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Hepatoprotective effects of xiaoyao San formula on hepatic steatosis and inflammation via regulating the sex hormones metabolism

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World Journal of Hepatology 2024年第7期16卷 1051-1066页

作者： xiao-Li Mei Shu-Yi Wu Si-Lan Wu xiao-lin luo Si-Xing Huang Rui Liu Zhe Qiang Department of Pharmacology and Toxicology Sichuan-Chongqing Joint Key Laboratory of New Chinese Medicine Creation LaboratoryChongqing Academy of Chinese Materia MedicaChongqing 400061China College of Chinese Medicine Chongqing College of Traditional Chinses MedicineChongqing 402760China Department of Oncology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China College of Pharmacy Chongqing Medical UniversityChongqing 400010China

BACKGROUND The modified xiaoyao San(MXS)formula is an adjuvant drug recommended by the National Health Commission of China for the treatment of liver cancer,which has the effect of preventing postoperative recurrence and metastasis of hepatocellular carcinoma and prolonging patient ***,the molecular mechanisms underlying that remain *** To investigate the role and mechanisms of MXS in ameliorating hepatic injury,steatosis and *** A choline-deficient/high-fat diet-induced rat nonalcoholic steatohepatitis(NASH)model was used to examine the effects of MXS on lipid accumulation in primary *** tissues were collected for western blotting and immunohisto chemistry(IHC)*** accumulation and hepatic fibrosis were detected using oil red staining and Sirius red *** serum samples were collected for biochemical assays and NMR-based metabonomics *** inflammation/lipid metabolism-related signaling and regulators in liver tissues were also detected to reveal the molecular mechanisms of MXS against *** MXS showed a significant decrease in lipid accumulation and inflammatory response in hepatocytes under metabolic *** western blotting and IHC results indicated that MXS activated AMPK pathway but inhibited the expression of key regulators related to lipid accumulation,inflammation and hepatic fibrosis in the pathogenesis of *** metabonomics analysis systemically indicated that the arachidonic acid metabolism and steroid hormone synthesis are the two main target metabolic pathways for MXS to ameliorate liver inflammation and hepatic ***,we found that MXS protected against NASH by attenuating the sex hormone-related metabolism,especially the metabolism of male *** MXS ameliorates inflammation and hepatic steatosis of NASH by inhibiting the metabolism of male *** male hormone related metabolic pathways may be the potential therapeutic app

关键词： Hepatic steatosis Inflammation Sex hormone metabolism Male hormone Phosphatase and tensin homolog deleted on chromosome ten

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Choline suppresses hepatocellular carcinoma progression by attenuating AMPK/mTOR-mediated autophagy via choline transporter SLC5A7 activation

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 393-411,I0001,I0002页

作者： Chen Wang Zhao-Yan Liu Wen-Ge Huang Zhi-Jun Yang Qiu-Ye Lan Ai-Ping Fang Meng-Jun Hou xiao-lin luo Yao-Jun Zhang Si Chen Hui-Lian Zhu Department of Nutrition School of Public HealthSun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Food Nutrition and HealthSchool of Public HealthSun Yat-sen UniversityGuangzhouChina Center of Experimental Animals Sun Yat-sen UniversityGuangzhouChina Experimental and Teaching Center for Public Health School of Public HealthSun Yat-sen UniversityGuangzhouChina Department of Hepatobiliary Oncology Sun Yat-sen University Cancer CenterGuangzhouChina

