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A study of the biodiversity and secondary metabolites of fungal endophytes from medicinal plants in Guizhou

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A study of the biodiversity and secondary metabolites of fun...

中国菌物学会2018年学术年会

作者： Ji-Chuan Kang Ting-Chi Wen Yi-Xin Qian Si-Xuan Zhou xiao-ya ma Engineering and Research Center of Southwest Bio-Pharmaceutical Resources Ministry of EducationGuizohu University School of Pharmacy Guizhou University

In southwest China, Guizhou province has a well-known fame for its prolific biodiversity of medicinal plants. For solving the problems of plant shortage, environmental disruption and obtaining novel structural as well as bio-active natural products, we have been studying the fungal endophytes and their secondary metabolites from medicinal plants in Guizhou province for a number of years. We isolated over five thousand fungal strains from medicinal plants including Artemisia carvifolia, Artemisia japonica, Blumea balsamifera, Camptotheca acuminate, Dendrobium orchids, Ginkgo biloba, Nothapodytes pittosporoides, Reineckia carnea, Taxus *** even hundreds of different fungal isolates were obtained from each plant species. Most of the fungal endophytes belong to Ascomycota which mainly distribute in Pezizomycete, Dothediomycete and Sordariomycete.A few of them are classified into basidiomycota and Zygomycota. The status of fungal endophyte taxa depends on vary kinds of factors, for example, the age of host, organ, humidity of sample site, altitude, season, surrounding plant, extent of environmental contamination and so on. We combined in vitro bio-activity analysis, chemical composition identification and gene detection in fungal endophyte to screen and evaluate 1003 fungal ***-six of them showed anti-inflammatory, antitumor, antioxidant, anti-pathogen and P-gp inhibitory bio-activity to different extent. At present, we accomplished the study for secondary metabolites of ten fungal strains that possess high bio-activity. More than 200 bio-active compounds were isolated. Ten of them have new ***, there is a long way to produce bio-active compounds in large scale because of the low ***, it is necessary to improve cultivation methods or alter inner gene in fungal endophyte by genetic engineering for achieving novel chemical structure as potential new drug.

关键词： Fungal endophytes morphology phylogeny bio-active compounds P-gp inhibitory

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基于主题映射元数据的数据库访问和集成系统

系统仿真学报 2009年第14期21卷 4268-4273页

作者：陈小青马亚平段永强国防大学信息作战与指挥训练教研部中国人民解放军公共平台服务中心北京100091

系统为战争模拟数据的有效访问提供了一个基于主题映射元数据的完整解决方案,并已广泛应用。该解决方案改善了数据到处放、需要数据找不到、拿到数据不会用的问题;实现了数据的物理分布、逻辑集中;降低了数据访问逻辑和数据之间的耦合程... 详细信息

系统为战争模拟数据的有效访问提供了一个基于主题映射元数据的完整解决方案,并已广泛应用。该解决方案改善了数据到处放、需要数据找不到、拿到数据不会用的问题;实现了数据的物理分布、逻辑集中;降低了数据访问逻辑和数据之间的耦合程度;考虑了数据使用中的安全性和权限控制;提供了高度简洁、统一和规范的数据访问接口;为数据访问引入含有语义、更自然的方式,为逐步提高数据访问的"智能"程度奠定基础。

关键词：主题映射元数据数据访问查询语言数据库

Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang Ying Zhu Pu Chen Tong Zhou Zhe-Yi Han Jun xiao Jian-Feng ma Wen ma Peng Zang Ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

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大跨悬索桥主缆温湿度长期监测与分布规律

科学技术与工程 2017年第14期17卷 309-313页

作者：田浩曹素功李晓娅张勇马如进浙江省交通运输科学研究院杭州311305 同济大学桥梁工程系上海200092

长期处于潮湿易腐蚀环境中的悬索桥主缆受到太阳辐射和空气对流的影响,很可能生锈断裂而影响大桥的安全。以西堠门大桥主缆系统为研究对象,为数值研究其温湿度变化机理提供物性参数,设计主缆室外温湿度监测试验。根据太阳运行轨迹提出... 详细信息

