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Hepatoprotective effects of xiaoyao San formula on hepatic steatosis and inflammation via regulating the sex hormones metabolism

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World Journal of Hepatology 2024年第7期16卷 1051-1066页

作者： xiao-li mei Shu-Yi Wu Si-Lan Wu xiao-lin Luo Si-Xing Huang Rui liu Zhe Qiang Department of Pharmacology and Toxicology Sichuan-Chongqing Joint Key Laboratory of New Chinese Medicine Creation LaboratoryChongqing Academy of Chinese Materia MedicaChongqing 400061China College of Chinese Medicine Chongqing College of Traditional Chinses MedicineChongqing 402760China Department of Oncology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China College of Pharmacy Chongqing Medical UniversityChongqing 400010China

BACKGROUND The modified xiaoyao San(MXS)formula is an adjuvant drug recommended by the National Health Commission of China for the treatment of liver cancer,which has the effect of preventing postoperative recurrence and metastasis of hepatocellular carcinoma and prolonging patient ***,the molecular mechanisms underlying that remain *** To investigate the role and mechanisms of MXS in ameliorating hepatic injury,steatosis and *** A choline-deficient/high-fat diet-induced rat nonalcoholic steatohepatitis(NASH)model was used to examine the effects of MXS on lipid accumulation in primary *** tissues were collected for western blotting and immunohisto chemistry(IHC)*** accumulation and hepatic fibrosis were detected using oil red staining and Sirius red *** serum samples were collected for biochemical assays and NMR-based metabonomics *** inflammation/lipid metabolism-related signaling and regulators in liver tissues were also detected to reveal the molecular mechanisms of MXS against *** MXS showed a significant decrease in lipid accumulation and inflammatory response in hepatocytes under metabolic *** western blotting and IHC results indicated that MXS activated AMPK pathway but inhibited the expression of key regulators related to lipid accumulation,inflammation and hepatic fibrosis in the pathogenesis of *** metabonomics analysis systemically indicated that the arachidonic acid metabolism and steroid hormone synthesis are the two main target metabolic pathways for MXS to ameliorate liver inflammation and hepatic ***,we found that MXS protected against NASH by attenuating the sex hormone-related metabolism,especially the metabolism of male *** MXS ameliorates inflammation and hepatic steatosis of NASH by inhibiting the metabolism of male *** male hormone related metabolic pathways may be the potential therapeutic app

关键词： Hepatic steatosis Inflammation Sex hormone metabolism Male hormone Phosphatase and tensin homolog deleted on chromosome ten

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Production and test of sPHENIX W/SciFiber electromagnetic calorimeter blocks in China

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Nuclear Science and Techniques 2024年第8期35卷 167-176页

作者： xiao‑Zhou Yu Xi‑Yang Wang Wei‑Hu Ma Shi‑Hong Fu Peng‑Fei Sun Jin‑Xing Song Wan‑Bing He Yang Shen Long Ma Jin‑Hui Chen Huan‑Zhong Huang Si‑Guang Wang Jing Zhou xiao‑mei li Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Physics and Ion‑Beam Application(MOE) Fudan UniversityShanghai 200433China Science and Technology on Nuclear Data Laboratory China Institute of Atomic EnergyBeijing 102413China Department of Physics and Astronomy University of CaliforniaLos AngelesCA 90095USA State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China

The sPHENIX experiment is a new generation of large acceptance detectors at the relativistic heavy ion collider at Brookhaven National Laboratory,with scientific goals focusing on probing the strongly interacting Quark–Gluon plasma with hard probes of jets,open heavy flavor particles,andγ*** EMCal detector,which covers the pseudo-rapidity region of|η|≤1.1,is an essential subsystem of *** this study,we focused on producing and testing EMCal blocks covering a pseudo-rapidity of|η|∈[0.8,1.1].These,in conjunction with the central pseudo-rapidity EMCal blocks,significantly enhance the sPHENIX physics capability of the jet andγparticle *** this paper,the detector module production and testing of sPHENIX W-powder/scintillating fiber(W/ScFi)electromagnetic calorimeter blocks are *** selection of the tungsten powder,mold fabrication,QA procedures,and cosmic ray test results are discussed.

