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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1531-1544页

作者： xiao-li wang Yun-Xia Gao Qiong-Zhen Yuan Ming Zhang Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

Retinal degenerative diseases were a large group of diseases characterized by the primary death of retinal ganglion cells(RGCs).Recent studies had shown an interaction between autophagy and nucleotide-binding oligomerization domain-like receptor 3(NLRP3)inflammasomes,which may affect RGCs in retinal degenerative *** NLRP3 inflammasome was a protein complex that,upon activation,produces caspase-1,mediating the apoptosis of retinal cells and promoting the occurrence and development of retinal degenerative *** autophagy could inhibit NLRP3 inflammasome activation,while inhibited autophagy can promote NLRP3 inflammasome activation,which leaded to the accelerated emergence of drusen and lipofuscin deposition under the neurosensory *** activated NLRP3 inflammasome could further inhibit autophagy,thus forming a vicious cycle that accelerated the damage and death of *** review discussed the relationship between NLRP3 inflammasome and autophagy and its effects on RGCs in age-related macular degeneration,providing a new perspective and direction for the treatment of retinal diseases.

关键词： autophagy age-related macular degeneration NLRP3 inflammasome retinal degeneration retinal ganglion cells

Protective effects of CY-09 and astaxanthin on NaIO_(3)-induced photoreceptor inflammation via the NLRP3/autophagy pathway

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1217-1231页

作者： xiao-li wang Yun-Xia Gao Qiong-Zhen Yuan Ming Zhang Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM:To study the effect of the NLRP3/autophagy pathway on the photoreceptor inflammatory response and the protective mechanism of CY-09 and astaxanthin(AST).METHODS:ICR mice were intraperitoneally injected NaIO_(3),CY-09,AST successively and divided into 5 groups,including the control,NaIO_(3),NaIO_(3)+CY-09,NaIO_(3)+AST,and NaIO_(3)+CY-09+AST *** domain optical coherence tomography and flash electroretinogram were examined and the retina tissues were harvested for immunohistochemistry,enzyme linked immunosorbent assay(EliSA),and Western *** pigment epithelium cell line(ARPE-19 cells)and mouse photoreceptor cells line(661W cells)were also treated with NaIO_(3),CY-09,and AST *** proliferation was assessed by cell counting kit-8(CCK-8)*** was analyzed by flow *** in autophagosome morphology were observed by transmission electron *** polymerase chain reaction(qPCR)was used to detect NLRP3 and ***3,caspase-1,cleaved caspase-1,p62,Beclin-1,and LC3 protein levels were measured by Western ***-1βand IL-18 were measured by ***:Compared with the control group,the activity of NaIO_(3)-treated 661W cells decreased within 24 and 48h,apoptosis increased,NLRP3,caspase-1,IL-1βand IL-18 levels increased,and autophagy-related protein levels increased(Plin-1,and LC3 in vitro and in vivo(P<0.05).CONCLUSION:CY-09 and AST inhibit NaIO_(3)-induced inflammatory damage through the NLRP3/autophagy pathway in vitro and in ***-09 and AST may protect retina from inflammatory injury.

关键词： CY-09 astaxanthin retinal degeneration photoreceptor cells inflammation NLRP3

Compound extreme inundation risk of coastal wetlands caused by climate change and anthropogenic activities in the Yellow River Delta,China

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Advances in Climate Change Research 2024年第1期15卷 134-147页

作者： xiao-li wang Ai-Qing FENG Xi-Yong HOU Qing-Chen CHAO Bai-Yuan SONG Yu-Bin liU Qi-Guang wang He XU Yu-Xin ZHANG Dong li li-Jie DONG Yu GUO CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Shandong Key Laboratory of Coastal Environmental Processes Yantai 264003China China Meteorological Administration Key Laboratory for Climate Prediction Studies National Climate CentreBeijing 100081China Tongji Urban Planning Design Research Institute Shanghai 200092China School of Geography and Tourism Qilu Normal UniversityJinan 250200China China Meteorological Administration Training Centre China Meteorological AdministrationBeijing 10008China University of Chinese Academy of Sciences Beijing 100049China Marine Science and Technology College Zhejiang Ocean UniversityZhoushan 316022China

