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Inhibition of Bcl-6 Expression Ameliorates Asthmatic Characteristics in Mice

Current Medical Science 2024年第1期44卷 110-120页

作者： Chang-zhi ZHOU Xiong XIONG Wei-jun TAN Ya-fei WANG Zhen YANG Xue-ying LI Xiu-wen YANG xiao-fan liu Sun-feng YU Liang-chao WANG Shuang GENG Department of Respiratory and Critical Care Medicine The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China Department of General Surgery Wuhan Wuchang HospitalWuhan University of Science and TechnologyWuhan 430063China

Objective The function of Bcl-6 in T follicular helper(Tfh)cell maturation is indispensable,and Tfh cells play a pivotal role in *** study investigated the impact of Bcl-6 on asthmatic *** The microscopic pathological alterations,airway resistance(AR),and lung compliance(LC)were determined in asthmatic mice and Bcl-6 interference *** surface molecular markers of Tfh cells and the Bcl-6 mRNA and protein expression were determined by flow cytometry,RT-qPCR,and Western blotting,*** relationships between the Tfh cell ratio and the IgE and IgG1 concentrations in peripheral blood mononuclear cells(PBMCs)and bronchoalveolar lavage fluid(BALF)were *** Asthmatic inflammatory changes were observed in the lung tissue and were attenuated by Bcl-6 siRNA and dexamethasone(DXM).Asthmatic mice exhibited an increased AR and a decreased LC,while Bcl-6 siRNA or DXM mitigated these *** percentages of Tfh cells and eosinophils were significantly increased in the asthmatic mice,and they significantly decreased after Bcl-6 inhibition or DXM ***-qPCR and Western blotting analyses revealed that the Bcl-6 expression level in PBMCs was significantly higher in asthmatic mice,and it decreased following Bcl-6 inhibition or DXM *** IgE expression in the serum and BALF and the B cell expression in PBMCs exhibited a similar *** asthmatic mice,the ratio of Tfh cells in the peripheral blood showed a strong positive correlation with the IgE levels in the serum and BALF,but not with the IgG1 *** The amelioration of airway inflammation and airway hyper-responsiveness is achieved through Bcl-6 suppression,which effectively hinders Tfh cell differentiation,ultimately resulting in a concurrent reduction in IgE production.

关键词： Bcl-6 Tfh asthma airway hyper-responsiveness mouse model

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The New Methods for Characterization of Molecular Weight of Supramolecular Polymers

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Chinese Journal of Polymer Science 2024年第10期42卷 1403-1413,I0006页

作者： Hui liu Rui Hu Zi-Qing Hu xiao-fan Ji Key Laboratory of Materials Chemistry for Energy Conversion and Storage Ministry of EducationHubei Key Laboratory of Materials Chemistry and Service FailureHubei Engineering Research Center for Biomaterials and Medical Protective MaterialsSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan430074China

Supramolecular polymers,as a type of dynamic polymers,are subordinate to the interdisciplinary field of polymer chemistry and supramolecular chemistry,whose development has greatly promoted the prosperity of new ***,molecular weight is one of the most important parameters of supramolecular polymers,which affects the physical/chemical properties and processing applications of *** new methods for characterizing the molecular weight of supramolecular polymers is crucial for advancing the development of supramolecular *** this review,we elaborate and summarize three strategies for characterizing the molecular weight of supramolecular polymers that recently reported by our research group according to the characteristics of supramolecular polymers,including(1)the molecular weight distinction corresponding to variable fluorescence colors,(2)matching different molecular weights with different fluorescence lifetime,(3)transforming supramolecular polymers into mechanically interlocked polymers or covalent ***,we also discuss the limitations of current methods for characterizing supramolecular *** hope that this review can promote the development of supramolecular polymers and significantly inspire to exploit new methods to characterizing molecular weight of supramolecular polymers.

关键词： Supramolecular polymers Molecular weight Self-assembly Mechanically interlocked polymers Dynamic polymers

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Assessing the spread risk of COVID-19 associated with multi-mode transportation networks in China

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Fundamental Research 2023年第2期3卷 305-310页

作者： xiao-Ke Xu xiao fan liu Lin Wang Ye Wu Xin Lu Xianwen Wang Sen Pei College of Information and Communication Engineering Dalian Minzu UniversityDalian 116600China Web Mining Laboratory Department of Media and CommunicationCity University of Hong KongHong Kong SARChina Department of Genetics University of CambridgeCambridge CB23EHUK School of Information Engineering Putian UniversityPutian 351100China School of Journalism and Communication Beijing Normal UniversityBeijing 100875China College of Systems Engineering National University of Defense TechnologyChangshaChina Department of Global Public Health Karolinska InstituteStockholmSweden WISE Lab Faculty of Humanities and Social SciencesDalian University of TechnologyDalian 116085China Department of Environmental Health Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032USA

