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Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats

World Journal of Gastroenterology 2004年第7期10卷 1032-1036页

作者： xiao-changxue Yong-JieWu Ming-TangGao Wen-GuangLi NingZhao Zeng-LuWang Chun-JieBao ZhenYan Ying-QiZhang BiotechnologyCentre FourthMilitaryMedicalUniversityXi'an710032ShaanxiProvinceChina DepartmentofPharmacology LanzhouMedicalCollegeLanzhou730000GansuProvinceChina BiotechnologyCentre FourthMilitaryMedicalUniversityXi'an710032ShaanxiProvinceChina

AIM: To investigate the protective effects of gastric pentadecapeptide BPC 157 on acute and chronic gastric ulcers in rats and to compare the results in therapy of human gastric ulcers by different administration methods. METHODS: Gastric pentadecapeptide BPC 157 was administered (initial single or continuous administration) into rats either intragastrically or intramuscularly before (induced acute gastric ulcer) or after (induced chronic gastric ulcer) the applications of inducing agents, and each animal was sacrificed to observe the protective effects of BPC 157 on gastric ulcers. RESULTS: Both intramuscular (im) and intragastric (ig) administration of BPC 157 could apparently reduce the ulcer area and accelerate the healing of induced ulcer in different models and the effect of im administered BPC 157 was better than that of ig. The rats treated with higher dosages (400 ng/kg, 800 ng/kg) of BPC 157 (im and ig) showed significantly less lesion (P<0.01 vs excipient or saline control), the inhibition ratio of ulcer formation varied between 45.7% and 65.6%, from all measurements except 400 ng/kg BPC 157 in pylorus ligation induced model (P<0.05), in which the inhibition rate was 54.2%. When im administered (800 ng/kg BPC 157) in three modeis, the inhibition ratio of ulcer formation was 65.5%, 65.6% and 59.9%, respectively, which was better than that of famotidine (its inhibition rate was 60.8%, 57.2% and 34.3%, respectively). Continuous application of BPC 157 (in chronic acetate induced gastric ulcer) could accelerate rebuilding of glandular epithelium and formation of granulation tissue (P<0.05 at 200 ng/kg and P<0.01 at 400 ng/kg and 800 ng/kg vs excipient or saline control). CONCLUSION: Both im and ig administered gastric pentadecapeptide BPC 157 can apparently ameliorate acute gastric ulcer in rats and antagonize the protracted effect of acetate challenge on chronic ulcer. The effect of im administration of BPC 157 is better than that of ig, and the effective dos

关键词：胃溃疡十五肽BPC157 动物实验作用机制胃粘膜

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Citrin缺陷致新生儿肝内胆汁淤积症29例临床分析及疗效随访

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中华实用儿科临床杂志 2016年第7期31卷 518-521页

作者：肖长雪李中跃重庆医科大学附属儿童医院消化科儿童发育疾病研究教育部重点实验室儿童发育重大疾病国家国际科技合作基地儿科学重庆市重点实验室400014

目的分析Citrin缺陷致新生儿肝内胆汁淤积症（NICCD）患儿的临床表现、实验室检查特点及预后。方法对2012年7月至2015年2月重庆医科大学附属儿童医院经血串联质谱和／或基因检测诊断的29例NICCD患儿临床表现、实验室检查结果进行回顾... 详细信息

目的分析Citrin缺陷致新生儿肝内胆汁淤积症（NICCD）患儿的临床表现、实验室检查特点及预后。方法对2012年7月至2015年2月重庆医科大学附属儿童医院经血串联质谱和／或基因检测诊断的29例NICCD患儿临床表现、实验室检查结果进行回顾性分析，随访患儿一般情况、喂养方式、肝功能、生长发育、饮食偏好等。结果29例NICCD患儿黄疸出现时间早，伴肝大（20／29例）、脾大（13／29例）、贫血（14／29例）、生长发育落后（9／29例）等主要临床表现。实验室检查提示29例患儿结合胆红素、总胆红素、碱性磷酸酶、1-谷氨酰转肽酶升高，28例天门冬氨酸氨基转移酶明显升高，大部分患儿（20／22例）有凝血功能障碍，伴血氨（20／25例）、乳酸（22／26例）、血脂（9／20例）、甲胎蛋白（14／14例）升高，清蛋白（24／29例）、血糖（17／22例）、铜蓝蛋白（4／4例）降低等异常改变。1例肝脏病理学检查提示肝细胞水肿变性、胆汁色素沉着及汇管区少量纤维组织增生。血串联质谱示甲硫氨酸、酪氨酸、苏氨酸、瓜氨酸、精氨酸及游离肉碱、长链酰基肉碱升高，尿气相-色谱以4-羟基苯乳酸、4-羟基苯丙酮酸升高为主。20例随访患儿中，18例患儿予无乳糖＋高中链甘油三酯奶粉喂养后1岁内症状缓解，肝功能明显好转或恢复正常，1例因肝硬化死亡。3例〉1岁的患儿有喜食高蛋白低碳水化合物的饮食偏好。结论对于黄疸出现早，以肝脾大、贫血、生长发育落后、凝血功能异常、低血糖、低蛋白血症、高氨血症、高脂血症、高乳酸及甲胎蛋白异常升高为特点的患儿，应及时鉴别NICCD，完善血串联质谱、尿气相一色谱及基因检查。

