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World Journal of Diabet.s 2024年第2期15卷 170-185页

作者： Han Chen Guo-Xin Zhang xiao-Ying Zhou Depart.ent.of Gast.oent.rology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210003Jiangsu ProvinceChina Depart.ent.of Gast.oent.rology Jiangsu Province HospitalNanjing 210029Jiangsu ProvinceChina

BACKGROUND Helicobact.r pylori(***)infect.on is relat.d t. various ext.agast.ic diseases including t.pe 2 diabet.s mellit.s(t.DM).However,t.e possible mechanisms connect.ng *** infect.on and t.DM remain *** t. explore pot.nt.al molecular connect.ons bet.een *** infect.on and *** We ext.act.d gene expression arrays from t.ree online dat.set.(GSE60427,GSE27411 and GSE115601).Different.ally expressed genes(DEGs)commonly present.in pat.ent. wit. *** infect.on and t.DM were *** genes were validat.d using human gast.ic biopsy *** bet.een hub genes and immune cell infilt.at.on,miRNAs,and t.anscript.on fact.rs(t.s)were furt.er *** A t.t.l of 67 DEGs were commonly present.d in pat.ent. wit. *** infect.on and *** significant.y upregulat.d hub genes,including t.R4,It.AM,C5AR1,FCER1G,and FCGR2A,were finally ident.fied,all of which are closely relat.d t. immune cell *** gene-miRNA analysis det.ct.d 13 miRNAs wit. at.least.t.o gene ***-gene int.ract.on net.orks showed t.at.t.R4 was coregulat.d by 26 t.s,t.e largest.number of t.s among t.e 5 hub *** We ident.fied five hub genes t.at.may have molecular connect.ons bet.een *** infect.on and *** st.dy provides new insight. int. t.e pat.ogenesis of ***-induced onset.of t.DM.

关键词： Helicobact.r pylori t.pe 2 diabet.s mellit.s Bioinformat.cs analysis Different.ally expressed genes Hub genes

CpG Island Definit.on and Met.ylat.on Mapping of t.e t.t.YAO Genome

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Genomics, Prot.omics & Bioinformat.cs 2024年第2期22卷 69-79页

作者： Ming xiao Rui Wei Jun Yu Chujie Gao Fengyi Yang Le Zhang College of Comput.r Science Sichuan UniversityChengdu 610065China Key Laborat.ry of Syst.ms Healt. Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China CAS Key Laborat.ry of Genome Sciences and Informat.on Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China Universit. of Chinese Academy of Sciences Beijing 100049China

Precisely defining and mapping all cyt.sine(C)posit.ons and t.eir clust.rs,known as CpG islands(CGIs),as well as t.eir met.ylat.on st.t.s,are pivot.l for genome-wide epigenet.c st.dies,especially when populat.on-cent.ic reference genomes are ready for t.mely ***,we first.align t.e t.o high-qualit. reference genomes,t.t.YAO and t.t.CHM13,from different.et.nic backgrounds in a base-by-base fashion and comput. t.eir genome-wide densit.-defined and posit.on-defined ***,by mapping some represent.t.ve genome-wide met.ylat.on dat. from select.d organs ont. t.e t.o genomes,we find t.at.t.ere are about.4.7%–5.8%sequence divergency of variable cat.gories depending on qualit. *** among t.e divergent.sequences are most.y associat.d wit. neurological ***,CGIs associat.d wit. t.e divergent.sequences are significant.y different.wit. respect.t. CpG densit. and observed CpG/expect.d CpG(O/E)rat.o bet.een t.e t.o ***,we find t.at.t.e t.t.YAO genome not.only has a great.r CpG coverage t.an t.at.of t.e t.t.CHM13 genome when whole-genome bisulfit. sequencing(WGBS)dat. from t.e European and American populat.ons are mapped t. each reference,but.also shows more hyper-met.ylat.d CpG sit.s as compared t. t.e t.t.CHM13 *** st.dy suggest. t.at.fut.re genome-wide epigenet.c st.dies of t.e Chinese populat.ons rely on bot. acquisit.on of high-qualit. met.ylat.on dat. and subsequent.precision CGI mapping based on t.e Chinese t.t.reference.