关键词： sPHENIX Tungsten/scintillating fiber electromagnetic calorimeter Cosmic ray test

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Exogenous electric field to accelerate wound healing

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Biomedical Engineering Communications 2024年第3期3卷 1-2页

作者： Kai-Qi Yang Jia Chen xiao-mei li Si-Yuan Chang Yan-Jun Yang Yan-ling Hu College of Material Engineering Fujian Agriculture and Forestry UniversityFuzhou 350108 China.2Medical Science and Technology Innovation Center School of RadiologyShandong First Medical University&Shandong Academy of Medical SciencesTai’an 271016 China.3School of Basic Medicine Medical College of Putian UniversityPutian 351100 China.4College of life and Health Nanjing Polytechnic InstituteNanjing 210048 China.5School of Electrical and Computer Engineering College of EngineeringThe University of GeorgiaAthens 30602USA.

Wound healing is a critical physiological process in living organisms that includes repair cell proliferation and migration,etc.[1,2].While effective wound-healing treatment strategies have been developed in the past,few have actively controlled the behavior of skin cells to accelerate wound healing[3,4].The importance of accelerated wound healing lies in its ability to shorten treatment time,reduce the risk of infection,and lower the cost of *** stimulation can modulate cell behavior during wound healing by simulating endogenous electric fields,boosting cell migration,fibroblast proliferation,and granulation tissue growth more significantly than traditional methods[5-7].However,electrical stimulation devices’size,space limitations,and unsustainability make them challenging to use in clinical surgery,hindering real-time and convenient *** is therefore crucial to explore the miniaturization of electrical stimulation devices to advance the healing of skin wounds in clinical ***,Chen et *** a flexible micro-Zn-MnO2(mZMB)battery-based woundplast for wound management,which shows a promising path in biomedical applications(Figure 1)[8].

关键词： healing wound stimulation

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Using CT imaging to delineate the prostatic apex for radiation treatment planning

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Chinese Journal of Cancer 2010年第11期29卷 914-922页

作者： xiao-mei li Xian-Shu Gao Xue-mei Guo Ya-Gang li xiao-Ying Wang Department of Radiation Oncology Peking University First Hospital Beijing 100034 P. R. China Department of Radiology Peking University First Hospital Beijing 100034 P. R. China

Background and Objective: In computed tomography (CT)-based radiotherapy planning for prostate cancer, it is difficult to precisely delineate the prostatic apex because of its relationship with the urogenital diaphragm and bulbospongiosus musculature. In this retrospective study, we analyzed the magnetic resonance imaging (MRI) and CT scans of the patients with prostate cancer to investigate the relationship between the prostatic apex and the anatomic structure visible on CT, and to provide evidence for localizing the prostatic apex in radiotherapy planning. Methods: MRI and CT scans of 108 patients with prostate cancer were analyzed to measure the distances between the prostatic apex and the bottom of ischial tuberosities, the bottom of obturator foramen, the bottom of pubic symphysis, and the bulb of the penis. The volume of the prostate was measured to analyze its relationship with the localization of the prostatic apex. Results: The prostatic apex was located (13.1 ± 3.3) mm above the bulb of the penis, (11.0 ± 5.4) mm above the bottom of the obturator foramen, (31.3 ± 5.5) mm above the ischial tuberosities, and (7.1 ± 4.7) mm above the bottom of the symphysis pubis. There was no correlation between the size of the prostate and the localization of the prostatic apex. Conclusions: The variance of the distance between the prostatic apex and the bulb of the penis is smaller than that of the distance between the apex and bony anatomy. Delineating the target to 6 mm above the bulb of the penis can cover the prostatic apex in 95% of the patients with prostate cancer, delineating to the bottom of obturator foramen can cover the prostatic apex in 100% of the patients.

