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Associations of tea consumption with blood pressure progression and hypertension incidence

Journal of geriatric Cardiology 2021年第8期18卷 645-653页

作者： xiao-ge niu Can CAI Fang-Chao LIU Jian-Xin LI Ke-Yong HUANG Xue-Li YANG Jie CAO Shu-Feng CHEN Hong-Fan LI Chong SHEN Ying-Xin ZHAO Dong-Sheng HU Shu-Jun GU Jian-Feng HUANG Xiang-Feng LU Dong-Feng GU Department of Epidemiology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Tianjin Key Laboratory of Environment Nutrition and Public HealthDepartment of Occupational and Environmental HealthSchool of Public HealthTianjin Medical UniversityTianjinChina Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical UniversityNanjingChina Cardio-Cerebrovascular Control and Research Center Institute of Basic MedicineShandong First Medical University(Shandong Academy of Medical Sciences)JinanChina Department of Epidemiology and Health Statistics College of Public HealthZhengzhou UniversityHenanChina Department of Biostatistics and Epidemiology School of Public HealthShenzhen University Health Science CentreShenzhenChina Changshu Center for Disease Control and Prevention JiangsuChina School of Medicine Southern University of Science and TechnologyShenzhenChina

BACKGROUND Association between tea consumption and incident hypertension remains *** study conducted to examine the health effects of tea consumption on blood pressure progression and hypertension *** A population-based cohort of 38,913 Chinese participants without hypertension at baseline were included in the current *** on tea consumption was collected through standardized *** of tea consump-tion with blood pressure progression and incident hypertension were analyzed using logistic regression models and Cox propor-tional hazards regression models,*** During a median follow-up of 5.9 years,17,657 individuals had experienced progression to a higher blood pressure stage and 5,935 individuals had developed *** multivariate analyses,habitual tea drinkers(≥3 times/week for at least six months)had a 17%lower risk for blood pressure progression[odds ratio(OR)=0.83,95%CI:0.79-0.88]and a 14%de-creased risk for incident hypertension[hazard ratio(HR)=0.86,95%CI:0.80-0.91]compared with non-habitual tea ***-dividuals in different baseline blood pressure groups could obtain similar benefit from habitual tea *** terms of tea con-sumption amount,an inverse,linear dose-response relation between monthly consumption of tea leaves and risk of blood pres-sure progression was observed,while the risk of incident hypertension did not reduce further after consuming around 100 g of tea leaves per *** Our study demonstrated that habitual tea consumption could provide preventive effect against blood pres-sure progression and hypertension incidence.

关键词： hypertension progression consuming

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Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin niu Jiafeng Fu Shining ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

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C19400引线框架高精铜带制造工艺研究

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铜陵学院学报 2017年第6期16卷 108-110页

作者：葛小牛徐向棋安徽鑫科铜业有限公司安徽芜湖241006 铜陵学院安徽铜陵244000

通过金相组织观察、硬度测试、拉伸性能测试、导电率等方法,对C19400引线框架高精铜带制造工艺中的铸造工艺、热轧工艺、热处理工艺和冷轧工艺等进行了研究和分析,发现添加适量的固溶Fe后,并优化铸造、热轧、热处理和冷轧工艺后提高了... 详细信息

通过金相组织观察、硬度测试、拉伸性能测试、导电率等方法,对C19400引线框架高精铜带制造工艺中的铸造工艺、热轧工艺、热处理工艺和冷轧工艺等进行了研究和分析,发现添加适量的固溶Fe后,并优化铸造、热轧、热处理和冷轧工艺后提高了成品的强度,硬度和导电性,且满足成品尺寸和表面精度的要求。

关键词： C19400铜合金力学性能制造工艺

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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian ge Hao Li Yu Deng Hongbin Wu xiaojian Xu Fei niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang xiaofei niu Yingkai Wang Yang Liu Cheng Yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

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Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety

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Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： Mingyu Zhang Chunyu Xiang Renrui niu xiaodong He Wenqi Luo Wanguo Liu Rui Gu Department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

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Surface Patterns of a Tetrahedral Polyelectrolyte Brush Induced by Grafting Density and Charge Fraction

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Chinese Journal of Polymer Science 2020年第4期38卷 394-402,I0007页

作者： Hong-ge Tan Gang Xia Li-Xiang Liu xiao-Hui niu Qing-Hai Hao College of Science Civil Aviation University of ChinaTianjin 300300China

A tetrahedral polyelectrolyte brush in the presence of trivalent counterions is researched under the condition of good solution by mea ns of molecular dynamics simulati *** density and charge fraction are varied to gen erate a series of surface patter *** microphase separation happens and various interesting pinned patches appear at appropriate charge fraction and grafting *** a careful analysis on the brush thickness,the pair correlation functions,the distributions of net charge,and the four states of trivalent counterions in the brush,we find that the ordered surface patterns and special properties are induced by the pure electrostatic correlation effect of trivalent ions even in the good ***,the dependences of electrostatic correlation on the charge fraction of tethered chains are evaluated for fixed grafting den ***,our results can serve as a guide for precise control over the stimuli-responsive materials rational and self-assembly of nanoparticles.

