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中国环保产业 2024年第6期 51-53页

作者：卢焕兼林健汉赵志杰广州珞珈环境技术有限公司广州510000

本文通过预设不同的固化剂添加比例,对滤液水质指标、固化土污染物指标以及物理指标的变化情况及趋势进行分析研究,验证压榨滤液回用技术的可行性,以期为淤泥处理处置技术的工艺改进、类似工程项目的实施提供参考。

关键词：河湖淤泥压榨滤液固化土滤液回用

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半山区滑坡灾害危险性评价——GIS支持下基于Kuenm包优化Maxent模型

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地质灾害与环境保护 2024年第3期35卷 1-10页

作者：解晋航石文君张杰张小亮李章杰王宇栋昆明理工大学公共安全与应急管理学院昆明650093 自然资源部高原山地地质灾害预报预警与生态保护修复重点实验室昆明650051

根据会泽县地处云贵高原半山区的地理环境特点,以滑坡灾害为研究对象,选取地貌、坡度、坡向、曲率、地形起伏度、降雨量、距道路距离、斜坡结构、高程9个评价因子,基于相关性分析和共线性诊断对其进行独立性检验。采用优化Maxent模型与... 详细信息

根据会泽县地处云贵高原半山区的地理环境特点,以滑坡灾害为研究对象,选取地貌、坡度、坡向、曲率、地形起伏度、降雨量、距道路距离、斜坡结构、高程9个评价因子,基于相关性分析和共线性诊断对其进行独立性检验。采用优化Maxent模型与加权信息量模型计算滑坡发生概率。基于GIS的自然间断法评价结果等级,通过合理性检验、敏感性检验及现场实地检验比较两种模型的合理性及准确性。结果表明:两种评价模型均能通过合理性检验,AUC值分别为0.902和0.769,优化Maxent模型精度更高,通过刀切法得出距道路距离因子贡献百分比最高,与野外调查的典型灾害点主要影响因子相吻合,其稳定、低、中和高的面积分别为1585.74 km^(2)(26.70%)、2138.42 km^(2)(36.90%)、1594.48 km^(2)(26.85%)和567.37 km^(2)(9.55%)。

关键词：半山区滑坡优化Maxent模型加权信息量模型

XS0601 REDUCES THE INCIDENCE OF RESTENOSIS: A PROSPECTIVE STUDY OF 335 PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION IN CHINA

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Chinese Medical Journal 2006年第1期119卷 6-13页

作者： CHEN Ke-ji SHI Da-zhuo XU Hao luE Shu-zheng LI Tian-chang KE Yuan-nan ZHANG Min-zhou lu xiao-yan SUN Rui-yuan YOU Shi-jie Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing 100091 China Department of Cardiology Anzhen Hospital Capital Universityof Medical Sciences Beijing 100029 China Department of Cardiology Tongren Hospital CapitalUniversity of Medical Sciences Beijing 100730 China Department of Cardiology China-Japan Friendship HospitalBeijing 100029 China Guangdong Provincial Hospital of Traditional ChineseMedicine Guangzhou 510120 China Clinical Drugs Evaluation Center of Anhui Province Hefei241001 China Division of Coronary Heart Disease Fuwai Hospital ChinaAcademy of Medical Sciences Beijing 100037 China

Background XS0601, consisting of active ingredients （Chuangxiongol and paeoniflorin）, has been shown to inhibit arterial neointimal hyperplasia in animal models and in preliminary human studies. The objective of this study was to evaluate the safety and efficacy of XS0601 in preventing restenosis following percutaneous coronary intervention （PCI）. Methods A multi-center, randomized, double-blind, placebo-controlled trial was conducted. A total of 335 patients were randomized into treatment with the oral administration of XS0601, or a placebo for 6 months after successful PCI. Angiographic follow-up was scheduled at 6 months, and clinical follow-ups performed at 1, 3 and 6 months after PCI. The primary end point was angiographic restenosis. The secondary end points were the combined incidence of death, target lesion nonfatal myocardial infarction, repeat angioplasty, and coronary artery bypass graft surgery. Results A total of 308 patients （91.9%） completed the study and 145 cases （47.1%） received angiographic follow-up. The restenosis rates were significantly reduced in the XS0601 group as compared with the placebo group （26.0% vs. 47.2%, P 〈 0.05）, and the minimum lumen diameter （MLD） was greater [（2.08 ± 0.89） mm for XS0601 vs. （1.73 ± 0.94） mm for placebo, P 〈 0.05]. XS0601 also significantly reduced the combined incidence of major adverse cardiac event （10.4% in the XS0601 group vs. 22.7% in the placebo group, P 〈 0.05）. The incidence of recurrent angina at 3 and 6 months after PCI was also significantly reduced in XS0601 group （7.1% and 11.0%） as compared with those in placebo group （19.5% and 42.9%）（P 〈 0.05）. No significant side effects occurred within the 6-month follow-up period in the XS0601 group.Conclusion Administration of XS0601 for 6 months is demonstrated to be safe and effective in reducing restenosis in post-PCI patients.

