检索结果-南通市图书馆

The complex effects of miR-146a in the pathogenesis of Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1309-1323页

作者： Yunfan long Jiajia Liu Yu Wang Haidong Guo Guohong cui Department of Neurology Shanghai No.9 People’s HospitalShanghai Jiaotong University School of MedicineShanghaiChina Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina School of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Neurology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina

Alzheimer's disease is a neurodegenerative disorder characterized by cognitive dysfunction and behavioral *** plaques formed through the extracellular deposition of amyloid-βproteins,as well as neurofibrillary tangles formed by the intracellular deposition of hyperphosphorylated tau proteins,comprise two typical pathological features of Alzheimer's *** symptomatic treatment,there are no effective therapies for delaying Alzheimer's disease ***(miR)are small,non-coding RNAs that negatively regulate gene expression at the transcriptional and translational levels and play important roles in multiple physiological and pathological ***,miR-146a,a NF-κB-regulated gene,has been extensively implicated in the development of Alzheimer's disease through several *** has demonstrated substantial dysregulation of miR-146a both during the initial phases and throughout the progression of this *** R-146a is believed to reduce amyloid-βdeposition and tau protein hyperphosphorylation through the TLR/IRAK1/TRAF6 pathway;however,there is also evidence supporting that it can promote these processes through many other pathways,thus exacerbating the pathological manifestations of Alzheimer's *** has been widely reported that miR-146a mediates synaptic dysfunction,mitochondrial dysfunction,and neuronal death by targeting m RNAs encoding synapticrelated proteins,mitochondrial-related proteins,and membrane proteins,as well as other *** the impact on glial cells,miR-146a also exhibits differential *** one hand,it causes widespread and sustained inflammation through certain pathways,while on the other hand,it can reverse the polarization of astrocytes and microglia,alleviate neuroinflammation,and promote oligodendrocyte progenitor cell differentiation,thus maintaining the normal function of the myelin sheath and exerting a protective effect on *** this review,we provide a

关键词： Alzheimer's disease amyloid-β glial cells microRNAs miR-146a neuroinflammatory

Co-participation of paternal and maternal genomes before the blastocyst stage is not required for full-term development of mouse embryos

在线全文

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2015年第5期7卷 486-488页

作者： Xin Li Jia-Qiang Wang Le-Yun Wang Hai-Feng Wan Yu-Fei Li Tian-Da Li Yu-Kai Wang Ling Shuai Yi-Huan Mao xiao-long cui Liu Wang Zhong-Hua Liu Wei Li Qi Zhou College of Life Sciences Northeast Agricultural UniversityHarbin 150030China State Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Dear Editor,The development of all the mammalian species begins from fertilization of a sperm and an egg into a diploid *** maternal and paternal genomes are not functionally equivalent in term of their differential contributions to the imprinting gene expressions,and they are complementary and both essential for embryonic and postnatal development(McGrath and Solter,1984;Surani et al.,1986).

关键词： genome state. complementary

Research on the balance optimization algorithm of image recognition accuracy and speed based on autocollimator measurement

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optoelectronics Letters 2025年第2期21卷 121-128页

作者： LI Renpu MA long cui Jiwen GUO Junqi Andrei KULIKOV WEN Dandan Chongqing Engineering Research Center of Intelligent Sensing Technology and Microsystem Chongqing University of Post and Telecommunications School of Instrumentation Science and Engineering Harbin Institute of Technology Higher School of Engineering and Technology ITMO University

The autocollimator is an important device for achieving precise,small-angle,non-contact *** primarily obtains angular parameters of a plane target mirror indirectly by detecting the position of the imaging *** is limited report on the core algorithmic techniques in current commercial products and recent scientific *** paper addresses the performance requirements of coordinate reading accuracy and operational speed in autocollimator image *** proposes a cross-image center recognition scheme based on the Hough transform and another based on Zernike moments and the least squares *** experimental evaluation of the accuracy and speed of both schemes,the optimal image recognition scheme balancing measurement accuracy and speed for the autocollimator is *** these,the center recognition method based on Zernike moments and the least squares method offers higher measurement accuracy and stability,while the Hough transform-based method provides faster measurement speed.

