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Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin Zhang Guangyu Yang Lei xiao Zhiyong Kan Jing Guo qiang li Wanqi Jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms

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刑事附带民事诉讼面临困境和对策的思考——基于宜宾市刑事附带民事诉讼案件的实证调查

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西华大学学报（哲学社会科学版） 2009年第2期28卷 90-95页

作者：肖乾利国建代松宜宾学院法学系四川宜宾644007 宜宾市人民检察院四川宜宾644002

我国刑事附带民事诉讼案件存在受案范围小、争议难点多、执行到位率低、检察机关提起偏少等缺陷,为完善这一制度,应将精神损害纳入附带民事诉讼赔偿范围,明确检察机关在其提起的附带民事诉讼案件中的法律地位,增设刑事被害人国家补偿制度。

关键词：刑事附带民事诉讼精神损害赔偿刑事被害人国家补偿

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高校心理学实验室建设存在的问题及发展对策

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扬州大学学报（高教研究版） 2008年第6期12卷 87-89页

作者：姜子云钱小莉扬州大学教育科学学院江苏扬州225002

心理学实验室的建设刚起步,其发展滞后于心理学专业的发展,且存在实验室模式雷同、实验教学师资力量短缺等问题。要加大资金投入,加强实验队伍建设,推进实验教学改革,建设有自身特色的心理学实验室。

关键词：心理学实验室心理学实验室建设心理测评系统

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国有企业资产减值会计实务研究

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辽宁财专学报 2002年第4期4卷 24-26页

作者：陈玉清钱小丽东北大学辽宁沈阳110004

随着《企业会计制度》的发布和实施 ,资产减值会计的推行势在必行。本文通过分析国有企业目前的资产减值状况 ,提出了国有企业应充分利用此次制度改革之契机 ,彻底清除企业的不良资产 ,正确理解和实施资产减值会计的观点。另外 ,本文还... 详细信息

随着《企业会计制度》的发布和实施 ,资产减值会计的推行势在必行。本文通过分析国有企业目前的资产减值状况 ,提出了国有企业应充分利用此次制度改革之契机 ,彻底清除企业的不良资产 ,正确理解和实施资产减值会计的观点。另外 ,本文还为国有企业的资产管理问题提供了管理建议。

关键词：资产减值账面价值现时价值计量标准国有企业资产减值会计实务研究

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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong li Hui-Min Xing Hai-Dong qian Qiao Gao Sheng-Lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

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Recent Strategies and Advances in Hydrogel-Based Delivery Platforms for Bone Regeneration

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NANO-MICRO LETTERS 2025年第1期17卷 1-51页

作者： Wang, xiao Zeng, Jia Gan, Donglin ling, Kun He, Mingfang li, Jianshu Lu, Yongping Guangyuan Cent Hosp Sci & Technol Innovat Ctr Biomed Mat & Clin Res Guangyuan Key Lab Multifunct Med Hydrogel Guangyuan 628000 Peoples R China Nanjing Normal Univ Jiangsu Collaborat Innovat Ctr Biomed Funct Mat Sch Chem & Mat Sci Jiangsu Key Lab Biofunct Mat Nanjing 210023 Peoples R China Sichuan Univ Coll Polymer Sci & Engn State Key Lab Polymer Mat Engn Chengdu 610065 Peoples R China

Recent advances in the combined delivery platform that integrate nano-/microscale carriers and with 3D hydrogel network for bone regeneration are *** strategies for bioactive molecules delivery involving nanoparticles, nanosheets, and microspheres, along with extra stimuli such as near-infrared light, temperature changes, ultrasonication, and inflammatory conditions, are *** prospects and challenges for the clinical translation and the development of nano-/microscale incorporated hydrogel-based delivery platform are discussed. Bioactive molecules have shown great promise for effectively regulating various bone formation processes, rendering them attractive therapeutics for bone regeneration. However, the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in vivo. Hydrogels have emerged as ideal carriers to address these challenges, offering the potential to prolong retention times at lesion sites, extend half-lives in vivo and mitigate side effects, avoid burst release, and promote adsorption under physiological conditions. This review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration, encompassing applications in cranial defect repair, femoral defect repair, periodontal bone regeneration, and bone regeneration with underlying diseases. Additionally, this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery, carrier-assisted delivery, and sequential delivery. Finally, this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

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肝癌血供灌注特征与个体化介入治疗相关性的超声造影研究

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中华超声影像学杂志 2010年第11期19卷 948-951页

