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Ghrelin inhibits autophagy mediated by AKT/mTOR pathway to ameliorate retinal angiogenesis induced by high glucose stress

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 785-793页

作者： Jiang-Li fan Rong Li Min Zhang Chao Chen Guo-Min Yao Ling-xiao Zhou Department of Ophthalmology Gongshu District People’s Hospital of Integrated Traditional Chinese and Western MedicineHangzhou 310004Zhejiang ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Xi’an Medical UniversityXi’an 710077Shaanxi ProvinceChina Department of Endocrinology the First Affiliated Hospital of Xi’an Medical UniversityXi’an 710077Shaanxi ProvinceChina Department of General Surgery the First Affiliated Hospital of Xi’an Medical UniversityXi’an 710077Shaanxi ProvinceChina

AIM:To observe the effect of ghrelin,a growth hormonereleasing peptide,on retinal angiogenesis in vitro under high glucose(HG)stress and to explore the possible mechanism of ***:Human retinal microvascular endothelial cells(HRMECs)were treated with high concentration of glucose alone or in combination with *** cell migration,tube formation and the expression of the autophagy-related proteins LC3-II/I,Beclin-1,p62,phosphorylated AKT(p-AKT)/AKT and phosphorylated mammalian target of rapamycin(p-mTOR)/mTOR were ***,to clarify the correlation between ghrelin effect and autophagy,AKT inhibitor VIII was adopted to treat HRMECs,and cell migration,tube formation as well as the protein expressions of LC3-II/I,Beclin-1 and p62 were ***:Under HG stress,ghrelin inhibited migration and tube formation of *** inhibited the increases in the protein levels of LC3-II/I,Beclin-1 and the decreases in the protein levels of p62,p-AKT/AKT and p-mTOR/mTOR induced by HG ***,under the action of AKT/mTOR pathway inhibitors,the effects of ghrelin on migration and tube formation were both *** addition,the expression of LC3-II/I and Beclin-1 were significantly up-regulated and the expression of p62 was ***:Retinal angiogenesis under in vitro HG stress can be inhibited by ghrelin through activating AKT/mTOR pathway to inhibit autophagy.

关键词： ghrelin retinal endothelial cell angiogenesis autophagy stress

Local coordination and electronic interactions of Pd/MXene via dual‐atom codoping with superior durability for efficient electrocatalytic ethanol oxidation

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Carbon Energy 2024年第8期6卷 166-177页

作者： Zhangxin Chen fan Jing Minghui Luo xiaohui Wu Haichang Fu Shengwei xiao Binbin Yu Dan Chen Xianqiang Xiong Yanxian Jin School of Pharmaceutical and Chemical Engineering Taizhou UniversityTaizhouZhejiangChina School of Sciences Zhejiang Sci‐Tech UniversityHangzhouZhejiangChina

Catalyst design relies heavily on electronic metal‐support interactions,but the metal‐support interface with an uncontrollable electronic or coordination environment makes it ***,we outline a promising approach for the rational design of catalysts involving heteroatoms as anchors for Pd nanoparticles for ethanol oxidation reaction(EOR)*** doped B and N atoms from dimethylamine borane(DB)occupy the position of the Ti_(3)C_(2)lattice to anchor the supported Pd *** electrons transfer from the support to B atoms,and then to the metal Pd to form a stable electronic center.A strong electronic interaction can be produced and the d‐band center can be shifted down,driving Pd into the dominant metallic state and making Pd nanoparticles deposit uniformly on the ***‐obtained Pd/DB–Ti_(3)C_(2)exhibits superior durability to its counterpart(∼14.6%retention)with 91.1%retention after 2000 cycles,placing it among the top single metal anodic ***,in situ Raman and density functional theory computations confirm that Pd/DB–Ti_(3)C_(2)is capable of dehydrogenating ethanol at low reaction energies.