关键词： XS0601 angioplasty stent restenosis

计及船体干扰的首尾侧推器粘性水动力数值计算

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舰船科学技术 2024年第9期46卷 53-59页

作者：卢浩南王化明邬宾杰汪家政郁惠民沈益骏浙江海洋大学船舶与海运学院浙江舟山316022 舟山长宏国际船舶修造有限公司浙江舟山316052 舟山海关综合技术服务中心浙江舟山316000

本文运用以雷诺平均N-S方程(RANS)为基础的粘性流CFD方法,结合MRF多重参考系模型,对某LNG运输及加注船的首尾侧推器粘性流场和水动力进行数值计算,在多种不同航速条件下,研究了在低速航行时船速对侧推器推力性能的影响规律。通过对比分... 详细信息

本文运用以雷诺平均N-S方程(RANS)为基础的粘性流CFD方法,结合MRF多重参考系模型,对某LNG运输及加注船的首尾侧推器粘性流场和水动力进行数值计算,在多种不同航速条件下,研究了在低速航行时船速对侧推器推力性能的影响规律。通过对比分析得出,首尾侧推器的侧推性能及其对船体水动力性能存在很大差别,并且这2个方面的性能对航速的敏感性也存在很大差异;采用独立尾侧推器舱室布局设计的尾侧推装置效率比独立首侧推器高。

关键词：首尾侧推器水动力粘性流

COMPARISONS OF THE CHARACTERISTICS OF TROPICAL CYCLONES EXPERIENCING EXTRATROPICAL TRANSITION IN THE WESTERN NORTH PACIFIC BASED ON DIFFERENT DATASETS

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Journal of Tropical Meteorology 2017年第3期23卷 281-291页

作者： SUN Hong-mei LEI xiao-tu TANG jie YAO Cai luO xiao-li Guangxi Meteorological Observatory Nanning 530022 China Shanghai Typhoon Institute of CMA Shanghai 200030 China Guangxi Institute of Meteorology and Disaster-Mitigation Research Nanning 530022 China Guangxi Weather Service Center Nanning 530022 China

The differences in the climatology of extratropical transition(ET) of western North Pacific tropical cyclones(TCs) were investigated in this study using the TCs best-track datasets of China Meteorological Administration(CMA),Japan Meteorological Agency(JMA) and the Joint Typhoon Warning Center(JTWC). The results show that the ET identification, ET completion time, and post-ET duration reported in the JTWC dataset are greatly different from those in CMA and JMA datasets during 2004-2010. However, the key differences between the CMA and JMA datasets from 1951 to 2010 are the ET identification and the post-ET duration, because of inconsistent objective ET criteria used in the centers. Further analysis indicates that annual ET percentage of CMA was lower than that of JMA, and exhibited an interannual decreasing trend, while that of JMA was an unchanged trend. The western North Pacific ET events occurred mainly during the period June to November. The latitude of ET occurrence shifted northward from February to August,followed by a southward shift. Most of ET events were observed between 35°N and 45°N. From a regional perspective,TCs tended to undergo ET in Japan and the ocean east to it. It is found that TCs which experienced the ET process at higher latitudes were generally more intense at the ET completion time. TCs completing the ET overland or offshore were weaker than those finishing the ET over the ocean. Most of the TCs weakened 24 h before the completion of *** contrast, 21%(27%) of the TCs showed an intensification process based on the CMA(JMA) dataset during the post-ET period. The results presented in this study indicate that consistent ET determination criteria are needed to reduce the uncertainty involved in ET identification among the centers.