关键词： Surface patterns Tetrahedral polyelectrolyte brush Molecular dyn amics simulation Electrostatic cor relation

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Effects of pairing correlation on neutron drop

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Science China(Physics,Mechanics & Astronomy) 2020年第4期63卷 88-97页

作者： Ying-Hui ge Ying Zhang Jin-niu Hu Department of Physics School of ScienceTianjin UniversityTianjin 300072China School of Physics Nankai UniversityTianjin 300071China

In this work, the effects of the pairing correlation on the properties of neutron drops N=6-50 trapped in a harmonic oscillator potential with ω = 10 Me V are investigated by comparing the results given by the Skyrme Hartree-Fock and Hartree-FockBogoliubov theories with the density-dependent delta interaction(DDDI) pairing force. The results showed that the pairing correlation slightly made the neutron drops more bound, and increased the central neutron density, the spin-orbit and pseudo spin-orbit splittings. Thus, the pairing correlation must be accounted for to improve the Skyrme functional compared with the ab initio calculations. Furthermore, although the single-particle energy gaps with or without pairing were similar, the shell closures varied due to pair scattering. Here, the shell closures in neutron drops using the Sk M* parameter set and DDDI pairing force were found at N=8, 16, and 32.

关键词： neutron drop Hartree-Fock theory Hartree-Fock-Bogoliubov theory pairing correlation

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Micromorphology and safety properties of meager and meager-lean coal for blast furnace injection

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International Journal of Minerals,Metallurgy and Materials 2021年第5期28卷 774-781页

作者： Long-zhe Jin xiao-meng niu School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China

Four types of meager and meager-lean coal and one type of high-quality anthracite were selected based on the safety requirements for blast furnace coal injection and domestic coal quality to conduct microstructure and component *** analyses of the organic and inorganic macerals and the chemical compositions of the selected coal samples indicate that the four types of meager and meager-lean coal have low volatilization,low ash content,and low sulfur content;these qualities are suitable for blast furnace *** test was conducted on the four types of meager and meager-lean coal and the anthracite mixed coal *** indicate that the mixture of meager and meager-lean coal and anthracite is beneficial to improve the grindability of pulverized *** explosive tests reveal that the selected coal samples are non-explosive or weakly *** the proportion of meager and meager-lean coal is less than 40wt%,the mixed coal powder would not explode during the blowing *** minimum ignition temperature test determines that the minimum ignition temperatures of the four types of meager and meager-lean coal and anthracite are 326,313,310,315,and 393°C,*** study provides a guiding research idea for the safety of meager and meager-lean coal used in blast furnace injection.

关键词： meager coal meager-lean coal microstructure safety property blast furnace injection

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Recycling Spent LiCoO_(2)Battery as a High-efficient Lithiumdoped Graphitic Carbon Nitride/Co_(3)O_(4)Composite Photocatalyst and Its Synergistic Photocatalytic Mechanism

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Energy & Environmental Materials 2023年第2期6卷 45-53页

作者： Bo niu Jiefeng xiao Zhenming Xu School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The ever-increasing quantity of spent lithium-ion batteries(LIBs)is both a potential environmental pollutant and a valuable *** spent LIBs recycling mainly aimed at the separation of valuable *** issues still exist in these processes such as high energy consumption and complex separation *** study avoided element separation and proposed a facile approach to transform spent LiCoO_(2) electrode into a lithium(Li)-doped graphitic carbon nitride(g-C_(3)N_(4))/Co_(3)O_(4) composite photocatalyst through one-pot in situ thermal *** the thermal process,melamine served as the reductant for LiCoO_(2) decomposition and the raw material for g-C_(3)N_(4) *** was in situ doped in g-C_(3)N_(4) and the generated Co_(3)O_(4) was in situ integrated,forming a Li-doped g-C_(3)N_(4)/Co_(3)O_(4) composite *** special composite exhibited an enhanced photocatalytic performance,and its photocatalytic H2 production and RhB degradation rates were 8.7 and 6.8 times higher than those of g-C_(3)N_(4).The experiments combined with DFT calculation revealed that such enhanced photocatalytic efficiency was ascribed to the synergy effect of Li doping and Co_(3)O_(4) integrating,which extended the visible light absorption(450-900 nm)and facilitated the charge transfer and *** study transforms waste into a high-efficient catalyst,realizing high-valued utilization of waste and environmental protection.

关键词： composite photocatalyst environmental protection spent LIBs synergy mechanism waste utilization

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