作者：司芩钱晓莉刘绪舜黄艳丽李增才杨璐全军肿瘤中心、肝病中心解放军第八一医院超声科南京210002 全军肿瘤中心、肝病中心解放军第八一医院普通外科南京210002 全军肿瘤中心、肝病中心解放军第八一医院肿瘤外科南京210002

目的探讨不同类型肝癌的血供特点及确立个体化介入治疗模式的价值.方法对315例经病理证实的肝癌应用彩色多普勒超声（CDUS）及超声造影（CEUS）行血供灌注特征分析并分型,采用不同介入治疗技术建立合理有效的个体化联合治疗模式,并采... 详细信息

目的探讨不同类型肝癌的血供特点及确立个体化介入治疗模式的价值.方法对315例经病理证实的肝癌应用彩色多普勒超声（CDUS）及超声造影（CEUS）行血供灌注特征分析并分型,采用不同介入治疗技术建立合理有效的个体化联合治疗模式,并采用CEUS、增强CT（CECT）、数字减影血管造影（DSA）进行疗效评估.结果 CDUS及CEUS可判定肝癌血供特征并分型.根据CDUS及CEUS确定的肝癌血供特征建立个体化介入治疗模式并评估疗效：①肿瘤直径≤3 cm单发小肝癌组,直接行无水酒精瘤内注射术（PEI）、射频消融术（RF）或微波消融术（PMCT）治疗模式,肿瘤坏死率95.0%～97.9%,1、3年生存率分别为98.0%、87.8%.②肿瘤直径≤5 cm病灶≤3个肝癌组,行多点、多面RF/PMCT＋PEI联合治疗模式,肿瘤坏死率93.7%～94.8%,1、3年生存率分别为89.8%、81.4%.③肿瘤直径＞5 cm以肝动脉为主多血供肝癌组,行肝动脉栓塞化疗术（TACE）＋PEI＋RF/PMCT联合治疗模式,肿瘤坏死率71.4%～73.8%,1、3年生存率分别为66.2%、47.6%.④肿瘤直径＞5 cm双重血供肝癌或合并门静脉癌栓组,在以上治疗基础上增加选择性门静脉栓塞化疗术（SPVE）治疗模式,肿瘤坏死率53.3%～55.6%,1、3年生存率分别为64.7%、40.0%.结论根据CDUS和CEUS确定肝癌血供特征并建立个体化联合介入治疗模式,对非手术治疗肝癌具有重要的临床价值.

关键词：超声检查微气泡肝肿瘤肿瘤治疗方案

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Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： ling-xiao Yi Hui Ren Woon Genevieve Saw li Zeng Eng King Tan Zhi Dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

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Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： xiao-xiao Zhang li Jia Xiu-Jun Zhan Charity Ngina Qing-Rui Zhang xiao-Ge li Qi-Bao Jiang Shi Bai Miao-Miao Jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

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外源寡核苷酸对大肠杆菌和双歧杆菌生长的影响

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中国海洋大学学报（自然科学版） 2017年第11期47卷 31-39页

作者：高晓梦苏健王晓倩李玉芝孔青董平梁兴国中国海洋大学食品科学与工程学院山东青岛266003 山东省莱阳市第九中学山东烟台265200

为研究外源寡核苷酸对2种典型肠道菌—双歧杆菌(Bifidobacterium adolescentis)和大肠杆菌(Escherichia coli)的影响,向核酸营养缺乏型的培养基中分别添加39和61nt的2种寡核苷酸,利用平板菌落计数和16SrDNA定量法比较了外源核酸对双歧... 详细信息

为研究外源寡核苷酸对2种典型肠道菌—双歧杆菌(Bifidobacterium adolescentis)和大肠杆菌(Escherichia coli)的影响,向核酸营养缺乏型的培养基中分别添加39和61nt的2种寡核苷酸,利用平板菌落计数和16SrDNA定量法比较了外源核酸对双歧杆菌和大肠杆菌单独生长及2种细菌混合生长的影响。研究显示,虽然添加2种外源寡核苷酸对单独培养的2种细菌的生长都有不同程度的促进效果,但对于混合培养的2种细菌,大肠杆菌的生长会因双歧杆菌的生长而受到一定的抑制,当大肠杆菌和双歧杆菌比例增加到1∶10时,大肠杆菌生长的抑制率可达到27.7%。结果表明,肠道微生物可以通过降解本研究中的2种寡核苷酸,达到主动利用外源的核酸类物质、促进自身生长的目的,体外实验结果预示,一些特殊序列的寡核苷酸可能对改善肠道菌群的平衡具有潜在的积极作用。

关键词：寡核苷酸肠道微生物双歧杆菌大肠杆菌

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