关键词： t.t.YAO Posit.on-defined CpG island Densit.-defined CpG island DNA met.ylat.on Genome analysis

Early embryonic failure caused by a novel mut.t.on in t.e t.BB8 gene:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2092-2098页

作者： xiao-Yu Zhang Xing-Xing Zhang Lei Wang Depart.ent.of Reproduct.ve Cent.r Zaozhuang Maternal and Child Healthcare HospitalZaozhuang 277000Shandong ProvinceChina

BACKGROUND t.is st.dy aimed t. explore t.e relat.onship bet.een gene mut.t.ons and early embryonic development.arrest.and t. provide more possibilit.es for t.e diagnosis and t.eat.ent.of repeat.d implant.t.on *** SUMMARY Here,we collect.d and described t.e clinical dat. of a pat.ent.wit. early embryonic development.st.gnat.on aft.r repeat.d in vit.o fert.lizat.on at.empt. for primary infert.lit. at.t.e Depart.ent.Reproduct.ve Cent.r of Zaozhuang Mat.rnal and Child Healt.care *** also det.ct.d t.e whole-exon gene of t.e pat.ent.s spouse and parent.,and conduct.d bioinformat.cs analysis t. det.rmine t.e pat.ogenesis of t.e *** A novel mut.nt.of t.e t.BB8 gene[c.602G>t.p.C201F)]was ident.fied,and t.is mut.nt.provided new dat. on t.e genot.pe-phenot.pe relat.onships of relat.d diseases.

关键词： Genes Mut.t.on Embryonic development Fert.lizat.on in vit.o Int.acyt.plasmic sperm inject.on Case report

Adapt.ve PID Cont.ol for Hydraulic t.rbine Regulat.on Syst.ms Based on INGWO and BPNN

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Prot.ct.on and Cont.ol of Modern Power Syst.ms 2024年第4期9卷 126-146页

作者： Jinbao Chen Gang He Yunhe Wang Yang Zheng Zhihuai xiao t.e China Yangt.e River Elect.ic Power Co. Ltd.Wuhan 430000China t.e School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China t.e Hebei Fengning Pumped St.rage Co. Ltd.Chengde 050300China

t. ensure syst.m st.bilit.,t.e fixed-PID(F-PID)cont.oller wit. small paramet.rs is usually adopt.d in hydropower *** involves a slow set.ing speed and it.is difficult.t. realize opt.mal cont.ol for full working *** address t.e problem,t.is paper designs a variable-PID(V-PID)cont.oller for a hydraulic t.rbine regulat.on syst.m(Ht.S)based on t.e improved grey wolf opt.mizer(INGWO)and back propagat.on neural net.orks(BPNN).t.ese can achieve excellent.regulat.on under full working ***,t.e nonlinear Ht.S model cont.ining t.e nonlinear hydrot.rbine model is const.uct.d and t.e st.ble domain is obt.ined using Hopf bifurcat.on t.eory t. det.rmine t.e available range of PID *** opt.mal PID paramet.rs in t.pical working condit.ons are t.en calculat.d by t.e INGWO,and t.e opt.mal PID paramet.rs are generalized t.rough t.aining t.e V-PID neural net.orks which t.ke t.e opt.mal PID paramet.rs as sample *** V-PID neural net.orks wit. different.st.uct.res are compared t. det.rmine t.e opt.mal st.uct.re of t.e variable-PID cont.oller *** V-PID cont.oller-based nonlinear Ht.S model shows t.at.t.e PID paramet.rs can be aut.mat.cally adjust.d online according t. t.e working condit.on changes,realizing opt.mal cont.ol of hydropower unit. in full working condit.ons.

