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Gadolinium-containing semiconducting polymer nanoparticles for magnetic resonance/fluorescence dual-modal imaging and photothermal therapy of oral squamous cell carcinoma

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Nano Research 2023年第2期16卷 2808-2820页

作者： xiao Pan Antian Gao Yanni hu Ziyang hu Chen Xie Zitong lin Department of Dentomaxillofacial Radiology Affiliated Stomatology Hospital of Medical SchoolNanjing UniversityNanjing 210008China Key Laboratory for Organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing University of Posts&TelecommunicationsNanjing 210023China

Oral squamous cell carcinoma(OSCC)is the most common malignant tumor of the oral and maxillofacial *** to its unique location,earlier and more accurate diagnosis and more minimally invasive treatment of OSCC is of major ***,gadolinium-containing semiconductor polymer nanoparticles(SPN-Gd)were designed and *** nanoparticles consist of a near-infrared(NIR)absorption semiconductor polymer(PCPDTBT)served as fluorescence signal source and a photothermal conversion agent(PTA)and a gadolinium-grafted triblock amphiphilic copolymer(F127-DTPA-Gd)served as a magnetic resonance imaging(MRI)contrast agent and *** experiments in vivo showed that SPN-Gd could act as an MRI contrast agent and optical image agent with a long retention time,and it had a significant inhibiting effect on tumors of OSCC mice model through photothermal therapy(PTT).Thus our study provides a simple nanotheranostic platform composed of two components for efficient MR/fluorescence dual-modal imaging-guided PTT.

关键词： oral squamous cell carcinoma magnetic resonance imaging fluorescence imaging dual-modal imaging photothermal therapy semiconducting polymer nanoparticles

普通小麦-长穗偃麦草杂种衍生后代SNTE0923形态学、细胞学和白粉病抗性鉴定

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西南农业学报 2012年第2期25卷 485-489页

作者：任学军孙蕾何莉炜胡铁峰孙会改周印富林小虎王洪刚河北科技师范学院河北秦皇岛066004 山东农业大学国家小麦改良中心山东(泰安)分中心作物生物学国家重点实验室山东泰安271018

对长穗偃麦草(Thinopurum ponticum,2n=70)与普通小麦品种烟农15的杂种衍生后代SNTE0923进行形态学、细胞学和白粉病抗性鉴定,初步筛选出抗白粉病普通小麦-长穗偃麦草育种新材料,为抗白粉病基因遗传学研究和小麦抗白粉病品种改良提供新... 详细信息

对长穗偃麦草(Thinopurum ponticum,2n=70)与普通小麦品种烟农15的杂种衍生后代SNTE0923进行形态学、细胞学和白粉病抗性鉴定,初步筛选出抗白粉病普通小麦-长穗偃麦草育种新材料,为抗白粉病基因遗传学研究和小麦抗白粉病品种改良提供新的种质资源。对杂种衍生后代材料SNTE0923进行考种,形态学观察,花粉母细胞减数分裂中期Ⅰ和根尖染色体有丝分裂中期观察并进行白粉病抗性鉴定,结果表明:杂种后代材料SNTE0923的株高介于亲本长穗偃麦草和普通小麦之间,穗较长,有芒,群体整齐度较好;体细胞染色体数目鉴定为2n=42,花粉母细胞减数分裂中期Ⅰ染色体配对情况表明,大部分单株染色体构型为21Ⅱ,极个别在后期Ⅰ发现一定数量的染色体桥和落后染色体;白粉病抗性鉴定表明SNTE0923对白粉病有较高的抗性。杂种衍生后代材料SNTE0923绝大部分单株在遗传上趋于稳定,并且高抗白粉病,通过选育,可以做为抗小麦白粉病育种新的种质资源。

关键词：小麦长穗偃麦草小麦白粉病形态学鉴定细胞学鉴定

Populations of Ethanol Conformers in Liquid CCI4 and CS2 by Raman Spectra in OH Stretching Region

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Chinese Journal of Chemical Physics 2015年第3期28卷 245-252,I0001页

作者： Nai-yin hu Ke lin xiao-guo Zhou Shi-lin Liu Hefei National Laboratory for Physical Sciences at the Microscale Department of Chemical PhysicsUniversity of Science and Technology of China Hefei 230025 China Synergetic Innovation Center of Quantum Information & Quantum Physics University of Science and Technology of China Hefei 230026 China

Combining Raman spectroscopy with density functional theory, the populations of the trans- and gaucheethanol conformers are investigated in carbon tetrachloride （CC14） and carbon disulfide （CS2）. The spectral contributions of two ethanol conformers are identified in OH stretching region. The energy difference between both conformers is estimated with the aid of the calculated Raman cross sections. It can be seen that the trans- ethanol is more stable in CC14 and CS2 solutions. The spectra are also obtained at different temperatures, and it is found the van＇t Hoff analysis is invalid in these solutions. By taking accounts of the Boltzmann distribution and theoretical Raman cross section, the energy difference is found to be increased with temperature, which shows the weak intermolecular interactions can enhance the population of transethanol.