关键词： Citrin蛋白缺陷肝内胆汁淤积临床表现辅助检查预后

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高氧肺损伤幼鼠Ⅱ型肺泡上皮细胞蛋白质组学变化的相关研究

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中华危重病急救医学 2019年第4期31卷 474-479页

作者：鲁雪汪超张超肖长雪梁木林许峰重庆医科大学附属儿童医院PICU 儿童发育疾病研究省部共建教育部重点实验室儿童发育重大疾病国家国际科技合作基地儿科学重庆重点实验室400014

目的通过蛋白质组学研究探讨高氧暴露后幼鼠Ⅱ型肺泡上皮细胞(AECⅡ)的损伤机制。方法将早产SD大鼠原代AECⅡ细胞分为常氧组和高氧组,分别置于常氧(21%O2)和高氧(95%O2)中培养24h,于倒置相差显微镜下观察细胞形态学改变,用蛋白质免疫印... 详细信息

目的通过蛋白质组学研究探讨高氧暴露后幼鼠Ⅱ型肺泡上皮细胞(AECⅡ)的损伤机制。方法将早产SD大鼠原代AECⅡ细胞分为常氧组和高氧组,分别置于常氧(21%O2)和高氧(95%O2)中培养24h,于倒置相差显微镜下观察细胞形态学改变,用蛋白质免疫印迹试验(Western Blot)检测凋亡相关蛋白Bcl-2、天冬氨酸特异性半胱氨酸蛋白酶3(caspase-3)表达水平,以保证高氧模型的成功建立;收集AECⅡ细胞总蛋白,采用串联质谱标签(TMT)标记定量蛋白质组技术检测其蛋白谱,以高氧暴露后差异倍数(FC)>1.5、P<0.05双标准筛选差异蛋白,并对其进行生物信息学分析;依据分析结果,将AECⅡ细胞分为常氧组、高氧组及高氧+MW167组〔细胞置于含95%O2的氧舱前30min加入10μmol/L的γ泌肽酶抑制剂MW167〕,培养24h后,用CCK-8细胞增殖及细胞毒性检测试剂盒检测细胞活性,用实时荧光定量反转录-聚合酶链反应(qRT-PCR)检测Notch通路下游蛋白毛状蛋白(Hes1)和促凋亡蛋白Bax的mRNA表达。结果①光镜下观察,常氧组细胞明显增殖、延展,胞质颗粒物质丰富;高氧组细胞核固缩,胞质内颗粒物质明显减少。与常氧组相比,高氧组细胞caspase-3蛋白表达明显增高,Bcl-2蛋白表达明显降低(caspase-3/GAPDH:1.352±0.086比0.769±0.080,Bcl-2/GAPDH:0.614±0.060比1.361±0.078,均P<0.01)。②蛋白质组学鉴定出差异蛋白162个,其中高氧暴露后上调的差异蛋白主要参与各种刺激的应答,定位于胞外区;高氧暴露后下调的差异蛋白主要与物质合成相关,定位于细胞基质区域。对差异蛋白通路富集分析(KEGGPathway分析)结果表明,细胞色素P450代谢、线粒体氧化磷酸化、Notch信号通路等可能与高氧损伤AECⅡ细胞机制相关。③与常氧组比较,高氧组AECⅡ细胞活性显著下降,Hes1、BaxmRNA表达水平明显升高〔细胞活性(A值):0.060±0.003比1.058±0.017,Hes1mRNA(2^-ΔΔCt):2.235±0.606比1.144±0.107,BaxmRNA(2^-ΔΔCt):2.210±0.240比1.084±0.096,均P<0.05〕。与高氧组比较,高氧+MW167组细胞活性明显升高,Hes1、BaxmRNA表达水平明显下降〔细胞活性(A值):0.271±0.025比0.060±0.003,Hes1mRNA(2^-ΔΔCt):0.489±0.046比2.235±0.606,BaxmRNA(2^-ΔΔCt):1.289±0.041比2.210±0.240,均P<0.05〕。结论高氧肺损伤幼鼠AECⅡ细胞损伤机制可能与细胞色素P450代谢、线粒体氧化磷酸化等途径的改变以及Notch信号通路的激活有关。