The spatial spread of COVID-19 during early 2020 in China was primarily driven by outbound travelers leaving the epicenter,Wuhan,Hubei *** studies focus on the influence of aggregated out-bound population flows originating from Wuhan;however,the impacts of different modes of transportation and the network structure of transportation systems on the early spread of COVID-19 in China are not well ***,we assess the roles of the road,railway,and air transportation networks in driving the spatial spread of COVID-19 in *** find that the short-range spread within Hubei province was dominated by ground traffic,notably,the railway *** contrast,long-range spread to cities in other provinces was mediated by multiple factors,including a higher risk of case importation associated with air transportation and a larger outbreak size in hub cities located at the center of transportation *** further show that,although the dissemination of SARS-CoV-2 across countries and continents is determined by the worldwide air transportation network,the early geographic dispersal of COVID-19 within China is better predicted by the railway *** the recent emergence of multiple more transmissible variants of SARS-CoV-2,our findings can support a better assessment of the spread risk of those variants and improve future pandemic preparedness and responses.

关键词： Complex network Human mobility COVID-19 Spatial spread Transportation networks

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Minimally invasive open reduction of greater tuberosity fractures by a modified suture bridge procedure

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World Journal of Clinical Cases 2022年第1期10卷 117-127页

作者： Ling-Peng Kong Juan-Juan Yang Fu Wang fan-xiao liu Yong-Liang Yang Department of Orthopaedics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Radiotherapy Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinan 250117Shandong ProvinceChina

BACKGROUND Most greater tuberosity fractures can be treated without surgery but some have a poor *** surgical procedures for avulsion fractures of the humeral greater tuberosity include screw fixation,suture anchor fixation,and plate fixation,all of which have treatment-associated *** decrease surgical complications,we used a modified suture bridge procedure under direct vision and a minimally invasive small incision to fix fractures of the greater tuberosity of the *** To investigate the clinical efficacy and outcomes of minimally invasive modified suture bridge open reduction of greater tuberosity evulsion *** Sixteen patients diagnosed between January 2016 and January 2019 with an avulsion-type greater tuberosity fracture of the proximal humerus and treated by minimally invasive open reduction and modified suture bridges with anchors were studied *** were followed up by clinical examination and radiographs at 3 and 6 wk,3,6 and 12 mo after surgery,and thereafter every 6 *** were assessed preoperatively and postoperatively by a visual analog scale(VAS),the University of California Los Angeles(UCLA)shoulder score,the American Shoulder and Elbow Surgeon score(ASES),and range of motion(ROM)for *** Seven men and nine women,with an average age of 44.94 years,were *** time between injury and surgery was 1-2 d,with an average of 1.75 *** mean operation time was 103.1±7.23 *** patients achieved bone union within 3 mo after *** scores were significantly decreased(P=0.002),and the mean degrees of forward elevation(P=0.047),mean degrees of abduction(P=0.035),ASES score(P=0.092)were increased at 3 *** UCLA score was increased at 6 wk(P=0.029)after *** average degrees of external rotation and internal rotation both improved at 3 mo after surgery(P=0.012 and P=0.007,respectively).No procedure-related deaths or incision-related superficial or deep tissue infectio

关键词： Minimally invasive Greater tuberosity fracture Open reduction Suture bridge Anchor

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Salvage of vascular graft infections via vacuum sealing drainage and rectus femoris muscle flap transposition: A case report

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World Journal of Clinical Cases 2021年第10期9卷 2296-2301页

作者： Peng Zhang Fu-Lin Tao Qing-Hu Li Dong-Sheng Zhou fan-xiao liu Department of Orthopaedics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina

BACKGROUND The management of vascular graft infections continues to be a significant challenge in a clinical *** aim of this report is to illustrate the novel vacuum sealing drainage(VSD)technique and rectus femoris muscle flap transposition for vascular graft infections,and to evaluate the prospective of future testing of this surgical *** SUMMARY We report the case of a 32-year-old male patient,who presented a severe infected groin wound with biological vascular graft Acinetobacter baumannii infection resulting in extensive graft *** the VSD and muscle flap transposition,the groin wound and vascular graft infection were finally treated *** Our case report highlights that VSD technique and rectus femoris muscle flap transposition could be considered in patients presenting with a severe infected groin wound with biological vascular graft Acinetobacter baumannii infection resulting in extensive graft exposure,especially in consideration of treatable conditions.