关键词： Raman spectroscopy Ethanol Conformer Energy difference

Experimental study on water-saving and emission-reduction effects of controlled drainage technology

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Water Science and Engineering 2015年第2期8卷 114-120页

作者： Meng-hua xiao Xiu-jun hu lin-lin Chu Research Center of Fluid Machinery Engineering and Technology Jiangsu University

Field experiments and laboratory analysis were carried out to determine the effects of controlled drainage（CTD） and conventional drainage（CVD） technologies on drainage volume, concentrations of NH4^＋ -N, NO3^-N, and total phosphorus（TP）, nitrogen and phosphorus losses, rice yield,and water utilization efficiency. Results show that CTD technology can effectively reduce drainage times and volume; NH4^＋ -N, NO3^-N, and TP concentrations, from the first to the fourth day after four rainstorms decreased by 28.7%e46.7%, 37.5%e47.5%, and 22.7e31.2%, respectively,with CTD. These are significantly higher rates of decrease than those observed with CVD. CTD can significantly reduce nitrogen and phosphorus losses in field drainage, compared with CVD; the reduction rates observed in this study were, respectively, 66.72%, 55.56%, and 42.81% for NH4^＋ -N, NO3^-N, and TP. Furthermore, in the CTD mode, the rice yield was cut slightly. In the CVD mode, the water production efficiencies in unit irrigation water quantity, unit field water consumption, and unit evapotranspiration were, respectively, 0.85, 0.48, and 1.22 kg/m^3, while in the CTD mode they were 2.91, 0.84, and 1.61 kg/m^3 din other words, 3.42, 1.75, and 1.32 times those of CVD. Furthermore, the results of analysis of variance（ANOVA） show that the indicators in both the CVD and CTD modes, including the concentrations of NH4^＋ -N, NO3^-N, and TP, the losses of NH4^＋ -N, NO3^-N, and TP, irrigation water quantity, and water consumption, showed extremely significant differences between the modes, but the rice yield showed no significant difference.

关键词： Controlled drainage Nitrogen Phosphorus Rice yield Drainage volume Water utilization efficiency

Study on Dynamic Response of the “Dualistic” Structure Rock Slope with Seismic Wave Theory

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Journal of Mountain Science 2013年第6期10卷 996-1007页

作者： CHEN Zhen-lin XU Qiang hu xiao State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of Technology

Currently, scant attention has been paid to the theoretical analysis on dynamic response mechanism of the ＂Dualistic＂ structure roek slope. The analysis presented here provides insight into the dynamic response of the ＂Dualistie＂ structure rock slope. By investigating the principle of energy distribution, it is shown that the effect of a joint plays a significant role in slope stability analysis. A dynamic reflection and transmission model （RTM） for the ＂Dualistic＂ structure rock slope and explicit dynamic equations are established to analyze the dynamic response of a slope, based on the theory of elastic mechanics and the principle of seismic wave propagation. The theoretical simulation solutions show that the dynamic response of the ＂Dualistic＂ structure rock slope （soft-hard） model is greater than that of the ＂Dualistic＂ strueture rock slope （hard-soft） model, especially in the slope crest. The magnifying effect of rigid foundation on the dynamic response is more obvious than that of soft foundation. With the amplitude increasing, the cracks could be found in the right slope （soft-hard） crest. The crest failure is firstly observed in the right slope （soft-hard） during the experimental process. The reliability of theoretical model is also investigated by experiment analysis. The conclusions derived in this paper could also be used in future evaluations of Multi-layer rock slopes.

关键词： Reflection and transmission waves Dualistic structure Seismic wave Dynamic response

Experimental study of motion characteristics of rock slopes with weak intercalation under seismic excitation

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Journal of Mountain Science 2016年第3期13卷 546-556页

作者： CHEN Zhen-lin hu xiao XU Qiang State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of Technology

In order to investigate the effect of a weak intercalation on slope stability, a large-scale shaking table model test was conducted to study the dynamic response of rock slope models with weak *** dynamic response of the prototype slopes were studied in laboratory with the consideration of law of similitude. The initiation failure was observed in the rock slope model with a counter-tilt thin-weak intercalation firstly, not in the slope model with a horizontal thin-weak intercalation. Furthermore, it was interesting that the fracture site is shifted from crest top to the slope surface near the weak intercalation, which is different with the location of failure position in a normal layered slope. We also discussed the effect of the dip angle and the thickness of weak intercalation on the failure mechanism and instability mode of the layered rock slope. From the experimental result, it was noted that the stability of the slope with a counter-tilt weak intercalation could be worse than that of the other slopes under seismic excitation. The findings showed the difference of failure in slopes with a horizontal and counter weak intercalation, and implicated the further evaluation of failure of layered slopes caused by seismic loads.