关键词： Western North Pacific different datasets tropical cyclone extratropical transition climatic differences comparative analysis

血浆高迁移率族蛋白B1对轻型缺血性脑卒中患者溶栓治疗预后的评估价值

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医学检验与临床 2024年第6期35卷 23-27页

作者：李玲杰曹俊景王小丽郑州人民医院神经内科河南郑州450000

目的:检测血浆高迁移率族蛋白B1(HMGB1)在轻型缺血性脑卒中的表达水平及对患者溶栓后3个月预后的评估价值。方法:收集2021年1月-2023年5月在我院接受治疗的急性缺血性脑卒中患者124例,根据出院后3个月的mRS评分将患者分为预后良好组(mR... 详细信息

目的:检测血浆高迁移率族蛋白B1(HMGB1)在轻型缺血性脑卒中的表达水平及对患者溶栓后3个月预后的评估价值。方法:收集2021年1月-2023年5月在我院接受治疗的急性缺血性脑卒中患者124例,根据出院后3个月的mRS评分将患者分为预后良好组(mRS评分≤2分,n=73)和预后不良组(mRS评分>2分,n=51)。比较两组患者的一般临床资料,分析影响预后的危险因素。采用酶联免疫吸附试验(ELISA)检测溶栓后不同时间点外周血中HMGB1水平并评估NIHSS评分和GCS评分。利用pearson检测溶栓后6h时HMGB1水平并与NIHSS评分、GCS评分的相关性。结果:两组间阻塞血管支数、治疗前Killip心功能分级、NIHSS评分、GCS评分、侧支循环不良、TnI、CK-MB和HMGB1相比有统计学差异(P<0.05)。Killip心功能Ⅲ-Ⅳ分级[OR(95%CI):1.801(1.164~2.819),P=0.008]、侧支循环不良[OR(95%CI):1.490(1.290~1.828),P=0.003]和HMGB1水平增加[OR(95%CI):3.625(1.254~5.306),P=0.013]为影响预后不良的独立危险因素。溶栓治疗后外周血中HMGB1水平呈逐渐升高趋势,至12h后逐渐降低,12h时HMGB1水平与NIHSS评分呈正相关(r=0.652,P<0.001)与GCS评分呈负相关(r=-0.517,P<0.001)。溶栓治疗6h时HMGB1评估患者预后不良的曲线下面积为0.874,截断值为80.6μg/L、灵敏度为85.3%、特异度为76.5%,临床预测价值最大。结论:HMGB1在缺血性脑卒中外周血中水平增加为预后不良的危险因素,溶栓治疗6h的水平对患者预后不良的预测价值最大。

关键词：缺血性脑卒中再灌注损伤静脉溶栓血浆迁移率族蛋白B1

基于贵金属纳米簇的电化学发光传感器在生命分析中的应用

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发光学报 2017年第5期38卷 675-684页

作者：安晓刚杜捷卢小泉西北师范大学生命科学学院甘肃兰州730070 甘肃省生物电化学与环境分析重点实验室甘肃兰州730070

为了更好地研究贵金属纳米簇的合成机理、扩展贵金属纳米簇-电化学传感器的应用,阐述和比较了贵金属纳米簇的制备方法、电化学发光原理及特点,重点介绍了贵金属纳米簇-电化学传感器在生命分析领域的应用进展及本课题组相关研究,并展望... 详细信息

为了更好地研究贵金属纳米簇的合成机理、扩展贵金属纳米簇-电化学传感器的应用,阐述和比较了贵金属纳米簇的制备方法、电化学发光原理及特点,重点介绍了贵金属纳米簇-电化学传感器在生命分析领域的应用进展及本课题组相关研究,并展望了其发展和应用前景,以期为贵金属纳米簇电化学传感器在生命分析中的研究提供一定的参考。

关键词：贵金属纳米簇电致化学发光电化学生物传感器生命分析

Acoustic emission generated during the gas sorption-desorption process in coal

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International Journal of Mining Science and Technology 2012年第3期22卷 391-397页

作者： Ma Yankun Wang Enyuan xiao Dong Li Zhonghui Liu jie Gan Lijia School of Safety Enneering China University of Mining & Technology Xuzhou 221008 China Mineral and Mining Resource Engineering Southern Illinois University Carbondale Carbondale 62901 USA

