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Predictive Ability of Hypertriglyceridemic Waist,Hypertriglyceridemic Waist-to-Height Ratio,and Waist-to-Hip Ratio for Cardiometabolic Risk Factors Clustering Screening among Chinese Children and Adolescents

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Biomedical and Environmental Sciences 2024年第3期37卷 233-241页

作者： xiao tian li YUAN Shu Qian GAO Jing Yu Julien SBaker YANG Yi De WANG Xi Jie ZHENG Chan Juan DONG Yan Hui ZOU Zhi Yong Key Laboratory of Molecular Epidemiology of Hunan Province School of MedicineHunan Normal UniversityChangsha 410081HunanChina The Institute of Interdisciplinary Studies Hunan Normal UniversityChangsha 410013HunanChina Chenzhou First People's Hospital Chenzhou 423000HunanChina Centre for Health and Exercise Science Research Hong Kong Baptist UniversityKowloon TongHong Kong 999077China Department of Sport Physical Education and HealthHong Kong Baptist UniversityKowloon TongHong Kong 999077China Vanke School of Public Health Tsinghua UniversityBeijing 100084China Institute of Child and Adolescent Health School of Public HealthPeking University Health Science CenterBeijing 100191China

Objective Hypertriglyceridemic waist(HW),hypertriglyceridemic waist-to-height ratio(HWHtR),and waist-to-hip ratio(WHR)have been shown to be indicators of cardiometabolic risk ***,it is not clear which indicator is more suitable for children and *** aimed to investigate the relationship between HW,HWHtR,WHR,and cardiovascular risk factors clustering to determine the best screening tools for cardiometabolic risk in children and *** This was a national cross-sectional *** and biochemical variables were assessed in approximately 70,000 participants aged 6–18 years from seven provinces in ***,physical activity,dietary intake,and family history of chronic diseases were obtained through ***,χ2 and logistic regression analysis was *** A significant sex difference was observed for HWHtR and WHR,but not for HW *** risk of cardiometabolic health risk factor clustering with HW phenotype or the HWHtR phenotype was significantly higher than that with the non-HW or non-HWHtR phenotypes among children and adolescents(HW:OR=12.22,95%CI:9.54-15.67;HWHtR:OR=9.70,95%CI:6.93-13.58).Compared with the HW and HWHtR phenotypes,the association between risk of cardiometabolic health risk factors(CHRF)clustering and high WHR was much weaker and not significant(WHR:OR=1.14,95%CI:0.97-1.34).Conclusion Compared with HWHtR and WHR,the HW phenotype is a more convenient indicator with higher applicability to screen children and adolescents for cardiovascular risk factors.

关键词： Hypertriglyceridemic waist Waist-to-hip ratio Children and adolescents China Hypertriglyceridemic waist-to-height ratio Cardiovascular risk factors

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耕地系统健康的时空演变及其驱动因素研究——以长江中下游地区为例

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自然资源学报 2024年第5期39卷 1174-1192页

作者：周小平梁颖李小天柴铎北京师范大学政府管理学院北京100875 中央财经大学政府管理学院北京100081

耕地系统健康与“三位一体”的耕地保护目标密切相关,对于保障社会经济的可持续发展具有重要意义。以粮食主产区长江中下游地区为例,基于系统论和生态系统健康理论构建了耕地系统健康评估模型,综合运用Sen-MK趋势分析、景观格局指数、... 详细信息

耕地系统健康与“三位一体”的耕地保护目标密切相关,对于保障社会经济的可持续发展具有重要意义。以粮食主产区长江中下游地区为例,基于系统论和生态系统健康理论构建了耕地系统健康评估模型,综合运用Sen-MK趋势分析、景观格局指数、多尺度地理加权回归、GIS空间分析等方法量化了2000—2020年长江中下游地区耕地系统健康的时空演变,并揭示了自然和社会经济等多要素对耕地系统健康的影响。研究结果表明:(1)从时间维度看,2000—2020年间长江中下游地区的耕地系统健康总体上呈现轻微下降趋势,这与耕地系统的组织结构稳定性和韧性变差有关;从空间维度看,安徽北部、江苏北部和东部沿海区域的耕地系统健康状况持续向好,长江三角洲、湖南和江西南部耕地呈现出由差转好的态势,但江汉平原呈现出明显的恶化趋势。(2)自然环境变化和人类活动对耕地系统健康的影响具有显著的空间异质性。其中,地表温度、日照时数、相对湿度、降水变化对整个区域的耕地系统健康变化起负向作用,年均GDP变化和耕地空间密度变化对耕地系统健康表现出正向影响。本文所构建的耕地系统健康评估模型可为构建“三位一体”耕地保护绩效评估提供参考,对于完善耕地系统评估的理论研究和推动区域耕地健康管理具有重要意义。

