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Hepatocyte growth factor promotes retinal pigment epithelium cell activity through MET/AKT signaling pathway

International Journal of Ophthalmology(English edition) 2024年第5期17卷 806-814页

作者： Si-Rui Zhou Yu-Sheng Zhu Wen-Ting Yuan xiao-yan Pan Tong Wang xiao-Dong Chen Faculty of Life Sciences and Medicine Northwest UniversityXi’an 710069Shaanxi ProvinceChina First Affiliated Hospital of Northwest University Northwest UniversityXi’an 710069Shaanxi ProvinceChina Department of Ophthalmology Xi’an No.1 HospitalXi’an 710002Shaanxi ProvinceChina Shaanxi Institute of Ophthalmology Shaanxi Provincial Key Lab of OphthalmologyClinical Research Center for Ophthalmology Diseases of Shaanxi ProvinceXi’an 710002Shaanxi ProvinceChina

AIM:To explore the effects of hepatocyte growth factor(HGF)on retinal pigment epithelium(RPE)cell ***:The human adult retinal pigment epithelial cell line-19(ARPE-19)were treated by HGF or mesenchymalepithelial transition factor(MET)inhibitor SU11274 in *** viability was detected by a Cell Counting Kit-8 *** proliferation and motility was detected by a bromodeoxyuridine incorporation assay and a wound healing assay,*** expression levels of MET,phosphorylated MET,protein kinase B(AKT),and phosphorylated AKT proteins were determined by Western blot *** MET and phosphorylated MET proteins were also determined by immunofluorescence ***:HGF increased ARPE-19 cells’viability,proliferation and migration,and induced an increase of phosphorylated MET and phosphorylated AKT ***11274 significantly reduced cell viability,proliferation,and migration and decreased the expression of MET and AKT ***11274 suppressed HGF-induced increase of viability,proliferation,and migration in ARPE-19 ***,SU11274 also blocked HGF-induced phosphorylation of MET and AKT ***:HGF enhances cellular viability,proliferation,and migration in RPE cells through the MET/AKT signaling pathway,whereas this enhancement is suppressed by the MET inhibitor ***-induced MET/AKT signaling might be a vital contributor of RPE cells survival.

关键词： hepatocyte growth factor mesenchymal epithelial transition factor SU11274 retinal pigment epithelial cells

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Lonicera Japonica Caulis Ameliorates LPS and TNF-α-Induced HT-29 Cell Injury by Inhibiting the MAPK/ERK/JNK/p38 Pathway

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Biomedical and Environmental Sciences 2024年第7期37卷 805-810页

作者： Hanxiu Lu Wei yan xiao Yuan Yongbo Kang Zhongjian Liu Qiang Guo Faculty of Life science and Technology Kunming University of Science and TechnologyKunming 650031YunnanChina School of medicine Kunming University of Science and TechnologyKunming 650031YunnanChina Department of Gastroenterology The First People’s Hospital of Yunnan ProvinceKunming 650032YunnanChina Department of Gastroenterology The First People’s Hospital of Yuxi CityYuxi 653100YunnanChina Institute of Basic and Clinical Medicine The First People’s Hospital of Yunnan ProvinceKunming 650032YunnanChina

Inflammatory bowel disease(IBD)is characterized by chronic inflammation of the intestinal tract,and shows a high rate of *** have accumulated extensive experience in the treatment of IBD,with biologics and small molecule drugs having greatly expanded the therapeutic scope of IBD in recent ***,such treatments involve a high price and a single target of drug action.

关键词： drugs treatment p38

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Association of Methionine Synthase rs1805087 Polymorphism With Arsenic-Related Skin Pigmentary Changes:A Population-Based Case-Control Study

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International Journal of Dermatology and Venereology 2024年第2期7卷 70-77页

作者： xiao-yan Huang Yi xiao Dan-Rong Jing Min-Xue Shen Li-Xia Lu Department of Pathology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Key Laboratory of Skin Cancer and Psoriasis Central South UniversityChangshaHunan 410008China Hunan Engineering Research Center of Skin Health and Disease Central South UniversityChangshaHunan 410008China Department of Social Medicine and Health Management Xiangya School of Public HealthCentral South UniversityChangshaHunan 410008China

