury Association Impairment Scale–A functional recovery human intramedullary decompression spinal cord injury surgical intervention walking training

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Rovai＇s Classroom Community Scale and Its Application in Chinese College English Class

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Sino-US English Teaching 2011年第9期8卷 592-598页

作者： ZHANG Yan-yang LIN xiao xu ming Zhejiang University Hangzhou China

The purpose of this study is to introduce the CCS （Classroom Community Scale） established by Rovai （2002） and its application among freshmen in China with regard to how well their college English class builds a sense of classroom community. In addition, the reliability of CCS as applied in face-to-face classroom setting and the influence of gender and graduating high school of students on their perceptions of classroom community are also examined.

关键词： CCS (Classroom Community Scale) connectedness learning gender graduating high school

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letter from the editors-in-chief

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Neural Regeneration Research 2021年第1期16卷 5-5页

作者： Kwok-fai So xiao-ming xu Neural Regeneration Research

Dear Colleagues,Welcome to the 1^st issue of Neural Regeneration Research(NRR)of *** would like to thank all the authors for their significant contributions and continued support for *** well,we would like to acknowledge and thank those who served on the journal staff and its editorial board,the associate editors,and especially the reviewers for providing objective,insightful,and rigorous critiques of submitted *** individuals have made essential contributions to enhance the clinical relevance and scientific quality of articles published in the journal.

关键词： journal thank letter

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LETTER FROM THE EDITORS-IN-CHIEF

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Neural Regeneration Research 2020年第1期15卷 5-5页

作者： Kwok-fai So xiao-ming xu Neural Regeneration Research

Dear NRR Contributors and Reviewers,Time flies!It has been 14 years since the founding of Neural Regeneration Research(NRR).With your continued support,the journal now becomes one of the finest journals in the field of neural regeneration *** ahead to 2020,we thought it is a good time to share our thinking on new ideas and directions for the journal in the year to come.

关键词： journal Regeneration founding

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Endoscopic diagnosis of gastrointestinal graft-versus-host disease

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World Journal of Gastroenterology 2008年第14期14卷 2262-2267页

作者： Chun-Fang xu Lan-Xiang Zhu xiao-ming xu Wei-Chang Chen De-Pei Wu Department of Gastroenterology The First Affiliated Hospital of SooChow University 188 Shizi Street Suzhou 215006 Jiangsu Province China

AIM:To evaluate the diagnostic value of endoscopy in patients with gastrointestinal graft-versus-host disease (GI GVHD). METHODS:We identified 8 patients with GI GVHD following allogeneic hematopoietic stem cell trans-plantation (HSCT). GVHD was defined histologically as the presence of gland apoptosis, not explained by other inflammatory or infectious etiologies. RESULTS:The symptoms of GI GVHD included anorexia, nausea, vomiting, watery diarrhea, abdominal pain, GI bleeding, etc. Upper endoscopic appearance varied from subtle mucosal edema, hyperemia, erythema to obvious erosion. Colonoscopic examination showed diffuse edema, hyperemia, patchy erosion, scattered ulcer, sloughing and active bleeding. Histological changes in GI GVHD included apoptosis of crypt epithelial cells, dropout of crypts, and lymphocytic infiltration in epithelium and lamina propria. The involvement of stomach and rectocolon varied from diffuse to focal. CONCLUSION:Endoscopy may play a significant role in early diagnosis of GI GVHD patients following allogeneic HSCT, and histologic examination of gastrointestinal biopsies is needed to confirm the final diagnosis.

关键词： Gastrointestinal graft-versus-host disease Endoscopy Diagnosis Allogeneic hematopoietic stem cell transplantation

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Impact of Baseline Bleeding Risk on Efficacy and Safety of Ticagrelor versus Clopidogrel in Chinese Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

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Chinese Medical Journal 2018年第17期131卷 2017-2024页

作者： He-Yang Wang Yi Li xiao-ming xu Jing Li Ya-Ling Han Department of Cardiology General Hospital of Shenyang Military Region Shenyang Liaoning 110016 China

Background： There was still conflict on the antithrombotic advantage of ticagrelor versus clopidogrel among East Asian population with acute coronary syndrome （ACS）. We considered that the baseline bleeding risk might be an undetected key factor that significantly affected the efficacy of ticagrelor. Methods： A total of 20,816 serial patients who underwent percutaneous coronary intervention （PCI） from October 20l 1 to August 2014 in the General Hospital of Shenyang Military Region were enrolled in the present study. Patients receiving ticagrelor or clopidogrel were further subdivided according to basic bleeding risk. The primary outcome was net adverse clinical events （NACEs） defined as major adverse cardiac or cerebral events （MACCE, including all-cause death, myocardial infarction, ischemia-driven target vessel revascularization, or stroke） and any bleeding during l-year lbllow-up. Comparison between ticagrelor and clopidogrel was adjusted by propensity score matching （PSM）. Results： Among the 20,816 eligible PCI patients who were included in this study, there were 1578 and 779 patients in the clopidogrel and ticagrelor groups, respectively, alter PSM, their clinical parameters were well matched. Patients receiving ticagrelor showed comparable NACE risk compared with those treated by c[opidogrel （5.3% vs. 5. I%, P = 0.842）. Furthermore, ticagrelor might reduce the MACCE risk in patients with low bleeding risk but increase MACCE in patients with moderate-to-high bleeding potential （ticagrelor vs. clopidogrel, low bleeding risk： 2.5% vs. 4.9%, P = 0.022： moderate-to-high bleeding risk： 4.8% vs. 3.0%, P =0.225; interaction P = 0.021）, with vast differences in all bleeding （low bleeding risk： 1.5% vs. 0.8%, P =0.210： moderate-to-high bleeding risk： 4.8% vs. 3.0%, P = 0.002; interaction P- 0.296）.Conclusion： Among real-world Chinese patients with ACS treated by PCI, ticagrelor only showed superior efficacy in patients with low bleeding risk but lost its advantage in pa