Background:Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-associated *** evidence suggests that autophagy plays a critical role in HCC tumorigenesis,metastasis,and *** is an essential nutrient related to prolonged survival and reduced risk of ***,it remains unclear whether this phenomenon is mediated by ***:Two HCC cell lines(HUH-7 and Hep3B)were used in the present *** growth was evaluated by cell counting kit 8(CCK-8),colony formation,and in vivo mouse xenografts *** motility was calculated by wound healing and transwell *** were measured by transmission electron microscope(TEM),and autophagy flux was detected by mRFP-GFP-labeled LC3 *** mRNA level of genes was measured by quantitative real-time polymerase chain reaction(qRT-PCR).The protein levels were detected by Western blotting(WB).Results:We found that choline inhibited the proliferation,migration,and invasion of HCC cells by downregulating autophagy in vitro and in *** expression of the solute carrier family 5 member 7(SLC5A7),a specific choline transporter,correlated with better HCC *** further discovered that choline could promote SLC5A7 expression,upregulate cytoplasm p53 expression to impair the AMPK/mTOR pathway,and attenuate ***,we found that choline acted synergistically with sorafenib to attenuate HCC development in vitro and in ***:Our findings provide novel insights into choline-mediated autophagy in HCC,providing the foothold for its future application in HCC treatment.

关键词： Hepatocellular carcinoma(HCC) autophagy choline solute carrier family 5 member 7(SLC5A7)

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Obstetrical Disease Spectrum in China： An Epidemiological Study of 111,767 Cases in 2011

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Chinese Medical Journal 2015年第9期128卷 1137-1146页

作者： xiao-lin luo Wei-Yuan Zhang Department of Obstetrics Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing 100026 China

Background：No national research on maternal and fetal complications and outcomes has been carried out in the mainland of China in recent *** study was to provide a scientific basis for better control of obstetrical and neonatal diseases and better allocation of medical resources by analyzing the epidemiological characteristics of obstetrical diseases in the mainland of ***：Hospitalized obstetrical cases from 19 tertiary and 20 secondary hospitals in 14 provinces （nationally representative） during the period January 1,2011 to December 31,2011 were randomly *** general condition,pregnancy complications,and perinatal outcomes of the patients were ***：The top five medical and surgical complications of pregnant women in the mainland of China were anemia （6.34％）,uterine fibroids （2.69％）,thyroid disease （1.11％）,thrombocytopenia （0.59％）,and heart disease （0.59％）.The incidences of premature rupture of membranes （PROM）,preterm birth,prolonged pregnancy,hypertensive disorders complicating pregnancy （HDCP）,multiple pregnancy,intrahepatic cholestasis of pregnancy （ICP）,placenta previa,placental abruption,postpartum hemorrhage,and amniotic fluid embolism were 15.27％,7.04％,6.71％,5.35％,1.57％,1.22％,1.14％,0.54％,3.26％ and 0.06％,*** incidences of anemia and prolonged pregnancy were significantly lower in tertiary than secondary hospitals （P ＜ 0.001）,whereas the incidence of uterine fibroids,thyroid diseases,thrombocytopenia,heart disease,PROM,preterm birth,HDCP,multiple pregnancy,ICP,placenta previa,and placental abruption were significantly higher in tertiary than secondary hospitals （P ＜ 0.001）.The cesarean section （CS） rate was 54.77％.The newborn sex ratio was 119：100,and 1.03％ of the neonates were *** percentages of low birth weight and fetal macrosomia in full-term babies were 2.10％ and 7.09％,***：The incidence of some obstetrical diseases is still high in the mainland of *** CS rate is much hig

关键词： Disease Spectrum Perinatal Outcomes Pregnancy Complications

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Structural engineering of hard carbon through spark plasma sintering for enhanced sodium-ion storage

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Rare Metals 2024年第9期43卷 4274-4285页

作者： Hao-Ming xiao Heng Zheng Ping Yuan Jun-Hui luo lin-lin Shen Jie-Feng Tan Xian-You luo De Li Yong Chen Guangdong Key Laboratory for Hydrogen Energy Technologies School of Materials Science and Hydrogen EnergyFoshan UniversityFoshan 528000China State Key Laboratory of Marine Resource Utilization in South China Sea Hainan Provincial Key Laboratory of Research on Utilization of Si-Zr-Ti ResourcesHainan UniversityHaikou 570228China