关键词： Least squares approximations

基于LUCC的陕西渭北旱塬区景观生态风险评价

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国环境科学 2022年第4期42卷 1963-1974页

作者：尉芳刘京夏利恒龙小翠徐仲炜西北农林科技大学资源环境学院农业部西北植物营养与农业环境重点实验室陕西杨凌712100

基于土地利用/土地覆被变化构建景观生态风险评价模型,评价了渭北旱塬区1980~2018年的生态风险状况.结果表明,随着城镇快速扩张,土地开发利用强度加大,各土地利用类型发生了不同程度的变化,其中,耕地减少量最多,共减少了636.36km^(2),... 详细信息

基于土地利用/土地覆被变化构建景观生态风险评价模型,评价了渭北旱塬区1980~2018年的生态风险状况.结果表明,随着城镇快速扩张,土地开发利用强度加大,各土地利用类型发生了不同程度的变化,其中,耕地减少量最多,共减少了636.36km^(2),建设用地增加量最大,共增加了496.17km^(2);受人口增长和退耕还林、还草政策实施等因素的影响,渭北旱塬区共有3492.40km^(2)土地发生了转化,变化比例为8.80%,耕地、林地、草地和建设用地之间的转化最明显,转化面积为3177.22km^(2),占转化总面积的90.98%;研究期间,低、中低风险区面积占比由20.23%降至19.01%,中风险区面积占比由41.62%升至43.23%,中高、高风险区面积占比由38.15%降为37.77%,生态风险等级整体表现偏高,呈现出"四周低,中间高"的分布特征,高风险区主要分布在景观较破碎的地区,这些地区容易受到人类活动的干扰.此外,研究区生态风险均值呈现先上升后下降的波动降低趋势,整体生态安全有所改善,但局部地区的生态环境质量减低;研究区5期生态风险值的全局Moran’s I指数均高于0.55,说明生态风险值在空间上呈显著的正相关性,高-高聚集区主要分布在中高、高风险区,外界活动对该区域自然生态的干扰较大,生态环境受到较为严重的破坏.

关键词：土地利用/土地覆被生态风险评价景观格局渭北旱塬区

在线全文

学校读者我要写书评

暂无评论

陕西渭北旱塬区农田土壤有机质空间预测方法

环境科学 2022年第2期43卷 1097-1107页

作者：尉芳刘京夏利恒徐仲炜龙小翠西北农林科技大学资源环境学院杨凌712100 农业部西北植物营养与农业环境重点实验室杨凌712100

准确预测土壤有机质(SOM)含量的空间分布对于改善土壤质量、提高区域土壤管理水平具有重要意义.为探索预测陕西渭北旱塬区农田SOM含量的最优模型,借助地理探测器选取与SOM含量密切相关的影响因子作为建模的协变量,选用普通克里格方法(OK... 详细信息

准确预测土壤有机质(SOM)含量的空间分布对于改善土壤质量、提高区域土壤管理水平具有重要意义.为探索预测陕西渭北旱塬区农田SOM含量的最优模型,借助地理探测器选取与SOM含量密切相关的影响因子作为建模的协变量,选用普通克里格方法(OK)、地理加权回归模型(GWR)、偏最小二乘回归模型(PLS)、地理加权回归扩展模型(GWR_(PLS))和随机森林模型(RF)这5种常用方法对训练集样本SOM含量的空间分布进行预测,并利用验证集样本对比分析了5种方法的预测精度.结果表明:(1)影响土壤有机质空间变异的主要因素分别为全氮、化肥施用量、速效钾、有效磷和海拔,且任意两因子间的交互作用对SOM的解释力均高于单因子;(2)农田ω(SOM)范围在2.25~30.23 g·kg^(-1)之间,均值为15.14 g·kg^(-1),变异系数为30.00,5种方法在农田土壤有机质预测结果,虽然局部存在差异,但在整体的空间分布趋势基本一致,在研究区域内呈现北部、东北部地区含量低,西部、东南部含量高的空间分布趋势;(3)从5种方法的预测精度来看,RF的均方根误差(RMSE)与平均绝对误差(MAE)最小,GWR_(PLS)的预测偏差(RPD)最大,相比于OK法,GWR、PLS、RF和GWR_(PLS)的相关系数(r)分别升至0.907、0.836、0.968和0.972.综合分析结果,随机森林模型的预测精度最高.