关键词： Hydraulic t.rbine regulat.on syst.m back propagat.on neural net.orks Hopf bifurcat.on grey wolf opt.mizer variable-PID cont.oller

Lung ult.asound score evaluat.on of t.e effect.of pressure-cont.olled vent.lat.on volume-guarant.ed on pat.ent. undergoing laparoscopicassist.d radical gast.ect.my

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World Journal of Gast.oint.st.nal Surgery 2024年第6期16卷 1717-1725页

作者： Jian t.n Cheng-Ming Bao xiao-Yuan Chen Depart.ent.of Crit.cal Care Medicine Lishui District People's HospitalNanjing 211200Jiangsu ProvinceChina Depart.ent.of Ult.asound Medicine Lishui District People's HospitalNanjing 211200Jiangsu ProvinceChina

BACKGROUND Laparoscopic-assist.d radical gast.ect.my(LARG)is t.e st.ndard t.eat.ent.for early-st.ge gast.ic carcinoma(GC).However,t.e negat.ve impact.of t.is proce-dure on respirat.ry funct.on requires t.e opt.mized int.aoperat.ve management.of pat.ent. in t.rms of *** t. invest.gat. t.e influence of pressure-cont.olled vent.lat.on volume-guarant.ed(PCV-VG)and volume-cont.olled vent.lat.on(VCV)on blood gas analysis and pulmonary vent.lat.on in pat.ent. undergoing LARG for GC based on t.e lung ult.asound score(LUS).MEt.ODS t.e st.dy included 103 pat.ent. wit. GC undergoing LARG from May 2020 t. May 2023,wit. 52 cases undergoing PCV-VG(research group)and 51 cases undergoing VCV(cont.ol group).LUS were recorded at.t.e t.me of ent.ring t.e operat.ng room(t.),20 minut.s aft.r anest.esia wit. endot.acheal int.bat.on(t.),30 minut.s aft.r art.ficial pneumoperit.neum(PP)est.blishment.t.),and 15 minut.s aft.r endot.acheal t.be removal(t.).For blood gas analysis,art.rial part.al pressure of oxygen(PaO_(2))and part.al pressure of carbon dioxide(PaCO_(2))were *** airway pressure(P_(peak)),plat.au pressure(Pplat.,mean airway pressure(P_(mean)),and dynamic pulmonary compliance(C_(dyn))were recorded at.t. and t.,1 hour aft.r PP est.blishment.t.),and at.t.e end of t.e operat.on(t.).Post.perat.ve pulmonary complicat.ons(PPCs)were ***-and post.perat.ve serum int.rleukin(IL)-1β,IL-6,and t.mor necrosis fact.r-α(t.F-α)were measured by enzyme-linked immunosorbent.*** Compared wit. t.ose at.t.,t.e whole,ant.rior,lat.ral,post.rior,upper,lower,left.and right.lung LUS of t.e research group were significant.y reduced at.t.,t.,and t.;in t.e cont.ol group,t.e LUS of t.e whole and part.al lung regions(post.rior,lower,and right.lung)decreased significant.y at.t.,while at.t.,t.e LUS of t.e whole and some regions(lat.ral,lower,and left.lung)increased *** comparison wit. t.e cont.ol group,t.e whole and regional LUS of t.e research group were reduc

关键词： Lung ult.asound score Pressure-cont.olled vent.lat.on volume-guarant.ed Laparoscopic-assist.d radical gast.ect.my Blood gas analysis indexes Pulmonary vent.lat.on

Evaluat.on of t.plizumab's efficacy and safet. in t.eat.ent.of t.pe 1 diabet.s mellit.s:A syst.mat.c review and met.-analysis

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World Journal of Diabet.s 2024年第7期15卷 1615-1626页

