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Advances in Manufacturing 2022年第3期10卷 443-458页

作者： Miao-Xian Guo Jin Liu Li-Mei Pan Chong-Jun Wu xiao-hui jiang Wei-Cheng Guo College of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093People's Republic of China College of Mechanical Engineering Donghua UniversityShanghai 201620People's Republic of China

Surface topography is an important factor in evaluating the surface integrity and service performance of milling *** dynamic characteristics of the manufacturing system and machining process parameters significantly influence the machining precision and surface quality of the parts,and the vibration control method is applied in high-precision milling to improve the machine *** this study,a novel surface topography model based on the dynamic characteristics of the process system,properties of the cutting process,and active vibration control system is theoretically developed and experimentally *** dynamic characteristics of the process system consist of the vibration of the machine tool and piezoelectric ceramic clamping *** dynamic path trajectory influenced by the processing parameters and workpiece-tool parameters belongs to the property of the cutting process,while different algorithms of active vibration control are considered as controller *** milling surface topography can be predicted by considering all these factors.A series of experiments were conducted to verify the effectiveness and accuracy of the prediction model,and the results showed a good correlation between the theoretical analysis and the actual milled surfaces.

关键词： Machine-process-controller Milling surface topography Vibration suppression Prediction model

Ten-channel mode-division-multiplexed silicon photonic integrated circuit with sharp bends

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Frontiers of Information Technology & Electronic Engineering 2019年第4期20卷 498-506页

作者： Chen-lei LI xiao-hui jiang Yung HSU Guan-hong CHEN Chi-wai CHOW Dao-xin DAI Centre for Optical and Electromagnetic Research State Key Laboratory for Modern Optical InstrumentationCollege of Optical Science and Engineering Zhejiang University Ningbo Research Institute Zhejiang University Department of Photonics and Institute of Electro-Optical Engineering Chiao Tung University

A multimode silicon photonic integrated circuit(PIC) comprising a pair of on-chip mode(de)multiplexers with 10-mode channels and a multimode bus waveguide with sharp bends is demonstrated to enable multi-channel on-chip transmissions. The core width of the multimode bus waveguide is chosen such that it can support 10 guided modes, of which there are four transverse-magnetic polarization modes and six transverse-electric polarization modes. This multimode bus waveguide comprises sharp bends based on modified Euler curves. Experimental results demonstrate that the present silicon PIC enables the 10-channel on-chip transmission with a low inter-mode crosstalk of approximately-20 dB over a broad bandwidth of 1520–1610 nm even when the bending radius of the S-bend is as small as 40 μm. Compared with a silicon PIC using a conventional arc-bend with the same bending radius, our proposed PIC demonstrates a significant improvement.

关键词： Silicon Multimode Waveguide Euler-bends

Loss-of-function CFTR p.G970D missense mutation might cause congenital bilateral absence of the vas deferens and be associated with impaired spermatogenesis

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Asian Journal of Andrology 2023年第1期25卷 58-65页

作者： Jian-Wen Hou xiao-Liang Li Li Wang Cong-Ling Dai Na Li xiao-hui jiang Yue-Qiu Tan Er-Po Tian Qin-Tong Li Wen-Ming Xu Department of Obstetrics/Gynecology Key Laboratory of ObstetricGynecologic and Pediatric Diseases and Birth Defects of Ministry of EducationWest China Second University HospitalSichuan UniversityChengdu 610041China Reproductive Medical Center Chengdu Xi'nan Gynecology HospitalChengdu 610041China Reproductive Medical Center of West China Second University Hospital Sichuan UniversityChengdu 610041China Reproductive Medical Center Gansu Provincial Maternal and Child-Care HospitalLanzhou 730050China Institute of Reproductive and Stem Cell Engineering School of Basic Medical ScienceCentral South UniversityChangsha 410000China Reproductive and Genetic Hospital of CITIC-Xiangya Changsha 410000China Institute of Pediatrics Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Human Sperm Bank West China Second University HospitalSichuan UniversityChengdu 610041China Clinical Research Center for Reproduction and Genetics in Hunan Province Changsha 410000China Department of Obstetrics Gynecology and PediatricsWest China Second University HospitalKey Laboratory of Birth Defects and Related Diseases of Women and ChildrenMinistry of EducationSichuan UniversityChengdu 610041China