关键词：高氧 Ⅱ型肺泡上皮细胞蛋白质组学

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全球货币政策转向对我国跨境资本流动的非对称冲击研究

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吉林金融研究 2023年第9期 19-24,51页

作者：王庆龙肖昌雪中国人民银行吉林省分行吉林长春130051 中国人民银行吉林市分行吉林吉林132000

2022年以来,美国等发达经济体大幅加息以应对历史性通货膨胀,引发了全球范围的加息潮,对全球跨境资本流动产生了深刻影响。本文考察了2008年全球金融危机以来四次全球货币政策大转向的背景及特征,剖析了本轮全球加息潮对我国跨境资本流... 详细信息

2022年以来,美国等发达经济体大幅加息以应对历史性通货膨胀,引发了全球范围的加息潮,对全球跨境资本流动产生了深刻影响。本文考察了2008年全球金融危机以来四次全球货币政策大转向的背景及特征,剖析了本轮全球加息潮对我国跨境资本流动的影响。基于SV-TVP-VAR模型,文章实证分析了全球货币政策转向对我国跨境资本流动的非对称冲击,并提出相关政策建议。

关键词：货币政策转向跨境资本流动 SV-TVP-VAR

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希特林蛋白缺陷的营养治疗及预后

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中华临床医师杂志(电子版) 2015年第9期 1728-1731页

作者：肖长雪李中跃重庆医科大学附属儿童医院消化科

希特林蛋白缺陷是一种常染色体隐性遗传病,由编码希特林蛋白的SLC25A13基因突变所致。最初在日本发现,而后在世界各地被相继发现并报道,现已成为全球范围内疾病。一直以来肝移植被认为是从根本上提高患者生存质量最实际的方法,但以饮食... 详细信息

希特林蛋白缺陷是一种常染色体隐性遗传病,由编码希特林蛋白的SLC25A13基因突变所致。最初在日本发现,而后在世界各地被相继发现并报道,现已成为全球范围内疾病。一直以来肝移植被认为是从根本上提高患者生存质量最实际的方法,但以饮食管理为主的营养治疗相对于肝移植来说会成为更合理、更可以负担得起的选择。故本文综述其以病理生理机制为基础的营养治疗进展及预后。

关键词：希特林蛋白缺陷病理生理营养治疗预后

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Electrochemical conversion of methane to bridge the gap in the artificial carbon cycle

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Journal of Energy Chemistry 2025年第1期100卷 286-308页

作者： Yuhao Peng Yuefeng Song Ihar Razanau Juanxiu xiao Wei xiao Di Hu Guoxiong Wang College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power Sources Wuhan University State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Dalian Institute of Chemical Physics Chinese Academy of Sciences Laboratory of Physical-Chemical Technologies SSPA Scientific and Practical Materials Research Centre of NAS of Belarus State Key Laboratory of Marine Resources Utilization in South China Sea Collaborative Innovation Center of Marine Science and Technology School of Marine Science and Engineering Hainan University Department of Chemical and Environmental Engineering University of Nottingham Ningbo China

Methane, an abundant one-carbon（C1） resource, is extensively used in the industrial production of vital fuels and value-added chemicals. However, current industrial methane conversion technologies are energy-and carbon-intensive, mainly due to the high activation energy required to break the inert C–H bond, low selectivity, and problematic side reactions, including CO2emissions and coke deposition. Electrochemical conversion of methane（ECM） using intermittent renewable energy offers an attractive solution, due to its modular reactor design and operational flexibility across a broad spectrum of temperatures and pressures. This review emphasizes conversion pathways of methane in various reaction systems, highlighting the significance and advantages of ECM in facilitating a sustainable artificial carbon cycle. This work provides a comprehensive overview of conventional methane activation mechanisms and delineates the complete pathways of methane conversion in electrolysis contexts. Based on surface/interface chemistry, this work systematically analyzes proposed reaction pathways and corresponding strategies to enhance ECM efficiency towards various target products, including syngas, hydrocarbons, oxygenates, and advanced carbon materials. The discussion also encompasses opportunities and challenges for the ECM process, including insights into ECM pathways, rational electrocatalyst design, establishment of benchmarking protocols, electrolyte engineering, enhancement of CH4conversion rates, and minimization of CO2emission.

