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Clinical Study with Randomized Control on the Therapy of Integrated Chinese and Western Medicine in Treating Neurological Autoimmune Diseases:A Meta-Analysis

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World Journal of Traditional Chinese Medicine 2018年第3期4卷 85-95页

作者： xiao-Yan Peng Jin-Yun Ma xiao-dong cheng Institute of Clinical Immunology Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine

Objective: The main objective of this study is to evaluate the effects of integrated Chinese and Western medicine in the treatment of neurological autoimmune diseases. Materials and Methods: The literature was comprehensively searched to collect the randomized controlled trials about integrated Chinese and Western medicine in the treatment of neurological autoimmune diseases. Neurological autoimmune diseases mainly occur in the central nervous system(CNS) and peripheral nervous system. Therefore, multiple sclerosis(MS) was chosen as the representative in the CNS, and Guillain–Barre syndrome(GBS) was chosen as the representative in the peripheral nervous system. Extended Disability Status Scale(EDSS) score, effective rate, clinical symptom score, neurological functional sign score, recurrence frequency, and incidence rate of adverse reactions were chosen as the markers of outcome variables of MS, and the effective rate and Hughes score were also chosen as the markers of outcome variables of GBS. Results: For MS, the results showed that there was a significant difference in statistical analysis between the experimental group and the control group in EDSS score, the effective rate, and the recurrence frequency. However, through the comparison of clinical symptom score, neurological functional sign score, and incidence rate of adverse reaction of both two groups, the results showed that there was no significant difference in the statistical analysis. For GBS, through the comparison of effective rate and Hughes score of both two groups, the results showed that there was a significant difference in statistical analysis. Conclusions: The study demonstrated that compared with Western medicine, the therapy of integrated Chinese and Western medicine was more effective in treating neurological autoimmune diseases.

关键词： Guillain-Barre syndrome integrated Chinese and Western medicine meta-analysis multiple sclerosis randomized controlled trial

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Therapeutics of Integrative Medicine Ameliorate Immunological Disorders of the Nervous System: A Meta-Analysis

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World Journal of Traditional Chinese Medicine 2022年第1期8卷 153-167页

作者： Jin-Yun Ma Jennifer Cruz Jason Jin xiao-Yan Peng Ai-Ming Zhang xiao-dong cheng Institute of Clinical Immunology Yue-yang Hospital of Integrative MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Doctoral Program of Acupuncture and Oriental Medicine The Atlantic Institute of Oriental MedicineFlorida 33301USA Department of Neurology Min-Hang Hospital of Integrative MedicineShanghai 200241China

Objective: The objective of the study is to evaluate the therapeutic efficacy of integrative medicine in the treatment of immunological disorders of the nervous system. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were adopted to conduct this study, which included randomized controlled trials with a confirmed diagnosis of multiple sclerosis(MS), myasthenia gravis(MG), and Guillain–Barre syndrome(GBS), all of which were treated with integrative medicine. The effective rate, recurrent frequency, and disease score were used as the markers of outcome variables for the meta-analysis. Results: A total of 48 randomized control trials were included. The effective rates of treatment with integrative medicine were noticeably higher than those with Western medicine alone for the three diseases. The recurrence frequency for MS and the recurrence rate for MG treated with integrative medicine were reduced more than those with Western medicine alone. The Extended Disability Status Scale, acetylcholine receptor antibody, and Hughes scores for MS, MG, and GBS, respectively, treated with integrative medicine were significantly lower than those with Western medicine alone. The risks of bias in the literature evaluation showed that the quality of the included studies was not high. Conclusions: Compared to treatment with Western medicine alone, integrative medicine might ameliorate immunological disorders of the nervous system.

关键词： Guillain–Barre syndrome integrative medicine meta-analysis multiple sclerosis myasthenia gravis

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Pathogen characteristics and its sensitivity against antimicrobial agents in fatal bacterial granuloma after eyelid trauma in vitro

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International Journal of Ophthalmology(English edition) 2011年第4期4卷 410-412页

作者： Xiu-Li Xu Jia-Yun Liu Tian-Wen Gao Peng-Liang Zhang Xian-Long Qi xiao-dong cheng and xiao-Ke Hao Department of Laborator and Department of Dermatology Xijing Hospital Fourth Military Medical University Xi'an 710033 Shaanxi Province China