An experimental system for monitoring the acoustic signals generated in coal during gas sorption and/or desorption was designed and the acoustic signals were observed under different gas pressures. The experimental results show that signals generated by the coal during gas adsorption are attenuated over time. Also, the signals are not continuous but are impulsive. The intensity of the signals generated during gas desorption is far smaller than that observed during adsorption. The signal seen during desorption remains essentially stable. Cycles of sorption and desorption cause acoustic emission signals that exhibit a memory effect, which depends upon the maximum gas pressure the sample was exposed to in earlier cycles. Lower pressures in subsequent cycles, compared to the maximum adsorption pressure in previous cycles, cause both the energy and impulse frequency to be lower than previously. On the contrary, a gas adsorption pressure that exceeds the maximum pressure seen by the sample during earlier cycles causes both the energy and impulse frequency to be high.

关键词： Sorption-desorptionGasAcoustic emissionCycleMemory effect

CC80硼衬基补偿电离室补偿电压的设定方法研究

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工程建设与设计 2024年第9期 56-58页

作者：关悦卢建朱鹏飞李捷黄靖中核核电运行管理有限公司维修三处浙江嘉兴314300

CC80硼衬基补偿电离室为堆外核测系统中间量程探测器,探测器性能曲线包含正高压坪曲线和补偿高压坪曲线,论文提出了CC80硼衬基补偿电离室补偿电压设定的新方法,对曲线绘制的时间、绘制程序进行优化,建立了补偿电压的算法模型并增加了补... 详细信息

CC80硼衬基补偿电离室为堆外核测系统中间量程探测器,探测器性能曲线包含正高压坪曲线和补偿高压坪曲线,论文提出了CC80硼衬基补偿电离室补偿电压设定的新方法,对曲线绘制的时间、绘制程序进行优化,建立了补偿电压的算法模型并增加了补偿电压的评判标准和验证方法。结果表明,新方法直接有效地缩短了大修的绝对主线时间,制定了合理的功能试验状态,给出了明确的补偿高压设定方法和补偿高压验收评判标准。

关键词：中间量程补偿电压坪曲线 CC80 主线优化评判标准

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Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells

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Cellular & Molecular Immunology 2021年第2期18卷 440-451页

作者： Ke Rui Yue Hong Qiugang Zhu xiaofei Shi Fan xiao Hailong Fu Qing Yin Yida Xing Xinfeng Wu xiaodan Kong Huaxi Xu jie Tian Shengjun Wang Liwei lu Department of Laboratory Medicine Affiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Immunology Jiangsu Key Laboratory of Laboratory MedicineSchool of MedicineJiangsu UniversityZhenjiangChina Department of Rheumatology The First Affiliated Hospital and College of Clinical MedicineHenan University of Science and TechnologyLuoyangChina Department of Pathology and Shenzhen Institute of Research and Innovation The University of Hong Kong Center for Clinical Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouChina Department of Rheumatology The Second Affiliated Hospital of Dalian Medical UniversityLiaoningChina

Sjögren’s syndrome(SS)is a systemic autoimmune disease characterized by progressive inflammation and tissue damage in salivary glands and lacrimal *** previous studies showed that myeloid-derived suppressor cells(MDSCs)exhibited impaired immunosuppressive function during disease progression in patients with SS and mice with experimental Sjögren’s syndrome(ESS),but it remains unclear whether restoring the function of MDSCs can effectively ameliorate the development of *** this study,we found that murine olfactory ecto-mesenchymal stem cell-derived exosomes(OE-MSC-Exos)significantly enhanced the suppressive function of MDSCs by upregulating arginase expression and increasing ROS and NO ***,treatment with OE-MSC-Exos via intravenous injection markedly attenuated disease progression and restored MDSC function in ESS ***,OE-MSC-Exo-secreted IL-6 activated the Jak2/Stat3 pathway in *** addition,the abundant S100A4 in OE-MSC-Exos acted as a key factor in mediating the endogenous production of IL-6 by MDSCs via TLR4 signaling,indicating an autocrine pathway of MDSC functional modulation by *** together,our results demonstrated that OE-MSC-Exos possess therapeutic potential to attenuate ESS progression by enhancing the immunosuppressive function of MDSCs,possibly constituting a new strategy for the treatment of Sjögren’s syndrome and other autoimmune diseases.

关键词： mesenchymal stem cells exosomes MDSCs Sjögren’s syndrome autoimmune diseases