检索结果-南通市图书馆

Prevalence of polymyxin-induced nephrotoxicity and its predictors in critically ill adult patients:A meta-analysis

World Journal of Clinical Cases 2022年第31期10卷 11466-11485页

作者： Jiang-Lin Wang Bi-xiao Xiang xiao-Li Song Rui-Man Que xiao-cong zuo Yue-Liang Xie Department of Pharmacy The Third Xiangya Hospital of Central South UniversityChangsha 410013Hunan ProvinceChina Department of Pharmacy Sanya Central HospitalSanya 572000Hainan ProvinceChina

BACKGROUND Polymyxin-induced nephrotoxicity is a major safety concern in clinical practice due to long-term adverse outcomes and high *** To conducted a systematic review and meta-analysis of the prevalence and potential predictors of polymyxin-induced nephrotoxicity in adult intensive care unit(ICU)*** PubMed,EMBASE,the Cochrane Library and Reference Citation Analysis database were searched for relevant studies from inception through May 30,*** pooled prevalence of polymyxin-induced nephrotoxicity and pooled risk ratios of associated factors were analysed using a random-effects or fixed-effects model by Stata SE ***,subgroup analyses and meta-regression were conducted to assess *** A total of 89 studies involving 12234 critically ill adult patients were included in the *** overall pooled incidence of polymyxin-induced nephrotoxicity was 34.8%.The pooled prevalence of colistin-induced nephrotoxicity was not higher than that of polymyxin B(PMB)-induced *** subgroup analyses showed that nephrotoxicity was significantly associated with dosing interval,nephrotoxicity criteria,age,publication year,study quality and sample size,which were confirmed in the univariable meta-regression *** was significantly increased when the total daily dose was divided into 2 doses but not 3 or 4 ***,older age,the presence of sepsis or septic shock,hypoalbuminemia,and concomitant vancomycin or vasopressor use were independent risk factors for polymyxin-induced nephrotoxicity,while an elevated baseline glomerular filtration rate was a protective factor against colistin-induced *** Our findings indicated that the incidence of polymyxin-induced nephrotoxicity among ICU patients was *** emphasizes the importance of additional efforts to manage ICU patients receiving polymyxins to decrease the risk of adverse outcomes.

关键词： Polymyxins Nephrotoxicity Critically ill adult patients Risk factors Meta-analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Novel Chinese Equation for Accurately Estimating Glomerular Filtration Rate:a Multi-center Large Study

A Novel Chinese Equation for Accurately Estimating Glomerula...

引用

2018年中国药理学会定量药理学专业委员会学术年会

作者： Dai-yang Li Wen-jun Yin Ling-yun Zhou xiao-cong zuo Department of Pharmacy The Third Xiangya HospitalCentral South University

Objective Glomerular filtration rate(GFR) is the best index of renal function but hard to directly measure,thus,using estimated GFR(eGFR) equations clinically becomes *** the inaccuracy of existing eGFR equations in Chinese,we aimed to develop a new eGFR equation in 2772 patients(1730 for development and 1042 for internal validation) and validated in 5799 patients(external validation) in 3 representative Class-Ⅲ/Grade-A hospitals from 2 regions of *** After excluding patients using drugs affecting serum creatinine(Scr) to improve accuracy,we established a novel eGFR equation(Xiangya equation) by linear regression,taking Tc-DTPA renal dynamic imaging as *** addition,we first evaluated the performance of 12 Scrbased eGFR equations including C-G,MDRD,CKD-EPI,and published Chinese/Asian equations in a multi-center Chinese large *** In equation development and internal validation,Xiangya equation performed better than other 12 equations in both inpatients and outpatients,especially with better accuracy(30% accuracy [P30],79.21% and 84.33%,respectively).Results of external validation showed that Xiangya equation yielded the greatest P among all eGFR equations,and P for other 12 reported equations was<75%(P≥75% is considered sufficient for making good clinical decisions based on K/DOQI Guidelines),less than that of the Xiangya *** This new equation could replace other existing eGFR equations and will be widely used for Chinese general clinical use.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Dlitiazem inhibits the oxidative stress induced by angiotensin Ⅱ through growth hormone secretagogue receptor type 1a in human umbilicus vein endothelial cells

Dlitiazem inhibits the oxidative stress induced by angiotens...

引用

首届东方药理论坛暨2018年全国心脑血管药理学术会议、上海市药理学会第十九届学术年会

作者： Ling-yun Zhou Meng Yang Shan-ru zuo xiao-feng Guan Jiang-lin Wang Qing-jie Chen xiao-cong zuo Su-jie Jia Ren Guo Department of Pharmacy The Third Xiangya HospitalCentral South University

Diltiazem has been used for post-transplant hypertension,but the mechanism underlying its protective effect of endothelial cells against angiotensin Ⅱ(Ang Ⅱ)induced impairment remains *** umbilicus vein endothelial cells(HUVECs) were cultured and divided into seven groups:control,Ang Ⅱ(10～6 M),diltiazem(10～6 M),[D-Lys3]-GHRP-6(25 mM),diltiazem(10～6 M)+Ang Ⅱ(10～6 M),losartan(10～6 M)+ Ang Ⅱ(10～6 M),[D-Lys3]-GHRP-6(25 mM) +Dil(10～6 M)+Ang Ⅱ(106 M) *** oxide(NO) production,intracellular reactive oxygen species(ROS) levels,protein and mRNA expressions of endothelial nitric oxide synthase(eNOS) and p47 phox subunit of NADPH were *** indicated that pretreatment with diltiazem significantly decreased the intracellular ROS levels and increased NO *** with 106 M Ang Ⅱ for 24 h induced a significant decrease in the mRNA and protein levels of eNOS,which was significantly increased by the pre-incubated with diltiazem(10～6 M).Treatment with 106 M Ang Ⅱ for 24 h induced a significant increase in the mRNA and protein levels of p47 phox subunit of NADHP oxidase,which was significantly decreased by the pre-incubated with ***,all of these protective roles of diltiazem were attenuated by pre-incubation of [D-Lys3]-*** results reveal that diltiazem inhibits the AngⅡ-induced oxidative stress in HUVECs,which may be partly mediated by GHSR1 a.

