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Zishenpingchan granules for the treatment of Parkinson＇s disease：a randomized,double-blind,placebo-controlled clinical trial

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Neural Regeneration Research 2018年第7期13卷 1269-1275页

作者： Qing Ye xiao-lei yuan Can-Xing yuan Hong-Zhi Zhang Xu-Ming Yang Department of Neurology LONGHUA Hospital Shanghai University of Traditional Chinese Medicine Shanghai China Department of Neurology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai China Acupuncture and Tuina College of Shanghai University of Traditional Chinese Medicine Shanghai China

Levodopa preparations remain the preferred drug for Parkinson＇s ***,long-term use of levodopa may lead to a series of motor *** studies have shown that the combination of levodopa and Zishenpingchan granules（consisting of Radix Rehmanniae preparata,Lycium barbarum,Herba Taxilli,Rhizoma Gastrodiae,Stiff Silkorm,Curcuma phaeocaulis,Radix Paeoniae Alba,Rhizoma Arisaematis,Scorpio and Centipede） can markedly improve dyskinesia and delay the progression of Parkinson＇s disease,with especially dramatic improvements of non-motor ***,the efficacy of this combination has not been confirmed by randomized controlled *** current study was approved by the Hospital Ethics Committee and was registered in the Chinese Clinical Trial Register（registration number：Chi CTR-INR-1701194）.From December 2014 to December 2016,128 patients（72 males and 56 females,mean age of 65.78 ± 6.34 years） with Parkinson＇s disease were recruited from the Department of Neurology of Longhua Hospital and Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine in *** were equally allocated into treatment and control *** addition to treatment with dopamine,patients in treatment and control groups were given Zishenpingchan granules or placebo,respectively,for 24 *** efficacy was assessed using the Unified Parkinson＇s Disease Rating Scale,on-off phenomenon,Hoehn-Yahr grade,Scales for Outcomes in Parkinson＇s disease–Autonomic,Parkinson＇s disease sleep scale,Hamilton Anxiety Scale,Hamilton Depression Scale,Mini-Mental State Examination,and the Parkinson＇s Disease Quality of Life *** neural networks were used to determine weights at which to scale these *** results demonstrated that Zishenpingchan granules significantly reduced the occurrence of motor complications,and were useful for mitigating dyskinesia and non-motor symptoms of Parkinson＇s *** combination of Chin

关键词： nerve regeneration levodopa motion complications non-motor symptoms traditional Chinese medicine treatment artificial neural networks Zishenpingchan granules randomized controlled trials neurodegenerative diseases neural regeneration

Hierarchical micro-mobility management in high-speed multihop access networks

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The Journal of China Universities of Posts and Telecommunications 2006年第4期13卷 7-12页

作者： TANG Bi-hua MA xiao-lei LIU yuan-an GAO Jin-chun School of Electronic Engineering Beijing University of Posts and Telecommunications Beijing 100876 China

This article integrates the hierarchical micro-mobility management and the high-speed multihop access networks （HMAN）, to accomplish the smooth handover between different access reuters. The proposed soft handover scheme in the high-speed HMAN can solve the micro-mobility management problem in the access network. This article also proposes the hybrid access muter （AR） advertisement scheme and AR selection algorithm, which uses the time delay and stable route to the AR as the gateway selection parameters. By simulation, the proposed micro-mobility,management scheme can achieve high packet delivery fraction and improve the lifetime of network.

