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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu xiao-Li Li xiao-Ting sun Li-Ting Wang Xia Wu Ling-Jie Zhu xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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FAST Continuum Mapping of the SNR VRO 42.05.01

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Research in Astronomy and Astrophysics 2022年第3期22卷 33-38页

作者： Li xiao Ming Zhu xiao-Hui sun Peng Jiang Chun sun National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Department of Astronomy Yunnan Universityand Key Laboratory of Astroparticle Physics of Yunnan ProvinceKunming 650091China

The relativistic electrons rotate in the enhanced magnetic field of the supernova remnants and emit the synchrotron radio *** aim to use the Five-hundred-meter Aperture Spherical radio Telescope(FAST)to obtain a sensitive continuum map of the supernova remnant VRO 42.05.01(G166.0+4.3)at 1240 *** 500 MHz bandwidth is divided into low and high-frequency bands centered at 1085 and 1383 MHz to investigate the spectral index variations within the remnant,together with the Effelsberg 2695 MHz *** obtained an integrated flux density of 6.2±0.4 Jy at 1240 MHz for VRO 42.05.01,consistent with previous *** spectral index found from temperature-temperature plot(TT-plot)between 1240 and 2695 MHz agrees with previous values from408 MHz up to 5 *** three-band spectral index distribution shows a clear flatter value ofα~-0.33 in the shell region and steeper index ofα=-0.36 to-0.54 in the wing *** flatter spectral index in the shell region could be attributed to a second-order Fermi process in the turbulent medium in the vicinity of the shock and/or a higher compression ratio of shock and a high post-shock density than that in elsewhere.

关键词： ISM:supernova remnants radio continuum:ISM methods:observational

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Existence of p-mean Almost Periodic Mild Solution for Fractional Stochastic Neutral Functional Differential Equation

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Acta Mathematicae Applicatae Sinica 2021年第3期37卷 645-656页

作者： xiao-ke sun Ping HE School of Mathematics Shanghai University of Finance and EconomicsShanghai200433China

A class of fractional stochastic neutral functional differential equation is analyzed in this *** the utilization of the fractional calculations,semigroup theory,fixed point technique and stochastic analysis theory,a sufficient condition of the existence for p-mean almost periodic solution is obtained,which are supported by two examples.

关键词： p-mean almost periodic solution fractional stochastic neutral functional differential equation fixed point theorem sectorial operator analytic semigroup

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Homogenization heat treatment of 2099 Al–Li alloy

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Rare Metals 2014年第1期33卷 28-36页

作者： Fei Zhang Jian Shen xiao-Dong Yan Jian-Lin sun xiao-Long sun Yin Yang Nonferrous Metals Processing Division General Research Institute for Nonferrous Metals School of Materials Science and Engineering University of Science and Technology Beijing

Abstract The microstructure evolution and composition distribution of as-cast and homogenized 2099 aluminumlithium （Al-Li） alloy were studied by optical microscopy （OM）, differential thermal analysis （DTA）, scanning electron microscopy （SEM）, energy dispersive spectrometry （EDS）, area and line scanning, X-ray diffraction （XRD）, and Vickers microhardness test methods. The results show that severe dendrite exists in the as-cast alloy. Cu, Zn, Mn, and Mg distribute unevenly from the grain boundary to inside. The low-melting point nonequilibrium eutectic phases dis- solve into the matrix during the first-step homogenization, whereas the melting point of residual eutectic phases is elevated. After the second-step homogenization, most of the remaining eutectic phases dissolve into the matrix, except a small amount of A1-Cu-Fe phases. An optimized homogenization process of the 2099 A1-Li alloy is developed （515℃ - 18 h ＋ 525℃ - 16 h）, which shows a good agreement with the homogenization kinetic analysis results.

关键词： 2099 A1-Li alloy Homogenization treatment Nonequilibrium eutectic Kinetic analysis

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Polarised radio emission associated with HESS J1912+101

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Research in Astronomy and Astrophysics 2019年第3期19卷 123-130页

作者： Wolfgang Reich xiao-Hui sun Max-Planck-Institut für Radioastronomie Department of Astronomy Yunnan Universityand Key Laboratory of Astroparticle Physics of Yunnan Province

The shell-type TeV source HESS J1912+101 was tentatively identified as an old supernova remnant, but is missing counterparts at radio and other frequencies. We analysed the Sino-German Urumqiλ6 cm survey and the Effelsberg λ11 cm and λ21 cm surveys to identify radio emission from HESS J1912+101 to clarify the question of a supernova origin. We find a partial shell of excessive polarisation at λ6 cm at the periphery of HESS J1912+101. At λ11 cm, its polarised emission is faint and suffers from depolarisation, while at λ21 cm, no related polarisation is seen. We could not separate the shell's total intensity signal from the confusing intense diffuse emission from the inner Galactic plane. However, a high percentage of polarisation in the shell's synchrotron emission is indicated. Our results support earlier suggestions that HESS J1912+101 is an old supernova remnant. The synchrotron emission is highly polarised,which is typical for evolved supernova remnants with low surface brightness.

关键词： radio continuum ISM-ISM individual objects HESS J1912+101-ISM magnetic fields

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Gnomon shadow lengths recorded in the Zhoubi Suanjing:the earliest meridian observations in China?