The coastal wetlands of the Yellow River Delta(YRD)in China are crucial for their valuable resources,environmental significance,and economic ***,these wetlands are also vulnerable to the dual threats of climate change and human *** substantial attention to the historical shifts in YRD's coastal wetlands,uncertainties remain regarding their future trajectory in the face of compound risks from climate change and anthropogenic *** on a range of remote sensing data sources,this study undertakes a comprehensive investigation into the evolution of YRD's coastal wetlands between 2000 and ***,the potential fate of coastal wetlands is thoroughly analyzed through the Land Use/Cover Change(LUCC)simulation using System Dynamic-Future Land Use Simulation(SD-FLUS)model and the extreme water levels projection integrated future sea-level rise,storm surge,and astronomical high tide in 2030,2050,and 2100 under scenarios of SSP1-2.6,SSP2-4.5,and *** revealed that YRD's coastal wetlands underwent a marked reduction,shrinking by 1688.72 km²from 2000 to *** decline was mostly attributed to the substantial expansion in the areas of artificial wetlands(increasing by 823.78 km2),construction land(increasing by 767.71 km²),and shallow water(increasing by 274.58 km²).Looking ahead to 2030-2100,the fate of coastal wetlands appears to diverge based on different *** the SSP1-2.6 scenario,the area of coastal wetland is projected to experience considerable *** contrast,the SSP5-8.5 scenario anticipates a notable decrease in coastal *** to the inundated area suffered from the current extreme water levels,the study projects a decrease of 6.8%-10.6%in submerged coastal wetlands by 2030 and 9.4%-18.2%by 2050 across all *** 2100,these percentages are projected to decrease by 0.4%(SSP2-4.5)and 27.1%(SSP5-8.5),but increase by 35.7%(SSP1-2.6).Results suggest that coastal wetlands in th

关键词： Climate change Anthropogenic activities Compound extreme risk Coastal wetlands Yellow River Delta

N-acetylserotonin alleviates retinal ischemia-reperfusion injury via HMGB1/RAGE/NF-κB pathway in rats

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 228-238页

作者： Yu-Ze Zhao Xue-Ning Zhang Yi Yin Pei-Lun xiao Meng Gao Lu-Ming Zhang Shuan-Hu Zhou Shu-Na Yu xiao-li wang Yan-Song Zhao Department of Ophthalmology Affiliated Hospital of Weifang Medical UniversityWeifang 261031Shandong ProvinceChina School of Medical Imaging Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Anatomy Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Departments of Orthopedic Surgery Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA

AIM:To observe the effects of N-acetylserotonin(NAS)administration on retinal ischemia-reperfusion(RIR)injury in rats and explore the underlying mechanisms involving the high mobility group box 1(HMGB1)/receptor for advanced glycation end-products(RAGE)/nuclear factor-kappa B(NF-κB)signaling ***:A rat model of RIR was developed by increasing the pressure of the anterior chamber of the *** male Sprague Dawley were randomly divided into five groups:sham group(n=8),RIR group(n=28),RIR+NAS group(n=28),RIR+FPS-ZM1 group(n=8)and RIR+NAS+FPS-ZM1 group(n=8).The therapeutic effects of NAS were examined by hematoxylin-eosin(H&E)staining,and retinal ganglion cells(RGCs)*** expression of interleukin 1 beta(IL-1β),HMGB1,RAGE,and nod-like receptor 3(NLRP3)proteins and the phosphorylation of nuclear factorkappa B(p-NF-κB)were analyzed by immunohistochemistry staining and Western blot *** expression of HMGB1 protein was also detected by enzyme-linked immunosorbent assay(EliSA).RESULTS:H&E staining results showed that NAS significantly reduced retinal edema and increased the number of RGCs in RIR *** NAS therapy,the HMGB1 and RAGE expression decreased significantly,and the activation of the NF-κB/NLRP3 pathway was antagonized along with the inhibition of p-NF-κB and NLRP3 protein ***,NAS exhibited an anti-inflammatory effect by reducing IL-1β*** inhibitory of RAGE binding to HMGB1 by RAGE inhibitor FPS-ZM1 led to a significant decrease of p-NF-κB and NLRP3 expression,so as to the IL-1βexpression and retinal edema,accompanied by an increase of RGCs in RIR ***:NAS may exhibit a neuroprotective effect against RIR via the HMGB1/RAGE/NF-κB signaling pathway,which may be a useful therapeutic target for retinal disease.

关键词： retinal diseases retinal ischemia—reperfusion injury N-acetylserotonin high mobility group box 1 receptor for advanced glycation end-products nuclear factor-κB rats

Role of tumor necrosis factor alpha-induced protein 6(TNFAIP6)in tumors:a pan-cancer analysis

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Oncology and Translational Medicine 2024年第1期10卷 22-29页

作者： Yang Yang Zhi-Gang liu Yan-Qi Yang Zhi-Gang Zhang xiao-li wang Yu-Long li Rui-Fang Sun School of Public Health Shaanxi University of Chinese MedicineXianyangChina Department of Thoracic Surgery Shaanxi Provincial Cancer HospitalXi'an Jiaotong UniversityXi'anChina Department of Pathology School of Basic Medical SciencesHealth Science CenterXi'an Jiaotong UniversityXi'anChina Department of Dermatology Affiliated Hospital of Shaanxi University of Chinese MedicineShaanxiChina Department of Gastroenterology Shaanxi Provincial People's HospitalXi'anChina.