Objective:Chronic arsenic exposure causes skin lesions including skin cancers,pigmentary changes,and *** polymorphism in arsenic metabolism may increase susceptibility to the development of arsenic-related skin *** study was performed to determine whether arsenic metabolism-related gene variants are associated with arsenic-related pigmentary ***:This case-control study involved 189 patients with arsenic-related pigmentary changes and 103 ***-eight polymorphisms in 10 genes determined by mass spectrometry assay served as candidate drivers of arsenic-induced pigmentary *** and plasma arsenic levels were determined by inductively coupled plasma mass *** arsenic concentrations were measured by nondispersive atomic fluorescence *** metabolites in urine were determined using high-performance liquid chromatography with inductively coupled plasma mass *** folate was measured using a folate radio assay *** of variance,nonparametric test,or the chi-square test was selected according to the data *** correlation analysis was used to determine the correlation between two *** regression was used to estimate the effect of single-nucleotide ***:The arsenic concentrations in urine,plasma,and hair and the urine arsenic species were not significantly different between patients and *** regression revealed that among the polymorphisms,the methionine synthase(MTR)rs1805087 polymorphism showed a protective effect against arsenic-related pigmentary *** the codominant model,the adjusted odds ratio for age,sex,and ethnicity was 0.41(95%confidence interval[CI],0.21-0.80;P=0.008)for the AG genotype and 0.11(95%CI,0.02-0.60;P=0.012)for the GG ***:MTR polymorphism showed a protective effect against arsenic-related pigmentary changes in the logistic regression *** effect of MTR rs1805087 might

关键词： methionine synthase arsenic-related pigmentary changes arsenic metabolism

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Study on the optimal incident proton energy of ^(7)Li(p,n)^(7)Be neutron source for boron neutron capture therapy

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Nuclear Science and Techniques 2024年第3期35卷 170-180页

作者： Yi-Nan Zhu Zuo-Kang Lin Hai-yan Yu Ye Dai Zhi-Min Dai xiao-Han Yu Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Science Beijing 100049China

Boron neutron capture therapy(BNCT)is recognized as a precise binary targeted radiotherapy technique that effectively eliminates tumors through the^(10)B(n,α)^(7)Li nuclear *** various neutron sources,accelerator-based sources have emerged as particularly promising for BNCT ***^(7)Li(p,n)^(7)Be reaction is highly regarded as a potential neutron source for BNCT,owing to its low threshold energy for the reaction,significant neutron yield,appropriate average neutron energy,and additional *** study utilized Monte Carlo simulations to model the physical interactions within a lithium target subjected to proton bombardment,including neutron moderation by an MgF_(2)moderator and subsequent BNCT dose analysis using a Snyder head *** study focused on calculating the yields of epithermal neutrons for various incident proton energies,finding an optimal energy at 2.7 ***,the Snyder head phantom was employed in dose simulations to validate the effectiveness of this specific incident energy when utilizing a^(7)Li(p,n)^(7)Be neutron source for BNCT purposes.

关键词： Boron neutron capture therapy ^(7)Li(p,n)7Be neutron source Incident proton energy Monte Carlo simulation

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Stable carbon isotope composition and intrinsic water use efficiency in plants along an altitudinal gradient on the eastern slope of Yulong Snow Mountain, China

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Ecological Processes 2024年第2期13卷 218-230页

作者： Feng Jiang Tao Pu Zi-Jing Xue yan-Wei Ma xiao-Yi Shi Fu-Xi Shi College of Geography and Environmental Sciences Zhejiang Normal University Yulong Snow Mountain Glacier and Environment Observation and Research Station/State Key Laboratory of Cryospheric Sciences Northwest Institute of Eco-Environment and ResourcesChinese Academy of Sciences Key Laboratory of National Forestry and Grassland Administration on Forest Ecosystem Protection and Restoration of Poyang Lake Watershed College of Forestry Jiangxi Agricultural University