AIM: To understand the pathogen characteristics and its sensitivity against antimicrobial agents in fatal bacterial granuloma after eyelid trauma (FBGT) in vitro, and to provide laboratory evidence for diagnosis. METHODS: The FBGT pathogens were isolaated and cultured with reformed rabbit-brain anaerobic enriched broth (RRAB), and identified by ATB/API 20A system. The minimum inhibiting concentration (MIC) was determined by anaerobic broth dilution method. RESULTS: A total of 22 strains of pathogen were separated from 21 patients with FBGT and identified as Propionibacterium acnes (PA) by ATB/API 20A system. The MIC of ciprofloxacin for 22 PA strains was 0.0625-0.5mg/L, the MIC of penicillin, ampicillin, ampicillin/sulbactam, cefoperazone, lincomycin, and imipenem/cilastatin were 0.125-0.5mg/L, the MIC of ticarcillin/clavulanic acid was 0.250-1.000mg/L, and the MIC of metronidazole was 64-256mg/L. The pathogen of FBGT was strictly anaerobic PA, which growed slowly and better in nutritious RRAB broth. All PA were resistant to metronidazole, but susceptive to other routine antimicrobial agents, such as penicillin, ampicillin and lincomycin. CONCLUSION: FBGT should not be treated with metronidazole. Clinicians should choose combined use of drugs or operation to treat FBGT according to patients' individual condition and the results of drug sensitivity test.

关键词： Fatal bacteria granuloma after trauma Propionibacterium Acnes Antimicrobial agents Minimum inhibiting concentration

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Oncological and Reproductive Outcomes of Fertility-sparing Surgery in Women with Early-stage Epithelial Ovarian Carcinoma:A Multicenter Retrospective Study

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Current Medical Science 2020年第4期40卷 745-752页

作者： Jing CHEN Fen-fen WANG Yan ZHANG Bin YANG Ji-hui AI Xin-yu WANG xiao-dong cheng Ke-zhen LI Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Gynecologic Oncology Women's HospitalZhejiang UniversityHangzhou 310006China Reproductive Medicine Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Summary:With delayed childbearing in women,preservation of fertility is an important issue for reproductive-age patients with epithelial ovarian carcinoma(EOC).Fertility-sparing surgery(FSS)can be considered in patients with early-stage disease in order to preserve fertility and improve quality of *** order to evaluate oncological safety,attitudes toward childbearing and reproductive outcomes in women with EOC who underwent FSS,this multicenter retrospective study was *** January 2005 and December 2014,total of 87 young women with FIGO stage I EOC were included,with their clinicopathologic parameters in relation to disease-free survival(DFS)and overall survival(OS)*** toward childbearing,ovarian function and fertility were studied in women undergoing FSS(n=36).As a result,in contrast to radical sur ery,FSS did not affect prognosis by Kaplan-Meier curves(log-rank test;DFS:P=0.484;OS:P=0.125).However,two of the three recurrence cases and both death cases were in FSS group stage *** women undergoing FSS resumed regular menstrual periods after *** 16(44.44%)had tried to conceive,and 17 pregnancies occurred in 15(93.75%)*** 20 women who did not attempt conception,the most common reason was not being married(70%),followed by already having children(15%).In summary,FSS is considered safe in young women with stage IA *** menstruation and good obstetric outcomes can be *** study also provides some insight into the attitudes and social factors regarding fertility in EOC patients.

关键词： epithelial ovarian cancer fertility outcome fertility preservation fertility sparing surgery ovarian function

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Investigating the Mechanism of Qu Du Qiang Fei 1 Hao Fang Formula against Coronavirus Disease 2019 Based on Network Pharmacology Method

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 93-103页

作者： Yuan-Hua Wang He-Yang Zhou Jin-Yun Ma Gui-Qing Ding Hua Yu Yong-Sheng Jin xiao-dong cheng Institute of Clinical Immunology Yue-Yang Hospital of Integrative MedicineShanghai University of Traditional Chinese MedicineShanghaiChina School of Pharmacy Naval Medical UniversityShanghaiChina