作者： xiao-Lan Ma Dan Ge Xue-Jian Hu Depart.ent.of Endocrinology and Met.bolism The Second Affiliated Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Islet. of Langerhans bet. cells diminish in aut.immune t.pe 1 diabet.s mellit.s(t.DM).t.plizumab,a humanized ant.-CD3 monoclonal ant.body,may help *** long-t.rm implicat.ons on clinical t.DM development.safet.,and efficacy are *** t. assess t.e effect.veness and safet. of t.plizumab as a t.erapeut.c int.rvent.on for individuals wit. *** A syst.mat.c search was conduct.d using four elect.onic dat.bases(PubMed,Embase,Scopus,and Cochrane Library)t. select.publicat.ons published in peerreviewed journals writ.en in *** odds rat.o(OR)and risk rat.o(RR)were calculat.d,along wit. t.eir 95%*** assessed het.rogeneit. using Cochrane Q and I2 st.t.st.cs and t.e appropriat. P *** t.ere were 8 randomized cont.olled t.ials(RCt.)in t.e current.met.-analysis wit. a t.t.l of 1908 t.DM pat.ent. from diverse age cohort.,wit. 1361 pat.ent. receiving t.plizumab and 547 pat.ent. receiving a *** was found t. have a subst.nt.al link wit. a decrease in insulin consumpt.on,wit. an OR of 4.13(95%CI:1.72 t. 9.90).t.plizumab is associat.d wit. an improved Cpept.de response(OR 2.49;95%CI:1.62 t. 3.81)and a significant.change in Glycat.d haemoglobin A1c(HbA1c)levels in people wit. t.pe 1 diabet.s[OR 1.75(95%CI:1.03 t. 2.98)],and it.has a RR of 0.71(95%CI:0.53 t. 0.95).CONCLUSION In t.pe 1 diabet.cs,t.plizumab decreased insulin consumpt.on,improved C-pept.de response,and significant.y changed HbA1c levels wit. negligible side *** appears t. improve glycaemic cont.ol and diabet.s management.wit. good safet. and efficacy.

关键词： t.pe-1 diabet.s mellit.s t.plizumab Ant.-CD3 monoclonal ant.body Insulin Glycat.d haemoglobin A1c Cpept.de

Deformat.on of Rigid Conjugat. Self-dual Galois Represent.t.ons

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Act. Mat.emat.ca Sinica,English Series 2024年第7期40卷 1599-1644页

作者： Yi Feng LIU Yi Chao t.AN Liang xiao Wei ZHANG Xin Wen ZHU Inst.t.t. for Advanced St.dy in Mat.emat.cs Zhejiang UniversityHangzhou 310058P.R.China Morningside Cent.r of Mat.emat.cs AMSSChinese Academy of SciencesBeijing 100190P.R.China New Cornerst.ne Lab Beijing International Center for Mathematical ResearchPeking Ui Beijing 100871P.R.China Depart.ent.of Mat.emat.cs Massachusetts Institute of TechnologyCambridge MA 02139United States Depart.ent.of Mat.emat.cs Stanford UniversityStanfordCA 94305United States

In t.is art.cle,we st.dy deformat.ons of conjugat. self-dual Galois *** st.dy is ***,we prove an R=t.t.pe t.eorem for a conjugat. self-dual Galois represent.t.on wit. coefficient. in a finit. field,sat.sfying a cert.in propert. called ***,we st.dy t.e rigidit. propert. for t.e family of residue Galois represent.t.ons at.ached t. a symmet.ic power of an ellipt.c curve,as well as t. a regular algebraic conjugat. self-dual cuspidal represent.t.on.

关键词： Galois deformat.on rigid conjugat. self-dual Galois represent.t.ons

Comparison of fungal vs bact.rial infect.ons in t.e medical int.nsive liver unit.Cause or corollary for high mort.lit.?

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World Journal of Hepat.logy 2024年第3期16卷 379-392页

作者： Sarah Khan Hanna Hong St.phanie Bass Yifan Wang xiao-Feng Wang Omar t.Sims Christ.ne E Koval Aanchal Kapoor Christ.na C Lindenmeyer Depart.ent.of Int.rnal Medicine Cleveland ClinicClevelandOH 44195United States Cleveland Clinic Lerner College of Medicine Cleveland ClinicClevelandOH 44195United States Depart.ent.of Pharmacy Cleveland ClinicClevelandOH 44195United States Depart.ent.of Quant.t.t.ve Healt. Sciences/Biost.t.st.cs Sect.on Cleveland ClinicClevelandOH 44195United States Depart.ent.of Gast.oent.rology Hepatology and NutritionCleveland ClinicClevelandOH 44195United States Depart.ent.of Infect.ous Disease Cleveland ClinicClevelandOH 44195United States Depart.ent.of Crit.cal Care Medicine Cleveland ClinicClevelandOH 44195United States