关键词： Dlitiazem inhibits the oxidative stress induced by angiotensin through growth hormone secretagogue receptor type 1a in human umbilicus vein endothelial cells

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

引用

Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Vector meson's spin alignments in high energy reactions

引用

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 5-20页

作者： Jin-Hui Chen zuo-Tang Liang Yu-Gang Ma Xin-Li Sheng Qun Wang Key Laboratory of Nuclear Physics and Ion-beam Application (MoE) Institute of Modern PhysicsFudan University Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation (MOE)Shandong University INFN-Firenze Department of Modern Physics University of Science and Technology of China School of Mechanics and Physics Anhui University of Science and Technology

The global spin alignment of vector mesons has been observed by the STAR collaboration at the Relativistic Heavy Ion Collider （RHIC） at Brookhaven National Laboratory （BNL）.It provides a unique opportunity to probe the correlation between the polarized quark and antiquark in the strongly coupled quark-gluon plasma （sQGP） produced in relativistic heavy ion collisions,opening a new window to explore the properties of s *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e+e-annihilations at high energies where hadron production is dominated by quark fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimental advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

An Actuarial Approach to Reload Option Valuation for a Non-tradable Risk Assets under Jump-diffusion Process and Stochastic Interest Rate

引用

Acta Mathematicae Applicatae Sinica 2018年第3期34卷 451-468页

作者： cong-cong XU zuo-liang XU School of Information Renmin University of China Beijing 100872 China Department of Basic Course Shijiazhuang Institute of Railway Technology Shijiazhuang 050041 China

We use an actuarial approach to estimate the valuation of the reload option for a non-tradable risk asset under the jump-diffusion processes and Hull-White interest rate. We verify the validity of the actuarial approach to the European vanilla option for non-tradable assets. The formulas of the actuarial approach to the reload option are derived from the fair premium principle and the obtained results are arbitrage. Numerical experiments are conducted to analyze the effects of different parameters on the results of valuation as well as their differences from those obtained by the no-arbitrage approach. Finally, we give the valuations of the reload options under different parameters.

关键词： Non-tradable assets reload option actuarial approach jump-diffusion processes stochastic inter-est rate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

万古霉素联用哌拉西林他唑巴坦致急性肾损伤的研究进展

引用

药物流行病学杂志 2023年第9期32卷 975-984页

作者：林小青尹文俊周凌云谢悦良汪江林左笑丛遵义医科大学药学院贵州遵义563000 中南大学湘雅三医院药学部长沙410013 中南大学湘雅三医院临床药理中心长沙410013

万古霉素与哌拉西林他唑巴坦联用是临床常见的联合治疗方案,该方案治疗成本较低,可同时覆盖耐甲氧西林金黄色葡萄球菌和假单胞菌,常用于重症监护病房的患者,在严重感染如急性脓毒症患者的一线治疗中发挥着关键作用。但多项临床研究表明... 详细信息

万古霉素与哌拉西林他唑巴坦联用是临床常见的联合治疗方案,该方案治疗成本较低,可同时覆盖耐甲氧西林金黄色葡萄球菌和假单胞菌,常用于重症监护病房的患者,在严重感染如急性脓毒症患者的一线治疗中发挥着关键作用。但多项临床研究表明该联用方案可能会增加急性肾损伤的发生风险,导致治疗失败和住院时间延长,严重时可危及患者生命安全。因此,本研究对万古霉素与哌拉西林他唑巴坦联用致急性肾损伤的流行病学、发病机制和防治措施进行综述,旨在为临床安全使用万古霉素和哌拉西林他唑巴坦提供依据。

关键词：万古霉素哌拉西林他唑巴坦急性肾损伤联合用药

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

引用

Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi Ye Runqing Liu Hangxing Wang Aizhen zuo Cen Jin Nan Wang Huiqi Sun Luqian Feng Hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An Unprecedented Efficiency with Approaching 21%Enabled by Additive‑Assisted Layer‑by‑Layer Processing in Organic Solar Cells

引用

Nano-Micro Letters 2025年第2期17卷 372-375页

作者： Shuai Xu Youdi Zhang Yanna Sun Pei Cheng Zhaoyang Yao Ning Li Long Ye Lijian zuo Ke Gao Key Laboratory of Advanced Green Functional Materials College of ChemistryChangchun Normal UniversityChangchun 130032People’s Republic of China Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237People’s Republic of China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China State Key Laboratory and Institute of Elemento‑Organic Chemistry Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071People’s Republic of China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Tianjin Key Laboratory of Molecular Optoelectronic Sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300350People’s Republic of China State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Recently published in Joule,Feng Liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network active layer morphology,featuring a bulk p-in structure and proper vertical segregation achieved through additive-assisted layer-by-layer *** optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion,reduces recombination losses,and enhances light capture *** approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs.

关键词： Organic solar cells Additive-assisted layer-by-layer processing Three-dimensional fibril morphology Bulk p-i-n structure Optical management

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

引用

Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：