关键词： durability electronic interactions ethanol oxidation heteroatom codoping Pd/MXene

Anti-Byzantine Attacks Enabled Vehicle Selection for Asynchronous Federated Learning in Vehicular Edge Computing

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China Communications 2024年第8期21卷 1-17页

作者： Zhang Cui Xu xiao Wu Qiong fan Pingyi fan Qiang Zhu Huiling Wang Jiangzhou School of Internet of Things Engineering Wuxi Institute of TechnologyWuxi 214121China School of Internet of Things Engineering Jiangnan UniversityWuxi 214122China Department of Electronic Engineering Beijing National Research Center for Information Science and TechnologyTsinghua UniversityBeijing 100084China Qualcomm San Jose CA 95110USA School of Engineering University of KentCT27NT CanterburyU.K

In vehicle edge computing(VEC),asynchronous federated learning(AFL)is used,where the edge receives a local model and updates the global model,effectively reducing the global aggregation *** to different amounts of local data,computing capabilities and locations of the vehicles,renewing the global model with same weight is *** above factors will affect the local calculation time and upload time of the local model,and the vehicle may also be affected by Byzantine attacks,leading to the deterioration of the vehicle ***,based on deep reinforcement learning(DRL),we can consider these factors comprehensively to eliminate vehicles with poor performance as much as possible and exclude vehicles that have suffered Byzantine attacks before *** the same time,when aggregating AFL,we can focus on those vehicles with better performance to improve the accuracy and safety of the *** this paper,we proposed a vehicle selection scheme based on DRL in *** this scheme,vehicle’s mobility,channel conditions with temporal variations,computational resources with temporal variations,different data amount,transmission channel status of vehicles as well as Byzantine attacks were taken into *** results show that the proposed scheme effectively improves the safety and accuracy of the global model.

关键词： asynchronous federated learning byzantine attacks vehicle selection vehicular edge computing

MoS2 as a cocatalyst applied in advanced oxidation processes for enhancing degradation of organic pollutants: a review

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Tungsten 2024年第3期6卷 473-487页

作者： Ming-Hao fan Cong-Hui Wang Xiang Yu Jun Ding Ao-Qi xiao Yue Li Wei-Ya Huang School of Material Science and Engineering Henan Polytechnic University School of Chemical and Printing-Dyeing Engineering Henan International Joint Laboratory of Rare Earth Composite Materials Henan University of Engineering School of Chemistry and Chemical Engineering Jiangxi University of Science and Technology Department of Chemical and Environmental Engineering University of Cincinnati

Fenton technology,as a typical advanced oxidation processes（AOPs）,can generate reactive oxygen species（ROS） of strong oxidation capacity to degrade organic pollutants,which has attracted wide ***,it is accompanied by the slow Fe3+/Fe2+cycle rate,easy to generate iron sludge and so ***,it has been proven that the inorganic cocatalysts represented by MoS2can effectively solve the above ***,MoS2can accelerate the activation of peroxy mono sulfate（PMS） and peroxodisulfate（PDS） by Fe2+.In this paper,MoS2as the cocatalyst in H2O2+Fe2+,PMS+Fe2+and PDS+Fe2+were comprehensively ***,the cycling processes of Fe3+/Fe2+in different systems,the cocatalytic effect of MoS2by the exposed active sites,the ROS generation mechanism as well as the microscopic mechanism during the reaction were elaborated *** results indicate that the reductive active sites on the surface of MoS2can promote the regeneration of Fe2+through the cycle between Fe3+/Fe2+and Mo4+/Mo5+/Mo6+.Thus,ROS such as ·OH,SO4·-and1O2with strong oxidizing property can be produced to improve the degradation efficiency of organic *** last,the challenges and developments of MoS2cocatalysts in AOPs for practical applications were *** review contributes to a deeper understanding of the cocatalytic effect of two-dimensional metal sulfides in AOPs and facilitates their industrial application.

关键词： Cocatalyst Fenton reaction Degradation of organic pollutant Molybdenum disufide Reactive oxygen species

Remaining Useful Life Prediction Method for Multi-Component System Considering Maintenance:Subsea Christmas Tree System as A Case Study

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China Ocean Engineering 2024年第2期38卷 198-209页

作者： WU Qi-bing CAI Bao-ping fan Hong-yan WANG Guan-nan RAO Xi GE Weifeng SHAO xiao-yan LIU Yong-hong CNOOC Safety Technology Services Co. Ltd.Tianjin 300456China College of Mechanical and Electronic Engineering China University of PetroleumQingdao 266580China CNOOC EnerTech Safety&Environmental Protection BranchTianjin 300456China