关键词：耕地系统健康耕地保护多尺度地理加权回归长江中下游地区

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基于广义改进分解策略的多目标代理优化方法

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控制与决策 2024年第6期39卷 1829-1839页

作者：林成龙马义中肖甜丽南京理工大学经济管理学院南京210094

为解决多目标代理优化方法中代理模型选择单一问题,提出基于广义改进函数分解策略的多目标代理优化方法.该方法充分利用模型预测信息构建广义改进多目标分解准则和广义改进R2指标准则,有效拓展多目标代理优化中代理模型的选择空间.所提... 详细信息

为解决多目标代理优化方法中代理模型选择单一问题,提出基于广义改进函数分解策略的多目标代理优化方法.该方法充分利用模型预测信息构建广义改进多目标分解准则和广义改进R2指标准则,有效拓展多目标代理优化中代理模型的选择空间.所提两种准则通过随机均匀权重实现全局探索和局部搜索能力的自适应平衡.研究结果表明,所提方法在有限仿真条件下拥有良好的寻优性能,获得Pareto前沿在收敛性、多样性及空间分布性方面均具有一定优势.相比同类方法,该方法具有优势:(1)不需要模型预测不确定性信息,适用于基于不同种类代理模型的代理优化方法;(2)实现简单且计算复杂度低,能够有效提升昂贵黑箱问题优化效率.

关键词：昂贵多目标优化代理模型多目标代理优化方法广义改进多目标分解准则广义改进R2指标准则

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人工智能及机器学习深度算法在产科母胎疾病中的应用

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中国实用妇科与产科杂志 2024年第8期40卷 804-809页

作者：温慧莹李笑天深圳市妇幼保健院深圳市孕产疾病与母婴健康重点实验室广东深圳518000

人工智能(artificial intelligence,AI)是机器对人的思维方式的模拟,其强大的算法、算力和大数据是AI发展的三大支撑力。近年,AI在产科母胎疾病研究领域快速发展,有效提升了各种医学任务的性能,为提高医疗技术水平与医疗服务效率、保障... 详细信息

人工智能(artificial intelligence,AI)是机器对人的思维方式的模拟,其强大的算法、算力和大数据是AI发展的三大支撑力。近年,AI在产科母胎疾病研究领域快速发展,有效提升了各种医学任务的性能,为提高医疗技术水平与医疗服务效率、保障母儿安全提供了强大抓手。文章简要介绍了现有AI研究的数据偏倚问题,并探讨通用AI在产科母胎疾病的发展趋势,旨在促进AI+产科母胎医学领域的科技创新高质量发展。

关键词：人工智能母胎疾病疾病预测

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Endothelial Cell Senescence and Age-Related Vascular Diseases

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Journal of Genetics and Genomics 2014年第9期41卷 485-495页

作者： xiao-li tian Yang li Department of Human Population Genetics and Beijing Key Laboratory of Cardiometabolic Molecular Medicine Institute of Molecular Medicine(IMM)Peking University

Advanced age is an independent risk factor for ageing-related complex diseases, such as coronary artery disease, stroke, and hypertension, which are common but life threatening and related to the ageing-associated vascular dysfunction. On the other hand, patients with progeria syndromes suffer from serious atherosclerosis, suggesting that the impaired vascular functions may be critical to organismal ageing, or vice versa. However, it remains largely unknown how vascular cells, particularly endothelial cell, become senescent and how the senescence impairs the vascular functions and contributes to the age-related vascular diseases over time. Here, we review the recent progress on the characteristics of vascular ageing and endothelial cell senescence in vitro and in vivo, evaluate how genetic and envi- ronmental factors as well as autophagy and stem cell influence endothelial cell senescence and how the senescence contributes to the age- related vascular phenotypes, such as atherosclerosis and increased vascular stiffness, and explore the possibility whether we can delay the age-related vascular diseases through the control of vascular ageing.