Hard carbon(HC)has emerged as one of the superior anode materials for sodium-ion batteries(SIBs),with its electrochemical performance significantly influenced by the presence of oxygen functional groups and its closed pore ***,current research on the structural adjustment of these oxygen functional groups and the closed pore architecture within HC remains ***,energy-efficient and contamination-free spark plasma sintering technology was employed to tune the structure of coconut-shell HC,resulting in significant adjustments to the content of carboxyl(decreasing from 5.71 at%to 2.12 at%)and hydroxyl groups(decreasing from 7.73 at%to 6.26 at%).Crucially,these modifications reduced the irreversible reaction of oxygen functional groups with Na^(+).Simultaneously,a substantial number of closed pores with an average diameter of 1.22 nm were generated within the HC,offering an ideal environment for efficient Na^(+)*** structural changes resulted in a remarkable improvement in the electrochemical performance of the modified *** reversible specific capacity of the modified HC surged from 73.89 mAh·g^(-1)to an impressive 251.97 m Ah·g^(-1)at a current density of 50 mA·g^(-1).Even at 400 mA·g^(-1),the reversible specific capacity increased significantly from 14.55 to 85.44 mAh·g^(-1).Hence,this study provides a novel perspective for designing tailored HC materials with the potential to develop high-performance SIBs.

关键词： Hard carbon Spark plasma sintering Sodiumion batteries Closed pores Oxygen functional groups

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Recent advances in electrocatalytic generation of indole-derived radical cations and their applications in organic synthesis

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Chinese Chemical Letters 2024年第4期35卷 106-123页

作者： Wei Zhou Xi Chen lin Lu Xian-Rong Song Mu-Jia luo Qiang xiao Key Laboratory of Organic Chemistry of Jiangxi Province Jiangxi Science&Technology Normal UniversityNanchang 330013China

Indole-derived radical cations, open-shell reactive species, display distinctive dual reactivity due to the carbon-centered radical and more electrophilic carbocation, which frequently appear in a variety of single electron oxidation reactions for synthesizing structurally diverse functionalized indoles and indolines. Electrocatalysis is considered as a synthetically attractive and environmentally friendly alternative for driving the single electron oxidation of indoles. Remarkable achievements in electrocatalytic indolederived radical cation-mediated indole functionalization have been realized so far. This review comprehensively summarizes the recent progresses in the applications of electrocatalytic indole radical cations,including C(sp~2)–H functionalization, dearomative 2,3-difunctionalization, and ring-opening reaction, emphasizing the vital single electron oxidation steps of indoles, the substrates scope and limitations, and the reaction mechanisms.

关键词： Electrocatalysis Indole radical cation C-H functionalizatin Dearomative 2 3-difunctionalization

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On the Shallowing of Antarctic Low-Level Temperature Inversions Projected by CESM-LE under RCP8.5

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Journal of Meteorological Research 2024年第3期38卷 586-599页

作者： Minghu DING lin ZHANG Tingfeng DOU Yi HUANG Yingyan luo Junmei LYU Cunde xiao State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing100081China Key Laboratory of Meteorology and Ecological Environment of Hebei Province Hebei Provincial Institute of Meteorological SciencesShijiazhuang050021China College of Resources and Environment University of Chinese Academy of SciencesBeijing100049China State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijing100875China

Temperature inversions are frequently observed in the boundary layer and lower troposphere of polar *** variations of the low-level temperature inversions in these regions,especially the Antarctic,are still poorly *** to the scarcity of observations in the Antarctic,reanalysis data and numerical simulations are often used in the study of Antarctic climate *** on ERA-Interim,ERA5,JRA-55,and NCEP-NCAR reanalysis products,this study examines temporal and spatial variations of Antarctic inversion depth in austral autumn and winter during *** inversions are found to occur over the high plateau areas of the Antarctic *** on the Mann-Kendall test,ERA-Interim and ERA5 data reveal that the Antarctic inversion depth in austral autumn and winter increased during 1992-2007,roughly maintained afterwards,and then significantly decreased since around *** decrease trend is more obvious in the last two months of ***,JRA-55 better represents the spatial distribution of inversion depth,and ERA-Interim has better interannual *** Community Earth System Model Large Ensemble(CESM-LE)30-member simulations in 1979-2005 were first verified against JRA-55,showing reasonable consistency,and were then used to project the future changes of Antarctic low-level inversion depth over 2031-2050 under *** CESM-LE projection results reveal that the temperature inversion will shallow in the Antarctic at the end of the 21st century,and the decrease in depth in autumn will be more pronounced than that in *** particular,the temperature inversion will weaken over the ice-free ocean,while it will remain stable over the ice sheet,showing certain spatial heterogeneity and seasonal dependence on the underlying cryospheric surface *** addition,the decrease of inversion depth is found closely linked with the reduction in sea ice,suggesting the strong effect of global warming on the thermal structure change o