关键词： Baseline Bleeding Risk: Clopidogrel Crusade Score: Efficacy: Ticagrelor

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Dipping cells in acidic bath could make stem cells

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Neural Regeneration Research 2014年第6期9卷 575-576页

作者： Jinhui Chen Yiwen Ruan Kwok-fai So xiao-ming xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research Institute Department of Neurosurgery Indiana University Gudong-Hongkong-Macao Institute of CNS Regeneration (GHMI-CR) Jinan University

The discovery that somatic mammalian cells can be epigeneti- cally reprogrammed to induced pluripotent stem cells （iPSCs） through the exogenous expression of the Oct4, Sox2, Klf4 and c-Myc （OSKM） has demonstrated a new way for cell-replace- ment therapy in regenerative medicine （Li et al., 2013; Nishimura and Takahashi, 2013; Takahashi and Yamanaka, 2013）. This novel technology has opened new therapeutic opportunities to gener- ate stem cells in any tissue for cell replacement therapy in a num- ber of disorders （Yamanaka, 2012; Li et al., 2013; Nishimura and Takahashi, 2013; Takahashi and Yamanaka, 2013）. Just last week, two papers published in Nature, describing a surprisingly sim- ple method to turn mature cells into embryonic-like stem ceils by culturing cells in a low pH medium （Obokata et al., 2014a, 2014b）. This method by Obokata and colleagues is truly the sim- plest, cheapest, and fastest method ever achieved for reprogram- min~ somatic cells into multiootent stem cells.

关键词： stem cell Dipping cells in acidic bath could make stem cells

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Automated monitoring of early neurobehavioral changes in mice following traumatic brain injury

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Neural Regeneration Research 2016年第2期11卷 248-256页

作者： Wenrui Qu Nai-kui Liu Xin-min (Simon) Xie Rui Li xiao-ming xu Hand & Foot Surgery and Reparative & Reconstructive Surgery Center Orthopaedic Hospital of the Second Hospital of Jilin UniversityChangchun Jilin Province China Spinal Cord and Brain Injury Research Group Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis IN USA Department of Neurological Surgery Indiana University School of Medicine Indianapolis IN USA Department of Anatomy and Cell Biology Indiana University School of Medicine Inclianapolis IN USA Goodman Campbell Brain and Spine Inctianapolis IN USA AfaSci Research Laboratories Redwood City CA USA

Traumatic brain injury often causes a variety of behavioral and emotional impairments that can develop into chronic disorders. Therefore, there is a need to shift towards identifying early symptoms that can aid in the prediction of traumatic brain injury outcomes and behavioral endpoints in patients with traumatic brain injury after early interventions. In this study, we used the Smart Cage system, an automated quantitative approach to assess behavior alterations in mice during an early phase of traumatic brain injury in their home cages. Female C57BL/6 adult mice were subjected to moderate controlled cortical impact（CCI） injury. The mice then received a battery of behavioral assessments including neurological score, locomotor activity, sleep/wake states, and anxiety-like behaviors on days 1, 2, and 7 after CCI. Histological analysis was performed on day 7 after the last assessment. Spontaneous activities on days 1 and 2 after injury were significantly decreased in the CCI group. The average percentage of sleep time spent in both dark and light cycles were significantly higher in the CCI group than in the sham group. For anxiety-like behaviors, the time spent in a light compartment and the number of transitions between the dark/light compartments were all significantly reduced in the CCI group than in the sham group. In addition, the mice suffering from CCI exhibited a preference of staying in the dark compartment of a dark/light cage. The CCI mice showed reduced neurological score and histological abnormalities, which are well correlated to the automated behavioral assessments. Our findings demonstrate that the automated Smart Cage system provides sensitive and objective measures for early behavior changes in mice following traumatic brain injury.

关键词： nerve regeneration traumatic brain injury controlled cortical impact automated behavior motor activity anxiety exploratoryactivity sleep neural regeneration

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Research on the Models of Automotive Suspension Springs Stress

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International Journal of Plant Engineering and Management 2010年第3期15卷 171-174页

作者： SHI xiao-hui xu ming-heng GAO Hong-li School of Mechanical Engineering Southwest Jiaotong University Chengdu 610031 P.R. China

This paper introduced two methods of automotive suspension springs stress analysis, the FEA （finite element analysis） and the experimental measurement, through which the maximum stress is found located where the cylinder number is the integer multiple of the first half cycle from the spring end. By scattering or removing the maximum stress points, optimum design, which is based on the cosmosworks method, will promote the fatigue reliability and the employ life of the springs.

关键词： automotive suspension springs stress experimental determination optimum design

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JY600型地铁及轻轨用内燃调车机车的研制

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内燃机车 2005年第12期 20-22,31页

作者：肖绪明襄樊金鹰轨道车辆有限公司湖北襄樊441001

介绍了JY600型地铁及轻轨用内燃调车机车的研制目标、总体布置、主要参数、性能及结构特点、试验及验证结果。

关键词： JY600型地铁及轻轨用内燃调车机车主要参数性能特点研制

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