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Expression and correlation of CD44v6, vascular endothelial growth factor, matrix metalloproteinase-2, and matrix metalloproteinase-9 in Krukenberg tumor

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World Journal of Gastroenterology 2005年第32期11卷 5032-5036页

作者： Ge Lou Ying Gao xiao-ming Ning Qi-fan Zhang Tumor Hospital of Harbin Medical University Harbin 150040 Heilongjiang Province China

AIM： To explore the expression and correlation of CD44v6, vascular endothelial growth factor （VEGF）, matrix metalloproteinase （MMP）-2 and matrix metalloproteinase （MMP）-9 in Krukenberg and primary epithelial ovarian carcinoma. METHODS： The expressions of CD44v6, VEGF, MMP-2 and MMP-9 were detected by immunohistochemical method in 20 cases of normal ovarian tissues, 38 cases of Krukenberg tumor and 45 cases of primary epithelial ovarian carcinoma. RESULTS： The expression of CD44v6 （primary epithelial ovarian carcinoma tissue vs normal ovarian tissue： χ^2= 4.516, P= 0.034; Krukenberg tumor tissue vsnormal ovarian tissue： χ^2 = 19.537, P = 0.001） and VEGF （primary epithelial ovarian carcinoma tissue vs normal ovarian tissue： P = 0.026; Krukenberg tumor tissue vs normal ovarian tissue： χ^2 = 22.895, P = 0.001） was significantly higher in primary epithelial ovarian carcinoma tissue and Krukenberg tumor tissue than in normal ovarian tissue. The positive expression rate of MMP-2 and MMP-9 was 0% in the normal ovarian tissue. The positive expression rate of CD44v6 （ χ^2= 10.398, P= 0.001）, VEGF （ χ^2= 13.149, P = 0.001）, MMP-2 （ χ^2 = 33.668, P = 0.001） and MMP-9 （ χ^2= 38.839, P = 0.001） was remarkably higher in Krukenberg tumor than in primary epithelial ovarian carcinoma. The correlation of CD44v6, VEGF, MMP-2, and MMP-9 was observed in primary epithelial ovarian carcinoma and Krukenberg tumor. CONCLUSION： CD44v6, VEGF, MMP-2, and MMP-9 are involved in ovarian carcinoma, gastric cancer and Krukenberg tumor. Detection of CD44v6, VEGF, MMP-2 and MMP-9 may contribute to the diagnosis of ovarian carcinoma, gastric cancer, and Krukenberg tumor.

关键词： CD44v6 VEGF, MMPs Krukenberg tumor

Transcatheter arterial chemoembolization after percutaneous microwave ablation and portal vein embolization for advanced hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2023年第2期22卷 213-216页

作者： Jian Cheng De-Fei Hong Cheng-Wu Zhang xiao-ming fan Zu-Yan Luo Wei-Feng Yao Li-ming Jin General Surgery Cancer CenterDepartment of Hepatobiliary&Pancreatic Surgery and Minimally Invasive SurgeryZhejiang Provincial People’s HospitalAffiliated People’s Hospital of Hangzhou Medical CollegeHangzhou 310014China Department of General Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020China

To the Editor: Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS) promotes the future liver remnant(FLR) rapid proliferation in the short term, which in turn provides an opportunity for... 详细信息

关键词： hepatocellular liver microwave

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Paths to Success

Women of China 1999年第10期 25-28页

作者： xiao ming fan fan

The female scientists have made remarkable academicachievements on a par with their male *** their lift scroll, each of them is a thick andrich book, tempting one to read, leading one to think.

