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Acta Mechanica Sinica 2011年第6期27卷 1081-1090页

作者： Li Wang Mei-Wen An xiao-Na Li fang yang yang Liu Institute of Applied Mechanics and Biomedical Engineering Taiyuan University of Technology 030024 Taiyuan China

To probe the contributions of polar cortical cytoskeleton and the surface tension of daughter cells to intercellular bridge thinning dynamics during cytokinesis,we applied cytochalasin D（CD） or colchicine（COLC） in a highly localized manner to polar regions of dividing normal rat kidney（NRK） *** observed cellular morphological changes and analyzed the intercellular bridge thinning trajectories of dividing cells with different polar cortical *** blebbistatin（BS） application was used to obtain cells losing active contractile force *** results show that locally released CD or colchicine at the polar region caused inhibition of cytokinesis before *** treatment at phases after ingression allowed completion of cytokinesis but dramatically influenced the trajectories of intercellular bridge *** single polar cortical actin induced transformation of the intercellular bridge thinning process,and polar cortical tension controlled deformation time of intercellular *** study provides a feasible framework to induce and analyze the effects of local changes in mechanical properties of cellular components on single cellular cytokinesis.

关键词： Cytokinesis Normal rat kidney epithelial cells Intercellular bridge Polar cortical cytoskeleton - Cortical surface tension

Effect of Annealing on the Microstructure and Properties of In-situ Cu-Nb Microcomposite Wires

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Acta Metallurgica Sinica(English Letters) 2016年第7期29卷 668-673页

作者： Li-Ping Deng Bing-Shu Wang Hong-Liang Xiang xiao-fang yang Rong-Mei Niu Ke Han School of Mechanical Engineering and Automation Fuzhou University Fuzhou 350116 China College of Materials Science and Engineering Chongqing University Chongqing 400044 China National High Magnetic Field Laboratory Tallahassee FL 32310 USA

The effects of annealing on microstructure, posite wire have been investigated. Neither changes in magnetoresistance, and hardness of an in situ Cu-Nb microcom- microstructure nor hardness were found until 500 ℃. Particularly, microstructural change within the Nb films was observed in the annealed samples. The room-temperature magnetoresistivity was almost negligible, while magnetoresistivity at -196℃increased with magnetic field. At temperature above 500 ℃, recovery and recrystallization occurred, and both the resistance and hardness decreased.

关键词： Annealing Microstructure Magnetoresistance Hardness Cu-Nb microcomposite wire

Over-activation of TLR5 signaling by high-dose flagellin induces liver injury in mice

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Cellular & Molecular Immunology 2015年第6期12卷 729-742页

作者： yang xiao fang Liu Jingyi yang Maohua Zhong Ejuan Zhang Yaoming Li Dihan Zhou Yuan Cao Wei Li Jie Yu Yi yang Huimin Yan Mucosal immunity Research Group State Key Laboratory of Virology Wuhan institute of Virology Chinese Academy of Sciences Wuhan China

Flagellin is a potent activator of a broad range of cell types that are involved in innate and adaptive immunity. Therefore, it is a good adjuvant candidate for vaccines, and it might function as a biological protectant against both major acute radiation syndrome during cancer radiotherapy and a mitigator of radiation emergencies. However, accumulating evidence has implicated flagellin in the occurrence of some inflammatory diseases, such as acute lung inflammation, cardiovascular collapse and inflammatory bowel disease. The aim of this study was to elucidate whether only flagellin-TLR5 signaling activation plays a role in the pathophysiology of liver or whether some other flagellin activity also contributes to liver injury either via bacterial infections or during clinical applications. Recombinant flagellin proteins with or without TLR5-stimulating activity were used to evaluate the role of flagellin-TLR5 signaling in liver injury in wild-type and TLR5 KO mice. Gross lesions and large areas of hepatocellular necrosis were observed in liver tissue 12 h after the intraperitoneal administration of 100 or 200 pg flagellin （FliC） in a dose-and time-dependent manner in wild-type mice, but not in TLR5 KO mice. Deletion of the N-terminal or TLR5 binding domain of flagellin inhibited flagellin-induced inflammatory responses and the subsequent acute liver function abnormality and damage. These data confirmed that flagellin is an essential determinant of liver injury and demonstrated that the over-activation of TLR5 signaling by high-dose flagellin caused acute inflammatory responses, neutrophil accumulation and oxidative stress in the liver, which contributes to the progression and severity of flagellin-induced liver injury.