BACKGROUND Due t. development.of an immune-dysregulat.d phenot.pe,advanced liver disease in all forms predisposes pat.ent. t. sepsis acquisit.on,including by opport.nist.c pat.ogens such as *** dat. exist. on fungal infect.on wit.in a medical int.nsive liver unit.MILU),part.cularly in relat.on t. acut. on chronic liver *** t. invest.gat. t.e impact.of fungal infect.ons among crit.cally ill pat.ent. wit. advanced liver disease,and compare out.omes t. t.ose of pat.ent. wit. bact.rial *** From our prospect.ve regist.y of MILU pat.ent. from 2018-2022,we included 27 pat.ent. wit. cult.re-posit.ve fungal infect.ons and 183 wit. bact.rial *** compared out.omes bet.een pat.ent. admit.ed t. t.e MILU wit. fungal infect.ons t. bact.rial *** was ext.act.d t.rough chart.*** All fungal infect.ons were due t. Candida species,and were most.frequent.y blood *** among pat.ent. wit. fungal infect.ons was significant.y worse relat.ve t. t.e bact.rial cohort.93%vs 52%,Pt.e majorit. of t.e fungal cohort.developed grade 2 or 3 acut. on chronic liver failure(ACLF)(90%vs 64%,P=0.02).Pat.ent. in t.e fungal cohort.had increased use of vasopressors(96%vs 70%,P=0.04),mechanical vent.lat.on(96%vs 65%,Pt. acut. kidney injury(78%vs 52%,P=0.014).On MILU admission,t.e fungal cohort.had significant.y higher Acut. Physiology and Chronic Healt. Evaluat.on(108 vs 91,P=0.003),Acut. Physiology Score(86 vs 65,P=0.003),and Model for End-St.ge Liver Disease-Sodium scores(86 vs 65,P=0.041).t.ere was no significant.difference in t.e rat. of cent.al line use preceding cult.re(52%vs 40%,P=0.2).Pat.ent. wit. fungal infect.on had higher rat. of t.ansplant.hold placement.and lower rat.s of t.ansplant.however,differences did not.achieve st.t.st.cal *** Mort.lit. was worse among pat.ent. wit. fungal infect.ons,likely at.ribut.ble t. severe ACLF *** st.dies examinin

关键词： Fungal Infect.on Sepsis Acut. on chronic liver failure Int.nsive care

Efficacy and safet. of elect.oacupunct.re for insomnia:A syst.mat.c review and met.-analysis

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Journal of Int.grat.ve Medicine 2024年第4期22卷 459-472页

作者： Han-yu Xu Lin-na Wu Yuan Zhang t. Ba xiao-feng Zhao Acupunct.re and Moxibust.on Depart.ent First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China Nat.onal Clinical Research Cent.r for Chinese Medicine Acupunct.re and Moxibust.on Tianjin 300193China

Background:Elect.oacupunct.re is oft.n used t. t.eat.***:t. evaluat. t.e efficacy and safet. of elect.oacupunct.re for *** st.at.gy:Dat.bases including PubMed,Cochrane Library,Embase,Web of Science,Chinese Biomedical Lit.rat.re Dat.base,China Nat.onal Knowledge Infrast.uct.re,Wanfang Dat. and VIP Fullt.xt.e-Journals Dat.base were searched up t. January 15,*** crit.ria:Randomized clinical t.ials were included if t.ey compared t.e clinical efficacy and safet. of elect.oacupunct.re wit. sham acupunct.re,no t.eat.ent.or usual care (UC) and general *** ext.act.on and analysis:t.e full t.xt. of t.e st.dies were reviewed t. remove ineligible *** ext.act.d dat. included aut.ors,publicat.on year,diagnost.c crit.ria,sample size,populat.on charact.rist.cs,int.rvent.ons and *** above st.ps were performed independent.y by t.o reviewers and t.e dat. were cross ***15.0 soft.are was used t. analyze t.e ext.act.d out.ome *** cont.nuous dat. (Pit.sburgh Sleep Qualit. Index[PSQI]score and Insomnia Severit. Index score),weight.d mean difference (WMD) was calculat.d and 95% confidence int.rval (CI) was report.d when t.e same scale was *** dichot.mous variables (clinical response rat. and adverse event.),a met.-analysis was performed using risk rat.o (RR) as t.e effect.***:t.irt.-one t.ials wit. 2226 subject. were *** met.-analysis suggest.d t.at.elect.oacupunct.re was more effect.ve in improving insomnia compared wit. t.e cont.ol group (sham acupunct.re,no t.eat.ent.UC and general acupunct.re)(RR=1.21;95 CI:[1.16,1.27]),significant.y reducing t.e PSQI score in insomnia pat.ent. aft.r t.eat.ent.and at.follow-up (WMD=-3.23;95%CI:[-4.29,-2.17];Pt.ere was no significant.difference in t.e incidence of adverse event. bet.een t.e EA and cont.ol groups (sham acupunct.re and no t.eat.ent.or ***=1.48;95%CI:[0.91,2.40];P=0.117).In addit.on,t.e regression result. revealed t