关键词： ABT In Paths to Success

Theoretical studies on structure-property relationships of cellulose and nitrocellulose ***,stability and conductivity

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Chinese Journal of Chemistry 1990年第5期8卷 390-395页

作者： xiao,He-ming fan,Jian-Fen LI,Yong-Fu East China Institute of Technology,Nanjing 210014 East China Institute of Technology Nanjing 210014

The banding and electronic structures of a series of long-chain macromolecules of cellu- lose,2-,3-,6-mononitrocellulose,2,3-,2,6-,3,6-dinitrocellulose and trinitrocellulose as well as their structural units(***-,double-or three-ring systems)have been calculated by both the EH and CNDO/2 *** increase of molecular total energies is consistent with the decrease of their stabilities at the three conformations of gg,gt and *** Mulliken bond order of O—NO_2 bond is the samllest in each molecule at any of the three conformations,which indicates that this bond is the weakest,and supports the view of initial homolytic cleavage of O—NO_2 bond on slow thermal *** band gap at the edge of the first Brillouin zone far surpasses 5 eV for cellu- lose,and is less than 3 eV for mono-,di-,and *** results show that cellulose is a typical insulator,as we know,and it can be predicted that nitrocellulose has electric conductivity similar to that of semiconductor.

关键词： Theoretical studies on structure-property relationships of cellulose and nitrocellulose I.Conformation stability and conductivity

Women and Advertising

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Women of China 1997年第8期 8-9页

作者： xiao ming fan YI

The Platform for Action adopted at the United Nations Fourth World Conference On Women acknowledges the media’s role in eliminating sexual discrimination and promoting women’s *** lists women and media as one of the... 详细信息

关键词： Women and Advertising

Influence of oxygen-rich hot air composite gas medium on sintering performance and function mechanism

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Journal of Iron and Steel Research International 2024年第5期31卷 1071-1081页

作者： Min Gan Hao-xiang Zheng xiao-hui fan Zhi-yun Ji Qiang Li ming Wu Yi-fan Wang xiao-long Wang Yu-feng Wu Xu-ling Chen Zeng-qing Sun xiao-xian Huang School of Minerals Processing and Bioengineering Central South UniversityChangsha410083HunanChina Shanxi Taigang Stainless Steel Co. Ltd.Taiyuan030003ShanxiChina

Hot air sintering technology is used to improve the quality and production efficiency of sintered ***,the current thick layer condition highlights the disadvantage of the low oxygen potential of the hot air sintering ***,it is considered to use oxygen enrichment sintering to improve the environment of hot air *** sintering,hot air sintering,and oxygen-rich hot air sintering were compared through sintering cup experiments,and the influence of hot air and oxygen-rich hot air on sintering indexes was *** air reduced the vertical sintering velocity,while improved the yield and tumbler ***-rich hot air sintering contributed to improving the vertical sintering velocity while ensuring the quality of sintered ore,thus comprehensively improving production *** the action of hot air,the highest temperature of the sintering layer increased and the high-temperature holding time was *** oxygen enrichment,the combustion efficiency of fuels in the upper layer of materials was promoted,which optimized heat distribution in the middle and lower layers of materials and increased the content of calcium ferrite in the sintered ore,thus strengthening the sintering process.

关键词： Iron ore sintering Hot air sintering Oxygen enrichment Function mechanism

A brand new green coating technology for realizing the regulation of spherical propellant energy release process

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Defence Technology（防务技术） 2024年第6期36卷 78-94页

作者： Wenhao fan Yajun Ding Zhongliang xiao School of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing210094China Key Laboratory of Special Energy Materials Nanjing University of Science and TechnologyMinistry of EducationNanjing 210094China

To achieve the controllable release of energy of nitrocellulose-based propellants,this paper combines the cellulose-based nanocomposites aqueous coating(Surelease®-NC)with fluidized bed coating equipment to successfully prepare the coated spherical propellant for the first *** effects of fluidized bed coating temperature,air velocity,flow speed and atomization pressure on the adhesion rate,coating integrity and coating uniformity of the coated spherical propellant were investigated,and the preparation of coated spherical propellant with homogeneous size and structural integrity was achieved for the first *** microscopic morphology,chemical structure,water vapor adsorption behavior,combustion performance,and ageing resistance property of the coated spherical propellant were systematically investigated by,Fourier transforms infrared spectroscopy(FTIR),Micro confocal raman spectrometer,field scanning electron microscopy(SEM),dynamic vapor adsorption techniques,and closed bomb test,confirming the surface core-shell structure and the tightly bonded interfacial structure of coated spherical ***,the coated spherical propellant has good hygroscopic,excellent progressive burning and long storage stability.