关键词： Vascular graft Infection Muscle flap transposition Rectus femoris muscle flap Vacuum sealing drainage Case report Trauma

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Resolution Enhancement of SOHO/MDI Magnetograms

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Research in Astronomy and Astrophysics 2024年第6期24卷 358-367页

作者： Ying Qin Kai-fan Ji Hui liu xiao-Guang Yu Yunnan Observatories Chinese Academy of SciencesKunming 650011China University of Chinese Academy of Sciences Beijing 100049China Yunnan Key Laboratory of Solar Physics and Space Science Kunming 650216China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China

Research on the solar magnetic field and its effects on solar dynamo mechanisms and space weather events has benefited from the continual improvements in instrument resolution and measurement *** augmentation and assimilation of historical observational data timelines also play a significant role in understanding the patterns of solar magnetic field *** the realm of astronomical data processing,super-resolution(SR)reconstruction refers to the process of using a substantial corpus of training data to learn the nonlinear mapping between low-resolution(LR)and high-resolution(HR)images,thereby achieving higherresolution astronomical *** paper is an application study in high-dimensional nonlinear *** learning models were employed to perform SR modeling on SOHO/MDI magnetograms and SDO/HMI magnetograms,thus reliably achieving resolution enhancement of full-disk SOHO/MDI magnetograms and enhancing the image resolution to obtain more detailed *** this study,a data set comprising 9717pairs of data from 2010 April to 2011 February was used as the training set,1332 pairs from 2011 March were used as the validation set and 1034 pairs from 2011 April were used as the test *** data preprocessing,we randomly cropped 128×128 sub-images as the LR cases from the full-disk MDI magnetograms,and the corresponding 512×512 sub-images as HR ones from the HMI full-disk magnetograms for model *** tests conducted have shown that the study successfully produced reliable 4×SR reconstruction of full-disk MDI *** MESR model's results(0.911)were highly correlated with the target HMI magnetographs as indicated by the correlation coefficient ***,the method achieved the best PSNR,SSIM,MAE and RMSE values,indicating that the MESR model can effectively reconstruct magnetograms.

关键词： magnetic fields techniques:image processing virtual observatory tools Sun:magnetic fields

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Optimization of Generator Based on Gaussian Process Regression Model with Conditional Likelihood Lower Bound Search

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CES Transactions on Electrical Machines and Systems 2024年第1期8卷 32-42页

作者： xiao liu Pingting Lin fan Bu Shaoling Zhuang Shoudao Huang CES&IEEE the College of Electrical and Information Engineering Hunan UniversityChangsha 410082China CES

The noise that comes from finite element simulation often causes the model to fall into the local optimal solution and over fitting during optimization of ***,this paper proposes a Gaussian Process Regression(GPR)model based on Conditional Likelihood Lower Bound Search(CLLBS)to optimize the design of the generator,which can filter the noise in the data and search for global optimization by combining the Conditional Likelihood Lower Bound Search *** the efficiency optimization of 15 kW Permanent Magnet Synchronous Motor as an ***,this method uses the elementary effect analysis to choose the sensitive variables,combining the evolutionary algorithm to design the super Latin cube sampling plan;Then the generator-converter system is simulated by establishing a co-simulation platform to obtain data.A Gaussian process regression model combing the method of the conditional likelihood lower bound search is established,which combined the chi-square test to optimize the accuracy of the model ***,after the model reaches the accuracy,the Pareto frontier is obtained through the NSGA-II algorithm by considering the maximum output torque as a ***,the constrained optimization is transformed into an unconstrained optimizing problem by introducing maximum constrained improvement expectation(CEI)optimization method based on the re-interpolation model,which cross-validated the optimization results of the Gaussian process regression *** above method increase the efficiency of generator by 0.76%and 0.5%respectively;And this method can be used for rapid modeling and multi-objective optimization of generator systems.

关键词： Generator optimization Gaussian Process Regression(GPR) Conditional Likelihood Lower Bound Search(CLLBS) Constraint improvement expectation(CEI) Finite element calculation

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Fast spreading of surface ozone in both temporal and spatial scale in Pearl River Delta

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Journal of Environmental Sciences 2024年第3期137卷 540-552页

作者： Tianhui Cao Haichao Wang Lei Li xiao Lu Yiming liu Shaojia fan School of Atmospheric Sciences Sun Yat-sen University and Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Guangdong Provincial Observation and Research Station for Climate Environment and Air Quality Change in the Pearl River Estuary Key Laboratory of Tropical Atmosphere-Ocean SystemMinistry of EducationZhuhai 519082China

Surface ozone(O_(3))is a major air pollutant and draw increasing attention in the Pearl River Delta(PRD),***,we characterize the spatial-temporal variability of ozone based on a dataset obtained from 57 national monitoring sites during *** results show that:(1)the seasonal difference of ozone distribution in the inland and coastal areas was significant,which was largely affected by the wind pattern reversals related to the East Asian monsoon,and local ozone production and destruction;(2)the daily maximum 8hr average(MDA8 O_(3))showed an overall upward trend by 1.11 ppbv/*** the trends in the nine cities varied differently by ranging from-0.12 to 2.51 ppbv/*** hot spots of ozone were spreading to southwestern areas from the central areas since *** ozone is becoming a year-round air pollution problem with the pollution season extending to winter and spring in PRD region.(3)at the central and southwestern PRD cities,the percentage of exceedance days from the continuous type(defined as≥3 days)was ***,the ozone concentration of continuous type was much higher than that of scattered exceedance type(<3 days).In addition,although the occurrence of continuous type starts to decline since2017,the total number of exceedance days during the continuous type is *** results indicate that it is more difficult to eliminate the continuous exceedance than the scatter pollution days and highlight the great challenge in mitigation of O_(3)pollution in these cities.

关键词： Surface ozone pollution Ozone trend Spatial and temporal variability Pearl River Delta Pollution mitigation

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The historical to future linkage of Arctic amplification on extreme precipitation over the Northern Hemisphere using CMIP5 and CMIP6 models

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Advances in Climate Change Research 2024年第4期15卷 573-583页

作者： Jun liu xiao-fan WANG Dong-You WU Xin WANG Key Laboratory for Semi-Arid Climate Change of the Ministry of Education College of Atmospheric SciencesLanzhou UniversityLanzhou 730000China

Arctic warming played a dominant role in recent occurrences of extreme events over the Northern Hemisphere,but climate models cannot accurately simulate the *** a significant positive correlation(0.33-0.95)between extreme precipitation and Arctic amplification(AA)is found using observations and CMIP5/6 multi-model ***,CMIP6 models are superior to CMIP5 models in simulating the temporal evolution of extreme precipitation and *** to 14 optimal CMIP6 models,the maximum latitude of planetary waves and the strength of Northern Hemisphere annular mode(NAM)will increase with increasing AA,contributing to increased extreme precipitation over the Northern *** the Shared Socioeconomic Pathway SSP5-8.5,AA is expected to increase by 0.85℃ per decade while the maximum latitude of planetary waves will increase by 2.82°per ***,the amplitude of the NAM will increase by 0.21 hPa per decade,contributing to a rise in extreme precipitation of 1.17% per decade for R95pTOT and 0.86% per decade for R99pTOT by 2100.

关键词： Arctic amplification Extreme precipitation CMIP5 CMIP6 Model evaluation Planetary waves Northern hemisphere annular mode

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Pedicle complex tissue flap transfer for reconstruction of duplicated thumbs with unequal size

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World Journal of Clinical Cases 2021年第35期9卷 10909-10918页

作者： De-Hua Wang Gui-Ping Zhang Zeng-Tao Wang Meng Wang Qin-Yi Han fan-xiao liu Department of Hand and Foot Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Anesthesiology The Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250000Shandong ProvinceChina Department of Hand and Foot Shandong Provincial Hospital Affiliated to Shandong UniversityJinan 250021Shandong ProvinceChina Department of Orthopaedics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina

BACKGROUND Thumb polydactyly is one of the most common congenital hand deformities,and the Bilhaut-Cloquet procedure or a modified one is often ***,controversy remains over the rare instances in which both thumbs are not of similar length or far apart in *** To evaluate the clinical outcomes of pedicle complex tissue flap transfer in the treatment of duplicated thumbs with unequal *** From January 2014 to December 2020,15 patients underwent duplicated thumb reconstruction by pedicle complex tissue flap transfer at our hand surgery *** technique was used when it was necessary to combine different tissues from both severed and preserved thumbs that were not of similar length or far apart in *** parents’evaluations and functional outcomes(ALURRA and TATA criteria)were *** alignment deviation,instability,range of motion(percent of opposite thumb)of the interphalangeal and metacarpophalangeal joints,and the aesthetic aspects,including circumference,length,nail size,and nail deformity,were used to assess the clinical *** The average age of patients at the time of surgery was 13 mo,and the mean final follow-up occurred at 42 *** appropriate volume with a stable joint and good appearance was obtained in 14 reconstructed *** unstable interphalangeal joint occurred in one *** flexion-extension arc at the metacarpophalangeal joint was good,while that at the interphalangeal joint was *** of the parents were satisfied with the cosmetic and functional results of the reconstructed *** mean ALURRA score was 21.8(range:20-24),and the Tada score was 6.9(range:5-8).Compared with the non-operated side,the length of the operated thumb was approximately 95%,the girth was 89%,and the nail width was 82.9%.The mean ranges of motion were 62.1%of that of the unaffected thumb in the interphalangeal joint and 78.3%in the metacarpophalangeal *** Harvesting a pedicle flap from a severed

关键词： Thumb duplication Deformity Pedicle flap Pedicle

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