关键词： Ad-hoc networks hierarchical micro-mobility management wireless multihop access network

Biological Fingerprinting Analysis of Interaction Between Taxoids in Taxus and Microtubule Protein by Microdialysis Coupled with High-performance Liquid Chromatography/Mass Spectrometry for Screening Antimicrotubule Agents

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Chemical Research in Chinese Universities 2008年第4期24卷 411-419页

作者： lei xiao-yuan KONG Liang SU Xing-ye GUO Ming ZOU Han-fa National Chromatographic R＆A Center Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 P. R. China College of Marine Environmental Engineering Dalian Fisheries University Dalian 116023 P R. China Department of Chemistry and Chemical Technology Dalian University Dalian 116622 P. R. China

Some natural products, such as traditional Chinese medicines（TCMs）, contain compounds with anticancer activity and have attracted a great interest in recent years as alternative anticancer therapies. A quick and convenient assay for screening antimicrotubule compounds in which in vitro microdialysis/high-performance liquid chromatography （HPLC） is used to monitor the binding of the compounds extracted from TCM Taxus cuspidata Siebold ＆ Zucc（Taxus） to microtubules is reported. It was observed that the extract of Taxus contains at least five compounds which have affinity interaction with microtubules by biological fingerprinting analysis, and they were identified as the taxoids of taxol, baccatin III, 10-deacetylbaccatin Ⅲ（10-DAB）, cephalomannine and 7-epi-10-deacetyltaxol （7-epi-10-DAT） based on the comparison of their high-performance liquid chromatographic/mass spectrometric and UV spectra with those of the standard samples, both assembly-promoting and disassembly-inhibiting characteristics of those compounds were evaluated. It was observed that baccatin Ⅲ and 10-DAB bound to microtubules and the binding degrees were influenced by GTP. Competitive binding behavior of taxol with other four taxoids to microtubules was also investigated.

关键词： Microdialysis/high-performance liquid chromatography(HPLC) Biological fingerprinting analysis Taxoids Microtubule Taxus

Anti-apoptotic effect of Shudipingchan granule in the substantia nigra of rat models of Parkinson＇s disease

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Neural Regeneration Research 2016年第10期11卷 1625-1632页

作者： Qing Ye xiao-lei yuan Jing He Jie Zhou Can-xingyuan Xu-ming Yang Department of Neurology Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai China College of Acupuncture and Manipulation Shanghai University of Traditional Chinese Medicine Shanghai China

Levodopa is the gold-standard treatment for Parkinson＇s disease. However, although it alleviates the clinical symptoms, it cannot delay the progressive apoptosis of dopaminergic neurons or prevent motor complications in the long term. In the present study, we investigated the effect of Shudipingchan granule on neuronal apoptosis in a rat model of Parkinson＇s disease, established by injecting 6-hydroxydopamine into the substantia nigra pars compacta and ventral tegmental area. We then administered levodopa （20 mg/kg intraperitoneally, twice daily） with or without Shudipingchan granule （7.5 mL/kg intragastrically, twice daily）, for 4 weeks. The long-term use of levodopa accel- erated apoptosis of nigral cells and worsened behavioral symptoms by activating the extracellular signal-regulated kinase pathway and downstream apoptotic factors. However, administration of Shudipingchan granule with levodopa reduced expression of phosphorylated extracellular signal-regulated kinase 1/2 and Bax, increased tyrosine hydroxylase and Bcl-2, reduced apoptosis in the substantia nigra, and markedly improved dyskinesia. These findings suggest that Shudipingchan granule suppresses neuronal apoptosis by inhibiting the hyper- phosphorylation of extracellular signal-regulated kinase and downregulating expression of anti-apoptotic genes. Shudipingchan granule, used in combination with levodopa, can effectively reduce the symptoms of Parkinson＇s disease.

关键词： nerve regeneration Parkinson's disease levodopa substantia nigra apoptosis Shudipingchan granule extracellular signal-regulatedkinase pathway behavior neural rege,eration

An effective method and its modifications for isolation of high-quality total RNA from fruit pulps

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Journal of Agricultural Science and Technology 2008年第1期2卷 58-62页

作者： JIA Hai-feng ZHU xiao-qin JIN xiao-lei SHEN yuan-yue Department of Plant Science and Technology Beijing University of Agriculture Beijing 102206 China

An effective method for isolation of total RNA from pulps of mainly deciduous fruit trees was discussed in this paper. Here we shown that total RNA was successfully isolated from pulps of apple, peach and strawberry, but not grape berry via the effective CTAB method modified by ZENG, et al. However, total RNA was isolated from grape berry according to ZENG＇s protocols with a modification including 16% of β-Mercatoethanol and 3% of PVP in extraction buffer, 1/3 （V/V） of 5mol/L potassium acetate （KAC PH4.8） in supernatant. The detection of the isolated total RNA above using ultraviolet spectrophoto-metry, electrophoresis, reverse transcription and RT-PCR shown that the CTAB and its modifications is a preferred method for isolation of high-quality total RNA from fruit pulps.