Maintenance is an important technical measure to maintain and restore the performance status of equipment and ensure the safety of the production process in industrial production,and is an indispensable part of prediction and health ***,most of the existing remaining useful life(RUL)prediction methods assume that there is no maintenance or only perfect maintenance during the whole life cycle;thus,the predicted RUL value of the system is obviously lower than its actual operating *** complex environment of the system further increases the difficulty of maintenance,and its maintenance nodes and maintenance degree are limited by the construction period and working conditions,which increases the difficulty of RUL *** RUL prediction method for a multi-omponent system based on the Wiener process considering maintenance is *** performance degradation model of components is established by a dynamic Bayesian network as the initial model,which solves the uncertainty of insufficient data *** on the experience of experts,the degree of degradation is divided according to Poisson process simulation random failure,and different maintenance strategies are used to estimate a variety of condition maintenance *** example of a subsea tree system is given to verify the effectiveness of the proposed method.

关键词： remaining useful life Wiener process dynamic Bayesian networks maintenance subsea Christmas tree system

Lossless Compression Method for the Magnetic and Helioseismic Imager(MHI)Payload

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Research in Astronomy and Astrophysics 2024年第4期24卷 214-221页

作者： Li-Yue Tong Jia-Ben Lin Yuan-Yong Deng Kai-fan Ji Jun-Feng Hou Quan Wang xiao Yang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Key Laboratory of Solar Activity and Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Yunnan Observatories Chinese Academy of SciencesKunming 650216China

The Solar Polar-orbit Observatory(SPO),proposed by Chinese scientists,is designed to observe the solar polar regions in an unprecedented way with a spacecraft traveling in a large solar inclination angle and a small ***,one of the most significant challenges lies in ultra-long-distance data transmission,particularly for the Magnetic and Helioseismic Imager(MHI),which is the most important payload and generates the largest volume of data in *** this paper,we propose a tailored lossless data compression method based on the measurement mode and characteristics of MHI *** background out of the solar disk is removed to decrease the pixel number of an image under *** predictive coding methods are combined to eliminate the redundancy utilizing the correlation(space,spectrum,and polarization)in data set,improving the compression *** results demonstrate that our method achieves an average compression ratio of *** compression time is also less than the general observation *** method exhibits strong feasibility and can be easily adapted to MHI.

关键词： methods:data analysis techniques:image processing Sun:magnetic fields Sun:photosphere

Study on the clogging mechanism of punching screen in sand control by the punching structure parameters

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Petroleum Science 2024年第1期21卷 609-620页

作者： Fu-Cheng Deng Fu-Lin Gui Bai-Tao fan Lei Wen Sheng-Hong Chen Ning Gong Yun-Chen xiao Zhi-Hui Xu Yangtze University Jingzhou434023HubeiChina CNOOC Research Institute Ltd. Beijing100028China CNOOC Ener Tech-Drilling&Production Co. Tianjin300457China Tianjin Branch of CNOOC Ltd. Tianjin300459China

As an independent sand control unit or a common protective shell of a high-quality screen,the punching screen is the outermost sand retaining unit of the sand control pipe which is used in geothermal well or oil and gas ***,most screens only consider the influence of the internal sand retaining medium parameters in the sand control performance design while ignoring the influence of the plugging of the punching screen on the overall sand retaining performance of the *** explore the clogging mechanism of the punching screen,this paper established the clogging mechanism calculation model of a single punching screen sand control unit by using the computational fluid mechanics-discrete element method(CFD-DEM)combined *** to the combined motion of particles and fluids,the influence of the internal flow state on particle motion and accumulation was *** results showed that(1)the clogging process of the punching sand control unit is divided into three stages:initial clogging,aggravation of clogging and stability of *** the initial stage of blockage,coarse particles form a loose bridge structure,and blockage often occurs preferentially at the streamline gathering place below chamfering inside the sand control *** the stage of blockage intensification,the particle mass develops into a relatively complete sand bridge,which develops from both ends of the opening to the center of the *** the stable plugging stage,the sand deposits show a“fan shape”and form a“V-shaped”gully inside the punching slot element.(2)Under a certain reservoir particle-size distribution,The slit length and opening height have a large influence on the permeability and blockage rate,while the slit width size has little influence on the permeability and blockage *** microscopic clogging mechanism and its law of the punching screen prevention unit are proposed in this study,which has some field guidance significance for the design of punching screen