关键词：土壤有机质(SOM) 空间预测地理探测器地理加权回归(GWR) 随机森林(RF)

无缝隙护理在极低出生体重儿脐静脉与PICC联合置管中的应用

在线全文

学校读者我要写书评

暂无评论

系统医学 2020年第10期5卷 151-153,156页

作者：龙小翠红河州第一人民医院(云南省滇南中心医院)儿科云南蒙自661199

目的研究极低出生体重儿脐静脉与经外周静脉穿刺中心静脉联合置管实施无缝隙护理的应用效果。方法选择60例该院所收治的极低出生体重儿,2017年6月—2018年6月作为该研究的时间范围,采用随机数字表法将其分为实验组与参照组,各30例。参... 详细信息

目的研究极低出生体重儿脐静脉与经外周静脉穿刺中心静脉联合置管实施无缝隙护理的应用效果。方法选择60例该院所收治的极低出生体重儿,2017年6月—2018年6月作为该研究的时间范围,采用随机数字表法将其分为实验组与参照组,各30例。参照组患儿给予常规的护理方法进行护理,参照组患儿给予无缝隙护理方法进行护理。观察比较两组患儿的出生体重以及出生后第1、第2、第4周的体重质量变化,比较两组患儿的不良反应症状发生情况,比较两组患儿的持续带管时间、住院时间以及两组患儿的家长对护理的满意程度以及负面情绪评分。结果①护理前两组患儿的体重差异无统计学意义(P>0.05),护理后,两组患儿的体重质量均有所上升。实验组患儿的体重质量在第1周、第2周、第4周均远高于参照组,分别为(1 298.56±145.13)g vs (1221.24±145.27)g、(1 318.67±103.96)g vs (1 245.67±104.54)g、(1 459.84±152.14)g vs (1 358.68±125.24)g。差异有统计学意义(t=2.062、2.712、2.812,P=0.044、0.009、0.007)。②实验组患儿的不良反应发生率以及置管不良事件的发生率远低于参照组,不良反应发生例数分别为1例,8例。差异有统计学意义(χ^2=6.540,P=0.030)。③两组患儿的住院时间以及持续带管时间存在一定的差异,实验组患儿的住院时间以及持续带管时间远低于参照组患儿,分别为(10.34±2.14)d vs(7.69±1.22)d、(14.95±3.14)d vs(19.67±5.02)d,差异有统计学意义(t=7.494、4.347,P=0.000、0.000)。④两组患儿家属在护理工作之前的负面情绪评分差异无统计学意义(P>0.05)。两组患儿家属的负面情绪评分相比于护理工作之前均有所下降,差异有统计学意义(P<0.05)。实验组患儿家属的负面情绪评分低于参照组,分别为(59.64±1.24)分vs(36.58±1.02)分、(56.22±1.28)分vs(34.59±1.22)分;实验组患儿家属对护理工作的满意度高于参照组患儿。两组之间差异有统计学意义(t=78.664、66.999、35.861,P=0.000、0.000、0.000)。结论无缝隙护理模式在极低出生体重儿经脐静脉与经外周静脉穿刺中心静脉联合置管中护理效果良好,可以有效的缓解患儿家属的情绪,提高患儿家属的护理满意度。减少患儿静脉输液外漏发生率,提高护理人员工作效率,缩短住院时间。具有一定的临床应用价值。