长期处于潮湿易腐蚀环境中的悬索桥主缆受到太阳辐射和空气对流的影响,很可能生锈断裂而影响大桥的安全。以西堠门大桥主缆系统为研究对象,为数值研究其温湿度变化机理提供物性参数,设计主缆室外温湿度监测试验。根据太阳运行轨迹提出了一种主缆太阳辐射模型,计算了不同工况日的年概率统计分布并对典型工况日的气温日变化函数曲线进行了拟合。研究结果表明:锚室内温湿度变化平稳,不易受外界环境影响,鞍座内温湿度变化剧烈,受外界环境影响较大;晴天工况下主缆温度受太阳辐射影响显著,而降雨/雪会使气温下降进而影响其太阳辐射规律。

关键词：大跨悬索桥主缆温湿度监测分布规律

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6700车汽车滚装船货舱结构风道设计

船舶设计通讯 2017年第2期 59-64页

作者：沈小兴马亚成上海船舶研究设计院上海201203

通风系统是汽车滚装船最重要的系统之一。介绍了汽车滚装船货舱通风布置特点、介绍了6700车汽车滚装船货舱结构风道设计,包括风道形式、甲板开孔形式、其他汽车滚装船的风道设计、风道出风口形式。详细分析了风道与固定甲板及活动甲板... 详细信息

通风系统是汽车滚装船最重要的系统之一。介绍了汽车滚装船货舱通风布置特点、介绍了6700车汽车滚装船货舱结构风道设计,包括风道形式、甲板开孔形式、其他汽车滚装船的风道设计、风道出风口形式。详细分析了风道与固定甲板及活动甲板连接处的疲劳强度及结构加强,风机房结构设计,为以后汽车滚装船的设计起参考借鉴作用。

关键词：汽车滚装船货舱通风结构风道设计疲劳分析

Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： Bin Xie Yuanhui Guo Yun Chen Hao Zhang Jiawei xiao maoxiang Hou Huilong Liu Li ma Xin Chen Chingping Wong State Key Laboratory of Precision Electronic manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan yang Zhi-Cheng Zhang Qi Dai xiao-yan Bao Lin-Jie Wu ya-Xin Qin Xin Tan xiao-yan Sun Xu-Fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

macular Perfusion Changes and Ganglion Cell Complex Loss in Patients with Silicone Oil-related Visual Loss

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Biomedical and Environmental Sciences 2020年第3期33卷 151-157页

作者： ma ya ZHU xiao Qing PENG xiao yan Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Ophthalmology and Visual Science Key LabBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beijing Tongren Eye Center Beijing Ophthalmology and Visual Science Key LabBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

Objective The aim of this study was to investigate macular perfusion changes and ganglion cell complex(GCC)loss in patients with unexplained visual loss following vitrectomy and silicone oil(SO)tamponade,and to evaluate the correlation between retinal blood flow and GCC loss using optical coherence tomography angiography(OCTA)and optical coherence tomography(OCT).Methods This retrospective study included seven eyes(seven patients)with unexpected visual loss after vitrectomy and SO *** was used to evaluate the alterations in retinal vessel density(VD)in the superficial capillary plexus(SCP),deep capillary plexus(DCP),and radial peripapillary capillary plexus(RPCP).OCT was used to measure the thickness of GCC and retinal nerve fiber layer(RNFL).Medical records of patients were *** Quantitative analysis of OCTA images revealed a significant reduction in SCP VD in the affected eyes compared with the controls(all sections Pmage and ganglion cell apoptosis.

关键词： Silicone oil Visual loss Optical coherence tomography angiography Ganglion cell complex

Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021

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World Journal of Psychiatry 2025年第1期15卷 93-105页

作者： ya-Xin Xu xiao-Xuan Niu Wen-Chang Jia Jing Wen Xue-Lin Cheng yan Han Ming-Hui Peng Jing Zhou yao Liu Sun-Fang Jiang xiao-Pan Li Department of Health management Centre Zhongshan HospitalFudan UniversityShanghai 200030China Department of General Practice Zhongshan HospitalFudan UniversityShanghai 200030China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China School of Public Health Fudan UniversityShanghai 200032China

BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and *** To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging *** We used data from the Global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to *** methods included age-standardisation and uncertainty analysis to address variations in population structure and data *** Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age *** and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum ***,New Zealand,and malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the ***,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk *** This study highlights the significant burden of MD in the WPR,with variations by age,gender,and *** coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

关键词： Mental disorders Western pacific region Global Burden of Disease Risk factors Disability-adjusted life years