Congenital bilateral absence of the vas deferens(CBAVD)is observed in 1%–2%of males presenting with infertility and is clearly associated with cystic fibrosis transmembrane conductance regulator(CFTR)*** is one of the most well-known genes related to male *** frequency of CFTR mutations or impaired CFTR expression is increased in men with nonobstructive azoospermia(NOA).CFTR mutations are highly polymorphic and have established ethnic *** with F508Del in Caucasians,the p.G970D mutation is reported to be the most frequent CFTR mutation in Chinese patients with cystic ***,whether p.G970D participates in male infertility remains ***,a loss-of-function CFTR p.G970D missense mutation was identified in a patient with CBAVD and *** retrospective analysis of 122 Chinese patients with CBAVD showed that the mutation is a common pathogenic mutation(4.1%,5/122),excluding polymorphic ***,we generated model cell lines derived from mouse testes harboring the homozygous Cftr p.G965D mutation equivalent to the CFTR variant in *** Cftr p.G965D mutation may be lethal in spermatogonial stem cells and spermatogonia and affect the proliferation of spermatocytes and Sertoli *** spermatocyte GC-2(spd)ts(GC2)Cftr p.G965D cells,RNA splicing variants were detected and CFTR expression decreased,which may contribute to the phenotypes associated with impaired ***,this study indicated that the CFTR p.G970D missense mutation might be a pathogenic mutation for CBAVD in Chinese males and associated with impaired spermatogenesis by affecting the proliferation of germ cells.

关键词： azoospermia congenital bilateral absence of the vas deferens CFTR mutation male infertility spermatogenesis

SCNN1B and CA12 play vital roles in occurrence of congenital bilateral absence of vas deferens(CBAVD)

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Asian Journal of Andrology 2019年第5期21卷 525-527页

作者： Ying Shen Huan-Xun Yue Fu-Ping Li Feng-Yun Hu xiao-Liang Li Qian Wan Wen-Rui Zhao Ji-Gang Jing Di-Ming Cai xiao-hui jiang Human Sperm Bank West China Second University HospitalSichuan UniversityChengdu 610041China Key Laboratory of Obstetric Gynecologic and Pediatric Diseases and Birth Defects of Ministry of EducationWest China Second University HospitalSichuan UniversityChengdu 610041China Auckland University Auckland 1142New Zealand Chengdu Neo-Life Hope Medical Testing Inc Chengdu 61CX341China Ultrasound Diagnosis Department West China HospitalSichuan UniversityChengdu 610041China

Dear Editor,Congenital bilateral absence of the vas deferens(CBAVD),a complete or partial defect of the Wolffian duct derivatives,is found in>25% of men with obstructive azoospermia(OA),but the underlying pathological mechanism remains poorly *** research has shown that the most common disease associated with CBAVD is cystic fibrosis(CF),the predominant manifestations of which include progressive lung disease,pancreatic dysfunction,elevated sweat chloride electrolyte,meconium ileus,and male infertility.

关键词： elevated CBAVD lung

Supplementation with L-Carnitine Rescues Sperm Epigenetic Changes in Asthenospermic Male Semen with Altered Acetyl-L-Carnitine Levels

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Reproductive and Developmental Medicine 2020年第3期4卷 146-155页

作者： xiao-hui jiang Chuan jiang Lin Yu xiao-Liang Li Tao Zuo Pei-Fei Gu Fu-Ping Li Wen-Ming Xu Human Sperm Bank West China Second University Hospital of Sichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children Ministry of EducationWest China Second University HospitalSichuan UniversityChengdu 610041China Reproductive Endocrinology and Regulation Laboratory West China Second University HospitalSichuan UniversityChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu610041China Northeast Pharmaceutical Group Shenyang 110023China Department of Sports Medicine Shenyang Sports UniversityShenyang 110101China