Background Stable carbon isotope composition(δ13Cp) can be used to estimate the changes in intrinsic water use efficiency（iWUE） in plants,which helps us to better understand plants' response strategies to climate *** study focused on the variations in δ13Cpand iWUE for the different life-form plants（i.e.,herbs,shrubs,and trees）along an altitudinal gradient（3300,3600,3900,4100,4300,and 4500 m） on the eastern slope of Yulong Snow Mountain,southeastern margin of the Qinghai-Tibet *** response mechanisms of δ13Cpand iWUE for different life-form plants to altitude were thoroughly analyzed in this mountain *** The δ13Cpvalues of plants on the eastern slopes of Yulong Snow Mountain ranged from-30.4‰to-26.55‰,with a mean of-28.02‰,indicating a dominance of *** δ13Cpand iWUE values varied among different life-form plants in the order of herbs> shrubs> trees,particularly in 3600,3900,and 4300 ***δ13Cpand iWUE values for herbs and shrubs increased with altitude and were mainly controlled by air *** two parameters for trees exhibited a trend of initial decrease followed by an increase with *** 3900 m,the δ13Cpand iWUE values decreased with altitude,influenced by soil ***,above 3900 m,the two parameters increased with altitude,mainly regulated by air *** addition,iWUE was positively correlated with leaf P content but negatively correlated with leaf N:P ratio,especially for herbs and trees,suggesting that P plays a key role in modulating iWUE in this *** The diffe rentiated responses of water availability for different life-form plants to a higher altitudinal gradient are regulated by air temperature,soil moisture,and leaf P content in the Yulong Snow *** results provide valuable insights into understanding the wate r-carbon relationships in high-altitude ecosystems.

关键词： Stable carbon isotope Water use efficiency Altitude Life form Yulong Snow Mountain

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Smart materials for safe lithium-ion batteries against thermal runaway

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Journal of Energy Chemistry 2024年第7期94卷 360-392页

作者： Yu Ou Pan Zhou Wenhui Hou xiao Ma Xuan Song Shuaishuai yan yang Lu Kai Liu Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

In recent years,the new energy storage system,such as lithium ion batteries(LIBs),has attracted much *** order to meet the demand of industrial progress for longer cycle life,higher energy density and cost efficiency,a quantity of research has been conducted on the commercial application of ***,it is difficult to achieve satisfying safety and cycling performance *** may be thermal runaway(TR),external impact,overcharge and overdischarge in the process of battery abuse,which makes the safety problem of LIBs more *** this review,we summarize recent progress in the smart safety materials design towards the goal of preventing TR of LIBs reversibly from different abuse *** from smart responsive materials and novel structural design,the safety of LIBs can be improved a *** expect to provide a comprehensive reference for the development of smart and safe lithium-based battery materials.

关键词： Lithium ion batteries(LIBs) Thermal runaway(TR) Smart materials Safe batteries Solid electrolyte interface(SEI)

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Highly Transparent Fire-resistant Coatings with Intumescent Three-source Integration

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Chinese Journal of Polymer Science 2024年第7期42卷 907-915,I0005页

作者： xiao-Liang Zeng Xin-Sheng Lan yan Wang Lin Zhang De-Ming Guo Hai-Bo Zhao State Grid Sichuan Electric Power Research Institute Chengdu610041China The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials(Ministry of Education) National Engineering Laboratory of Eco-Friendly Polymeric Materials(Sichuan)State Key Laboratory of Polymer Materials EngineeringCollege of ChemistrySichuan UniversityChengdu610064China

Wood,a readily available and sustainable natural resource,has found widespread use in construction and ***,its inherent flammability poses a potential fire *** intumescent fire-retardant coatings effectively mitigate this risk,achieving high transparency in such coatings presents a significant *** our approach,we employed a cross-linked network of phytic acid anion and N-[3-(trimethoxysilyl)propyl]-N,N,N-trimethylammonium cation to create a transparent"three-in-one"intumescent *** collaborative P/N/Si flame-retardant effect markedly improved the intumescent char-forming capability,preventing the wood from rapid *** resulted in a substantial reduction in heat release(13.9%decrease in THR)and an increased limiting oxygen index(LOI)value of 35.5%.Crucially,the high transparency of the coating ensured minimal impact on the wood's appearance,allowing the natural wood grains to remain clearly *** innovative approach provides a straightforward method for developing transparent intumescent flame-retardant coatings suitable for wooden *** potential applications extend to preserving ancient buildings and heritage conservation efforts.