关键词：前列腺癌 CT检查放射治疗断层扫描肌肉组织解剖结构磁共振成像扫描测量

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Zhongxian lin： Founder of color psychology in China

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Protein & Cell 2018年第7期9卷 593-595页

作者： Hai-Feng li xiao-mei li Bu-Xin Han Department of Psychology Fujian Normal University Fuzhou 350117 China Key Lab of Mental Health Insitute of Psychology Chinese Academy of Sciences Beijing 100101 China

Professor Zhongxian lin （林仲贤, 1931-2011 ） is the founder and the leader of color psychology in China. He made pioneering researches on the determination of the color vision and the Chinese skin color. He is a member of executive committee of the AFRO-ASIAN Psychological Association （AAPA）, the National Color Standardization Committee, the New York Academy of Sciences, and the American Association for the Advancement of Science （AAAS）（Fig. 1）.

关键词： Color Psychology Chinese Psychological Society (CPS) American Association For The Advancement Of Science (AAAS) Chinese Preschool Children International Biographical Centre

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Gnetupendin C, a New Stilbene Dimer from the lianas of Gnetum Pendulum

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Chinese Chemical Letters 2001年第7期12卷 611-612页

作者： xiao mei li Ying Hong WANG Mao liN Institute of Materia Medica Chinese Academy of Medical SciencesPerking Union Medical CollegeBeijing 100050

Gnetupendin C, a new dimer coupled by a resveratrol and an oxyresveratrol unit, was isolated from the lianas of Gnetum pendulum C.Y. Cheng (Gnetaceae). Its structure was established on the basis of spectroscopic evide... 详细信息

关键词： Gnetupendin C Gnetum pendulum Gnetaceae resveratrol oxyresveratrol dimer

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Controlled-Release Oxycodone Alone or Combined with Gabapentin for Management of Malignant Neuropathic Pain

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Chinese Journal of Cancer Research 2010年第1期22卷 80-86页

作者： xiao-mei li Duan-qi liu Hang-yu Wu Chun Yang li Yang Department of Medical Oncology Department of Anatomy Capital Medical University Beijing 100069 China Departement of Medical Training the Beijing Military General Hospital of PLA Beijing 100700 China

Objective： To evaluate the analgesic efficacy of controlled-release （CR） oxycodone and gabapentin in malignant neuropathic pain （NP）. Methods： Patients with malignant NP were enrolled and baseline pain intensity （PI） was recorded. They initially took one week CR oxycodone and were allocated to two different groups at day 8 by reevaluated PI. Patients with mild pain went to CR oxycodone mono-therapy group （OO group） and took another two weeks CR oxycodone. Others went to （CR oxycodone combined gabapentin group （OG group） and received additional gabapentin. Daily doses and side effects were recorded. Results： Fifty-eight （92.06%） of the 63 enrolled patients completed the initial week＇s therapy. Twenty-two （37.93%） went to OO group and PI significantly reduced at day 15 （2.00 vs. 2.62, P=0.004）, but not improved at day 22 （1.90 vs. 2.00, P=0.54）. Thirty-six （62.07%） patients went to OG group and PI was significantly reduced at day 15 （4,47 vs. 2.94, P〈0.001）, but not improved at day 22 （2.94 vs. 2.75, P=0.136）. Mean daily dose （MDD） of CR oxycodone at day 8 was 62.64 mg. It was significantly increased at days 15 and 22 （71.43 mg vs. 62.64 rag, P=0.021; 81.90 mg vs. 71.43 mg, P=0.004） in OO group. MDD of gabapentin was significantly increased at day 22 compared to day 15 （862.50 mg vs. 993.75 mg, P〈0.001）. Constipation was occurred in 13.64% of the patients in OO group and 14.26 % in OG group. Conclusion： Malignant NP may be well controlled by oxycodone mono-therapy. Early combination with gabapentin is sensible when pain is not satisfactory relieved by oxycodone alone. The side effects of them are manageable.