关键词： Counter-tilt Rock slope Weak intercalation Dynamic response Failure mechanism

Numerical Simulation of Thermocapillary-Buoyant Convection in an Annular Pool under Various Gravity Levels

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Chinese Physics Letters 2012年第7期29卷 175-178页

作者： ZHOU xiao-Ming huANG hu-lin Academy of Frontier Science Nanjing University of Aeronautics and AstronauticsNanjing 210016 Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190

Thermocapillary-buoyant convection in an annular two-layer system under various gravity levels is investigated,in which the level set method is employed to capture the interface,and the continuum surface force tension model is used to simulate the Marangoni *** results show that,under the influence of the Marangoni effect,the interface bulges out near the outer wall and bulges in near the inner *** flow pattern consists of static convective cells,but a transition of flow pattern occurs as the gravity level *** interface deformability decreases with increasing gravity level,and the change rate of deformability is the largest as the gravity level varies from 0.001g to 0.01g.

关键词： effect capillary interface

A Novel Hardware/Software Partitioning Method Based on Position Disturbed Particle Swarm Optimization with Invasive Weed Optimization

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Journal of Computer Science & Technology 2017年第2期32卷 340-355页

作者： xiao-hu Yan Fa-Zhi He Yi-lin Chen State Key Laboratory of Software Engineering Wuhan University Wuhan 430072 China School of Computer Science Wuhan University Wuhan 430072 China

With the development of the design complexity in embedded systems, hardware/software （HW/SW） partitioning becomes a challenging optimization problem in HW/SW co-design. A novel HW/SW partitioning method based on position disturbed particle swarm optimization with invasive weed optimization （PDPSO-IWO） is presented in this paper. It is found by biologists that the ground squirrels produce alarm calls which warn their peers to move away when there is potential predatory threat. Here, we present PDPSO algorithm, in each iteration of which the squirrel behavior of escaping from the global worst particle can be simulated to increase population diversity and avoid local optimum. We also present new initialization and reproduction strategies to improve IWO algorithm for searching a better position, with which the global best position can be updated. Then the search accuracy and the solution quality can be enhanced. PDPSO and improved IWO are synthesized into one single PDPSO-IWO algorithm, which can keep both searching diversification and searching intensification. Furthermore, a hybrid NodeRank （HNodeRank） algorithm is proposed to initialize the population of PDPSO-IWO, and the solution quality can be enhanced further. Since the HW/SW communication cost computing is the most time-consuming process for HW/SW partitioning algorithm, we adopt the GPU parallel technique to accelerate the computing. In this way, the runtime of PDPSO-IWO for large-scale HW/SW partitioning problem can be reduced efficiently. Finally, multiple experiments on benchmarks from state-of-the-art publications and large-scale HW/SW partitioning demonstrate that the proposed algorithm can achieve higher performance than other algorithms.

关键词： hardware/software partitioning particle swarm optimization invasive weed optimization communicationcost parallel computing

A Novel Model for Describing Rail Weld Irregularities and Predicting Wheel-Rail Forces Using a Machine Learning Approach

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 555-577页

作者： linlin Sun Zihui Wang Shukun Cui Ziquan Yan Weiping hu Qingchun Meng State Key Laboratory of High-Speed Railway Track System China Academy of Railway Sciences Corporation LimitedBeijing100081China Railway Engineering Research Institute China Academy of Railway Sciences Corporation LimitedBeijing100081China School of Aeronautic Science and Engineering Beihang UniversityBeijing100191China

Rail weld irregularities are one of the primary excitation sources for vehicle-track interaction dynamics in modern high-speed *** can cause significant wheel-rail dynamic interactions,leading to wheel-rail noise,component damage,and *** researchers have employed the vehicle-track interaction dynamic model to study the dynamic interactions between wheel and rail induced by rail weld geometry ***,the cosine wave model used to simulate rail weld irregularities mainly focuses on the maximum value and neglects the geometric *** this study,novel theoretical models were developed for three categories of rail weld irregularities,based on measurements of the high-speed railway from Beijing to *** vertical dynamic forces in the time and frequency domains were compared under different running *** forces generated by the rail weld irregularities that were measured and modeled,respectively,were compared to validate the accuracy of the proposed ***,based on the numerical study,the impact force due to rail weld irrregularity is modeled using an Artificial Neural Network(ANN),and the optimum combination of parameters for this model is *** results showed that the proposed model provided a more accurate wheel/rail dynamic evaluation caused by rail weld irregularities than that established in the *** ANN model used in this paper can effectively predict the impact force due to rail weld irrregularity while reducing the computation time.

关键词： Rail weld irregularity high-speed railway vehicle-track coupled dynamics wheel/rail dynamic vertical force artificial neural networks