关键词： boundary layer temperature inversion Antarctic climate change Community Earth System Model Large Ensemble(CESM-LE)

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A Self-Attention Based Dynamic Resource Management for Satellite-Terrestrial Networks

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China Communications 2024年第4期21卷 136-150页

作者： lin Tianhao luo Zhiyong School of Electronics and Communication Engineering Sun Yat-Sen UniversityShenzhen 518107China Peng Cheng Laboratory Shenzhen 518107China

The satellite-terrestrial networks possess the ability to transcend geographical constraints inherent in traditional communication networks,enabling global coverage and offering users ubiquitous computing power support,which is an important development direction of future *** this paper,we take into account a multi-scenario network model under the coverage of low earth orbit(LEO)satellite,which can provide computing resources to users in faraway areas to improve task processing ***,LEO satellites experience limitations in computing and communication resources and the channels are time-varying and complex,which makes the extraction of state information a daunting ***,we explore the dynamic resource management issue pertaining to joint computing,communication resource allocation and power control for multi-access edge computing(MEC).In order to tackle this formidable issue,we undertake the task of transforming the issue into a Markov decision process(MDP)problem and propose the self-attention based dynamic resource management(SABDRM)algorithm,which effectively extracts state information features to enhance the training *** results show that the proposed algorithm is capable of effectively reducing the long-term average delay and energy consumption of the tasks.

关键词： mobile edge computing resource management satellite-terrestrial networks self-attention

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Chemical derivatization strategies for enhancing the HPLC analytical performance of natural active triterpenoids

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Journal of Pharmaceutical Analysis 2024年第3期14卷 295-307页

作者： xiao-Feng Huang Ying Xue Li Yong Tian-Tian Wang Pei luo lin-Sen Qing Chengdu Institute of Biology Chinese Academy of SciencesChengdu610041China State Key Laboratory for Quality Research in Chinese Medicines Macao University of Science and TechnologyMacaoChina Sichuan Center for Disease Control and Prevention Chengdu610041China University of Chinese Academy of Sciences Beijing100049China

Triterpenoids widely exist in nature,displaying a variety of pharmacological *** triterpenoids in different matrices,especially in biological samples holds great ***-performance liquid chromatography(HPLC)has become the predominant method for triterpenoids analysis due to its exceptional analytical ***,due to the structural similarities among botanical samples,achieving effective separation of each triterpenoid proves challenging,necessitating significant improvements in analytical ***,triterpenoids are characterized by a lack of ultraviolet(UV)absorption groups and chromophores,along with low ionization efficiency in mass ***,routine HPLC analysis suffers from poor *** derivatization emerges as an indispensable technique in HPLC analysis to enhance its *** the structural characteristics of triterpenoids,various derivatization reagents such as acid chlorides,rhodamines,isocyanates,sulfonic esters,and amines have been employed for the derivatization analysis of *** review comprehensively summarized the research progress made in derivatization strategies for HPLC detection of ***,the limitations and challenges encountered in previous studies are discussed,and future research directions are proposed to develop more effective derivatization methods.