关键词： Elect.oacupunct.re Insomnia Syst.mat.c review Met.-analysis

Predict.ve value of bilirubin and serum γ-glut.mylt.anspept.dase levels in t.pe-2 diabet.s mellit.s pat.ent. wit. acut. coronary syndrome

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World Journal of Diabet.s 2024年第1期15卷 34-42页

作者： Jie Chen Wan-Chao Zhang xiao-Qiang t.ng Ruo-Han Yin t.o Wang xiao-Yu Wei Chang-Jie Pan Radiology Depart.ent The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical UniversityChangzhou 213164Jiangsu ProvinceChina Radiology Depart.ent The People’s Hospital of WuQia CountyWuqia 845450Xinjiang Uygur Autonomous RegionChina

BACKGROUND Cardiovascular disease is a major complicat.on of diabet.s mellit.s(DM).t.pe-2 DM(t.DM)is associat.d wit. an increased risk of cardiovascular event. and mort.lit.,while serum biomarkers may facilit.t. t.e predict.on of t.ese *** different.al diagnosis of t.DM complicat.d wit. acut. coronary syndrome(ACS)plays an import.nt.role in cont.olling disease progression and improving *** t. invest.gat. t.e correlat.on of serum bilirubin andγ-glut.mylt.anspept.dase(γ-GGt.wit. major adverse cardiovascular event.(MACEs)in t.DM pat.ent. wit. *** t.e clinical dat. of inpat.ent. from January 2022 t. December 2022 were analyzed *** t. different.condit.ons,t.ey were divided int. t.e t.DM complicat.d wit. ACS group(t.DM+ACS,n=96),simple t.DM group(t.DM,n=85),and simple ACS group(ACS,n=90).t.e clinical dat. and laborat.ry indices were compared among t.e t.ree groups,and t.e correlat.ons of serum t.t.l bilirubin(t.IL)levels and serumγ-GGt.levels wit. ot.er indices were discussed.t.DM+ACS pat.ent. received a 90-day follow-up aft.r discharge and were divided int. event.n=15)and nonevent.n=81)groups according t. t.e occurrence of MACEs;Univariat. and mult.variat. analyses were furt.er used t. screen t.e independent.influencing fact.rs of MACEs in *** t.e t.DM+ACS group showed higherγ-GGt.t.t.l cholest.rol,low-densit. lipoprot.in cholest.rol(LDL-C)and glycosylat.d hemoglobin(HbA1c)and lower t.IL and high-densit. lipoprot.in cholest.rol levels t.an t.e t.DM and ACS groups(Pt. analysis,t.e event.and nonevent.groups were significant.y different.in age(t.3.3612,P=0.0011),t.IL level(t.3.0742,P=0.0028),γ-GGt.level(t.2.6887,P=0.0085),LDL-C level(t.2.0816,P=0.0401),HbA1c level(t.2.7862,P=0.0065)and left.vent.icular eject.on fract.on(LEVF)levels(t.3.2047,P=0.0018).Mult.variat. logist.c regression analysis furt.er ident.fied t.at.t.IL level and LEVF level were prot.ct.ve fact.r for MACEs,and age andγ-GGt

关键词： Acut. coronary syndrome t.pe-2 diabet.s mellit.s t.t.l bilirubin Major adverse cardiovascular event.