关键词： Fire-resistant coating Flame retardancy Wood Transparency

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Development of a prognostic scoring system for hepatic vena cava Budd-Chiari syndrome with hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 370-375页

作者： Sheng-yan Liu Lu-Hao Li Zhao-Chen Liu Su-Xin Li xiao-Wei Dang Department of Hepatopancreatobiliary Surgery the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Budd-Chiari Syndrome Diagnosis and Treatment Center of Henan Province Zhengzhou 450052China

Background:Hepatocellular carcinoma(HCC)is a serious complication of hepatic vena cava Budd-Chiari syndrome(HVC-BCS)that significantly reduces the survival time of *** study aimed to analyze the prognostic factors influencing the survival of HVC-BCS patients with HCC and to develop a prognostic scoring ***:The clinical and follow-up data of 64 HVC-BCS patients with HCC who received invasive treatment at the First Affiliated Hospital of Zhengzhou University between January 2015 and December 2019 were retrospectively ***-Meier curves and log-rank tests were used to analyze the survival curve of patients and the difference in prognoses between the *** and multivariate Cox regression analyses were performed to analyze the influence of biochemical,tumor,and etiological characteristics on the total survival time of patients,and a new prognostic scoring system was developed according to the regression coefficients of the independent predictors in the statistical *** prediction efficiency was evaluated using the time-dependent receiver operating characteristics curve and concordance ***:Multivariate analysis showed that serum albumin level7 cm(HR=8.623,95%CI:3.771-19.715,P<0.001),and inferior vena cava stenosis(HR=3.612,95%CI:1.646-7.928,P=0.001)were independent predictors of survival.A prognostic scoring system was developed according to the above-mentioned independent predictors,and patients were classified into grades A,B,C and *** differences in survival were found among the four ***:This study successfully developed a prognostic scoring system for HVC-BCS patients with HCC,which is helpful for clinical evaluation of patient prognosis.

关键词： Budd-Chiari syndrome Hepatocellular carcinoma Prognostic factors Inferior vena cava stenosis Prognostic scoring system

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An ultra-deep TSV technique enabled by the dual catalysis-based electroless plating of combined barrier and seed layers

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Microsystems & Nanoengineering 2024年第3期10卷 409-419页

作者： Yuwen Su Yingtao Ding Lei xiao Ziyue Zhang yangyang yan Zhifang Liu Zhiming Chen Huikai Xie School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijingChina Chongqing Institute of Microelectronics and Microsystems Beijing Institute of TechnologyChongqingChina

Silicon interposers embedded with ultra-deep through-silicon vias(TSVs)are in great demand for the heterogeneous integration and packaging of opto-electronic chiplets and microelectromechanical systems(MEMS)*** the cost-effective and reliable manufacturing of ultra-deep TSVs,the formation of continuous barrier and seed layers remains a crucial challenge to ***,we present a novel dual catalysis-based electroless plating(ELP)technique by tailoring polyimide(PI)liner surfaces to fabricate dense combined Ni barrier/seed layers in ultradeep *** additional to the conventional acid catalysis procedure,a prior catalytic step in an alkaline environment is proposed to hydrolyze the PI surface into a polyamide acid(PAA)interfacial layer,resulting in additional catalysts and the formation of a dense Ni layer that can function as both a barrier layer and a seed layer,particularly at the bottom of the deep *** with depths larger than 500μm and no voids are successfully fabricated in this *** fabrication process involves low costs and *** a fabricated 530-μm-deep TSV with a diameter of 70μm,the measured depletion capacitance and leakage current are approximately 1.3 pF and 1.7 pA at 20 V,respectively,indicating good electrical *** proposed fabrication strategy can provide a cost-effective and feasible solution to the challenge of manufacturing ultra-deep TSVs for modern 3D heterogeneous integration and packaging applications.

关键词： properties catalysis alkaline

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Hsa_circ_0007099 and PIP4K2A coexpressed in diffuse large B-cell lymphoma with clinical significance

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Genes & Diseases 2024年第4期11卷 98-101页

作者： Jinghan Wang Xin Ku Qiuling Ma Haikuo Li Sujuan Huang Liping mao Fang Yu Jie Jin Wei yan Department of Hematology The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China Key Laboratory of Hematologic Malignancies Diagnosis and TreatmentHangzhouZhejiang 310003China Zhejiang Provincial Clinical Research Center for Hematologic Diseases HangzhouZhejiang 310003China Cancer Center Zhejiang UniversityHangzhouZhejiang 310003China Shanghai Center for Systems Biomedicine Key Laboratory of Systems Biomedicine(Ministry of Education)Shanghai JiaoTong UniversityShanghai 200240China The Second School of Clinical Medicine Henan University of Chinese MedicineZhengzhouHenan 450046China Department of Pathology The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China

Diffuse large B-cell lymphoma(DLBCL)is the most common subtype of B-cell lymphoma in adult *** to the clinical and molecular heterogeneity of DLBCL patients,robust biomarkers in clinical practice are still ***,the int... 详细信息

关键词： clinical lymphoma patients

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