Background:There is growing evidence that the gene named tumor necrosis factorα–induced protein 6(TNFAIP6)has an important role in various ***,a systematic pan-cancer analysis of TNFAIP6 is *** we aimed to analyze the expression of TNFAIP6 across multiple cancers and verify its expression during the progression of colon ***:We performed a comprehensive bioinformatics analysis to examine the expression of TNFAIP6 across 27 tumor ***2 was used to evaluate the effect of TNFAIP6 on clinical cancer *** was used to assess TNFAIP6 *** correlation between TNFAIP6 and cancer immune infiltrates was explored using *** CancerSEA database was used to perform functional analysis of *** was used to identify TNFAIP6-related gene enrichment *** was performed to detect TNFAIP6 protein expression in the colon *** addition,the Comparative Toxicogenomics Database was searched for known and possible antitumor drugs that may be associated with ***:We found that,in most of the cancers included in this analysis,TNFAIP6 was highly expressed,and there is a distinct relationship between TNFAIP6 expression and cancer ***6 expression is associated with cancer-associated fibroblasts,neutrophils,and endothelial ***6 and similar genes may also be involved in the PID_VEGF_VEGFR_*** revealed an increasing trend of TNFAIP6 protein expression in normal,adenoma,and colon cancer *** known and possible antitumor drugs that may be associated with TNFAIP6 were identified in the Comparative Toxicogenomics *** results suggest that a number of drugsmay target TNFAIP6 during cancer treatment,including cisplatin,irinotecan,resveratrol,U 0126,NSC689534,genistein,NSC668394,oxaliplatin,plerixafor,topotecan,vincristine,flutamide,doxorubicin,MRK 003,folic acid,demecolcine,tunicamycin,zoledronic acid,and schizandrin B.

关键词： Cancer IHC Mutation Survival TNFAIP6

乙烯-乙酸乙烯酯共聚物热熔胶黏剂在长期热退火过程中的结晶行为

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高分子学报 2024年第11期55卷 1538-1548页

作者：陈阁王小黎梁晓凡张欢陈晓彤沈雷侯磊赵月史伟超南开大学功能高分子材料教育部重点实验室、化学学院高分子化学研究所天津300071 航天材料及工艺研究所北京100076

乙烯-乙酸乙烯酯共聚物(EVA)热熔胶黏剂(简称EVA热熔胶)是一种环保、综合性能优良的高分子材料,其储存和使用条件,尤其是温度和湿度等因素,影响着热熔胶黏剂中的晶体结构,最终影响其力学性能.为了探究结晶与力学性质之间的关系,本文中... 详细信息

乙烯-乙酸乙烯酯共聚物(EVA)热熔胶黏剂(简称EVA热熔胶)是一种环保、综合性能优良的高分子材料,其储存和使用条件,尤其是温度和湿度等因素,影响着热熔胶黏剂中的晶体结构,最终影响其力学性能.为了探究结晶与力学性质之间的关系,本文中选用热熔胶黏剂分别在干热、湿热等条件下进行长期热退火实验.研究发现,短时间热退火会导致热熔胶黏剂力学性能的缓慢提升.结合示差量热扫描分析实验结果表明,热熔胶黏剂的力学性能变化主要源于热退火对热熔胶黏剂结晶行为的促进作用.小角X射线散射实验表明,热退火对于晶区厚度并没有显著影响,但通过广角X射线散射实验,发现热退火主要促进晶体在(110)晶面的生长,对于(200)晶面的影响可以忽略.进一步地,通过偏振小角激光散射实验发现,热熔胶黏剂的球晶结构主要由热稳定形较好的片晶构成,在80℃以上的较高温度才能完全熔融.相比较而言,不完善的细小晶体在60℃以下就可以完全熔融,长期热退火可以有效消除热熔胶黏剂中的细小晶体.本文工作研究了热熔胶黏剂在高温或湿热环境中的结晶和力学性能关系,为优化热熔胶黏剂的储存和服役条件提供了实验依据.