关键词： Endothelial cell senescence Genetic Vascular ageing Age-related diseases Stem cell

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On Mbius Form and Mbius Isoparametric Hypersurfaces

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Acta Mathematica Sinica,English Series 2009年第12期25卷 2077-2092页

作者： Ze Jun HU xiao li tian Department of Mathematics Zhengzhou University Zhengzhou 450052 P. R. China Department of Humanities and Social Sciences He 'nan Vocational and Technical College of Communications Zhengzhou 450007 P. R. China

An umbilic-free hypersurface in the unit sphere is called MSbius isoparametric if it satisfies two conditions, namely, it has vanishing MSbius form and has constant MSbius principal curvatures. In this paper, under the condition of having constant MSbius principal curvatures, we show that the hypersurface is of vanishing MSbius form if and only if its MSbius form is parallel with respect to the Levi-Civita connection of its MSbius metric. Moreover, typical examples are constructed to show that the condition of having constant MSbius principal curvatures and that of having vanishing MSbius form are independent of each other.

关键词： Mobius isoparametric hypersurface Mobius second fundamental form Mobius metric MSbius form paxallel Mobius form

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FHA domain of AGGF1 is essential for its nucleocytoplasmic transport and angiogenesis

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Science China(life Sciences) 2021年第11期64卷 1884-1894页

作者： Cui-Fang Zhang Han-Ming Wang Andong Wu Yang li xiao-li tian Department of Human Population Genetics Institute of Molecular MedicinePeking UniversityBeijing 100871China Aging and Vascular Diseases Human Aging Research Institute and School of Life ScienceNanchang Universityand Jiangxi Key Laboratory of Human AgingNanchang 330031China

Angiogenic factor with G-patch and FHA domains 1(AGGF1) exhibits a dynamic distribution from the nucleus to the cytoplasm in endothelial cells during angiogenesis, but the biological significance and underlying mechanism of this nucleocytoplasmic transport remains unknown. Here, we demonstrate that the dynamic distribution is essential for AGGF1 to execute its angiogenic function. To search the structural bases for this nucleocytoplasmic transport, we characterized three potential nuclear localization regions, one potential nuclear export region, forkhead-associated(FHA), and G-patch domains to determine their effects on nucleocytoplasmic transport and angiogenesis, and we show that AGGF1 remains intact during the dynamic subcellular distribution and the region from 260 to 288 amino acids acts as a signal for its nuclear localization. The distribution of AGGF1 in cytoplasm needs both FHA domain and 14-3-3α/β. Binding of AGGF1 via FHA domain to 14-3-3α/β is required to complete the transport. Thus, we for the first time established structural bases for the nucleocytoplasmic transport of AGGF1 and revealed that the FHA domain of AGGF1 is essential for its nucleocytoplasmic transport and angiogenesis.

关键词： AGGF1 nucleocytoplasmic transport angiogenesis FHA domain 14-3-3α/β

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Preparation and Photocatalysis of Mesoporous TiO_2 Nanofibers via an Electrospinning Technique

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Chemical Research in Chinese Universities 2012年第4期28卷 727-731页

作者： WANG Wei YUAN Qing CHI Yue SHAO Chang-lu li Nan li xiao-tian Key Laboratory of Automobile Materials Ministry of EducationSchool of Material Science and EngineeringJilin UniversityChangchun 130012P.R.China School of Chemical and Material Engineering Jilin Institute of Chemical TechnologyJilin 132022P.R.China Center for Advanced Optoelectronic Functional Materials Research Key Laboratory ofUV Light-Emitting Materials and TechnologyMinistry of EducationNortheast Normal UniversityChangehun 130024P.R.China

Mesoporous TiO2 nanofibers have been synthesized by a new method that combines sol-gel chemistry and electrospinning *** obtained mesoporous TiO2 nanofibers were characterized with scanning electron microscopy（SEM）,X-ray diffraction（XRD）,transmission electron microscopy（TEM） and nitrogen adsorptiondesorption *** photocatalytic performance was evaluated by the photocatalytic degradation of Rhodamine B under UV light *** results show that mesoporous TiO2 nanofibers exhibit higher photocatalytic activity compared with nonporous TiO2 nanofibers.