关键词： flagellin liver injury pathological effect TLR5

Relationship between serum inflammatory response cytokines and the change of plaque properties in patients with H-type hypertension complicated by carotid atherosclerosis

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Journal of Hainan Medical University 2017年第14期23卷 46-49页

作者： Li Lei xiao-fang yang Department of Cardiology Yulin Hospital of Traditional Chinese Medicine in Shaanxi ProvinceYulin CityShaanxi Province719000 Department of Internal Medicine Baishui County Hospital in Shaanxi ProvinceWeinan CityShaanxi Province715600

Objective:To study the relationship between serum inflammatory response cytokines and the change of plaque properties in patients with H-type hypertension complicated by carotid ***: Patients who were diagnosed with H-type hypertension complicated by carotid atherosclerosis in Yulin Hospital of Traditional Chinese Medicine between May 2014 and December 2016 were selected as group A, patients with H-type hypertension complicated by carotid atherosclerosis and normal Hcy levels were selected as group B, patients with carotid atherosclerosis and normal blood pressure levels and Hcy levels were selected as group C, and healthy volunteers during the same period were selected as control group. Serum levels of inflammatory response cytokines and plaque property-related cytokines were ***: Serum Hcy, sICAM-1, MCP-1, YKL-40, IL-6, PTX3, FGF23, MMP9 and Caspase-3 levels of group A, group B and group C were significantly higher than those of group D, serum Hcy, sICAM-1, MCP-1, YKL-40, IL-6, PTX3, FGF23, MMP9 and Caspase-3 levels of group A and group B were significantly higher than those of group C, and serum Hcy, sICAM-1, MCP-1, YKL-40, IL-6, PTX3, FGF23, MMP9 and Caspase-3 levels of group A were significantly higher than those of group B;serum Hcy, sICAM-1, MCP-1, YKL-40, IL-6, PTX3, FGF23, MMP9 and Caspase-3 levels of group A with vulnerable plaques were significantly higher than those of patients with stable plaques. Serum Hcy, sICAM-1, MCP-1, YKL-40 and IL-6 levels of group A were positively correlated with PTX3, FGF23, MMP9 and Caspase-3 ***: Serum inflammatory response cytokine secretion increases in patients with H-type hypertension complicated by carotid atherosclerosis, and it can result in the change in plaque properties and the decrease in stability.

关键词： H-type hypertension Carotid atherosclerosis Inflammatory response Cytokine

Recent Advances in Fibrous Materials for Hydroelectricity Generation

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Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can Ge Duo Xu xiao Feng Xing yang Zheheng Song Yuhang Song Jingyu Chen Yingcun Liu Chong Gao Yong Du Zhe Sun Weilin Xu Jian fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

基于包围跳跃的计算统一设备架构光线投射算法

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科学技术与工程 2014年第12期22卷 245-249页

作者：方军房晓阳肖亮南京理工大学计算机科学与工程学院南京210094

针对传统光线投射算法绘制速度慢和图形处理器(graphics processing unit,GPU)不能有效进行并行计算的缺点,文章提出一种基于包围跳跃的计算统一设备架构(compute unified device architecture,CUDA)光线投射算法。首先介绍了CUDA的编... 详细信息

针对传统光线投射算法绘制速度慢和图形处理器(graphics processing unit,GPU)不能有效进行并行计算的缺点,文章提出一种基于包围跳跃的计算统一设备架构(compute unified device architecture,CUDA)光线投射算法。首先介绍了CUDA的编程模型和线程结构,然后用包围盒技术隔离体数据周围无效的空体素,减少投射光线的数目;利用光线跳跃技术,在包围盒内进行快速光线的合成,跳过透明的体素,减少大量体素的重采样;最后使用CUDA强大的并行处理计算的功能实现光线投射算法。实验结果表明,在保证图像质量的同时,绘制速度上比基于GPU加速的光线投射算法有14倍的提高,能够接近实时绘制,有很好的应用价值。

关键词：光线投射体绘制光线跳跃包围盒统一计算设备结构

Cannabinoid CB1 receptor signaling dichotomously modulates excitatory and inhibitory synaptic transmission in rat inner retina

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Cannabinoid CB1 receptor signaling dichotomously modulates e...