关键词：乙烯-乙酸乙烯酯共聚物热熔胶黏剂热退火结晶散射

The Decomposability for Operator Matrices and Perturbations

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Acta Mathematica Sinica,English Series 2023年第3期39卷 497-512页

作者： xiao li wang ALATANCANG School of Mathematical Sciences Inner Mongolia UniversityHohhot 010021P.R.China Statistics and Mathematics College Inner Mongolia University of Finance and EconomicsHohhot 010070P.R.China Mathematics Science College Inner Mongolia Normal UniversityHohhot 010022P.R.China

Let X and Y be Banach *** A∈L(X),B∈L(Y),C∈L(Y,X),let MCbe the operator matrix defined on X⊕Y by M_(C)=(AC0B)∈L(X⊕Y).In this paper we investigate the decomposability for *** consider Bishop’s property(β),decomposition property(δ)and Dunford’s property(C)and obtain the relationship of these properties between M_(C) and its *** explore how σ_(*)(M_(C))shrinks from σ_(*)(A)∪σ_(*)(B),where σ_(*)denotes σ_(β),σ_(δ),σ_(C),σ_(dec).In particular,we develop some sufficient conditions for equality σ_(*)(MC)=σ_(*)(A)∪σ_(*)(B).Besides,we consider the perturbation of these properties for MCand show that in perturbing with certain operators C the properties for MCkeeps with A,*** examples are given to illustrate our ***,we study the decomposability for(0AB0).Finally,we give applications of decomposability for operator matrices.

关键词： Bishop’s property(β) decomposition property(δ) Dunford’s property(C) decomposability operator matrix perturbation local spectral theory

On n-Widths of a Sobolev Function Class in Orlicz Spaces

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Acta Mathematica Sinica,English Series 2015年第9期31卷 1475-1486页

作者： xiao li wang Ga Ridi WU College of Statistics and Mathematics Inner Mongolia University of Finance and Economics College of Mathematics Science Inner Mongolia Normal University

This paper considers the problem of n-widths of a Sobolev function class Ωr∞ determined by Pr（D） = DσПlj=1 （D2 - tj2I） in Orlicz spaces. The relationship between the extreme value problem and width theory is revealed by using the methods of functional analysis. Particularly, as σ = 0 or σ = 1, the exact values of Kolmogorov＇s widths, Gelfand＇s widths, and linear widths are obtained respectively, and the related extremal subspaces and optimal linear operators are given.

关键词： n-width extremal subspace optimal linear operator Orlicz space

Polycomb-group （Pc-G） Proteins Control Seed Development in Arabidopsis thaliana L.

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Journal of Integrative Plant Biology 2007年第1期49卷 52-59页

作者： xiao-Xue wang li-Geng Ma National Institute of Biological Sciences Beijing 102206 China

Polycomb-group （Pc-G） proteins repress their target gene expression by assemble complexes in Drosophila and mammals. Three groups of Pc-G genes, controlling seed development, flower development and vernalization response, have been identified in Arabidopsis （Arabidopsis thaliana L.）. MEDEA （MEA）, FERTIliZATION INDEPENDENT SEED2 （FIS2）, and FERTIliZATION INDEPENDENT ENDOSPERM （FIE） are Pc-G genes in Arabidopsis. Their functions in seed development have been extensively explored. The advanced findings of molecular mechanism on how MEA, FIS2 and FIE control seed development in Arabidopsis are reviewed in this paper.

关键词： Arabidopsis FIS1/MEA FIS2 FIS3/FIE Pc-G genes

Characterization of the protein expression and localization of hnRNP family members during murine spermatogenesis

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Asian Journal of Andrology 2023年第3期25卷 314-321页

作者： xiao-li wang Jin-Mei li Shui-Qiao Yuan Institute of Reproductive Health Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Laboratory of Animal Center Huazhong University of Science and TechnologyWuhan 430030China Shenzhen Huazhong University of Science and Technology Research Institute Shenzhen 518057China

Mammalian testis exhibits remarkably high transcriptome complexity,and spermatogenesis undergoes two periods of transcriptional *** make the RNA-binding proteins(RBPs)the utmost importance during male germ cell *** nuclear ribonucleoproteins(hnRNPs)are a large family of RBPs implicated in many steps of RNA processing;however,their roles in spermatogenesis are largely ***,we investigated the expression pattern of 12 hnRNP family members in mouse testes and found that most detected members are highly expressed in the ***,we found that most of the detected hnRNP proteins(hnRNPD,hnRNPK,hnRNPQ,hnRNPU,and hnRNPUL1)display the highest signals in the nuclei of pachytene spermatocytes,round spermatids,and Sertoli cells,whereas hnRNPE1 exclusively concentrates in the manchette of elongating *** expression of these hnRNP proteins showed both similarities and specificity,suggesting their diverse roles in spermatogenesis.

关键词： gene expression heterogeneous nuclear ribonucleoproteins mice Sertoli cells spermatogenesis