关键词：极低出生体重儿脐静脉与经外周静脉穿刺中心静脉联合置管无缝隙护理

在线全文

学校读者我要写书评

暂无评论

一种无人机锂电池剩余电量估计方法

电源技术 2017年第5期41卷 692-695页

作者：林凡强陈起传龙小翠成都理工大学信息科学与技术学院四川成都610059

为了准确得到多旋翼无人机锂聚合物电池在不同的工作状态下的剩余电量,以电流模拟积分法为电量统计基础,将电池温度、充放电电流等因素对锂聚合物电池电量的影响等效为电池内阻的变化,利用卡尔曼滤波估计法对锂聚合物电池的剩余电量进... 详细信息

为了准确得到多旋翼无人机锂聚合物电池在不同的工作状态下的剩余电量,以电流模拟积分法为电量统计基础,将电池温度、充放电电流等因素对锂聚合物电池电量的影响等效为电池内阻的变化,利用卡尔曼滤波估计法对锂聚合物电池的剩余电量进行估计。实验发现这种方法可自适应电池老化引起的电量衰减,并能有效地补偿充放电过程电流积分误差的累积,通过选择合理的参数可得到不同工作状态下电池较为真实的剩余电量。从而为全自主控制多旋翼无人机系统提供可靠的剩余电量参考。

关键词：锂聚合物电池剩余电量估计卡尔曼滤波电流模拟积分多旋翼无人机

Effects of Ti-and Nb-based transition element from single to multiple compound oxides and carbon-based composite additives on Mg-MgH2 hydrogen storage material

在线全文

学校读者我要写书评

暂无评论

Tungsten 2025年第1期7卷 32-49页

作者： Li-Rong xiao Chen Chen Shuo Wang Zi-Yin Dai Hideo Kimura cui Ni Chuan-Xin Hou Xue-Qin Sun Si-Jie Guo Wei Du Xiu-Bo Xie School of Environmental and Material Engineering Yantai University Bosch HUAYU Steering Systems (Yantai) Co. Ltd.Ytp/MFE University of Tennessee Knoxville Shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta Shandong University of Aeronautics

MgH2is considered as a promising hydrogen storage material for its high hydrogen storage capacity,low cost and abundant resource ***,the low kinetics and high enthalpy formation of MgH2limit its wide *** the perspective of adding catalysts to enhance the hydrogen storage properties of Mg-MgH2,this article elaborated the main catalysts based on Ti and Nb transition elements,including single oxide catalysts,binary oxides catalysts（combined with Ni,Na,Sr,V,etc.）,multiple catalysts bound to carbon,and composite catalysts with Ti and Nb elements combined with MXene ***,the main pathways of various catalysts to reduce the reaction activity and broaden the hydrogen desorption channel were also *** Ti-based catalysts can enhance the reactive sites of the matrix by forming multivalent states,while Nb-based catalysts broaden the hydrogen reaction channels by forming tiny *** improving the size structure and enhancing the grain size stability,combined with carbon materials should be the future considerations.

关键词： Catalysts Mg-based hydrogen storage alloys Solid hydrogen storage Transition metal elements

Research status and prospects of the fractal analysis of metal material surfaces and interfaces

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 20-38页

作者： Qinjin Dai Xuefeng Liu Xin Ma Shaojie Tian Qinghe cui Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China Laboratory for Advanced Materials Processing of Ministry of Education University of Science and Technology BeijingBeijing 100083China School of Mechanical and Electrical Engineering Xinjiang Institute of EngineeringUrumqi 830023China

As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine *** analysis has been used to characterize the shapes of metal materials at various scales and *** methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and ***,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal *** the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear *** relationship between the fractal dimensions and properties of metal material surfaces and interfaces is *** from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be *** is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.

关键词： metal material surfaces and interfaces fractal analysis fractal dimension homogeneity