Objective:To investigate the relationship between the concentration of L-carnitine in semen and sperm parameters and investigate the epigenetic profile in sperm cell after L-carnitine ***:From February 2017 to February 2018,46 semen samples from asthenospermic males and 41 semen samples from healthy donors were *** parameters were assessed using computer-assisted sperm analysis(CASA,n=78)and the DNA fragmentation index(DFI)was evaluated through flow cytometry(n=86),%DFI=%cells outside main *** oxidative stress markers,such as reactive oxygen species(ROS)levels(n=86)and the mitochondria DNA copy numbers,were detected(n=78).The concentration of L-carnitine and acetyl-L-carnitine was detected(n=82),and methylation was analyzed(n=30).After that,we collected 13 fresh semen samples from asthenospermic males and 23 fresh semen samples from healthy *** samples were used in a freeze-thaw model that was used to determine whether adding L-carnitine could change sperm progressive motility(n=23),apoptosis index(n=9),and methylation analysis(n=7).In total,we have done 13 asthenospermia samples for Western blot,and except for the poor Western result,we analyzed 6 samples for H3K9ac detection,7 samples for H3K9m3 and H3K27m3 detection,and immunofluorescence(n=3).Finally,we had recruited 30 volunteers,and they were given oral administration of L-carnitine for 3 months and then collected semen samples at different time points for methylation ***:The concentration of acetyl-L-carnitine is negatively correlated with the%DFI value(r^2=0.1090;P=0.0026),and the concentration of acetyl-L-carnitine is positively correlated with sperm forward motility(r^2=0.0543;P=0.0458)and ROS(r^2=0.1854;P<0.0001),and the acetyl-L-carnitine level is negatively correlated with%DFI in asthenospermia(r^2=0.1701;P=0.0066),and the level of acetyl-L-carnitine in asthenospermic semen is significantly lower than the normal group(P=0.0419).In addition,this

关键词： Acetyl-L-Carnitine Asthenospermia Epigenetic Sperm DNA Damage

Ca^(2+)在饮用水铜绿微囊藻控制中的应用

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中国环境科学 2021年第11期41卷 5187-5193页

作者：易晋聂小保王奕睿肖辉毅隆院男蒋昌波长沙理工大学水利与环境工程学院湖南长沙410114 洞庭湖水环境治理与生态修复湖南省重点实验室湖南长沙410114 湖南省环境保护河湖疏浚污染控制工程技术中心湖南长沙410114

为改善饮用水藻类的混凝去除效果,以铜绿微囊藻为研究对象,考察了单独投加Ca^(2+)、Ca^(2+)与PAC联用、Ca^(2+)与CO_(3)~(2-)原位结晶三种方法的除藻效果,并对Ca^(2+)和结晶产物CaCO_(3)的除藻机制进行探讨.结果表明,单独采用Ca^(2+)时,... 详细信息

为改善饮用水藻类的混凝去除效果,以铜绿微囊藻为研究对象,考察了单独投加Ca^(2+)、Ca^(2+)与PAC联用、Ca^(2+)与CO_(3)~(2-)原位结晶三种方法的除藻效果,并对Ca^(2+)和结晶产物CaCO_(3)的除藻机制进行探讨.结果表明,单独采用Ca^(2+)时,Ca^(2+)在低浓度下对藻细胞具有吸附电中和作用,高浓度时同时还有架桥作用,但两者均无法实现对铜绿微囊藻的去除.Ca^(2+)与PAC联用,Ca^(2+)可以通过吸附电中和显著提高PAC的除藻效果,最大去除率可达98.0%,同时Ca^(2+)与溶解性藻源有机物(dAOM)的络合可将残余铝降低50%以上.含藻水中原位CaCO_(3)结晶对铜绿微囊藻的去除率最高可达83.5%,其产物为带正电荷、粒径2~4μm左右的球型球霰石.球霰石对藻细胞的去除机制包括球霰石与藻细胞的互絮凝,以及球霰石团聚物对藻细胞的卷扫絮凝,同时球霰石还可以作为加重剂促进藻晶产物沉降分离.自来水厂采用CaCO_(3)原位结晶与PAC联用除藻,可望降低PAC投加量和残余铝风险,并解决CaCO_(3)原位结晶导致的浊度和pH偏高问题.研究成果为饮用水除藻提供了新思路.