关键词： CR oxyeodone Gabapentin Malignant neuropathic pain Analgesic efficacy

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Treating aplasia cutis congenita in a newborn with the combination of ionic silver dressing and moist exposed burn ointment: A case report

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World Journal of Clinical Cases 2019年第17期7卷 2611-2616页

作者： Guo-Feng Lei Jun-Ping Zhang xiao-Bing Wang xiao-li You Jin-Ya Gao xiao-mei li mei-ling Chen Xiu-Qin Ning Jiang-li Sun Department of Neonatal Intensive Care Unit Sanmenxia Central HospitalSanmenxia 472000Henan ProvinceChina Department of Intensive Care Unit Sanmenxia Central HospitalSanmenxia 472000Henan ProvinceChina Reproductive endocrine center Sanmenxia Central HospitalSanmenxia 472000Henan ProvinceChina

BACKGROUND Aplasia cutis congenita (ACC) in newborns is a condition in which congenital defects or hypoplasia is present in part of the epidermis,dermis and even subcutaneous tissue (including muscle and bones).First reported by Cordon in 1767,ACC is a rare disease with a low incidence of 1/100000 to 3/***,there are 500 cases reported *** can be accompanied by other *** onset mechanism of the disease remains unknown but is thought to be correlated to factors such as genetics,narrow uterus,foetal skin and amniotic membrane adhesion,use of teratogenic drugs in early pregnancy and viral *** SUMMARY In August 2018,we treated a newborn with ACC on the left lower limbs using a combination of ionic silver dressing and moist exposed burn ointment (MEBO) and achieved a satisfactory treatment *** skin defects were observed on the external genitals and on areas from the left foot to 3/4 of the upper left *** tissue and blood vessels were observed in the regions with skin *** following treatments were ***,the wound was rinsed with 0.9% sodium chloride solution followed by disinfection with povidone-iodine *** then MEBO was applied to the wound at a thickness of approximately 1 *** applying ionic silver dressing,the wound was covered with sterile *** wound dressing was replaced every 2-3 *** the 4-mo follow-up,the treatment outcome was *** was minimal scar tissue formation,and limb function was not *** The combination of ionic silver dressing and MEBO to ACC is helpful.

关键词： Aplasia cutis congenita Newborns Ionic silver dressing Moist exposed burn ointment

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Investigation of Catecholaminergic Polymorphic Ventricular Tachycardia Children in China:Clinical Characteristics,Delay to Diagnosis,and Misdiagnosis

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Chinese Medical Journal 2018年第23期131卷 2864-2865页

作者： He Jiang xiao-mei li Hai-Yan Ge Yi Zhang Hai-Ju liu mei-Ting li Department of Pediatric Cardiology Heart CenterThe First Hospital of Tsinghua University (Beijing Huaxin Hospital)Beijing 100016China

To the Editor:Catecholaminergic polymorphic ventricular tachycardia (CPVT)often occurs in children or adolescents without organic heart *** is a rare malignant arrhythmic disorder with hereditary features characterized by exercise-or emotional stress-induced ventricular arrhythmias,especially bidirectional/ polymorphic ventricular tachycardia (VT),syncope,or sudden death.[1]

关键词： DEATH

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CsPbBrI perovskites with low energy loss for high-performance indoor and outdoor photovoltaics

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Science Bulletin 2021年第4期66卷 347-353,M0004页

作者： Kai-li Wang xiao-mei li Yan-Hui Lou Meng li Zhao-Kui Wang Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China College of Physics Soochow Institute for Energy and Materials InnovationsSoochow UniversitySuzhou 215006China

Over the years,the efficiency of inorganic perovskite solar cells(PSCs)has increased at an unprecedented ***,energy loss in the device has limited a further increase in efficiency and *** this work,we used(NH4)2C2O4·H2O to treat CsPbBrI2 perovskite film during *** CsPbBrI2 underwent secondary crystallization to form high quality films with micrometer-scale and low trap density.(NH4)2C2O4·H2O treatment promoted charge transfer capacity and reduced the ideal *** also dropped the energy loss from 0.80 to 0.64 *** resulting device delivered a power conversion efficiency(PCE)of 16.55%with an open-circuit voltage(Voc)of 1.24 V,which are largely improved compared with the reference device which exhibited a PCE of 13.27%and a Voc of 1.10 *** addition,the optimized treated device presented a record indoor PCE of 28.48%under a fluorescent lamp of 1000 lux,better than that of the reference device(19.05%).

关键词： Perovskite solar cells Energy loss Indoor light Carrier dynamics Grain size

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