关键词： fruit fruit pulps total RNA CTAB method

A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： xiao Liang Xingping Quan xiaorui Geng Yujing Huang Yonghua Zhao lei Xi Zhen yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

The C-Abl-MSTl signaling pathway mediates oxidative stress-induced neuronal cell death

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The C-Abl-MSTl signaling pathway mediates oxidative stress-i...

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： lei xiao,Zengqiang yuan State Key Laboratory of Brain and Cognitive Sciences,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China

＜正＞Oxidative stress influences cell survival and homeostasis,but the mechanisms underlying the biological effects of oxidative stress remain to be *** protein kinase MST1 plays a major role in oxidative stressinduced cell death in primary mammalian ***,the mechanisms that regulate MST1 in oxidative stress responses remain largely *** the present study,we demonstrate that the protein kinase c-Ab1 phosphorylates MST1 at Y433,which triggers the stabilization and activation of *** of c-Abl promotes the degradation of MSTl through CHIP-mediated ubiquitination,and thereby attenuates cell *** stress induces the c-Abl-dependent tyrosine phosphorylation of MST1 and increases the interaction between MST1 and FOXO3, thereby activating the MST1-FOXO signaling pathway,leading to cell death in both primary culture neurons and rat hippocampal *** identification of the c-Abl tyrosine kinase as a novel upstream activator of MST1 suggests that the c-Abl-MST1 signaling cascade plays an important role in cellular responses to oxidative stress.

关键词： c-Abl MSTl neuronal cell death signaling transduction FOXO

来源： cnki会议评论

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超声测量跖筋膜的数字化评价

中国临床解剖学杂志 2017年第5期35卷 513-520页

作者：吴静高阳王晓磊张元智内蒙古医科大学附属医院影像科呼和浩特010050 内蒙古医科大学附属医院超声科呼和浩特010050 内蒙古医科大学附属医院骨科呼和浩特010050

目的通过数字化分析评价超声测量跖筋膜的准确度。方法选取2014年5月至2016年5月内蒙古医科大学附属医院50名健康成人志愿者,男25名,女25名;年龄为18~51岁,平均(31.6±3.5)岁,身高155~181 cm,平均(172.3±7.6)cm;体重49~90 kg,平均(78.3... 详细信息

目的通过数字化分析评价超声测量跖筋膜的准确度。方法选取2014年5月至2016年5月内蒙古医科大学附属医院50名健康成人志愿者,男25名,女25名;年龄为18~51岁,平均(31.6±3.5)岁,身高155~181 cm,平均(172.3±7.6)cm;体重49~90 kg,平均(78.3±3.6)kg,分别行双足CT断层、MRI断层与超声检查,记录超声图像上的跖筋膜厚度,将CT、MRI原始图像数据以dicom格式导入Materialise Mimics Innovation Suite 16.0软件,进行数字化分析、测量,比较三者的相关性。结果超声、CT、MRI三者之间的测量在同性别之间差异无统计学意义(P>0.05)。同一性别的左、右两侧差异无统计学意义(P>0.05),而同一侧在男、女性别之间差异有统计学意义,三种检查结果跖筋膜平均厚度男性大于女性,(P<0.05)。结论超声检查能够为跖筋膜厚度的测量提供相对简便的方法而且准确度较高。

关键词：超声跖筋膜数字化

Preparation of Anti-Fumonisin B1 Single Chain Antibody Fragment(scFv)and Establishment of Detection System for Fumonisin B1

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Preparation of Anti-Fumonisin B1 Single Chain Antibody Fragm...