关键词： Triterpenoid HPLC Derivatization Quantification

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Performance test of a half-feed peanut-cleaning picker suitable for clay hill areas in southern China

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International Journal of Agricultural and Biological Engineering 2024年第4期17卷 156-164页

作者： Shenying Wang Zhaoyan You Dawei Sun Qiang xiao Qiaojun luo lin He Key Laboratory of Modern Agricultural Intelligent Equipment in South China Ministry of Agriculture and Rural AffairsGuangzhou 510630China Nanjing Institute of Agricultural Mechanization Ministry of Agriculture and Rural AffairsNanjing 210014China Key Laboratory of Agricultural Equipment for Hilly and Mountainous Areas in Southeastern China(Co-construction by Ministry and Province) Ministry of Agriculture and Rural AffairsHangzhou 310021China Inner Mongolia Autonomous Region Agricultural and Animal Husbandry Technology Promotion Center Hohhot 010000China

To solve the problems of excessive soil lumps,broken branches and seedlings in pods and difficulty in removing impurities in the harvested pods of peanuts in the hilly areas of southern China,which is due to the high soil viscosity and easy hardening,and to improve the soil removal effect of the peanut half-feed pod picker in hilly areas of China,this article designed a half-feed peanut-cleaning picker suitable for southern clay hilly areas and provided a detailed introduction to the overall structure,working principle,and adjustment methods of various operating *** field measurement experiments,the influencing factors and laws of soil removal performance indicators,such as the comprehensive soil removal rate and POD drop rate,were *** results showed that the comprehensive soil removal rate gradually increased with increasing soil patting frequency,soil patting amplitude,and picking roller speed,first increased and then decreased with increasing picking roller gap and gradually decreased with increasing soil patting plate gap and clamping conveyor chain *** comprehensive soil removal rate of the soil patting plate using the opposite patting method was greater than that of the swinging patting *** soil removal pod drop rate increased gradually with increasing soil patting frequency and amplitude and decreased with increasing soil patting plate gap and clamping conveyor chain *** soil removal pod drop rate of the soil patting plate using swing patting was lower than that using the opposite patting *** speed and gap of the picking roller had no effect on the soil removal pod drop *** frequency,amplitude,form,and gap of the soil patting plate had extremely significant impacts on the rate of decrease in the number of soil removal pod drop *** clamping conveyor chain speed had a significant impact,while the speed and gap of the picking roller had no significant *** influence of all factors on the comprehens

关键词： peanut southern clay hilly areas picker comprehensive soil removal rate soil removal pod drop rate

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Along-track Calibration of the Zhurong Rover Magnetometer

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Science China Earth Sciences 2024年第2期67卷 552-565页

作者： Hao luo Aimin DU Yasong GE Ying ZHANG Haiying LI lin TIAN Kuixiang ZHANG Shuquan SUN lin ZHAO Zhi LI xiao FENG CAS Engineering Laboratory for Deep Resources Equipment and Technology Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China College of Earth Science University of Chinese Academy of SciencesBeijing100049China National Astronomical Observatories Chinese Academy of SciencesBeijing100101China

As part of the Chinese Tianwen-1 mission,the Zhurong Rover began its scientific investigation in the southern Utopia Planitia after its successful landing in 15 May,*** Zhurong Rover magnetometer(RoMAG),one of the six payloads onboard the rover,includes two identical high-sensitivity triaxial fluxgate magnetometers and can implement mobile magnetic measurements on the surface of *** a rover magnetic compensation procedure was conducted to remove the magnetic interferences pre-launch,due to the different state of the payloads and electric power system such as the solar panel,an along-track calibration of the magnetometer is necessary to obtain a more accurate Martian magnetic *** methods,mast yaw rotations and Rover yaw rotations were utilized separately to determine the Martian horizontal magnetic *** show that the Martian horizontal magnetic components determined by the two methods are in good agreement,with the root mean square deviation less than 2.0 *** vertical component was also constrained through the pitch movements of the mast by assuming the interferences field distributes like a dipole field.A linear correlation between magnetic field measurements and the solar array currents was derived to calibrate the body field during the regular *** conclude that more accurate measurements could be made when applying the calibration results in the magnetic survey on the surface of Mars.

关键词： The Zhurong Rover Magnetometer Along-track calibration Remnant magnetization

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