关键词： Methane Electrochemical conversion Reaction mechanism Catalyst design Electrode Electrocatalysis

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Design of a cationic accelerator enabling ultrafast ion diffusion kinetics in aqueous zinc-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 377-384页

作者： Yawei xiao Qianqian Gu Haoyu Li Mengyao Li Yude Wang National Center for International Research on Photoelectric and Energy Materials School of Materials and Energy Yunnan University Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources School of Chemistry and Chemical Engineering Hainan University College of Chemical Engineering Fuzhou University Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon Technologies Yunnan University

Aqueous zinc-ion batteries are highly favored for grid-level energy storage owing to their low cost and high safety,but their practical application is limited by slow ion *** address this,a strategy has been developed to create a cation-accelerating electric field on the surface of the cathode to achieve ultrafast Zn2+diffusion *** employing electrodeposition to coat MoS2on the surface of BaV6O16·3H2O nanowires,the directional built-in electric field generated at the heterointerface acts as a cation accelerator,continuously accelerating Zn2+diffusion into the active *** optimized Zn2+diffusion coefficient in CC@BaV-6O16·3H2O@MoS2(7.5×10～8cm2s-1) surpasses that of most reported V-based ***,MoS2serving as a cathodic armor extends the cycling life of the Zn-CC@BaV6O16·3H2O@MoS2full batteries to over 10000 *** work provides valuable insights into optimizing ion diffusion kinetics for high-performance energy storage devices.

关键词： Internal electric field Cationic accelerator Ion diffusion kinetics Cathode modification strategy Aqueous zinc ion battery

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Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan Liu Jing Zhang Jing Yang Jinghui Chen Xingyue xiao Xiayin Yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant LiCoO2/Li5.4PS4.4Cl1.4I0.2/Li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LiCoO2/Li5.4PS4.4Cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Argyrodite electrolytes Iodine doping Ionic conductivity Stability All-solid-state lithium battery

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Enhanced post-combustion CO2 capture and direct air capture by plasma surface functionalization of graphene adsorbent

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Journal of Energy Chemistry 2025年第1期100卷 653-664页

作者： Rahul Navik Eryu Wang xiao Ding Huang Yunyi Yiyu Liu Jia Li Guangdong-Hong Kong Joint Laboratory for Carbon Neutrality Jiangmen Laboratory of Carbon and Science and Technology Guangzhou HKUST Fok Ying Tung Research Institute The Hong Kong University of Science and Technology (Guangzhou) Carbon Neutrality and Climate Change Thrust Society Hub The Hong Kong University of Science and Technology (Guangzhou) Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University

Graphene has enormous potential to capture CO2due to its unique properties and ***,graphene-based adsorbents have drawbacks of lower CO2adsorption capacity and poor *** work demonstrates a one-step rapid and sustainable N2/H2plasma treatment process to prepare graphene-based sorbent material with enhanced CO2adsorption *** treatment directly enriches amine species,increases surface area,and improves textural *** CO2adsorption capacity increases from 1.6 to 3.3 mmol/g for capturing flue gas,and from 0.14 to 1.3 mmol/g for direct air capture （DAC）.Importantly,the electrothermal property of the plasma-modified aerogels has been significantly improved,resulting in faster heating rates and significantly reducing energy consumption compared to conventional external heating for regeneration of *** aerogels display improved selectivity of 42 and 87 after plasma modification for 5 and 10 min,*** plasma-treated aerogels display minimal loss between 17%and 19% in capacity after 40 adsorption/desorption cycles,rendering excellent *** N2/H2plasma treatment of adsorbent materials would lower energy expenses and prevent negative effects on the global economy caused by climate change.

关键词： Carbon neutrality CO 2 capture Climate change Plasma treatment Graphene aerogel

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Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： xiao Xiang Feng Gao Yu-Gui Peng Peng Wu Zong-Lin Li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

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