Objective:Qu Du Qiang Fei 1 Hao Fang(QDQF1)is a novel Chinese herbal medicine formula used to treat coronavirus disease 2019(COVID-19).However,the pharmacological mechanisms of action of QDQF1 remain *** objective of this study was to identify the effective ingredients and biological targets of QDQF1 for COVID-19 *** and Methods:The effective ingredients and mechanisms of action of QDQF1 were analyzed by using network pharmacology methods,which included an analysis of the effective ingredients and corresponding targets,COVID-19-related target acquisition,compound-target network analyses,protein-protein interaction network analysis,Kyoto Encyclopedia of Genes and Genomes(KEGG)and Gene Ontology(GO)enrichment analyses,and molecular docking ***:In total,288 effective QDQF1 ingredients were *** identified 51 core targets from the 148 targets through an overlap between putative QDQF1 targets and COVID-19-related *** key components,including formononetin,kaempferol,luteolin,naringenin,quercetin,and wogonin were identified through component-target network *** functional enrichment analysis of the core targets revealed 1296 items,while KEGG pathway enrichment analysis identified 148 signaling *** central targets(CCL2,CXCL8,IL1B,IL6,MAPK1,MAPK3,MAPK8,STAT3,and TNF)related to the COVID-19 pathway were identified in the KEGG pathway enrichment ***,molecular docking analysis suggested that the docking scores of the six key components to the nine central targets were better than those to ***:QDQF1 may regulate multiple immune-and inflammation-related targets to inhibit the progression of severe acute respiratory syndrome coronavirus 2,and thus,may be suitable for the treatment of COVID-19.

关键词： Coronavirus disease 2019 molecular docking molecular mechanism network pharmacology Qu Du Qiang Fei 1 Hao Fang formula

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Prognostic value of human papillomavirus 16/18 genotyping in low-grade cervical lesions preceded by mildly abnormal cytology

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第3期18卷 249-255页

作者： Jing YE Bei cheng Yi-fan cheng Ye-li YAO Xing XIE Wei-guo LU xiao-dong cheng Department of Gynecologic Oncology Women 's Hospital School of Medicine Zhejiang University Hangzhou 310006 China

Histological low-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia grade 1 （LSIL/CIN1） preceded by normal or mildly abnormal cytology is recommended for conservative follow-up, with no separated management. In this study, we assessed the triage value of human papillomavirus （HPV） 16/18 genotyping in 273 patients with LSIL/CINI. HPV16/18 genotyping was performed at baseline and follow-up was at 6-monthly intervals for up to 2 years. At each follow-up, women positive for cytology or high-risk HPV （hrHPV） were referred for colposcopy. Enrollment cytology, HPV16/18 genotyping, and questionnaire-obtained factors were linked to the 2-year cumulative progression rate. Univariate and multivariate analyses were performed taking into account time-to-event with Cox proportional hazard regression. The results showed that 190 cases （69.6%） regressed, 37 （13.6%） persisted, and 46 （16.8%） progressed. HPV16/18 positivity （hazard ratio （HR）, 2.708; 95% confidence interval （CI）, 1.432-5.121; P=-0.002） is significantly associated with higher 2-year cumulative progression rate. Sub-analysis by enrollment cytology and age restricted the positive association among patients preceded by mildly abnormal cytology and aged 30 years or older. Immediate treatment is a rational recommendation for the high-risk subgroup, when good compliance is not assured.

关键词： Low-grade squamous intraepithelial lesion (LSIL) Cervical intraepithelial neoplasia grade 1 (CIN1) Human papillomavirus (HPV) HPV16/18 genotyping Prognostic value Prospective study

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Pattern Recognition of EEG Signals and Applications in Robotics

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Chinese Journal of Biomedical Engineering(English Edition) 2006年第4期15卷 159-170页

作者： ZHANG xiao-dong cheng Zhi-qiang LI De-jun School of Mechanical Engineering Xi''an Jiaotong University710049 Xi''anChina School of Mechanical EngineeringXi''an Jiaotong University710049 Xi''anChina School of Mechanical EngineeringXi''an Jiaotong University710049 Xi''anChina

With the rapid development of brain computer interface (simply called BCI), electroencephalography (EEG) will be another interesting bio-electrical signal applied in robotics after EMG. In order to realize it finally, the accurate measurement and pattern recognition of EEG signal must be a very important and elementary research objective. Based on our current researches and some reports from the other international colleagues in the field, we deeply discuss the basic characteristics of EEG signal, the development and selection of EEG measurement system, feature extraction and recognition methods of EEG signal, and then review EEG’s applications in robotics as well as the future research trends in this paper.

关键词： Electroencephalography Pattern recognition Robotics Control

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Platelet RNA signature independently predicts ovarian cancer prognosis by deep learning neural network model

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Protein & Cell 2023年第8期14卷 618-622页

作者： Chun-Jie Liu Hua-Yi Li Yue Gao Gui-Yan Xie Jian-Hua Chi Gui-Ling Li Shao-Qing Zeng xiao-Ming Xiong Jia-Hao Liu Lin-Li Shi Xiong Li xiao-dong cheng Kun Song Ding Ma An-Yuan Guo Qing-Lei Gao Department of Gynecological Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China National Clinical Research Center for Obstetrics and Gynecology Cancer Biology Research Center(Key Laboratory of the Ministry of Education)Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Center for Artificial Intelligence Biology Hubei Bioinformatics&Molecular Imaging Key LaboratoryKey Laboratory of Molecular Biophysics of the Ministry of EducationCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Gynecology and Obstetrics The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Gynecological Oncology Women's HospitalSchool of MedicineZhejiang UniversityHangzhou 310011China Gynecological Oncology Key Laboratory Qilu HospitalShandong UniversityJinan 250100China