关键词： Electrospinning Mesoporous TiO Photocatalyst

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Research,application and development of inorganic binder for casting process

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China Foundry 2024年第5期21卷 461-475页

作者： xiao-long Gong Sheng-li Hu Zi-tian Fan State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China

Inorganic binder used in casting process has the advantages of low odor,labor-friendly conditions,and relatively low cost,which is one of the main development directions for casting molding materials in the ***,compared to organic binders(such as resin binders),inorganic binders exhibit lower bonding strength and are more sensitive to environmental *** sensitivity poses challenges,particularly in the reclamation of used sand,thus limiting their broader *** this paper,the research and application status of inorganic binders(mainly silicate inorganic binders)and their curing methods are *** addition,the research and application of phosphate inorganic binders and 3D printing inorganic binders that are being developed are ***,a detailed comparative analysis is conducted on the challenging issue of“reclamation for used sand”in the application of inorganic ***,the development direction of inorganic binders is clarified.

关键词： inorganic binder silicate system phosphate system 3D printing used sand reclamation development trend

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肾动脉粥样硬化斑块特征与血流动力学的关系及其对肾功能的影响

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中国临床医学影像杂志 2024年第3期35卷 186-191页

作者：李笑天王慧颖赵玉娇赵雨蒙秦佳明张程陈丽华夏爽沈文南开大学医学院天津300071 天津市第一中心医院放射科、南开大学医学院天津市影像医学研究所天津300192 天津医科大学一中心临床学院天津300192

目的:探讨血流动力学指标和肾动脉粥样硬化斑块特征之间的关系,及其在预测肾功能受损方面的效能。方法:回顾性分析2021年11月—2023年5月单侧肾动脉中重度狭窄患者的肾动脉CTA图像,评估肾动脉斑块特征(狭窄程度、斑块最大厚度、斑块面... 详细信息

目的:探讨血流动力学指标和肾动脉粥样硬化斑块特征之间的关系,及其在预测肾功能受损方面的效能。方法:回顾性分析2021年11月—2023年5月单侧肾动脉中重度狭窄患者的肾动脉CTA图像,评估肾动脉斑块特征(狭窄程度、斑块最大厚度、斑块面积、斑块体积、斑块负荷、动脉重塑和钙化)及肾皮质厚度差值(Cortical thickness difference,CTD)。使用有限元软件评估血流动力学参数时间平均壁剪切力(Time-averaged wall shear stress,TAWSS)及跨病变壁剪切力比(Wall shear stress ratio,WSSR)。测量并比较不同WSSR组间斑块特征的差异,并分析其与斑块特征的相关性。采用Logistic回归分析评价影响肾皮质厚度的独立危险因素。结果:最终纳入104例患者。狭窄处TAWSS高于狭窄前TAWSS和狭窄后TAWSS(P均<0.001),狭窄前TAWSS高于狭窄后TAWSS(P<0.001)。高WSSR组的狭窄程度、斑块负荷、非钙化斑块比例均高于低WSSR组(P=0.019、P=0.008、P=0.011)。WSSR与狭窄程度(r=0.028,P=0.020)和斑块负荷(r=0.028,P=0.020)呈正相关。斑块负荷(OR=1.764;95%CI 1.008~8.087;P=0.047)和高WSSR(OR=3.047;95%CI 1.123~8.262;P=0.029)是与高CTD独立相关的影像学因素。二者联合预测高CTD的AUC为0.72。结论:WSSR和斑块特征可能是肾动脉狭窄后反映肾功能指标的重要参数,斑块负荷和高WSSR可以预测肾功能的受损程度。

关键词：斑块动脉粥样硬化肾动脉计算机体层摄影血管造影术

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