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Research in Astronomy and Astrophysics 2009年第12期9卷 1377-1386页

作者： Yong Li xiao-Chun sun National Astronomical Observatories Chinese： Academy of Sciences Beijing 100012 China Institute for the History of Natural Science Chinese Academy of Sciences Beijing 100010 China

The Zhoubi Suanjing, one of the most important ancient Chinese books on mathematical astronomy, was compiled about 100 BC in the Western Han dynasty （BC 206 - AD 23）. We study the gnomon shadow lengths for the 24 solar terms as recorded in the book. Special attention is paid to the so-called law of ‘cun qian li’, which says the shadow length of a gnomon of 8 chi （about 1.96 m） high will increase （or decrease） 1 cun （1/10chi） for every 10001i （roughly 400kin） the gnomon moves northward （or south- ward）. From these data, one can derive the time and location of the observations. The resuits, however, do not fit historical facts. We suggest that compilers of the Zhoubi Suanjing must have modified the original data according to the law of ‘cun qian li’. Through reversing the situation, we recovered the original data, our analysis of which reveals the best possible observation time as 564 BC and the location of observation as 35.78° N latitude. We conclude that this must be the earliest records of solar meridian observations in China. In the meantime, we give the errors of solar altitudes for the 24 solar terms. The average deviation is 5.22°, and the mean absolute deviation is 5.52°, signifying the accuracy of astronomical calculations from that time.

关键词： history and philosophy of astronomy -- solar meridian observation -- ac-curacy -- solar-terrestrial relations -- methods: statistical

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Impact of inter-particle collision on elbow erosion based on DSMC-CFD method

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Petroleum Science 2021年第3期18卷 909-922页

作者： xiao-Yang sun Xue-Wen Cao College of Pipeline and Civil Engineering China University of PetroleumQingdao 266580China

In this work,computational fuid dynamics(CFD)is used to study elbow erosion due to a gas-solid two-phase *** particular,the direct simulation Monte Carlo(DSMC)method is used to study the impact of inter-particle collision on the erosion *** two-way coupled Euler-Lagrange method is used to solve the gas-solid fow,and the DSMC method is used to consider the collision behavior between *** efects of key factors,such as the particle concentration distribution and inter-particle collision,on the erosion ratio are evaluated and *** efectiveness of the method is verifed from experimental *** results show that the inter-particle collision signifcantly infuences the particle movement path and erosion *** the inter-particle collision is considered,the maximum erosion position is *** erosion model proposed by Oka et al.,who used the DSMC method,agrees best with the experimental data,and the average percentage error decreases from 39.2 to 27.4%.

关键词： Elbow CFD DSMC Solid particle erosion Inter-particle collision

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Serotonin suppresses lung ILC2 activation and proliferation

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Cellular & Molecular Immunology 2023年第5期20卷 546-547页

作者： xiao-Hong sun Oklahoma Medical Research Foundation Program in Arthritis and Clinical ImmunologyOklahoma CityOKUSA

In recent issue, Wang et al. [1] reported the suppressive effects of serotonin (5-hydroxytryptamine, 5-HT) on the activation and proliferation of group 2 innate lymphoid cells (ILC2s) in the lungs. ILC2s belong to a family of newly appreciated immune cells with a broad impact on a variety of immunological functions [2]. In particular, ILC2 activation has been implicated in the pathophysiology of asthma [3]. Although serotonin is known to play important roles in diverse physiological functions in the body [4], the effects of serotonin on innate lymphoid cells are less understood. The findings described here could potentially establish a new therapeutic avenue for respiratory disorders.

关键词： al. activation finding

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Pointwise A Priori Estimates for Solutions to Some p-Laplacian Equations

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Acta Mathematica Sinica,English Series 2022年第12期38卷 2150-2162页

作者： xiao Qiang sun Ji Guang BAO School of Mathematics Sun Yat-sen UniversityGuangzhou 510275P.R.China School of Mathematical Sciences Beijing Normal UniversityLaboratory of Mathematics and Complex SystemsMinistry of EducationBeijing 100875P.R.China

In this article,we apply blow-up analysis to study pointwise a priori estimates for some p-Laplacian equations based on Liouville type *** newly developed analysis techniques,we first extend the classical results of interior gradient estimates for the harmonic function to that for the p-harmonic function,i.e.,the solution ofΔpu=0,x∈Ω.We then obtain singularity and decay estimates of the sign-changing solution of Lane-Emden-Fowler type p-Laplacian equation-Δp^(u)=|u|^(λ-1)u,x∈Ω,which are then extended to the equation with general right hand term f(x,u)with certain asymptotic *** addition,point wise estimates for higher order derivatives of the solution to Lane-Emden type p-Laplacian equation,in a case of p=2,are also discussed.

关键词： Priori estimates Blow-up analysis p-Laplacian

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An algorithm of image segmentation for overlapping grain image

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光学精密工程 2005年第5期13卷 592-598页

作者： WANG Zhi JIN Guang sun xiao-wei Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of SciencesChangchun 130033 China Graduate School of Chinese Academy of Sciences Beijing 100039 China

Aiming at measurement of granularity size of nonmetal grain, an algorithm of image segmentation and parameter calculation for microscopic overlapping grain image was studied. This algorithm presents some new attributes of graph sequence from discrete attribute of graph,and consequently achieves the geometrical characteristics from input graph, and the new graph sequence in favor of image segmentation is recombined. The conception that image edge denoted with “twin-point” is put forward, base on geometrical characters of point, image edge is transformed into serial edge, and on recombined serial image edge, based on direction vector definition of line and some additional restricted conditions, the segmentation twin-points are searched with, thus image segmentation is accomplished. Serial image edge is transformed into twin-point pattern, to realize calculation of area and granularity size of nonmetal grain. The inkling and uncertainty on selection of structure element which base on mathematical morphology are avoided in this algorithm, and image segmentation and parameter calculation are realized without changing grain’s self statistical characters.

关键词：图象分割脉冲神经网络人工神经网络模式识别周期性差异

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