Effect of acetylcholine on pain-related electric activities in hippocampal CA1 area of normal and morphinistic rats

中国神经科学学会第十届全国学术会议

作者： xiao-Han Wang Yi Wu xiao-fang yang Yanying Miao Ling-Dan Dong Xiong-Li yang Zhongfeng Wang Institutes of Brain Science Institute of Neurobiology and State Key Laboratory of Medical NeurobiologyFudan University

In the inner retina,a neuronal circuit formed by ganglion cells（RGCs）,amacrine cells（ACs） and bipolar cells（BCs） integrates and modulates visual *** investigated how activation of the cannabinoid CB1receptor（CB1R）,expressed on the terminals of ACs and BCs,as demonstrated by multiple labeling immunohistochemistry,regulates mTPSCs and mEPSCs of RGCs in rat ***55121-2（WIN）,a CB1R agonist,suppressed mTPSCs of RGCs by inhibiting L-type calcium channels of *** contrast,the existence of inhibitory inputs from ACs to BCs was indispensable for WTN-induced suppression of mEPSCs of ***,the depolarized membrane potential of BCs in the absence of inhibitory inputs from ACs inactivated the T-type calcium channel that was responsible for the generation of RGC mEPSCs,so mat this channel could not be *** the inactivation was eliminated by the hyperpolarization caused by the inhibitory inputs,the T-type channel was inhibited by activation of presynaptic CBlRs on BCs,which resulted in the suppression of the *** unique feature of CB lR-mediated retrograde regulation provides a novel mechanism for modulating excitatory synaptic transmission in the inner retina.

关键词： cannabinoid CB1 receptor inner retina synaptic transmission mEPSCs mIPSCs T-type calcium channel retinal ganglion cell

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Neuroscience Bulletin 2007年第6期23卷 323-328页

作者：肖宇杨晓芳徐满英哈尔滨医科大学生理教研室哈尔滨150081

Objective To examine the effect of acetylcholine（ACh）on the electric activities of pain-excitation neurons （PEN）and pain-inhibitation neurons（PIN）in the hippocampal CA1 area of normal rats or morphinistic rats,and to explore the role of ACh in regulation of pain perception in CA1 area under normal condition and morphine *** The trains of electric impulses applied to sciatic nerve were set as noxious *** discharges of PEN and PIN in the CA l area were recorded extracellularly by glass *** observed the influence of intracerebroventricular （i.c.v.）injection of ACh and atropine on the noxious stimulation-evoked activities of PEN and PIN in the CA1 *** Noxious stimulation enhanced the electric activity of PEN and depressed that of PIN in the CA1 area of both normal and addiction *** normal rats,ACh decrease the pain-evoked discharge frequency of PEN,while increased the frequency of *** effects reached the peak value at 4 min after injection of *** morphinistic rats,ACh also inhibited the PEN electric activity and potentialized the PIN electric activity,but the maximum effect appeared at 6 min after administration. The ACh-induced responses were significantly blocked by muscarinic receptor antagonist *** Cholinergic neurons and muscarinic receptors in the hippocampal CA1 area are involved in the processing of nociceptive information and they may play an analgesia role in pain *** addiction attenuated the sensitivity of painrelated neurons to the noxious information.

关键词： acetylcholine hippocampal CA1 area morphine electric activity

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清代陶活字数字建模与虚拟修复实验研究

数字印刷 2019年第6期 31-37页

作者：訾威方晓阳中国科学院大学人文学院北京100049

活字印刷术是中国先民的伟大发明之一,其陶活字制作技艺尤为值得关注,也是当前亟须保护的文化遗产。本研究首先对清代一批不同大小的陶活字进行三维扫描,建立数字模型;其次使用自由设计系统对数字模型进行虚拟修复;然后用3D打印技术获... 详细信息

活字印刷术是中国先民的伟大发明之一,其陶活字制作技艺尤为值得关注,也是当前亟须保护的文化遗产。本研究首先对清代一批不同大小的陶活字进行三维扫描,建立数字模型;其次使用自由设计系统对数字模型进行虚拟修复;然后用3D打印技术获得树脂字范;利用树脂字范压制出陶活字的泥胚并进行焙烧;最后将烧制出的陶活字与修复的模型在软件中进行比较。结果显示:新烧制的陶活字不仅较好地保存了原活字实物的数字信息,而且原缺损处也得到了较为理想的修复。本研究运用现代科技手段将印刷文物数字化,不仅有效保存了印刷文物信息,还为印刷文物的复制和修复提供了有效路径。

关键词：陶活字印刷文物数字建模虚拟修复三维量测

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao xiao Chaoyang Chu Zhicheng Lin Tianyuan fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites