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运动疗法对妊娠糖尿病的临床价值

中国城乡企业卫生 2024年第2期39卷 55-58页

作者：颜晓华刘倩滕州市中心人民医院产二科山东滕州277599

目的探讨运动疗法对妊娠糖尿病的临床价值,为妊娠糖尿病的临床治疗提供参考。方法回顾性选取2022年1—12月滕州市中心人民医院收治的妊娠糖尿病患者120例作为研究对象,根据就医顺序分为观察组和对照组各60例。对照组实施常规干预,观... 详细信息

目的探讨运动疗法对妊娠糖尿病的临床价值,为妊娠糖尿病的临床治疗提供参考。方法回顾性选取2022年1—12月滕州市中心人民医院收治的妊娠糖尿病患者120例作为研究对象,根据就医顺序分为观察组和对照组各60例。对照组实施常规干预,观察组在对照组基础上实施运动疗法。比较两组血糖水平、妊娠不良结局发生率、新生儿不良结局发生率及分娩后不良转归发生率。结果观察组FBG、2h PBG、Hb A1c水平均低于对照组,差异均有统计学意义(P<0.05)。观察组妊娠不良结局发生率为11.67%,低于对照组的28.33%,差异有统计学意义(χ^(2)=5.208,P<0.05)。观察组新生儿不良结局发生率为10.00%,低于对照组的30.00%,差异有统计学意义(χ^(2)=7.500,P<0.05)。观察组产妇分娩后不良转归发生率为5.00%,低于对照组的16.67%,差异有统计学意义(P<0.05)。结论运动疗法在妊娠糖尿病中应用能有效降低血糖水平,改善产妇妊娠结局、新生儿结局及产妇分娩后转归,值得临床推广应用。

关键词：妊娠糖尿病运动疗法临床价值

混合施肥对玉米生产和土壤生态的影响研究进展

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玉米科学 2024年第5期32卷 96-104页

作者：赵新颖张淑莹肖丹刘迎春滕星肖艳华吉林省农业科学院长春130033 吉林省动物疫病预防控制中心长春130062

过量的化肥投入对增产的作用已经不明显,如何提高肥料利用率,如何在稳产的同时提高耕地质量,确保农业可持续发展,已成为国家农业战略调整行动方案的主要内容。梳理秸秆、粪污、新型有机肥料和化肥施用对我国玉米种植的应用研究现状,就... 详细信息

过量的化肥投入对增产的作用已经不明显,如何提高肥料利用率,如何在稳产的同时提高耕地质量,确保农业可持续发展,已成为国家农业战略调整行动方案的主要内容。梳理秸秆、粪污、新型有机肥料和化肥施用对我国玉米种植的应用研究现状,就化肥减施条件下各有机措施和化肥的混合施肥对玉米生产和农田土壤的研究成果进行综述。在技术和政策层面,提出以提高耕地综合生产力为目标,依靠技术引领肥料高效利用,按照增产潜力做好区域性的施肥管理建议,粪污无害化处置后的有机肥应纳入当地政府还田实施项目中的优先采购产品,促进本地循环农业良性发展。

关键词：玉米混合施肥有机肥化肥减施秸秆品质

β-溶血性链球菌对红霉素、克林霉素耐药性及对大环内酯类抗生素耐药机制研究

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山东医学高等专科学校学报 2024年第1期46卷 1-4页

作者：程振娜张凤华董立李霞闫晓华山东医学高等专科学校山东临沂276000 临沂市人民医院山东医专附属医院

目的探讨BHS的耐药性及耐药基因携带情况。方法采用药敏纸片法测定BHS对红霉素、克林霉素的药物敏感性,应用PCR法检测其对大环内酯类药物耐药基因ermB、mefA。结果BHS群对红霉素及林可酰胺类药物克林霉素的耐药率较高。ermB基因阳性率为... 详细信息

目的探讨BHS的耐药性及耐药基因携带情况。方法采用药敏纸片法测定BHS对红霉素、克林霉素的药物敏感性,应用PCR法检测其对大环内酯类药物耐药基因ermB、mefA。结果BHS群对红霉素及林可酰胺类药物克林霉素的耐药率较高。ermB基因阳性率为84.4%,其中GCS、GFS对该基因携带率最高均为100%,7株红霉素敏感菌株中检测出ermB基因,与耐药表型不符。mefA基因阳性率为3.1%,均在红霉素耐药菌株中检出。有1株同时携带ermB、mefA基因。结论BHS群对大环内酯类药物及林可酰胺类药物耐药率较高,其对红霉素耐药主要与核糖体糖蛋白甲基化有关。

关键词： β-溶血性链球菌红霉素克林霉素耐药基因

DSC and NMR Study on the Inclusion Complex of Lappaconitine with b-Cyclodextrin

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Chinese Chemical Letters 2002年第3期13卷 227-230页

作者： Kai Jun LIAO xiao hua yan Dong Yun ZHAO Xue Yi MA Department of Chemistry National Laboratory of Applied Organic ChemistryLanzhou UniversityLanzhou 730000

The inclusion complex of lappaconitine (Lap) with b-cyclodextrin (b-CD) has been studied by the differential scanning calorimetry (DSC) and 1H-NMR, 2D-NMR spectroscopy. The structure of the complex has been deduced.

关键词： Aconitum delphinium lappaconitine b-cyclodextrin inclusion complex DSC NMR.

Interactions between mycoplasma lipid-associated membrane proteins and the host cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第5期7卷 342-350页

作者： YOU xiao-xing ZENG yan-hua WU Yi-mou Institute of Pathogenic Biology School of Medicine Nanhua University Hengyang 421001 China

Mycoplamas are a group of wall-less prokaryotes widely distributed in nature, some of which are pathogenic for humans and animals. There are many lipoproteins anchored on the outer face of the plasma membrane, called lipid-associated membrane proteins (LAMPs). LAMPs are highly antigenic and could undergo phase and size variation, and are recognized by the innate immune system through Toll-like receptors (TLR) 2 and 6. LAMPs can modulate the immune system, and could induce immune cells apoptosis or death. In addition, they may associate with malignant transformation of host cells and are also con-sidered to be cofactors in the progression of AIDS.

关键词： Mycoplasma Lipid-associated membrane proteins (LAMPs) Toll-like receptor (TLR) Immunomodulin

Troglitazone, a peroxisome proliferator-activated receptor γ ligand, induces growth inhibition and apoptosis of HepG2 human liver cancer cells

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World Journal of Gastroenterology 2008年第14期14卷 2168-2173页

作者： yan-Ming Zhou Yin-Hao Wen xiao-yan Kang Hai-hua Qian Jia-Mei yang Zheng-Feng Yin Department of Molecular Oncology Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China

AIM: To examine the effect of troglitazone, a peroxisome proliferator-activated receptor γ (PPARγ) ligand, on the proliferation and apoptosis of human liver cancer cells. METHODS: Liver cancer cell line HepG2 was cultured and treated with troglitazone. Cell proliferation was detected by 3-(4-,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay; apoptosis was detected by flow cytometry and terminal deoxynucleotidyl transferase- mediated nick end labeling of DNA fragmentation sites (TUNEL) assay; and apoptosis-related protein was detected by immunocytochemistry and Western blotting. RESULTS: Troglitazone inhibited growth and induced apoptosis of HepG2 cells in a dose-dependent manner, and induced activation of caspase-3 expression. Troglitazone not only drove apoptosis-inhibiting factor survivin to translocate incompletely from the nucleus to the cytoplasm, but also inhibited expression of survivin, while it did not affect expression of apoptosis-promoting factor Bax. CONCLUSION: PPARγ ligands inhibit growth and induce apoptosis of liver cancer cells, and may have applications for the prevention and treatment of liver cancer.

关键词： Peroxisome proliferator-activated receptor γ Troglitazone Liver neoplasms Apoptosis

Baicalin protects neonatal rat brains against hypoxicischemic injury by upregulating glutamate transporter 1 via the phosphoinositide 3-kinase/protein kinase B signaling pathway

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Neural Regeneration Research 2017年第10期12卷 1625-1631页

作者： Zhi-qing Zhou Yong-liang Li Zhen-bo Ao Zhi-li Wen Qi-wen Chen Zheng-gang huang Bing xiao xiao-hua yan Department of Pediatrics the Second People's Hospital of Huaihua CityHuaihuaHunan ProvinceChina Department of Ontology the Second People's Hospital of Huaihua CityHuaihuaHunan ProvinceChina Department of Gastroenterology'the Second Affiliated Hospital of Nanchang University NanchangJiangxi ProvinceChina Department of Pediatrics the First Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Department of Neurosurgery the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina

Baicalin is a flavonoid compound extracted from Scutellaria baicalensis *** evidence indicates that baicalin is neuroprotective in models of ischemic ***,we investigate the neuroprotective effect of baicalin in a neonatal rat model of hypoxic-ischemic ***-day-old pups underwent left common carotid artery ligation followed by hypoxia（8% oxygen at 37°C） for 2 hours,before being injected with baicalin（120 mg/kg intraperitoneally） and examined 24 hours *** effectively reduced cerebral infarct volume and neuronal loss,inhibited apoptosis,and upregulated the expression of p-Akt and glutamate transporter *** injection of the phosphoinositide 3-kinase/protein kinase B（PI3 K/Akt） inhibitor LY294002 30 minutes before injury blocked the effect of baicalin on p-Akt and glutamate transporter 1,and weakened the associated neuroprotective *** findings provide the first evidence,to our knowledge that baicalin can protect neonatal rat brains against hypoxic-ischemic injury by upregulating glutamate transporter 1 via the PI3 K/Akt signaling pathway.

关键词： nerve regeneration baicalin hypoxia ischemia PI3K/Akt signaling pathway glutamate transporter 1 excitotoxicity neonatal rats apoptosis neural regeneration

Breaking the efficiency limitations of dissipative Kerr solitons using nonlinear couplers

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 88-94页

作者： Ming Li xiao-xiao Xue yan-Lei Zhang Xin-Biao Xu Chun-hua Dong Guang-Can Guo Chang-Ling Zou CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Centerfor Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Department of Electronic Engineering Beijing National Research Center for Information Science and TechnologyTsinghua University Beijing 100084China

Dissipative Kerr solitons(DKS) have long been suffering from poor power conversion efficiency when driven by continuous-wave lasers. By deriving the critical coupling condition of a multimode nonlinear optics system in a generalized theoretical framework,two efficiency limitations of the conventional pump method of DKS are revealed: the effective coupling rate is too small and is also power-dependent. A general approach is provided to resolve this challenge by introducing two types of nonlinear couplers to couple the soliton cavity and CW input through nonlinear processes. The collective coupler opens multiple coupling channels and the self-adaptive coupler builds a power-independent effective external coupling rate to the DKS for approaching the generalized critical coupling condition, which promises near-unity power conversion efficiencies. For instance, a conversion efficiency exceeding 90% is predicted for aluminum nitride microrings with a nonlinear coupler utilizing second-harmonic generation. The mechanism applies to various nonlinear processes, including Raman and Brillouin scattering, and thus paves the way for micro-solitons toward practical applications.

关键词： Kerr frequency comb conversion efficiency nonlinear coupler

Associations between Geriatric Nutrition Risk Index,bone mineral density and body composition in type 2 diabetes patients

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World Journal of Diabetes 2024年第3期15卷 403-417页

作者： xiao-xiao Zhu Kai-Feng Yao Hai-yan huang Li-hua Wang Department of Pediatrics The Second Affiliated Hospital of Nantong UniversityFirst People’s Hospital of Nantong CityNantong 226001Jiangsu ProvinceChina Department of Nursing The Second Affiliated Hospital of Nantong UniversityFirst People’s Hospital of Nantong CityNantong 226001Jiangsu ProvinceChina Department of Endocrinology The Second Affiliated Hospital of Nantong UniversityFirst People’s Hospital of Nantong CityNantong 226001Jiangsu ProvinceChina

BACKGROUND Type 2 diabetes mellitus(T2DM),a fast-growing issue in public health,is one of the most common chronic metabolic disorders in older *** and sarcopenia are highly prevalent in T2DM patients and may result in fractures and *** people with T2DM,the association between nutrition,sarcopenia,and osteoporosis has rarely been *** To evaluate the connections among nutrition,bone mineral density(BMD)and body composition in patients with *** We enrolled 689 patients with T2DM for this cross-sectional *** patients underwent dual energy X-ray absorptiometry(DXA)examination and were categorized according to baseline Geriatric Nutritional Risk Index(GNRI)values calculated from serum albumin levels and body *** GNRI was used to evaluate nutritional status,and DXA was used to investigate BMD and body *** forward linear regression analysis was used to identify the factors associated with BMD and skeletal muscle mass *** Of the total patients,394 were men and 295 were *** with patients in tertile 1,those in tertile 3 who had a high GNRI tended to be younger and had lower HbA1c,higher BMD at all bone sites,and higher appendicular skeletal muscle index(ASMI).These important trends persisted even when the patients were divided into younger and older *** GNRI was positively related to ASMI(men:r=0.644,P<0.001;women:r=0.649,P<0.001),total body fat(men:r=0.453,P<0.001;women:r=0.557,P<0.001),BMD at all bone sites,lumbar spine(L1-L4)BMD(men:r=0.110,P=0.029;women:r=0.256,P<0.001),FN-BMD(men:r=0.293,P<0.001;women:r=0.273,P<0.001),and hip BMD(men:r=0.358,P<0.001;women:r=0.377,P<0.001).After adjustment for other clinical parameters,the GNRI was still significantly associated with BMD at the lumbar spine and femoral ***,a low lean mass index and higherβ-collagen special sequence were associated with low BMD at all bone *** was negatively correlated with

关键词： Geriatric Nutrition Risk Index Bone mineral density Skeletal muscle mass Type 2 diabetes