关键词： Punching screen Plugging CFD-DEM Size parameter Sand control

Photonic crystal-connected bidirectional micro-ring resonator array for duplex mode and wavelength channel(de) multiplexing

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Photonics Research 2024年第8期12卷 1802-1812页

作者： ZHIWEI GUAN CHAOFENG WANG CHUANGXIN XIE HAISHENG WU JUNMIN LIU HUAPENG YE DIANYUAN fan JIANGNAN xiao SHUQING CHEN International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology Institute of Microscale OptoelectronicsShenzhen University College of Physics and Engineering Technology Minzu Normal University of Xingyi College of New Materials and New Energies Shenzhen Technology University Guangdong Provincial Key Laboratory of Optical Information Materials and Technology and Institute of Electronic Paper Displays South China Academy of Advanced OptoelectronicsSouth China Normal University Terahertz Technology Innovation Research Institute Shanghai Key Laboratory of Modern Optical SystemTerahertz Science Cooperative Innovation CenterSchool of Optical-Electrical Computer EngineeringUniversity of Shanghai for Science and Technology

The progress of on-chip optical communication relies on integrated multi-dimensional mode（de）multiplexers to enhance communication capacity and establish comprehensive networks. However, existing multi-dimensional（de）multiplexers, involving modes and wavelengths, face limitations due to their reliance on single-directional total internal reflection and multi-level mode conversion based on directional coupling principles. These constraints restrict their potential for full-duplex functionality and highly integrated communication. We solve these problems by introducing a photonic-like crystal-connected bidirectional micro-ring resonator array（PBMRA）and apply it to duplex mode-wavelength multiplexing communication. The directional independence of total internal reflection and the cumulative effect of the subwavelength-scale pillar within the single-level photonic crystal enable bidirectional mode and wavelength multiplexed signals to transmit among multi-pair nodes without interference, improving on-chip integration in single-level mode conversion. As a proof of concept, we fabricated a nine-channel bidirectional multi-dimensional（de）multiplexer, featuring three wavelengths and three TE modes, compactly housed within a footprint of 80 μm × 80 μm, which efficiently transmits QPSK-OFDM signals at a rate of 216 Gbit/s, achieving a bit error rate lower than 10-4. Leveraging the co-ring transmission characteristic and the orthogonality of the mode-wavelength channel, this（de）multiplexer also enables a doubling of communication capacity using two physical transmission channels.

关键词： Mode conversion Mode division multiplexing Optical networks Phase modulation Total internal reflection Wavelength division multiplexing

In situ forming injectable MSC-loaded GelMA hydrogels combined with PD for vascularized sweat gland regeneration

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Military Medical Research 2024年第1期11卷 152-155页

作者： Enhe Jirigala Bin Yao Zhao Li Yi-Jie Zhang Chao Zhang Li-Ting Liang fan-Liang Zhang Xing-Yu Yuan Xian-lan Duan Wei Song Meng-De Zhang Yi Kong xiao-Bing Fu Sha Huang Research Center for Tissue Repair and Regeneration Medical Innovation Research DepartmentChinese PLA General Hospital and PLA Medical CollegeBeijing 100048China Institute of Basic Medical Research Inner Mongolia Medical UniversityHohhot 010110China Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China School of Medicine Nankai UniversityTianjin 300071China

Dear Editor,Three dimensional(3D)bioprinted extracellular matrix(ECM)can be used to provide both biochemical and biophysical cues to direct mesenchymal stem cells(MSCs)differentiation,and then differentiated cells were isolated for implantation in vivo using surgical ***,the reduced cell activity after cell isolation from 3D constructs and low cell retention in injured sites limit its application[1].Methacrylated gelatin(GelMA)hydrogel has the advantage of fast crosslinking,which could resemble complex architectures of tissue construct in vivo[2].Here,we adopted a noninvasive bioprinting procedure to imitate the regenerative microenvironment that could simultaneously direct the sweat gland(SG)and vascular differentiation from MSCs and ultimately promote the replacement of glandular tissue in situ(Fig.1a).

关键词： Sweat gland GelMA In situ niche Cell differentiation Tissue incorporation Vascularization