Dear Editor,Platelets are circulating anucleate cytoplasmic fragments of megakaryocytes and characterized by their functions in wound healing and vascular integrity *** evidence highlights the extensive reciprocal signaling interactions between platelets and tumor cells(Haemmerle et al.,2018).Tumor cells activate and aggregate platelets to sustain proliferation(Cho et al.,2012),resist apoptosis,and promote metastasis(Haemmerle et al.,2017).

关键词： Platelet healing

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急性心肌梗死患者血清瘦素的改变及临床意义

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现代预防医学 2011年第13期38卷 2652-2653页

作者：肖成东海口市琼山区人民医院

[目的]观察临床急性心肌梗死(AMI)患者血清瘦素水平的变化,探讨其临床意义。[方法]随机选取临床研究对象68例,其中AMI组患者36例,正常对照组32例。所有研究对象均测定血压(Bp)、血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL... 详细信息

[目的]观察临床急性心肌梗死(AMI)患者血清瘦素水平的变化,探讨其临床意义。[方法]随机选取临床研究对象68例,其中AMI组患者36例,正常对照组32例。所有研究对象均测定血压(Bp)、血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高敏C-反应蛋白(hs-CRP)和瘦素水平。[结果]与正常对照组比较,AMI组患者的Bp、TC、LDL-C、hs-CRP和瘦素水平均有明显升高(P﹤0.05),而两组间TG无明显差别。AMI患者的瘦素水平与hs-CRP有明显的正相关性(r=0.319,P﹤0.05)。[结论]AMI患者瘦素水平明显升高,提示它可能是一种重要的损伤因子,在AMI的发病中起重要作用。

关键词：急性心肌梗死瘦素 C-反应蛋白

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Biomechanical Comparison of Two Kinds of Internal Fixation in a Type C Zone II Pelvic Fracture Model

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Chinese Medical Journal 2015年第17期128卷 2312-2317页

作者： Tao Wu Wei Chen Qi Zhang Zhan-Le Zheng Hong-Zhi Lyu Yun-Wei Cui xiao-dong cheng Ying-Ze Zhang Yan-Jiang Yang Department of Orthopaedics Third Hospital Hebei Medical University Shijiazhuang Hebei 050051 China

Background： Unstable pelvic fractures are complex and serious injuries. Selection of a fixation method for these fractures remains a challenging problem for orthopedic surgeons. This study aimed to compare the stability of Tile C pelvic fractures fixed with two iliosacral （IS） screws and minimally invasive adjustable plate （MIAP） combined with one IS screw. Methods： This study was a biomechanical experiment. Six embalmed specimens of the adult pelvis were used. The soft tissue was removed from the specimens, and the spines from the fourth lumbar vertebra to the proximal one-third of both femurs were retained. The pubic symphysis, bilateral sacroiliac joints and ligaments, bilateral hip joints, bilateral sacrotuberous ligaments, and bilateral sacrospinous ligaments were intact. Tile C pelvic fractures were made on the specimens. The symphysis pubis was fixed with a plate, and the fracture on the posterior pelvic ring was fixed with two kinds of internal fixation in turn. The specimens were placed in a biomechanical machine at a standing neutral posture. A cyclic vertical load of up to 500 N was applied, and displacement was recorded. Shifts in the fracture gap were measured by a grating displacement sensor. Statistical analysis used： Paired-samples t-test. Results： Under the vertical load of 100, 200, 300, 400, and 500 N, the average displacement of the specimens fixed with MIAP combined with one IS screw was 0.46, 0.735, 1.377, 1.823, and 2.215 mm, respectively, which was significantly lower than that of specimens fixed with two IS screws under corresponding load （P 〈 0.05）. Under the vertical load of 500 N, the shift in the fracture gap of specimens fixed with MIAP combined with one IS screw was 0.261 ± 0.095 mm, and that of specimens fixed with two IS screws was 0.809 ± 0.170 mm. The difference was significant （P 〈 0.05）. Conclusion： The stability of Tile C pelvic fractures fixed with MIAP combined with one IS screw was better than that fixed with two IS screws.

关键词： Biomechanics Internal Fixation Pelvis Unstable

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