关键词： Nanocomposites aqueous coating Fluidized bed coating equipment Coated spherical propellant Controllable release of energy Long storage stability

Role of cyclooxygenase-2 in gastric cancer development and progression

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World Journal of Gastroenterology 2013年第42期19卷 7361-7368页

作者： Jian Cheng xiao-ming fan Department of Gastroenterology and Hepatology Jinshan Hospital of Fudan University

Although the incidence of gastric cancer has been declining in recent decades,it remains a major public health issue as the second leading cause of cancer death *** China,gastric cancer is still the main cause of death in patients with malignant *** patients are diagnosed at an advanced stage and mortality is ***-2(COX-2)is a ratelimiting enzyme in prostanoid synthesis and plays an important role in the development and progression of gastric *** expression of COX-2 in gastric cancer is upregulated and its molecular mechanisms have been *** pylori infection,tumor suppressor gene mutation and the activation of nuclear factor-kappa B may be responsible for the elevated expression of COX-2 in gastric *** mechanisms of COX-2 in the development and progression of gastric cancer are probably through promoting the proliferation of gastric cancer cells,while inhibiting apoptosis,assisting angiogenesis and lymphatic metastasis,and participating in cancer invasion and *** review is intended to discuss,comment and summarize recent research progress on the role of COX-2 in gastric cancer development and progression,and elucidate the molecular mechanisms which might be involved in the carcinogenesis.

关键词： Cyclooxygenase-2 Gastric cancer Prostagladin Carcinogenesis Molecular mechanism

Combined effects of ultrasonic vibration and FeCoNiCrCu coating on interfacial microstructure and mechanical properties of Al/Mg bimetal by compound casting

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China Foundry 2024年第5期21卷 588-598页

作者： Yuan-cai Xu Wen-ming Jiang Qing-qing Li Ling-hui Yu xiao-peng Yu Zi-tian fan State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

In this work,a new treatment method combining ultrasonic vibration with FeCoNiCrCu high entropy alloy(HEA)coating was used to prepared Al/Mg bimetal through the lost foam compound *** effects of composite treatment involving ultrasonic vibration and HEA coating on interfacial microstructure and mechanical properties of Al/Mg bimetal were *** demonstrate that the interface thickness of the Al/Mg bimetal with composite treatment significantly decreases to only 26.99%of the thickness observed in the untreated Al/Mg *** HEA coating hinders the diffusion between Al and Mg,resulting the significant reduction in Al/Mg intermetallic compounds in the *** Al/Mg bimetal interface with composite treatment is composed of Al_(3)Mg_(2)and Mg_(2)Si/AlxFeCoNiCrCu+FeCoNiCrCu/δ-Mg+Al_(12)Mg_(17)eutectic *** interface resulting from the composite treatment has a lower hardness than that without *** acoustic cavitation and acoustic streaming effects generated by ultrasonic vibration promote the diffusion of Al elements within the HEA coating,resulting in a significant improvement in the metallurgical bonding quality on the Mg *** fracture position shifts from the Mg side of the Al/Mg bimetal only with HEA coating to the Al side with composite *** shear strength of the Al/Mg bimetal increases from 32.16 MPa without treatment to 63.44 MPa with ultrasonic vibration and HEA coating,increasing by 97.26%.

关键词： ultrasonic vibration FeCoNiCrCu HEA coating Al/Mg bimetal interfacial microstructure shear strength compound casting