关键词： Ca^(2+) 铜绿微囊藻饮用水 CaCO_(3)原位结晶电中和

Treatment of malignant digestive tract obstruction by combined intraluminal stent installation and intra-arterial drug infusion

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World Journal of Gastroenterology 2001年第4期7卷 587-592页

作者： Ai-Wu Mao Zhong-Du Gao Jia-Yu Xu Ren-Jie Yang Xiang-Seng xiao Ting-hui jiang Wei-Jun jiang Department of Interventional Radiology,Shanghai S.T,Luke’s Hospital,768 Yu Yuan Road,Shanghai 200050,ChinaDepartment of Gastroenterology Rui Jin Hospital,Shanghai Second Medical University,Departrnent of Tumor Hospital,Beijing Medical UniversityDepartment of Imaging Chang Zheng Hospital,Shanghai Second Military Medical University Department of Interventional Radiology Shanghai S.T Luke's Hospital 768 Yu Yuan Road Shanghai 200050 China. maw1@***

AIM: To study the palliative treatment of malignant obstruction of digestive tract with placement of intraluminal stent combined with intra-arterial infusion of chemotherapeutic drugs. METHODS: A total of 281 cases of digestive tract malignant obstruction were given per oral (esophagus, stomach, duodenum and jejunum), per anal (colon and rectum) and percutaneous transhepatic (biliary) installation of metallic stent. Among them, 203 cases received drug infusion by cannulation of tumor supplying artery with Seldinger's technique. RESULTS: Altogether 350 stents were installed in 281 cases, obstructive symptoms were relieved or ameliorated after installation. Occurrence of restenotic obstruction was 8-43 weeks among those with intra-arterial drug infusion, which was later than 4-26 weeks in the group with only stent installation. The average survival time of the former group was 43 (3-105) weeks, which was significantly longer than 13 (3-24) weeks of the latter group. CONCLUSION: Intraluminal placement of stent combined with intra-arterial infusion chemotherapy is one of the effective palliative therapies for malignant obstruction of the digestive tract with symptomatic as well as etiological treatment.

关键词： Stents Adult Aged Aged, 80 and over Antineoplastic Agents dosage Combined Modality Therapy Female Gastrointestinal Neoplasms Humans Infusions, Intra-Arterial Intestinal Obstruction Male Middle Aged Palliative Care Quality of Life Treatment Outcome

CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui Mao hui-Lin jiang Bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface

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云计算环境下企业网站泄露信息高效检测仿真

计算机仿真 2017年第4期34卷 460-463页

作者：杨晓晖谭江平河北大学计算机科学与技术学院河北保定071000

云计算环境下对企业网站泄露信息的检测,能够更好的保障云计算环境安全稳定性。对泄露信息的高效检测,需要得到隐藏目录泄露路径,并计算泄露指数,完成对泄露信息的检测。传统方法先细粒度地定位企业网站泄露源和信息泄露点,追踪企业网... 详细信息

云计算环境下对企业网站泄露信息的检测,能够更好的保障云计算环境安全稳定性。对泄露信息的高效检测,需要得到隐藏目录泄露路径,并计算泄露指数,完成对泄露信息的检测。传统方法先细粒度地定位企业网站泄露源和信息泄露点,追踪企业网站信息传播路径,但忽略了泄露指数的计算,导致检测精度偏低。提出基于K-Q的云计算环境下企业网站泄露信息检测方法。先遵循关系型数据模型定义企业网站信息表,快速计算信息泄漏源和信息泄露点之间的可达性,得到隐藏目录泄露路径,并计算泄露指数,利用计算的结果完成对云计算环境下企业网站泄露信息检测。仿真证明,所提方法检测精度高,可以有效的完成对云计算环境下企业网站泄露信息检测,为保障云计算环境安全稳定性提供了可行的依据。

关键词：云计算环境网站信息检测

Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-hui jiang hui-Li Kang Yi jiang Hua-Wei Zhang xiao-Mei Song Yu-Ze Li Wen-Li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC